Reference on EC 1.13.11.31 - arachidonate 12-lipoxygenase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Matsuda, S.; Suzuki, H.; Yoshimoto, T.; Yamamoto, S.; Miyatake, A.
Analysis of non-heme iron in arachidonate 12-lipoxygenase of porcine leukocytes
Biochim. Biophys. Acta
1084
202-204
1991
Sus scrofa
Hada, T.; Ueda, N.; Takahashi, Y.; Yamamoto, S.
Catalytic properties of human platelet 12-lipoxygenase as compared with the enzymes of other origins
Biochim. Biophys. Acta
1083
89-93
1991
Bos taurus, Homo sapiens, Sus scrofa
Van der Donk, E.M.M.; Dubois, G.R.; Verhagen, J.; Veldink, G.A.; Vliegenhart, J.F.G.
Improved purification of 12-lipoxygenase from rat basophilic leukemia cells and conditions for optimal enzyme activity
Biochim. Biophys. Acta
1074
443-447
1991
Rattus norvegicus
Van der Donk, E.M.M.; Verhagen, J.; Veldink, G.A.; Vliegenhart, J.F.G.
12-Lipoxygenase from rat basophilic leukemia cells: separation from 5-lipoxygenase and temperature-dependent inactivation by hydroperoxy fatty acid
Biochim. Biophys. Acta
1081
135-140
1991
Rattus norvegicus
Kroneck, P.M.H.; Cucurou, C.; Ullrich, V.; Ueda, N.; Suzuki, H.; Yoshimoto, T.; Matsuda, S.; Yamamoto, S.
Porcine leukocyte 5- and 12-lipoxygenases are iron enzymes
FEBS Lett.
287
105-107
1991
Sus scrofa
Hansbrough, J.R.; Takahashi, Y.; Ueda, N.; Yamamoto, S.; Holtzman, M.J.
Identification of a novel arachidonate 12-lipoxygenase in bovine tracheal epithelial cells distinct from leukocyte and platelet forms of the enzyme
J. Biol. Chem.
265
1771-1776
1990
Bos taurus
Labelle, M.; Falgueyret, J.P.; Riendeau, D.; Rokach, J.
Synthesis of two analogues of arachidonic acid and their reactions with 12-lipoxygenase
Tetrahedron
46
6301-6310
1990
Sus scrofa
-
Brash, A.R.; Yokoyama, C.; Oates, J.A.; Yamamoto, S.
Mechanistic studies of the dioxygenase and leukotriene synthase activities of the porcine leukocyte 12S-lipoxygenase
Arch. Biochem. Biophys.
273
414-422
1989
Sus scrofa
Takahashi, Y.; Ueda, N.; Yamamoto, S.
Two immunologically and catalytically distinct arachidonate 12-lipoxygenases of bovine platelets and leukocytes
Arch. Biochem. Biophys.
266
613-621
1988
Bos taurus
Yokoyama, C.; Shinjo, F.; Yoshimoto, T.; Yamamoto, S.; Oates, J.A.; Brash, A.R.
Arachidonate 12-lipoxygenase purified from porcine leukocytes by immunoaffinity chromatography and its reactivity with hydroperoxyeicosatetraenoic acids
J. Biol. Chem.
261
16714-16721
1986
Sus scrofa
Ueda, N.; Yokoyama, C.; Yamamoto, S.; Fitzsimmons, B.J.; Rokach, J.; Oates, J.A.; Brash, A.R.
Lipoxin synthesis by arachidonate 12-lipoxygenase purified from porcine leukocytes
Biochem. Biophys. Res. Commun.
149
1063-1069
1987
Sus scrofa
Shinjo, F.; Yoshimoto, T.; Yokoyama, C.; Yamamoto, S.; Izumi, S.I.; Komatsu, N.; Watanabe, K.
Studies on porcine arachidonate 12-lipoxygenase using its monoclonal antibodies
J. Biol. Chem.
261
3377-3381
1986
Sus scrofa
Flatman, S.; Hurst, J.S.; McDonald-Gibson, R.G.; Jonas, G.E.G.; Slater, T.F.
Biochemical studies on a 12-lipoxygenase in human uterine cervix
Biochim. Biophys. Acta
883
7-14
1986
Homo sapiens
German, J.B.; Kinsella, J.E.
Production of trihydroxy derivatives of arachidonic and docosahexanoic acid by lipoxygenase activity in trout gill tissue
Biochim. Biophys. Acta
877
290-298
1986
Salmo sp.
-
German, J.B.; Bruckner, G.G.; Kinsella, J.E.
Lipoxygenase in trout gill tissue acting on arachidonic, eicosapentaenoic and docosahexaenoic acids
Biochim. Biophys. Acta
875
12-20
1986
Salmo sp.
Hamasaki, Y.; Tai, H.H.
Gossypol, a potent inhibitor of arachidonate 5- and 12-lipoxygenases
Biochim. Biophys. Acta
834
37-41
1985
Rattus norvegicus
Mitchell, P.D.; Hallam, C.; Hemsley, P.E.; Lord, G.H.; Wilkinson, D.
Inhibition of platelet 12-lipoxygenase by hydroxy-fatty acids
Biochem. Soc. Trans.
12
839-841
1984
Homo sapiens
-
Hamasaki, Y.; Tai, H.H.
Calcium stimulation of a novel 12-lipoxygenase from rat basophilic leukemia (RBL-1) cells
Biochim. Biophys. Acta
793
393-398
1984
Rattus norvegicus
Yokoyama, C.; Mizuno, K.; Mitachi, H.; Yoshimoto, T.; Yamamoto, S.
Partial purification and characterization of arachidonate 12-lipoxygenase from rat lung
Biochim. Biophys. Acta
750
237-243
1983
Rattus norvegicus
Yoshimoto, T.; Miyamoto, Y.; Ochi, K.; Yamamoto, S.
Arachidonate 12-lipoxygenase of porcine leukocyte with activity for 5-hydroxyeicosatetraenoic acid
Biochim. Biophys. Acta
713
638-646
1982
Sus scrofa
Nugteren, D.H.
Arachidonic acid-12-lipoxygenase from bovine platelets
Methods Enzymol.
86
49-54
1982
Bos taurus
Wallach, D.P.; Brown, V.R.
A novel preparation of human platelet lipoxygenase. Characteristics and inhibition by a variety of phenyl hydrazones and comparisons with other lipoxygenases
Biochim. Biophys. Acta
663
361-372
1981
Homo sapiens
Koshihara, Y.; Mizumura, M.; Murota, S.I.
Predominant synthesis of 5-hydroxyeicosatetraenoic acid by a cloned mastocytoma P-815 line, 2-E-6 cells
Biochim. Biophys. Acta
712
42-47
1982
Mus musculus
Reddy, G.R.; Ueda, N.; Suzuki, T.; Yamamoto, S.; Ishimura, K.; Kawada, N.; Mizoguchi, Y.
Characterization of arachidonate 12-lipoxygenase found in the liver of mongrel dog and its immunohistochemical localization in neutrophils
Tokushima J. Exp. Med.
42
27-35
1995
Canis lupus familiaris
McDonnell, M.; Davis, W.; Li, H.; Funk, C.D.
Characterization of the murine epidermal 12/15-lipoxygenase
Prostaglandins Other Lipid Mediat.
63
93-107
2001
Mus musculus
Coffa, G.; Hill, E.M.
Discovery of an 11(R)- and 12(S)-lipoxygenase activity in ovaries of the mussel Mytilus edulis
Lipids
35
1195-1204
2000
Mytilus edulis
Richards, K.M.; Marnett, L.J.
Leukocyte 12-lipoxygenase: Expression, purification, and investigation of the role of methionine residues in turnover-dependent inactivation and 5,8,11,14-eicosatetraynoic acid inhibition
Biochemistry
36
6692-6699
1997
Sus scrofa
Krieg, P.; Kinzig, A.; Ress-Lschke, M.; Vogel, S.; Vanlandingham, B.; Stephan, M.; Lehmann, W.D.; Marks, F.; Furstenberger, G.
12-Lipoxygenase isoenzymes in mouse skin tumor development
Mol. Carcinog.
14
118-129
1995
Homo sapiens, Mus musculus
Hada, T.; Hagiya, H.; Suzuki, H.; Arakawa, T.; Nakamura, M.; Matsuda, S.; Yoshimoto, T.; Yamamoto, S.; Azekawa, T.; Morita, Y.; et al.
Arachidonate 12-lipoxygenase of rat pineal glands: catalytic properties and primary structure deduced from its cDNA
Biochim. Biophys. Acta
1211
221-228
1994
Rattus norvegicus
Reddy, R.G.; Yoshimoto, T.; Yamamoto, S.; Funk, C.D.; Marnett, L.J.
Expression of porcine leukocyte 12-lipoxygenase in a baculovirus/insect cell system and its characterization
Arch. Biochem. Biophys.
312
219-226
1994
Sus scrofa
Moody, J.S.; Marnett, L.J.
Kinetics of Inhibition of Leukocyte 12-Lipoxygenase by the Isoform-Specific Inhibitor 4-(2-Oxapentadeca-4-yne)phenylpropanoic Acid
Biochemistry
41
10297-10303
2002
Sus scrofa
Lomnitski, L.; Sklan, D.; Grossman, S.
Lipoxygenase activity in rat dermis and epidermis: partial purification and characterization
Biochim. Biophys. Acta
1255
351-359
1995
Rattus norvegicus
Richards, K.M.; Moody, J.S.; Marnett, L.J.
Mechanism of Inhibition of Porcine Leukocyte 12-Lipoxygenase by the Isoform-Specific Inhibitor 4-(2-Oxapentadeca-4-yne)phenylpropanoic Acid
Biochemistry
38
16529-16538
1999
Sus scrofa
Nie, D.; Tang, K.; Diglio, C.; Honn, K.V.
Eicosanoid regulation of angiogenesis: role of endothelial arachidonate 12-lipoxygenase
Blood
95
2304-2311
2000
Homo sapiens, Mus musculus, Rattus norvegicus
Shornick, L.P.; Holtzman, M.J.
A cryptic, microsomal-type arachidonate 12-lipoxygenase is tonically inactivated by oxidation-reduction conditions in cultured epithelial cells
J. Biol. Chem.
268
371-376
1993
Ovis aries
Siebert, M.; Krieg, P.; Lehmann, W.D.; Marks, F.; Furstenberger, G.
Enzymic characterization of epidermis-derived 12-lipoxygenase isoenzymes
Biochem. J.
355
97-104
2001
Mus musculus
Takahashi, Y.; Reddy, G.R.; Ueda, N.; Yamamoto, S.; Arase, S.
Arachidonate 12-lipoxygenase of platelet-type in human epidermal cells
J. Biol. Chem.
268
16443-16448
1993
Homo sapiens
Pratico, D.; Zhukareva, V.; Yao, Y.; Uryu, K.; Funk, C.D.; Lawson, J.A.; Trojanowski, J.Q.; Lee, V.M.
12/15-lipoxygenase is increased in Alzheimer's disease: possible involvement in brain oxidative stress
Am. J. Pathol.
164
1655-1662
2004
Homo sapiens
Prasad, K.M.; Thimmalapura, P.R.; Woode, E.A.; Nadler, J.L.
Evidence that increased 12-lipoxygenase expression impairs pancreatic beta cell function and viability
Biochem. Biophys. Res. Commun.
308
427-432
2003
Mus musculus
Segraves, E.N.; Holman, T.R.
Kinetic investigations of the rate-limiting step in human 12- and 15-lipoxygenase
Biochemistry
42
5236-5243
2003
Homo sapiens
Chen, C.J.; Huang, H.S.; Chang, W.C.
Depletion of phospholipid hydroperoxide glutathione peroxidase up-regulates arachidonate metabolism by 12(S)-lipoxygenase and cyclooxygenase 1 in human epidermoid carcinoma A431 cells
FASEB J.
17
1694-1696
2003
Homo sapiens
Gronert, K.; Maheshwari, N.; Khan, N.; Hassan, I.R.; Dunn, M.; Laniado Schwartzman, M.
A role for the mouse 12/15-lipoxygenase pathway in promoting epithelial wound healing and host defense
J. Biol. Chem.
280
15267-15278
2005
Mus musculus
Senger, T.; Wichard, T.; Kunze, S.; Gobel, C.; Lerchl, J.; Pohnert, G.; Feussner, I.
A multifunctional lipoxygenase with fatty acid hydroperoxide cleaving activity from the moss Physcomitrella patens
J. Biol. Chem.
280
7588-7596
2005
Physcomitrium patens (Q70EX8), Physcomitrium patens
Segraves, E.N.; Shah, R.R.; Segraves, N.L.; Johnson, T.A.; Whitman, S.; Sui, J.K.; Kenyon, V.A.; Cichewicz, R.H.; Crews, P.; Holman, T.R.
Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase
J. Med. Chem.
47
4060-4065
2004
Homo sapiens
Feinmark, S.J.; Begum, R.; Tsvetkov, E.; Goussakov, I.; Funk, C.D.; Siegelbaum, S.A.; Bolshakov, V.Y.
12-lipoxygenase metabolites of arachidonic acid mediate metabotropic glutamate receptor-dependent long-term depression at hippocampal CA3-CA1 synapses
J. Neurosci.
23
11427-11435
2003
Mus musculus
Gonzalez-Nunez, D.; Sole, M.; Natarajan, R.; Poch, E.
12-Lipoxygenase metabolism in mouse distal convoluted tubule cells
Kidney Int.
67
178-186
2005
Mus musculus
Coffa, G.; Brash, A.R.
A single active site residue directs oxygenation stereospecificity in lipoxygenases: Stereocontrol is linked to the position of oxygenation
Proc. Natl. Acad. Sci. USA
101
15579-15584
2004
Homo sapiens
Chang, W.C.
Cell signaling and gene regulation of human 12(S)-lipoxygenase expression
Prostaglandins
71
277-285
2003
Homo sapiens
Pei, H.; Gu, J.; Thimmalapura, P.; Mison, A.; Nadler, J.L.
Activation of the 12-lipoxygenase and signal transducer and activator of transcription pathway during neointima formation in a model of the metabolic syndrome
Am. J. Physiol.
290
E92-E102
2006
Rattus norvegicus
Mortimer, M.; Jaerving, R.; Brash, AA.R.; Samel, N.; Jaerving, I.
Identification and characterization of an arachidonate 11R-lipoxygenase
Arch. Biochem. Biophys.
445
147-155
2006
Gersemia fruticosa
Bolick, D.T.; Srinivasan, S.; Whetzel, A.; Fuller, L.C.; Hedrick, C.C.
12/15 lipoxygenase mediates monocyte adhesion to aortic endothelium in apolipoprotein E-deficient mice through activation of RhoA and NF-kB
Arterioscler. Thromb. Vasc. Biol.
26
1260-1266
2006
Mus musculus
Meruvu Sunith, M.S.; Walther Matthia, W.M.; Ivanov Igo, I.I.; Hammarstrom Sve, H.S.; Furstenberger Gerhar, F.G.; Krieg Pete, K.P.; Reddanna Pall, R.P.; Kuhn Hartmu, K.H.
Sequence determinants for the reaction specificity of murine (12R)-lipoxygenase: targeted substrate modification and site-directed mutagenesis
J. Biol. Chem.
280
36633-36641
2005
Oryctolagus cuniculus
Chen, T.; Shiao, M.; Pan, B.S.
Inhibition of 12- and 15-lipoxygenase activities and protection of human and tilapia low density lipoprotein oxidation by I-Tiao-Gung (Glycine tomentella)
Lipids
40
1171-1177
2005
Oreochromis niloticus
Poeckel, D.; Tausch, L.; Kather, N.; Jauch, J.; Werz, O.
Boswellic acids stimulate arachidonic acid release and 12-lipoxygenase activity in human platelets independent of Ca2+ and differentially interact with platelet-type 12-lipoxygenase
Mol. Pharmacol.
70
1071-1078
2006
Homo sapiens
Collins, J.F.; Hu, Z.; Ranganathan, P.N.; Feng, D.; Garrick, L.M.; Garrick, M.D.; Browne, R.W.
Induction of arachidonate 12-lipoxygenase (Alox15) in intestine of iron-deficient rats correlates with the production of biologically active lipid mediators
Am. J. Physiol. Gastrointest. Liver Physiol.
294
G948-G962
2008
Rattus norvegicus (Q02759)
Wen, Y.; Gu, J.; Vandenhoff, G.E.; Liu, X.; Nadler, J.L.
Role of 12/15-lipoxygenase in the expression of MCP-1 in mouse macrophages
Am. J. Physiol. Heart Circ. Physiol.
294
H1933-H1938
2008
Mus musculus, Sus scrofa
Assimes, T.L.; Knowles, J.W.; Priest, J.R.; Basu, A.; Borchert, A.; Volcik, K.A.; Grove, M.L.; Tabor, H.K.; Southwick, A.; Tabibiazar, R.; Sidney, S.; Boerwinkle, E.; Go, A.S.; Iribarren, C.; Hlatky, M.A.; Fortmann, S.P.; Myers, R.M.; Kuhn, H.; Risch, N.; Quertermous, T.
A near null variant of 12/15-LOX encoded by a novel SNP in ALOX15 and the risk of coronary artery disease
Atherosclerosis
198
136-144
2008
Homo sapiens, Mus musculus, Mus musculus C57BL/6
Weisinger, G.; Limor, R.; Marcus-Perlman, Y.; Knoll, E.; Kohen, F.; Schinder, V.; Firer, M.; Stern, N.
12S-lipoxygenase protein associates with alpha-actin fibers in human umbilical artery vascular smooth muscle cells
Biochem. Biophys. Res. Commun.
356
554-560
2007
Homo sapiens
Jacquot, C.; Wecksler, A.T.; McGinley, C.M.; Segraves, E.N.; Holman, T.R.; van der Donk, W.A.
Isotope sensitive branching and kinetic isotope effects in the reaction of deuterated arachidonic acids with human 12- and 15-lipoxygenases
Biochemistry
47
7295-7303
2008
Homo sapiens (P18054), Homo sapiens
Huang, L.S.; Kim, M.R.; Jeong, T.S.; Sok, D.E.
Linoleoyl lysophosphatidic acid and linoleoyl lysophosphatidylcholine are efficient substrates for mammalian lipoxygenases
Biochim. Biophys. Acta
1770
1062-1070
2007
Sus scrofa
Deschamps, J.D.; Gautschi, J.T.; Whitman, S.; Johnson, T.A.; Gassner, N.C.; Crews, P.; Holman, T.R.
Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries
Bioorg. Med. Chem.
15
6900-6908
2007
Homo sapiens (P18054), Homo sapiens
Vasquez-Martinez, Y.; Ohri, R.V.; Kenyon, V.; Holman, T.R.; Sepulveda-Boza, S.
Structure-activity relationship studies of flavonoids as potent inhibitors of human platelet 12-hLO, reticulocyte 15-hLO-1, and prostate epithelial 15-hLO-2
Bioorg. Med. Chem.
15
7408-7425
2007
Homo sapiens
Chen, F.L.; Wang, X.Z.; Li, J.Y.; Yu, J.P.; Huang, C.Y.; Chen, Z.X.
12-lipoxygenase induces apoptosis of human gastric cancer AGS cells via the ERK1/2 signal pathway
Digest. Dis. Sci.
53
181-187
2008
Homo sapiens
Chen, C.J.; Chang, W.C.; Chen, B.K.
Attenuation of c-Jun and Sp1 expression and p300 recruitment to gene promoter confers the trichostatin A-induced inhibition of 12(S)-lipoxygenase expression in EGF-treated A431 cells
Eur. J. Pharmacol.
591
36-42
2008
Homo sapiens
Endsley, M.P.; Aggarwal, N.; Isbell, M.A.; Wheelock, C.E.; Hammock, B.D.; Falck, J.R.; Campbell, W.B.; Nithipatikom, K.
Diverse roles of 2-arachidonoylglycerol in invasion of prostate carcinoma cells: location, hydrolysis and 12-lipoxygenase metabolism
Int. J. Cancer
121
984-991
2007
Homo sapiens
Moran, J.L.; Qiu, H.; Turbe-Doan, A.; Yun, Y.; Boeglin, W.E.; Brash, A.R.; Beier, D.R.
A mouse mutation in the 12R-lipoxygenase, Alox12b, disrupts formation of the epidermal permeability barrier
J. Invest. Dermatol.
127
1893-1897
2007
Mus musculus (O70582), Mus musculus, Mus musculus A/J (O70582)
Aleem, A.M.; Jankun, J.; Dignam, J.D.; Walther, M.; Kuehn, H.; Svergun, D.I.; Skrzypczak-Jankun, E.
Human platelet 12-lipoxygenase, new findings about its activity, membrane binding and low-resolution structure
J. Mol. Biol.
376
193-209
2008
Homo sapiens (P18054), Homo sapiens
Succol, F.; Pratico, D.
A role for 12/15 lipoxygenase in the amyloid beta precursor protein metabolism
J. Neurochem.
103
380-387
2007
Homo sapiens
Vincent, C.; Fiancette, R.; Donnard, M.; Bordessoule, D.; Turlure, P.; Trimoreau, F.; Denizot, Y.
5-LOX, 12-LOX and 15-LOX in immature forms of human leukemic blasts
Leuk. Res.
32
1756-1762
2008
Homo sapiens
Higuchi, Y.; Tanii, H.; Koriyama, Y.; Mizukami, Y.; Yoshimoto, T.
Arachidonic acid promotes glutamate-induced cell death associated with necrosis by 12-lipoxygenase activation in glioma cells
Life Sci.
80
1856-1864
2007
Rattus norvegicus
Nagasawa, K.; Kakuda, T.; Higashi, Y.; Fujimoto, S.
Possible involvement of 12-lipoxygenase activation in glucose-deprivation/reload-treated neurons
Neurosci. Lett.
429
120-125
2007
Rattus norvegicus
Saam, J.; Ivanov, I.; Walther, M.; Holzhuetter, H.G.; Kuhn, H.
Molecular dioxygen enters the active site of 12/15-lipoxygenase via dynamic oxygen access channels
Proc. Natl. Acad. Sci. USA
104
13319-13324
2007
Oryctolagus cuniculus
Lim, K.M.; Kim, J.S.; Bae, O.N.; Noh, J.Y.; Chung, S.M.; Chung, K.Y.; Chung, J.H.
Co-oxidation-mediated xenobiotic activation and cytotoxicity by 12-lipoxygenase in intact platelets
Toxicology
247
154-160
2008
Rattus norvegicus (Q02759)
Rapp, J.; Xu, S.; Sharp, A.M.; Griffith, W.P.; Kim, Y.W.; Funk, M.O.
EPR spectroscopy and electrospray ionization mass spectrometry reveal distinctive features of the iron site in leukocyte 12-lipoxygenase
Arch. Biochem. Biophys.
490
50-56
2009
Sus scrofa (P16469), Sus scrofa
Nagelin, M.H.; Srinivasan, S.; Lee, J.; Nadler, J.L.; Hedrick, C.C.
12/15-Lipoxygenase activity increases the degradation of macrophage ATP-binding cassette transporter G1
Arterioscler. Thromb. Vasc. Biol.
28
1811-1819
2008
Sus scrofa
Wecksler, A.T.; Jacquot, C.; van der Donk, W.A.; Holman, T.R.
Mechanistic investigations of human reticulocyte 15- and platelet 12-lipoxygenases with arachidonic acid
Biochemistry
48
6259-6267
2009
Homo sapiens
Walther, M.; Roffeis, J.; Jansen, C.; Anton, M.; Ivanov, I.; Kuhn, H.
Structural basis for pH-dependent alterations of reaction specificity of vertebrate lipoxygenase isoforms
Biochim. Biophys. Acta
1791
827-835
2009
Danio rerio, Mus musculus
Reddy, M.V.; Billa, V.K.; Pallela, V.R.; Mallireddigari, M.R.; Boominathan, R.; Gabriel, J.L.; Reddy, E.P.
Design, synthesis, and biological evaluation of 1-(4-sulfamylphenyl)-3-trifluoromethyl-5-indolyl pyrazolines as cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) inhibitors
Bioorg. Med. Chem.
16
3907-3916
2008
Homo sapiens
Piao, Y.S.; Du, Y.C.; Oshima, H.; Jin, J.C.; Nomura, M.; Yoshimoto, T.; Oshima, M.
Platelet-type 12-lipoxygenase accelerates tumor promotion of mouse epidermal cells through enhancement of cloning efficiency
Carcinogenesis
29
440-447
2008
Mus musculus
Yoo, H.; Jeon, B.; Jeon, M.S.; Lee, H.; Kim, T.Y.
Reciprocal regulation of 12- and 15-lipoxygenases by UV-irradiation in human keratinocytes
FEBS Lett.
582
3249-3253
2008
Homo sapiens
Chou, D.S.; Hsiao, G.; Lai, Y.A.; Tsai, Y.J.; Sheu, J.R.
Baicalein induces proliferation inhibition in B16F10 melanoma cells by generating reactive oxygen species via 12-lipoxygenase
Free Radic. Biol. Med.
46
1197-1203
2009
Mus musculus
Middleton, M.K.; Zukas, A.M.; Rubinstein, T.; Kinder, M.; Wilson, E.H.; Zhu, P.; Blair, I.A.; Hunter, C.A.; Pure, E.
12/15-lipoxygenase-dependent myeloid production of interleukin-12 is essential for resistance to chronic toxoplasmosis
Infect. Immun.
77
5690-5700
2009
Mus musculus, Mus musculus C57BL/6
Nagelin, M.H.; Srinivasan, S.; Nadler, J.L.; Hedrick, C.C.
Murine 12/15-lipoxygenase regulates ATP-binding cassette transporter G1 protein degradation through p38- and JNK2-dependent pathways
J. Biol. Chem.
284
31303-31314
2009
Mus musculus (P39654), Mus musculus
Kayama, Y.; Minamino, T.; Toko, H.; Sakamoto, M.; Shimizu, I.; Takahashi, H.; Okada, S.; Tateno, K.; Moriya, J.; Yokoyama, M.; Nojima, A.; Yoshimura, M.; Egashira, K.; Aburatani, H.; Komuro, I.
Cardiac 12/15 lipoxygenase-induced inflammation is involved in heart failure
J. Exp. Med.
206
1565-1574
2009
Mus musculus
Dioszeghy, V.; Rosas, M.; Maskrey, B.H.; Colmont, C.; Topley, N.; Chaitidis, P.; Kuehn, H.; Jones, S.A.; Taylor, P.R.; ODonnell, V.B.
12/15-Lipoxygenase regulates the inflammatory response to bacterial products in vivo
J. Immunol.
181
6514-6524
2008
Mus musculus, Mus musculus C57BL/6
Kroenke, G.; Katzenbeisser, J.; Uderhardt, S.; Zaiss, M.M.; Scholtysek, C.; Schabbauer, G.; Zarbock, A.; Koenders, M.I.; Axmann, R.; Zwerina, J.; Baenckler, H.W.; van den Berg, W.; Voll, R.E.; Kuehn, H.; Joosten, L.A.; Schett, G.
12/15-lipoxygenase counteracts inflammation and tissue damage in arthritis
J. Immunol.
183
3383-3389
2009
Mus musculus
Aparoy, P.; Leela, T.; Reddy, R.N.; Reddanna, P.
Computational analysis of R and S isoforms of 12-lipoxygenases: homology modeling and docking studies
J. Mol. Graph. Model.
27
744-750
2009
Homo sapiens (O75342), Homo sapiens
Pallast, S.; Arai, K.; Wang, X.; Lo, E.H.; van Leyen, K.
12/15-Lipoxygenase targets neuronal mitochondria under oxidative stress
J. Neurochem.
111
882-889
2009
Mus musculus
Prasad, V.V.; Nithipatikom, K.; Harder, D.R.
Ceramide elevates 12-hydroxyeicosatetraenoic acid levels and upregulates 12-lipoxygenase in rat primary hippocampal cell cultures containing predominantly astrocytes
Neurochem. Int.
53
220-229
2008
Rattus norvegicus
Jacquot, C.; McGinley, C.M.; Plata, E.; Holman, T.R.; van der Donk, W.A.
Synthesis of 11-thialinoleic acid and 14-thialinoleic acid, inhibitors of soybean and human lipoxygenases
Org. Biomol. Chem.
6
4242-4252
2008
Homo sapiens
Sears, D.D.; Miles, P.D.; Chapman, J.; Ofrecio, J.M.; Almazan, F.; Thapar, D.; Miller, Y.I.
12/15-lipoxygenase is required for the early onset of high fat diet-induced adipose tissue inflammation and insulin resistance in mice
PLoS ONE
4
e7250
2009
Mus musculus, Mus musculus C57BL6
Mascayano, C.; Nez, G.; Acevedo, W.; Rezende, M.
Binding of arachidonic acid and two flavonoid inhibitors to human 12- and 15-lipoxygenases: A steered molecular dynamics study
J. Mol. Model.
16
1039-1045
2010
Homo sapiens
Wuest, S.J.; Crucet, M.; Gemperle, C.; Loretz, C.; Hersberger, M.
Expression and regulation of 12/15-lipoxygenases in human primary macrophages
Atherosclerosis
225
121-127
2012
Homo sapiens
Ivanov, I.; Di Venere, A.; Horn, T.; Scheerer, P.; Nicolai, E.; Stehling, S.; Richter, C.; Skrzypczak-Jankun, E.; Mei, G.; Maccarrone, M.; Kuehn, H.
Tight association of N-terminal and catalytic subunits of rabbit 12/15-lipoxygenase is important for protein stability and catalytic activity
Biochim. Biophys. Acta
1811
1001-1010
2011
Oryctolagus cuniculus
Di Venere, A.; Horn, T.; Stehling, S.; Mei, G.; Masgrau, L.; Gonzalez-Lafont, A.; Kuehn, H.; Ivanov, I.
Role of Arg403 for thermostability and catalytic activity of rabbit 12/15-lipoxygenase
Biochim. Biophys. Acta
1831
1079-1088
2013
Oryctolagus cuniculus
Dilly, A.K.; Ekambaram, P.; Guo, Y.; Cai, Y.; Tucker, S.C.; Fridman, R.; Kandouz, M.; Honn, K.V.
Platelet-type 12-lipoxygenase induces MMP9 expression and cellular invasion via activation of PI3K/Akt/NF-kappaB
Int. J. Cancer
133
1784-1791
2013
Homo sapiens
Schurmann, K.; Anton, M.; Ivanov, I.; Richter, C.; Kuhn, H.; Walther, M.
Molecular basis for the reduced catalytic activity of the naturally occurring T560M mutant of human 12/15-lipoxygenase that has been implicated in coronary artery disease
J. Biol. Chem.
286
23920-23927
2011
Homo sapiens, Mus musculus
Blazevic, T.; Schwaiberger, A.V.; Schreiner, C.E.; Schachner, D.; Schaible, A.M.; Grojer, C.S.; Atanasov, A.G.; Werz, O.; Dirsch, V.M.; Heiss, E.H.
12/15-Lipoxygenase contributes to platelet-derived growth factor- induced activation of signal transducer and activator of transcription 3
J. Biol. Chem.
288
35592-35603
2013
Homo sapiens, Rattus norvegicus
Kenyon, V.; Rai, G.; Jadhav, A.; Schultz, L.; Armstrong, M.; Jameson, J.B.; Perry, S.; Joshi, N.; Bougie, J.M.; Leister, W.; Taylor-Fishwick, D.A.; Nadler, J.L.; Holinstat, M.; Simeonov, A.; Maloney, D.J.; Holman, T.R.
Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase
J. Med. Chem.
54
5485-5497
2011
Homo sapiens
Ivanov, I.; Shang, W.; Toledo, L.; Masgrau, L.; Svergun, D.; Stehling, S.; Gmez, H.; Di Venere, A.; Mei, G.; Lluch, J.; Skrzypczak-Jankun, E.; Gonzlez-Lafont, A.; Khn, H.
Ligand-induced formation of transient dimers of mammalian 12/15-lipoxygenase: A key to allosteric behavior of this class of enzymes?
Proteins
80
703-712
2012
Oryctolagus cuniculus
Xu, S.; Mueser, T.C.; Marnett, L.J.; Funk, M.O.
Crystal structure of 12-lipoxygenase catalytic-domain-inhibitor complex identifies a substrate-binding channel for catalysis
Structure
20
1490-1497
2012
Sus scrofa (P16469)
Yeung, J.; Apopa, P.L.; Vesci, J.; Stolla, M.; Rai, G.; Simeonov, A.; Jadhav, A.; Fernandez-Perez, P.; Maloney, D.J.; Boutaud, O.; Holman, T.R.; Holinstat, M.
12-lipoxygenase activity plays an important role in PAR4 and GPVI-mediated platelet reactivity
Thromb. Haemost.
110
569-581
2013
Homo sapiens, Mus musculus
Halade, G.V.; Kain, V.; Ingle, K.A.; Prabhu, S.D.
Interaction of 12/15-lipoxygenase with fatty acids alters the leukocyte kinetics leading to improved postmyocardial infarction healing
Am. J. Physiol. Heart Circ. Physiol.
313
H89-H102
2017
Mus musculus, Mus musculus C57BL/6J
Ibrahim, A.S.; Tawfik, A.M.; Hussein, K.A.; Elshafey, S.; Markand, S.; Rizk, N.; Duh, E.J.; Smith, S.B.; Al-Shabrawey, M.
Pigment epithelium-derived factor inhibits retinal microvascular dysfunction induced by 12/15-lipoxygenase-derived eicosanoids
Biochim. Biophys. Acta
1851
290-298
2015
Mus musculus (P39654), Mus musculus C57BL/6J (P39654)
Mittal, M.; Hasan, M.; Balagunaseelan, N.; Fauland, A.; Wheelock, C.; Radmark, O.; Haeggstroem, J.; Rinaldo-Matthis, A.
Investigation of calcium-dependent activity and conformational dynamics of zebra fish 12-lipoxygenase
Biochim. Biophys. Acta
1861
2099-2111
2017
Danio rerio (Q7T2A9), Danio rerio
Ackermann, J.A.; Hofheinz, K.; Zaiss, M.M.; Kroenke, G.
The double-edged role of 12/15-lipoxygenase during inflammation and immunity
Biochim. Biophys. Acta
1862
371-381
2017
Mus musculus (P39654)
Yeung, J.; Tourdot, B.E.; Fernandez-Perez, P.; Vesci, J.; Ren, J.; Smyrniotis, C.J.; Luci, D.K.; Jadhav, A.; Simeonov, A.; Maloney, D.J.; Holman, T.R.; McKenzie, S.E.; Holinstat, M.
Platelet 12-LOX is essential for FcgammaRIIa-mediated platelet activation
Blood
124
2271-2279
2014
Mus musculus, Homo sapiens (O75342), Homo sapiens
Suzuki, H.; Kayama, Y.; Sakamoto, M.; Iuchi, H.; Shimizu, I.; Yoshino, T.; Katoh, D.; Nagoshi, T.; Tojo, K.; Minamino, T.; Yoshimura, M.; Utsunomiya, K.
Arachidonate 12/15-lipoxygenase-induced inflammation and oxidative stress are involved in the development of diabetic cardiomyopathy
Diabetes
64
618-630
2015
Mus musculus (P39654), Mus musculus C57BL/6 (P39654)
Weisinger, G.; Grafi-Cohen, M.; Hirsh, M.; Knoll, E.; Sharon, O.; Many, A.; Limor, R.; Stern, N.
12S-Lipoxygenase is necessary for human vascular smooth muscle cell survival
Exp. Cell Res.
319
1586-1593
2013
Homo sapiens (P18054), Homo sapiens
Ho, X.L.; Liu, J.J.; Loke, W.M.
Plant sterol-enriched soy milk consumption modulates 5-lipoxygenase, 12-lipoxygenase, and myeloperoxidase activities in healthy adults - a randomized-controlled trial
Free Radic. Res.
50
1396-1407
2016
Homo sapiens (P18054)
Lieb, D.C.; Brotman, J.J.; Hatcher, M.A.; Aye, M.S.; Cole, B.K.; Haynes, B.A.; Wohlgemuth, S.D.; Fontana, M.A.; Beydoun, H.; Nadler, J.L.; Dobrian, A.D.
Adipose tissue 12/15 lipoxygenase pathway in human obesity and diabetes
J. Clin. Endocrinol. Metab.
99
E1713-E1720
2014
Homo sapiens (P16050), Homo sapiens
Rothe, T.; Gruber, F.; Uderhardt, S.; Ipseiz, N.; Roessner, S.; Oskolkova, O.; Blueml, S.; Leitinger, N.; Bicker, W.; Bochkov, V.N.; Yamamoto, M.; Steinkasserer, A.; Schett, G.; Zinser, E.; Kroenke, G.
12/15-Lipoxygenase-mediated enzymatic lipid oxidation regulates DC maturation and function
J. Clin. Invest.
125
1944-1954
2015
Homo sapiens (P16050), Homo sapiens, Mus musculus (P39654), Mus musculus, Mus musculus C57BL/6 (P39654)
Sun, L.; Xu, Y.W.; Han, J.; Liang, H.; Wang, N.; Cheng, Y.
12/15-Lipoxygenase metabolites of arachidonic acid activate PPARgamma a possible neuroprotective effect in ischemic brain
J. Lipid Res.
56
502-514
2015
Rattus norvegicus (Q02759), Rattus norvegicus Sprague-Dawley (Q02759)
Ito, H.; Otsuki, A.; Mori, H.; Li, P.; Kinoshita, M.; Kawakami, Y.; Tsuji, H.; Fang, D.; Takahashi, Y.
Two new monoterpene glycosides from Qing Shan Lu Shui tea with inhibitory effects on leukocyte-type 12-lipoxygenase activity
Molecules
18
4257-4266
2013
Sus scrofa (P16469)
Adel, S.; Karst, F.; Gonzalez-Lafont, A.; Pekarova, M.; Saura, P.; Masgrau, L.; Lluch, J.M.; Stehling, S.; Horn, T.; Kuhn, H.; Heydeck, D.
Evolutionary alteration of ALOX15 specificity optimizes the biosynthesis of antiinflammatory and proresolving lipoxins
Proc. Natl. Acad. Sci. USA
113
E4266-E4275
2016
Homo sapiens (P16050), Homo sapiens neanderthalensis, Homo sapiens subsp. 'Denisova', Macaca mulatta (F7EPQ4), Macaca mulatta, Nomascus leucogenys (G1S6D2), Oryctolagus cuniculus (P12530), Oryctolagus cuniculus, Pan paniscus, Pan troglodytes (H2QBX9), Pan troglodytes, Papio anubis (A0A096P2G1), Pongo abelii (Q5RBE8), Pongo pygmaeus (Q5RBE8), Pongo pygmaeus
Cole, B.; Lieb, D.; Dobrian, A.; Nadler, J.
12- and 15-lipoxygenases in adipose tissue inflammation
Prostaglandins Other Lipid Mediat.
104-105
84-92
2013
Homo sapiens (P18054)
-
Zhang, C.; Ma, C.; Yao, H.; Zhang, L.; Yu, X.; Liu, Y.; Shen, T.; Zhang, L.; Zhang, F.; Chen, X.; Zhu, D.
12-lipoxygenase and 12-hydroxyeicosatetraenoic acid regulate hypoxic angiogenesis and survival of pulmonary artery endothelial cells via PI3K/Akt pathway
Am. J. Physiol. Lung Cell. Mol. Physiol.
314
L606-L616
2018
Rattus norvegicus (Q2KMM4)
Green, A.R.; Freedman, C.; Tena, J.; Tourdot, B.E.; Liu, B.; Holinstat, M.; Holman, T.R.
5 S,15 S-Dihydroperoxyeicosatetraenoic Acid (5,15-diHpETE) as a lipoxin intermediate Reactivity and kinetics with human leukocyte 5-lipoxygenase, platelet 12-lipoxygenase, and reticulocyte 15-lipoxygenase-1
Biochemistry
57
6726-6734
2018
Homo sapiens (P18054), Homo sapiens
Freedman, C.; Tran, A.; Tourdot, B.E.; Kalyanaraman, C.; Perry, S.; Holinstat, M.; Jacobson, M.P.; Holman, T.R.
Biosynthesis of the maresin intermediate, 13S,14S-epoxy-DHA, by human 15-lipoxygenase and 12-lipoxygenase and its regulation through negative allosteric modulators
Biochemistry
59
1832-1844
2020
Homo sapiens (P16050), Homo sapiens (P18054), Homo sapiens
Perry, S.C.; Horn, T.; Tourdot, B.E.; Yamaguchi, A.; Kalyanaraman, C.; Conrad, W.S.; Akinkugbe, O.; Holinstat, M.; Jacobson, M.P.; Holman, T.R.
Role of human 15-lipoxygenase-2 in the biosynthesis of the lipoxin intermediate, 5S,15S-diHpETE, implicated with the altered positional specificity of human 15-lipoxygenase-1
Biochemistry
59
4118-4130
2020
Homo sapiens (P16050), Homo sapiens (P18054)
Tsai, W.C.; Aleem, A.M.; Whittington, C.; Cortopassi, W.A.; Kalyanaraman, C.; Baroz, A.; Iavarone, A.T.; Skrzypczak-Jankun, E.; Jacobson, M.P.; Offenbacher, A.R.; Holman, T.
Mutagenesis, hydrogen-deuterium exchange, and molecular docking investigations establish the dimeric interface of human platelet-type 12-lipoxygenase
Biochemistry
60
802-812
2021
Homo sapiens (P18054), Homo sapiens
Schaefer, M.; Fan, Y.; Gu, T.; Heydeck, D.; Stehling, S.; Ivanov, I.; Yao, Y.G.; Kuhn, H.
The lipoxygenase pathway of Tupaia belangeri representing Scandentia. Genomic multiplicity and functional characterization of the ALOX15 orthologs in the tree shrew
Biochim. Biophys. Acta Mol. Cell Biol. Lipids
1865
158550
2020
Tupaia chinensis (A0A8A0R1W6), Tupaia chinensis (A0A8A0R235)
Leiria, L.O.; Wang, C.H.; Lynes, M.D.; Yang, K.; Shamsi, F.; Sato, M.; Sugimoto, S.; Chen, E.Y.; Bussberg, V.; Narain, N.R.; Sansbury, B.E.; Darcy, J.; Huang, T.L.; Kodani, S.D.; Sakaguchi, M.; Rocha, A.L.; Schulz, T.J.; Bartelt, A.; Hotamisligil, G.S.; Hirshman, M.F.; van Leyen, K.; Goodyear, L.J.; Blueher, M.
12-Lipoxygenase regulates cold adaptation and glucose metabolism by producing the omega-3 lipid 12-HEPE from brown fat
Cell Metab.
30
768-783.e7
2019
Homo sapiens, Mus musculus (P55249), Mus musculus
Ogawa, M.; Ishihara, T.; Isobe, Y.; Kato, T.; Kuba, K.; Imai, Y.; Uchino, Y.; Tsubota, K.; Arita, M.
Eosinophils promote corneal wound healing via the 12/15-lipoxygenase pathway
FASEB J.
34
12492-12501
2020
Mus musculus (P39654)
Miyata, J.; Yokokura, Y.; Moro, K.; Arai, H.; Fukunaga, K.; Arita, M.
12/15-Lipoxygenase regulates IL-33-induced eosinophilic airway inflammation in mice
Front. Immunol.
12
687192
2021
Mus musculus (P39654)
Mori, Y.; Kawakami, Y.; Kanzaki, K.; Otsuki, A.; Kimura, Y.; Kanji, H.; Tanaka, R.; Tsukayama, I.; Hojo, N.; Suzuki-Yamamoto, T.; Kawakami, T.; Takahashi, Y.
Arachidonate 12S-lipoxygenase of platelet-type in hepatic stellate cells of methionine and choline-deficient diet-fed mice
J. Biochem.
168
455-463
2020
Mus musculus (P39655)
Sarsour, E.H.; Son, J.M.; Kalen, A.L.; Xiao, W.; Du, J.; Alexander, M.S.; OLeary, B.R.; Cullen, J.J.; Goswami, P.C.
Arachidonate 12-lipoxygenase and 12-hydroxyeicosatetraenoic acid contribute to stromal aging-induced progression of pancreatic cancer
J. Biol. Chem.
295
6946-6957
2020
Homo sapiens (P18054), Homo sapiens
Nagasaki, T.; Schuyler, A.J.; Zhao, J.; Samovich, S.N.; Yamada, K.; Deng, Y.; Ginebaugh, S.P.; Christenson, S.A.; Woodruff, P.G.; Fahy, J.V.; Trudeau, J.B.; Stoyanovsky, D.; Ray, A.; Tyurina, Y.Y.; Kagan, V.E.; Wenzel, S.E.
15LO1 dictates glutathione redox changes in asthmatic airway epithelium to worsen type 2 inflammation
J. Clin. Invest.
132
e151685
2022
Homo sapiens (P16050)
Coppey, L.; Obrosov, A.; Shevalye, H.; Davidson, E.; Paradee, W.; Yorek, M.A.
Characterization of mice ubiquitously overexpressing human 15-lipoxygenase-1 effect of diabetes on peripheral neuropathy and treatment with menhaden oil
J. Diabetes Res.
2021
5564477
2021
Homo sapiens (P16050), Homo sapiens
Adams, W.; Bhowmick, R.; Bou Ghanem, E.N.; Wade, K.; Shchepetov, M.; Weiser, J.N.; McCormick, B.A.; Tweten, R.K.; Leong, J.M.
Pneumolysin induces 12-lipoxygenase-dependent neutrophil migration during Streptococcus pneumoniae infection
J. Immunol.
204
101-111
2020
Homo sapiens, Mus musculus (P55249)
Goloshchapova, K.; Stehling, S.; Heydeck, D.; Blum, M.; Kuhn, H.
Functional characterization of a novel arachidonic acid 12S-lipoxygenase in the halotolerant bacterium Myxococcus fulvus exhibiting complex social living patterns
MicrobiologyOpen
8
e775
2018
Myxococcus fulvus
Goftari, S.N.; Sadeghian, H.; Bahrami, A.R.; Maleki, F.; Matin, M.M.
Stylosin and some of its synthetic derivatives induce apoptosis in prostate cancer cells as 15-lipoxygenase enzyme inhibitors
Naunyn Schmiedebergs Arch. Pharmacol.
392
1491-1502
2019
Homo sapiens (P16050), Homo sapiens
Archambault, A.S.; Turcotte, C.; Martin, C.; Provost, V.; Larose, M.C.; Laprise, C.; Chakir, J.; Bissonnette, E.; Laviolette, M.; Bosse, Y.; Flamand, N.
Comparison of eight 15-lipoxygenase (LO) inhibitors on the biosynthesis of 15-LO metabolites by human neutrophils and eosinophils
PLoS ONE
13
e0202424
2018
Homo sapiens (P16050), Homo sapiens
Dobrian, A.D.; Huyck, R.W.; Glenn, L.; Gottipati, V.; Haynes, B.A.; Hansson, G.I.; Marley, A.; McPheat, W.L.; Nadler, J.L.
Activation of the 12/15 lipoxygenase pathway accompanies metabolic decline in db/db pre-diabetic mice
Prostaglandins Other Lipid Mediat.
136
23-32
2018
Mus musculus (P39654), Mus musculus
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