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Abortion, Spontaneous
Whole exome sequencing in recurrent early pregnancy loss.
Acquired Immunodeficiency Syndrome
ALOX15 Immunohistochemistry Aids in the Diagnosis of Eosinophilic Esophagitis on Pauci-Eosinophilic Biopsies in Children.
Acquired Immunodeficiency Syndrome
ALOX15 Immunohistochemistry Aids in the Diagnosis of Eosinophilic Esophagitis on Pauci-eosinophilic Biopsies in Children.
Acute Coronary Syndrome
Platelet-derived 12-hydroxyeicosatetraenoic acid plays an important role in mediating canine coronary thrombosis by regulating platelet glycoprotein IIb/IIIa activation.
Acute Kidney Injury
A dual role of 12/15-lipoxygenase in LPS-induced acute renal inflammation and injury.
Acute Lung Injury
Eliminating or blocking 12/15-lipoxygenase reduces neutrophil recruitment in mouse models of acute lung injury.
Acute Lung Injury
Improved survival and reduced vascular permeability by eliminating or blocking 12/15-lipoxygenase in mouse models of acute lung injury (ALI).
Acute Lung Injury
ITRAQ-Based Proteomics Analysis of Acute Lung Injury Induced by Oleic Acid in Mice.
Adenocarcinoma
15-lipoxygenase metabolites of gamma-linolenic acid/eicosapentaenoic acid suppress growth and arachidonic acid metabolism in human prostatic adenocarcinoma cells: possible implications of dietary fatty acids.
Adenocarcinoma
5 alpha-reductase-catalyzed conversion of testosterone to dihydrotestosterone is increased in prostatic adenocarcinoma cells: suppression by 15-lipoxygenase metabolites of gamma-linolenic and eicosapentaenoic acids.
Adenocarcinoma
Concordant induction of 15-lipoxygenase-1 and mutant p53 expression in human prostate adenocarcinoma: correlation with Gleason staging.
Adenocarcinoma
Elevated 12-lipoxygenase mRNA expression correlates with advanced stage and poor differentiation of human prostate cancer.
Adenocarcinoma
Overexpression of 12/15-lipoxygenase, an ortholog of human 15-lipoxygenase-1, in the prostate tumors of TRAMP mice.
Adenocarcinoma
Platelet-type 12-lipoxygenase in a human prostate carcinoma stimulates angiogenesis and tumor growth.
Adenocarcinoma
The role of 15-lipoxygenase-1 expression and its potential role in the pathogenesis of endometrial hyperplasia and endometrial adenocarcinomas.
Adenocarcinoma of Lung
Aspirin-Triggered Resolvin D1 Reduces Proliferation and the Neutrophil to Lymphocyte Ratio in a Mutant KRAS-Driven Lung Adenocarcinoma Model.
Adenoma
Common polymorphisms in 5-lipoxygenase and 12-lipoxygenase genes and the risk of incident, sporadic colorectal adenoma.
Adenoma
Genetic variability in prostaglandin synthesis, fish intake and risk of colorectal polyps.
Adenoma
Oxylipin patterns in human colon adenomas.
Adenoma
The critical role of 15-lipoxygenase-1 in colorectal epithelial cell terminal differentiation and tumorigenesis.
Adenoma
Tumor-associated down-regulation of 15-lipoxygenase-1 is reversed by celecoxib in colorectal cancer.
Adenomatous Polyposis Coli
12/15-lipoxygenase expression is increased in oligodendrocytes and microglia of periventricular leukomalacia.
Adenomatous Polyposis Coli
Eicosanoid profiling in colon cancer: Emergence of a pattern.
Airway Obstruction
Bradykinin sensitizes the cough reflex via a B2 receptor dependent activation of TRPV1 and TRPA1 channels through metabolites of cyclooxygenase and 12-lipoxygenase.
Airway Obstruction
Linoleic acid metabolite leads to steroid resistant asthma features partially through NF-?B.
Albuminuria
12/15-lipoxygenase inhibitors in diabetic nephropathy in the rat.
Albuminuria
Association of arachidonate 12-lipoxygenase genotype variation and glycemic control with albuminuria in type 2 diabetes.
Albuminuria
Effects of cholesterol-tagged small interfering RNAs targeting 12/15-lipoxygenase on parameters of diabetic nephropathy in a mouse model of type 1 diabetes.
Alopecia
Anti-inflammatory role of 15-lipoxygenase contributes to the maintenance of skin integrity in mice.
Alzheimer Disease
12/15-Lipoxygenase Inhibition Reverses Cognitive Impairment, Brain Amyloidosis, and Tau Pathology by Stimulating Autophagy in Aged Triple Transgenic Mice.
Alzheimer Disease
12/15-lipoxygenase is increased in Alzheimer's disease: possible involvement in brain oxidative stress.
Alzheimer Disease
5-Lipoxygenase (ALOX5) and FLAP (ALOX5AP) gene polymorphisms as factors in vascular pathology and Alzheimer's disease.
Alzheimer Disease
5-lipoxygenase pathway and its downstream cysteinyl leukotrienes as potential therapeutic targets for Alzheimer's disease.
Alzheimer Disease
A role for 12/15 lipoxygenase in the amyloid beta precursor protein metabolism.
Alzheimer Disease
Absence of ALOX5 gene prevents stress-induced memory deficits, synaptic dysfunction and tauopathy in a mouse model of Alzheimer's disease.
Alzheimer Disease
Amelioration of the Alzheimer's disease phenotype by absence of 12/15-lipoxygenase.
Alzheimer Disease
Benefits of neuropsychiatric phenomics: example of the 5-lipoxygenase-leptin-Alzheimer connection.
Alzheimer Disease
Differential contribution of lipoxygenase isozymes to nigrostriatal vulnerability.
Alzheimer Disease
Elevation of 12/15 lipoxygenase products in AD and mild cognitive impairment.
Alzheimer Disease
Mice deficient in L-12/15 lipoxygenase show increased vulnerability to 3-nitropropionic acid neurotoxicity.
Alzheimer Disease
Overexpression of 12/15-lipoxygenase increases anxiety behavior in female mice.
Alzheimer Disease
Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase.
Alzheimer Disease
The 12-15-lipoxygenase is a modulator of Alzheimer's-related tau pathology in vivo.
Alzheimer Disease
The 12/15-lipoxygenase as an emerging therapeutic target for Alzheimer's disease.
Alzheimer Disease
The Sp1/Egr1-tandem repeat polymorphism in the 5-lipoxygenase gene promoter is not associated with late onset Alzheimer disease.
Alzheimer Disease
Transcriptional regulation of ?-secretase-1 by 12/15-lipoxygenase results in enhanced amyloidogenesis and cognitive impairments.
Amyloidosis
12/15-Lipoxygenase Inhibition Reverses Cognitive Impairment, Brain Amyloidosis, and Tau Pathology by Stimulating Autophagy in Aged Triple Transgenic Mice.
Amyotrophic Lateral Sclerosis
Combined Analysis of Phenotypic and Target-Based Screening in Assay Networks.
Anaphylaxis
Differential effects of a series of hydroxamic acid derivatives on 5-lipoxygenase and cyclooxygenase from neutrophils and 12-lipoxygenase from platelets and their in vivo effects on inflammation and anaphylaxis.
Anemia
Inducible Endothelium-derived Hyperpolarizing Factor: Role of the 15-Lipoxygenase-EDHF Pathway.
Anemia
Interleukin-4 and -13 induce upregulation of the murine macrophage 12/15-lipoxygenase activity: evidence for the involvement of transcription factor STAT6.
Anemia
Regulation of cellular 15-lipoxygenase activity on pretranslational, translational, and posttranslational levels.
Aneurysm
miR-566 expression and immune changes in patients with intracranial aneurysm.
Angioedema
Copy number variation in ALOX5 and PTGER1 is associated with NSAIDs-induced urticaria and/or angioedema.
arachidonate 12-lipoxygenase deficiency
12/15-Lipoxygenase Deficiency Impairs Neutrophil Granulopoiesis and Lung Proinflammatory Responses to Aspergillus fumigatus.
arachidonate 12-lipoxygenase deficiency
12/15-Lipoxygenase deficiency protects mice from allergic airways inflammation and increases secretory IgA levels.
arachidonate 12-lipoxygenase deficiency
12/15-Lipoxygenase Deficiency Reduces Densities of Mesenchymal Stem Cells in the Dermis of Wounded and Unwounded Skin.
arachidonate 12-lipoxygenase deficiency
12R-lipoxygenase deficiency disrupts epidermal barrier function.
arachidonate 12-lipoxygenase deficiency
Altered arachidonate metabolism by leukocytes and platelets in myeloproliferative disorders.
arachidonate 12-lipoxygenase deficiency
Anti-inflammatory role of 15-lipoxygenase contributes to the maintenance of skin integrity in mice.
arachidonate 12-lipoxygenase deficiency
Atherosclerosis: evidence for impairment of resolution of vascular inflammation governed by specific lipid mediators.
arachidonate 12-lipoxygenase deficiency
Decreased messenger RNA of arachidonate 12-lipoxygenase in platelets of patients with myeloproliferative disorders.
arachidonate 12-lipoxygenase deficiency
Development of myeloproliferative disease in 12/15-lipoxygenase deficiency.
arachidonate 12-lipoxygenase deficiency
Different roles of 12/15-lipoxygenase in diabetic large and small fiber peripheral and autonomic neuropathies.
arachidonate 12-lipoxygenase deficiency
Differential contribution of lipoxygenase isozymes to nigrostriatal vulnerability.
arachidonate 12-lipoxygenase deficiency
Effects of cocaine in 5-lipoxygenase-deficient mice.
arachidonate 12-lipoxygenase deficiency
Experimental allergic encephalomyelitis is exacerbated in mice deficient for 12/15-lipoxygenase or 5-lipoxygenase.
arachidonate 12-lipoxygenase deficiency
Inhibition of 12/15-Lipoxygenase Reduces Renal Inflammation and Injury in Streptozotocin-Induced Diabetic Mice.
arachidonate 12-lipoxygenase deficiency
Leukotriene production by fresh human bone marrow cells: evidence of altered lipoxygenase activity in chronic myelocytic leukemia.
arachidonate 12-lipoxygenase deficiency
Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia.
arachidonate 12-lipoxygenase deficiency
Myeloid 12/15-LOX regulates B cell numbers and innate immune antibody levels in vivo.
arachidonate 12-lipoxygenase deficiency
Omega-3 fatty acids protect from colitis via an Alox15-derived eicosanoid.
arachidonate 12-lipoxygenase deficiency
Partially disturbed lamellar granule secretion in mild congenital ichthyosiform erythroderma with ALOX12B mutations.
arachidonate 12-lipoxygenase deficiency
Reduced dietary omega-6 to omega-3 fatty acid ratio and 12/15-lipoxygenase deficiency are protective against chronic high fat diet-induced steatohepatitis.
arachidonate 12-lipoxygenase deficiency
Selective interleukin-12 synthesis defect in 12/15-lipoxygenase-deficient macrophages associated with reduced atherosclerosis in a mouse model of familial hypercholesterolemia.
arachidonate 12-lipoxygenase deficiency
Unbound Corneocyte Lipid Envelopes in 12R-Lipoxygenase Deficiency Support A Specific Role in Lipid-Protein Crosslinking.
Arthritis
12/15-lipoxygenase counteracts inflammation and tissue damage in arthritis.
Arthritis
In vitro 12(S)-HETE inhibitory activities of naphthoquinones isolated from the root bark of Euclea racemosa ssp. schimperi.
Arthritis
Involvement of 15-lipoxygenase in the inflammatory arthritis.
Arthritis
Platelet microparticles are internalized in neutrophils via the concerted activity of 12-lipoxygenase and secreted phospholipase A2-IIA.
Arthritis, Rheumatoid
Effects of a single dose of methotrexate on 5- and 12-lipoxygenase products in patients with rheumatoid arthritis.
Arthritis, Rheumatoid
Expression of 5-lipoxygenase and 15-lipoxygenase in rheumatoid arthritis synovium and effects of intraarticular glucocorticoids.
Arthritis, Rheumatoid
Expression of arachidonate platelet-type 12-lipoxygenase in human rheumatoid arthritis type B synoviocytes.
Arthritis, Rheumatoid
Interleukin-8 secretion and 15-lipoxygenase activity in rheumatoid arthritis: in vitro anti-inflammatory effects by interleukin-4 and interleukin-10, but not by interleukin-1 receptor antagonist protein.
Arthritis, Rheumatoid
Systems pharmacology dissection of the anti-inflammatory mechanism for the medicinal herb folium eriobotryae.
Arthritis, Rheumatoid
The 12/15-lipoxygenase pathway promotes osteoclast development and differentiation.
Aspergillosis
12/15-Lipoxygenase Deficiency Impairs Neutrophil Granulopoiesis and Lung Proinflammatory Responses to Aspergillus fumigatus.
Asthma
12/15-lipoxygenase expressed in non-epithelial cells causes airway epithelial injury in asthma.
Asthma
15-lipoxygenase immunoreactivity in normal and in asthmatic airways.
Asthma
15-lipoxygenase metabolites play an important role in the development of a T-helper type 1 allergic inflammation induced by double-stranded RNA.
Asthma
15-lipoxygenase-1 induces expression and release of chemokines in cultured human lung epithelial cells.
Asthma
5-lipoxygenase pathway and its downstream cysteinyl leukotrienes as potential therapeutic targets for Alzheimer's disease.
Asthma
5-Lipoxygenase pathway gene polymorphisms: lack of association with asthma in a Spanish population.
Asthma
A Cell-based Assay for Screening Lipoxygenase Inhibitors.
Asthma
ALOX5 polymorphism associates with increased leukotriene production and reduced lung function and asthma control in children with poorly controlled asthma.
Asthma
ALOX5 promoter genotype and response to montelukast in moderate persistent asthma.
Asthma
ALOX5 promoter genotype, asthma severity and LTC production by eosinophils.
Asthma
Arachidonic Acid 15-Lipoxygenase: Effects of Its Expression, Metabolites, and Genetic and Epigenetic Variations on Airway Inflammation.
Asthma
Association of the -1072G/A Polymorphism in the LTC4S Gene with Asthma in an Indian Population.
Asthma
Candidate gene analysis of asthma in a population of Arab descent: a case-control study in Jordan.
Asthma
Cysteinyl Leukotrienes Pathway Genes, Atopic Asthma and Drug Response: From Population Isolates to Large Genome-Wide Association Studies.
Asthma
Effects of vitamin E on mitochondrial dysfunction and asthma features in an experimental allergic murine model.
Asthma
Eicosanoid mediator expression in mononuclear and polymorphonuclear cells in normal subjects and patients with atopic asthma and cystic fibrosis.
Asthma
Environment Changes Genetic Effects on Respiratory Conditions and Allergic Phenotypes.
Asthma
Eoxins: a new inflammatory pathway in childhood asthma.
Asthma
Expression and activation of 15-lipoxygenase pathway in severe asthma: relationship to eosinophilic phenotype and collagen deposition.
Asthma
Fish Oil Supplementation in Overweight/Obese Patients with Uncontrolled Asthma: A Randomized Trial.
Asthma
Foxa2 Regulates Leukotrienes to Inhibit Th2-mediated Pulmonary Inflammation.
Asthma
Functional classes of bronchial mucosa genes that are differentially expressed in asthma.
Asthma
Gene expression profiling in human asthma.
Asthma
Genetic mechanism of aspirin-induced urticaria/angioedema.
Asthma
Genetic variation in immune signaling genes differentially expressed in asthmatic lung tissues.
Asthma
Genome-wide analysis revealed sex-specific gene expression in asthmatics.
Asthma
Histochemical evidence for induction of arachidonate 15-lipoxygenase in airway disease.
Asthma
Identification of differentially expressed genes in childhood asthma.
Asthma
Implications of pharmacogenomics in the current and future treatment of asthma.
Asthma
Interleukin-4 receptor in moderate atopic asthma. A phase I/II randomized, placebo-controlled trial.
Asthma
Interleukin-4-mediated 15-lipoxygenase-1 trans-activation requires UTX recruitment and H3K27me3 demethylation at the promoter in A549 cells.
Asthma
Leukotriene pathway polymorphisms are associated with altered cysteinyl leukotriene production in children with acute asthma.
Asthma
Leukotriene signaling via ALOX5 and cysteinyl leukotriene receptor 1 is dispensable for in vitro growth of CD34(+)CD38(-) stem and progenitor cells in chronic myeloid leukemia.
Asthma
Leukotriene-related gene polymorphisms in patients with aspirin-intolerant urticaria and aspirin-intolerant asthma: differing contributions of ALOX5 polymorphism in Korean population.
Asthma
Nutrigenetic response to omega-3 fatty acids in obese asthmatics (NOOA): Rationale and methods.
Asthma
Pharmacogenetic association between ALOX5 promoter genotype and the response to anti-asthma treatment.
Asthma
Pharmacogenetic Factors Affecting Asthma Treatment Response. Potential Implications for Drug Therapy.
Asthma
Pharmacogenetics of the 5-lipoxygenase biosynthetic pathway and variable clinical response to montelukast.
Asthma
Promoter polymorphism in the 5-lipoxygenase (ALOX5) and 5-lipoxygenase-activating protein (ALOX5AP) genes and asthma susceptibility in a Caucasian population.
Asthma
Pseudoperoxidase investigations of hydroperoxides and inhibitors with human lipoxygenases.
Asthma
Reversed changes of lipoxin A4 and leukotrienes in children with asthma in different severity degree.
Asthma
Single-Cell RNA Sequencing Reveals a Unique Monocyte Population in Bronchoalveolar Lavage Cells of Mice Challenged With Afghanistan Particulate Matter and Allergen.
Asthma
Substituted (E)-2-(2-benzylidenehydrazinyl)-4-methylthiazole-5-carboxylates as dual inhibitors of 15-lipoxygenase & carbonic anhydrase II: synthesis, biochemical evaluation and docking studies.
Asthma
Zileuton inhibits arachidonate-5-lipoxygenase to exert antitumor effects in preclinical cervical cancer models.
Asthma
[Effects of dexamethasone on 15-lipoxygenase expression in lungs of asthmatic rats.]
Asthma
[Reversed changes of the 15-lipoxygenase product lipoxin A? and the 5-lipoxygenase product leukotriene C? in children with asthma].
Asthma, Exercise-Induced
Transcription in response to physical stress--clues to the molecular mechanisms of exercise-induced asthma.
Atherosclerosis
αM{beta}2 Integrin Activation Prevents Alternative Activation of Human and Murine Macrophages and Impedes Foam Cell Formation.
Atherosclerosis
12/15 lipoxygenase mediates monocyte adhesion to aortic endothelium in apolipoprotein E-deficient mice through activation of RhoA and NF-kappaB.
Atherosclerosis
12/15-Lipoxygenase activity increases the degradation of macrophage ATP-binding cassette transporter G1.
Atherosclerosis
12/15-Lipoxygenase activity mediates inflammatory monocyte/endothelial interactions and atherosclerosis in vivo.
Atherosclerosis
12/15-Lipoxygenase gene disruption and vitamin E administration diminish atherosclerosis and oxidative stress in apolipoprotein E deficient mice through a final common pathway.
Atherosclerosis
12/15-Lipoxygenase gene disruption attenuates atherogenesis in LDL receptor-deficient mice.
Atherosclerosis
12/15-lipoxygenase is required for the early onset of high fat diet-induced adipose tissue inflammation and insulin resistance in mice.
Atherosclerosis
12/15-Lipoxygenase mediates high-fat diet-induced endothelial tight junction disruption and monocyte transmigration: a new role for 15(S)-hydroxyeicosatetraenoic acid in endothelial cell dysfunction.
Atherosclerosis
12/15-Lipoxygenase Products Induce Inflammation and Impair Insulin Signaling in 3T3-L1 Adipocytes.
Atherosclerosis
12/15-lipoxygenase regulates intercellular adhesion molecule-1 expression and monocyte adhesion to endothelium through activation of RhoA and nuclear factor-kappaB.
Atherosclerosis
12/15-lipoxygenase, oxidative modification of LDL and atherogenesis.
Atherosclerosis
15-Lipoxygenase gene variants are associated with carotid plaque but not carotid intima-media thickness.
Atherosclerosis
15-Lipoxygenase induction as an index of oxidative stress and atherogenesis.
Atherosclerosis
15-Lipoxygenase inhibitors as anti-atherosclerosis agents.
Atherosclerosis
15-oxoeicosatetraenoic acid mediates monocyte adhesion to endothelial cell.
Atherosclerosis
5-Lipoxygenase (ALOX5) and FLAP (ALOX5AP) gene polymorphisms as factors in vascular pathology and Alzheimer's disease.
Atherosclerosis
5-Lipoxygenase Gene Variants Are Not Associated With Atherosclerosis or Incident Coronary Heart Disease in the Multi-Ethnic Study of Atherosclerosis Cohort.
Atherosclerosis
6-substituted purines as inhibitors of 15-lipoxygenase; a structure-activity study.
Atherosclerosis
?(9)-tetrahydrocannabinol and its major metabolite ?(9)-tetrahydrocannabinol-11-oic acid as 15-lipoxygenase inhibitors.
Atherosclerosis
A functional Sp1/Egr1-tandem repeat polymorphism in the 5-lipoxygenase gene is not associated with myocardial infarction.
Atherosclerosis
A hyperresponsive 15-lipoxygenase phenotype in rabbit and human populations: relationship to atherosclerosis.
Atherosclerosis
A near null variant of 12/15-LOX encoded by a novel SNP in ALOX15 and the risk of coronary artery disease.
Atherosclerosis
A possible role for 15-lipoxygenase in atherogenesis.
Atherosclerosis
A primary determinant for lipoxygenase positional specificity.
Atherosclerosis
A specific 15-lipoxygenase inhibitor limits the progression and monocyte-macrophage enrichment of hypercholesterolemia-induced atherosclerosis in the rabbit.
Atherosclerosis
Absence of 12/15-lipoxygenase expression decreases lipid peroxidation and atherogenesis in apolipoprotein e-deficient mice.
Atherosclerosis
Activation of NADPH oxidase required for macrophage-mediated oxidation of low-density lipoprotein.
Atherosclerosis
Aldosterone up-regulates 12- and 15-lipoxygenase expression and LDL oxidation in human vascular smooth muscle cells.
Atherosclerosis
ALOX12 In Human Toxoplasmosis.
Atherosclerosis
Arachidonate 12/15-lipoxygenase-induced inflammation and oxidative stress are involved in the development of diabetic cardiomyopathy.
Atherosclerosis
Arachidonate 15-lipoxygenase type B knockdown leads to reduced lipid accumulation and inflammation in atherosclerosis.
Atherosclerosis
Association of ALOX15 Gene Polymorphism with Ischemic Stroke in Northern Chinese Han Population.
Atherosclerosis
Association of polymorphisms in the ALOX15B gene with coronary artery disease.
Atherosclerosis
Atherosclerosis: evidence for impairment of resolution of vascular inflammation governed by specific lipid mediators.
Atherosclerosis
Attenuation of diet-induced atherosclerosis in rabbits with a highly selective 15-lipoxygenase inhibitor lacking significant antioxidant properties.
Atherosclerosis
Cannabidiol-2',6'-dimethyl Ether as an Effective Protector of 15-Lipoxygenase-Mediated Low-Density Lipoprotein Oxidation in Vitro.
Atherosclerosis
Catalytic consumption of nitric oxide by 12/15- lipoxygenase: inhibition of monocyte soluble guanylate cyclase activation.
Atherosclerosis
Cellular and molecular mechanisms of the selective regulation of IL-12 production by 12/15-lipoxygenase.
Atherosclerosis
Characterization of a human 12/15-lipoxygenase promoter variant associated with atherosclerosis identifies vimentin as a promoter binding protein.
Atherosclerosis
Cholesteryl ester acyl oxidation and remodeling in murine macrophages: formation of oxidized phosphatidylcholine.
Atherosclerosis
Cigarette smoking stimulates lipoxygenase but not cyclooxygenase pathway in platelets.
Atherosclerosis
Comparative effect of lipoxygenase products of arachidonic acid on rat aortic smooth muscle cell migration.
Atherosclerosis
Critical role of macrophage 12/15-lipoxygenase for atherosclerosis in apolipoprotein E-deficient mice.
Atherosclerosis
CTRP5 promotes transcytosis and oxidative modification of low-density lipoprotein and the development of atherosclerosis.
Atherosclerosis
Disruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apo E-deficient mice.
Atherosclerosis
Dual 12/15- and 5-lipoxygenase deficiency in macrophages alters arachidonic acid metabolism and attenuates peritonitis and atherosclerosis in ApoE knock-out mice.
Atherosclerosis
Effects of silencing leukocyte-type 12/15-lipoxygenase using short interfering RNAs.
Atherosclerosis
Eicosanoids and Docosanoids in Plasma and Aorta of Healthy and Atherosclerotic Rabbits.
Atherosclerosis
Elevated endothelial nitric oxide bioactivity and resistance to angiotensin-dependent hypertension in 12/15-lipoxygenase knockout mice.
Atherosclerosis
Elevating microRNA-122 in blood improves outcomes after temporary middle cerebral artery occlusion in rats.
Atherosclerosis
Epigenetics and atherosclerosis.
Atherosclerosis
Essential involvement of 12-lipoxygenase in regiospecific andstereospecific oxidation of low density lipoprotein by macrophages.
Atherosclerosis
Evidence that increased 12-lipoxygenase activity induces apoptosis in fibroblasts.
Atherosclerosis
Expression and regulation of 12/15-lipoxygenases in human primary macrophages.
Atherosclerosis
Expression of 12/15-lipoxygenase attenuates intracellular lipid deposition during in vitro foam cell formation.
Atherosclerosis
Gene expression in macrophage-rich human atherosclerotic lesions. 15-lipoxygenase and acetyl low density lipoprotein receptor messenger RNA colocalize with oxidation specific lipid-protein adducts.
Atherosclerosis
Genetic effects in the leukotriene biosynthesis pathway and association with atherosclerosis.
Atherosclerosis
Genome-Wide Association Meta-Analysis of Single-Nucleotide Polymorphisms and Symptomatic Venous Thromboembolism during Therapy for Acute Lymphoblastic Leukemia and Lymphoma in Caucasian Children.
Atherosclerosis
Heterodimers of the transcriptional factors NFATc3 and FosB mediate tissue factor expression for 15(S)-hydroxyeicosatetraenoic acid-induced monocyte trafficking.
Atherosclerosis
High density lipoprotein inhibits platelet 12-lipoxygenase activity.
Atherosclerosis
High expression of human 15-lipoxygenase induces NF-kappaB-mediated expression of vascular cell adhesion molecule 1, intercellular adhesion molecule 1, and T-cell adhesion on human endothelial cells.
Atherosclerosis
Human 15-lipoxygenase: induction by interleukin-4 and insights into positional specificity.
Atherosclerosis
Human lipoxygenase pathway gene variation and association with markers of subclinical atherosclerosis in the diabetes heart study.
Atherosclerosis
In vitro 12(S)-HETE inhibitory activities of naphthoquinones isolated from the root bark of Euclea racemosa ssp. schimperi.
Atherosclerosis
In vivo action of 15-lipoxygenase in early stages of human atherogenesis.
Atherosclerosis
Indolizines as novel potent inhibitors of 15-lipoxygenase.
Atherosclerosis
Inducible Endothelium-derived Hyperpolarizing Factor: Role of the 15-Lipoxygenase-EDHF Pathway.
Atherosclerosis
Induction of 15-lipoxygenase by interleukin-13 in human blood monocytes.
Atherosclerosis
Induction of 15-lipoxygenase mRNA and protein in early atherosclerotic lesions.
Atherosclerosis
Inflammation and immune regulation by 12/15-lipoxygenases.
Atherosclerosis
Inhibition of 12/15 lipoxygenase by baicalein reduces myocardial ischemia/reperfusion injury via modulation of multiple signaling pathways.
Atherosclerosis
Inhibition of leukocyte-type 12-lipoxygenase by guava tea leaves prevents development of atherosclerosis.
Atherosclerosis
Interaction between ALOX15 polymorphisms and coronary artery disease in North Indian population.
Atherosclerosis
Interaction between cytokines and inflammatory cells in islet dysfunction, insulin resistance and vascular disease.
Atherosclerosis
Involvement of 15-lipoxygenase in early stages of atherogenesis.
Atherosclerosis
Is there a role for 15-lipoxygenase in atherogenesis?
Atherosclerosis
Lipid metabolism: 5-lipoxygenase, 12/15-lipoxygenase, and atherogenesis.
Atherosclerosis
Lipoxygenase and prostaglandin G/H synthase cascades in cardiovascular disease.
Atherosclerosis
Lipoxygenase inhibitors from natural plant sources. Part 2: medicinal plants with inhibitory activity on arachidonate 12-lipoxygenase, 15-lipoxygenase and leukotriene receptor antagonists.
Atherosclerosis
Lipoxygenase products increase monocyte adhesion to human aortic endothelial cells.
Atherosclerosis
Lipoxygenases and lipid signaling in vascular cells in diabetes.
Atherosclerosis
Low density lipoprotein receptor-related protein is required for macrophage-mediated oxidation of low density lipoprotein by 12/15-lipoxygenase.
Atherosclerosis
Macrophage 12/15 lipoxygenase expression increases plasma and hepatic lipid levels and exacerbates atherosclerosis.
Atherosclerosis
Macrophage-mediated 15-lipoxygenase expression protects against atherosclerosis development.
Atherosclerosis
Macrophages and oxidized low density lipoproteins in the pathogenesis of atherosclerosis.
Atherosclerosis
Murine 12/15-lipoxygenase regulates ATP-binding cassette transporter G1 protein degradation through p38- and JNK2-dependent pathways.
Atherosclerosis
No association of two functional polymorphisms in human ALOX15 with myocardial infarction.
Atherosclerosis
Nutrigenetic Disruption of Inflammation-Resolution Homeostasis and Atherogenesis.
Atherosclerosis
Overexpression of 15-lipoxygenase in vascular endothelium accelerates early atherosclerosis in LDL receptor-deficient mice.
Atherosclerosis
Oxidation of free fatty acids in low density lipoprotein by 15-lipoxygenase stimulates nonenzymic, alpha-tocopherol-mediated peroxidation of cholesteryl esters.
Atherosclerosis
Oxidation of LDL by recombinant human 15-lipoxygenase: evidence for alpha-tocopherol-dependent oxidation of esterified core and surface lipids.
Atherosclerosis
Paradoxical increase in LDL oxidation by endothelial cells from an atherosclerosis-resistant mouse strain.
Atherosclerosis
Platelet activation triggered by Chlamydia pneumoniae is antagonized by 12-lipoxygenase inhibitors but not cyclooxygenase inhibitors.
Atherosclerosis
Platelets stimulate aortic smooth muscle cell migration in vitro. Involvement of 12-L-hydroxy-5,8,10,14-eicosatetraenoic acid.
Atherosclerosis
Pro-resolving lipid mediators in the resolution of neointimal hyperplasia pathogenesis in atherosclerotic diseases.
Atherosclerosis
Promoter methylation changes in ALOX12 and AIRE1: novel epigenetic markers for atherosclerosis.
Atherosclerosis
Redox inactivation of human 15-lipoxygenase by marine-derived meroditerpenes and synthetic chromanes: archetypes for a unique class of selective and recyclable inhibitors.
Atherosclerosis
Reduced growth factor responses in vascular smooth muscle cells derived from 12/15-lipoxygenase-deficient mice.
Atherosclerosis
Regulation of human 12/15-lipoxygenase by Stat6-dependent transcription.
Atherosclerosis
Regulation of monocyte chemoattractant protein-1 by the oxidized lipid, 13-hydroperoxyoctadecadienoic acid, in vascular smooth muscle cells via nuclear factor-kappa B (NF-kappa B).
Atherosclerosis
Relationship of vascular 15-lipoxygenase induction to atherosclerotic plaque formation in rabbits.
Atherosclerosis
Role of 12-lipoxygenase and oxidant stress in hyperglycaemia-induced acceleration of atherosclerosis in a diabetic pig model.
Atherosclerosis
Role of 12/15-lipoxygenase in the expression of MCP-1 in mouse macrophages.
Atherosclerosis
ROS-dependent Syk and Pyk2-mediated STAT1 activation is required for 15(S)-hydroxyeicosatetraenoic acid-induced CD36 expression and foam cell formation.
Atherosclerosis
Selective interleukin-12 synthesis defect in 12/15-lipoxygenase-deficient macrophages associated with reduced atherosclerosis in a mouse model of familial hypercholesterolemia.
Atherosclerosis
Selective uptake and efflux of cholesteryl linoleate in LDL by macrophages expressing 12/15-lipoxygenase.
Atherosclerosis
Skeletal inflammation and attenuation of Wnt signaling, Wnt ligand expression, and bone formation in atherosclerotic ApoE-null mice.
Atherosclerosis
Specific inflammatory cytokines regulate the expression of human monocyte 15-lipoxygenase.
Atherosclerosis
Structure elucidation of oxygenated lipids in human atherosclerotic lesions.
Atherosclerosis
Systemic activation of 15-lipoxygenase in heart, lung, and vascular tissues by hypercholesterolemia: relationship to lipoprotein oxidation and atherogenesis.
Atherosclerosis
The arachidonate 12/15 lipoxygenases. A review of tissue expression and biologic function.
Atherosclerosis
The role of 12/15-lipoxygenase in the expression of interleukin-6 and tumor necrosis factor-alpha in macrophages.
Atherosclerosis
The role of 15-lipoxygenase in atherogenesis: pro- and antiatherogenic actions.
Atherosclerosis
The role of lipoxygenase-isoforms in atherogenesis.
Atherosclerosis
The Transcription Factor CREB Enhances Interleukin-17A Production and Inflammation in a Mouse Model of Atherosclerosis.
Atherosclerosis
The two faces of the 15-lipoxygenase in atherosclerosis.
Atherosclerosis
Transgenic rabbits with the integrated human 15-lipoxygenase gene driven by a lysozyme promoter: macrophage-specific expression and variable positional specificity of the transgenic enzyme.
Atherosclerosis
Transient experimental anemia in cholesterol-fed rabbits induces systemic overexpression of the reticulocyte-type 15-lipoxygenase and protects from aortic lipid deposition.
Atherosclerosis
Transient overexpression of human 15-lipoxygenase in aortic endothelial cells enhances tumor necrosis factor-induced vascular cell adhesion molecule-1 gene expression.
Atherosclerosis
Two single nucleotide polymorphisms in ALOX15 are associated with risk of coronary artery disease in a Chinese Han population.
Atherosclerosis
Variants in ALOX5, ALOX5AP and LTA4H are not associated with atherosclerotic plaque phenotypes: The Athero-Express Genomics Study.
Atherosclerosis
Vitamin E suppresses isoprostane generation in vivo and reduces atherosclerosis in ApoE-deficient mice.
Atherosclerosis
[Leukotriene-lipoxygenase pathway and drug discovery]
Autoimmune Diseases
12/15-lipoxygenase orchestrates the clearance of apoptotic cells and maintains immunologic tolerance.
Autoimmune Diseases
12/15-Lipoxygenase-mediated enzymatic lipid oxidation regulates DC maturation and function.
Autoimmune Diseases
Inhibition of 12/15-lipoxygenase by baicalein induces microglia PPAR?/?: a potential therapeutic role for CNS autoimmune disease.
Bacteremia
Systemic Disease during Streptococcus pneumoniae Acute Lung Infection Requires 12-Lipoxygenase-Dependent Inflammation.
Barrett Esophagus
Platelet 12-lipoxygenase and stem cells in Barrett's esophagus.
Blast Crisis
Low leukotriene B4 receptor 1 leads to ALOX5 downregulation at diagnosis of chronic myeloid leukemia.
Blister
Altered epididymal sperm maturation and cytoplasmic droplet migration in subfertile male Alox15 mice.
Blister
Partially disturbed lamellar granule secretion in mild congenital ichthyosiform erythroderma with ALOX12B mutations.
Bone Resorption
The effect of Lipoxin A4 on the interaction between macrophage and osteoblast: possible role in the treatment of aseptic loosening.
Brain Diseases
12/15 Lipoxygenase as a Therapeutic Target in Brain Disorders.
Brain Diseases
Exploring the molecular approach of COX and LOX in Alzheimer's and Parkinson's disorder.
Brain Edema
Impact of 12/15-Lipoxygenase on Brain Injury After Subarachnoid Hemorrhage.
Brain Injuries
12/15-Lipoxygenase targets neuronal mitochondria under oxidative stress.
Brain Injuries
Impact of 12/15-Lipoxygenase on Brain Injury After Subarachnoid Hemorrhage.
Brain Injuries
Increased 12/15-Lipoxygenase Leads to Widespread Brain Injury Following Global Cerebral Ischemia.
Brain Injuries
Potent and Selective Inhibitors of Human Reticulocyte 12/15- Lipoxygenase as Anti-Stroke Therapies.
Brain Injuries, Traumatic
Ferroptosis Contributes to Neuronal Death and Functional Outcome After Traumatic Brain Injury.
Brain Ischemia
Increased 12/15-Lipoxygenase Leads to Widespread Brain Injury Following Global Cerebral Ischemia.
Brain Ischemia
Neuroprotection of early and short-time applying atorvastatin in the acute phase of cerebral ischemia: down-regulated 12/15-LOX, p38MAPK and cPLA2 expression, ameliorated BBB permeability.
Brain Ischemia
Neuroprotection of taurine through inhibition of 12/15 lipoxygenase pathway in cerebral ischemia of rats.
Breast Neoplasms
15-LOX-1 has diverse roles in the resensitization of resistant cancer cell lines to doxorubicin.
Breast Neoplasms
5-lipoxygenase and 5-lipoxygenase-activating protein gene polymorphisms, dietary linoleic Acid, and risk for breast cancer.
Breast Neoplasms
A Sucrose-Enriched Diet Promotes Tumorigenesis in Mammary Gland in Part through the 12-Lipoxygenase Pathway.
Breast Neoplasms
Aberrant ALOX5 Activation Correlates with HER2 Status and Mediates Breast Cancer Biological Activities through Multiple Mechanisms.
Breast Neoplasms
ALOX12 inhibition sensitizes breast cancer to chemotherapy via AMPK activation and inhibition of lipid synthesis.
Breast Neoplasms
ALOX12B promotes carcinogenesis in cervical cancer by regulating the PI3K/ERK1 signaling pathway.
Breast Neoplasms
Association of a functional polymorphism (Gln261Arg) in 12-lipoxygenase with breast cancer.
Breast Neoplasms
Associations between ALOX, COX, and CRP polymorphisms and breast cancer among Hispanic and non-Hispanic white women: The breast cancer health disparities study.
Breast Neoplasms
Candidate gene approach evaluates association between innate immunity genes and breast cancer risk in Korean women.
Breast Neoplasms
Characterization of a 15-lipoxygenase in human breast carcinoma BT-20 cells: stimulation of 13-HODE formation by TGF alpha/EGF.
Breast Neoplasms
COX-2 expression in invasive breast cancer: correlation with prognostic parameters and outcome.
Breast Neoplasms
Cyclooxygenase and lipoxygenase gene expression in the inflammogenesis of breast cancer.
Breast Neoplasms
Enhanced angiogenesis and growth of 12-lipoxygenase gene-transfected MCF-7 human breast cancer cells in athymic nude mice.
Breast Neoplasms
Evaluation of human LOX-12 as a serum marker for breast cancer.
Breast Neoplasms
Expression of cyclooxygenase-2 and 12-lipoxygenase in human breast cancer and their relationship with HER-2/neu and hormonal receptors: impact on prognosis and therapy.
Breast Neoplasms
Genetic Variants in COX2 and ALOX Genes and Breast Cancer Risk in White and Black Women.
Breast Neoplasms
Increased 12-lipoxygenase expression in breast cancer tissues and cells. Regulation by epidermal growth factor.
Breast Neoplasms
Induction of apoptosis by Trichostatin A in human breast cancer cell lines: involvement of 15-Lox-1.
Breast Neoplasms
Involvement of 15-lipoxygenase-1 in the regulation of breast cancer cell death induced by sodium butyrate.
Breast Neoplasms
Levels of expression of lipoxygenases and cyclooxygenase-2 in human breast cancer.
Breast Neoplasms
Mechanisms regulating tumor angiogenesis by 12-lipoxygenase in prostate cancer cells.
Breast Neoplasms
Metabolic suppression of platelet-type 12-lipoxygenase in human uterine cervix with invasive carcinoma.
Breast Neoplasms
Oleic acid induces migration through a FFAR1/4, EGFR and Akt-dependent pathway in breast cancer cells.
Breast Neoplasms
Radiotherapy Increases 12-LOX and CCL5 Levels in Esophageal Cancer Cells and Promotes Cancer Metastasis via THP-1-Derived Macrophages.
Breast Neoplasms
Reduction of isoforms of 15-lipoxygenase (15-LOX)-1 and 15-LOX-2 in human breast cancer.
Breast Neoplasms
Role of lipoxygenases in breast cancer.
Breast Neoplasms
Serum 5-LOX: a progressive protein marker for breast cancer and new approach for therapeutic target.
Breast Neoplasms
Structure Based Design and Synthesis of Peptide Inhibitor of Human LOX-12: In Vitro and In Vivo Analysis of a Novel Therapeutic Agent for Breast Cancer.
Breast Neoplasms
Tetrahydrofurandiol stimulation of phospholipase A2, lipoxygenase, and cyclooxygenase gene expression and MCF-7 human breast cancer cell proliferation.
Breast Neoplasms
The 12-lipoxygenase gene-transfected MCF-7 human breast cancer cell line exhibits estrogen-independent, but estrogen and omega-6 fatty acid-stimulated proliferation in vitro, and enhanced growth in athymic nude mice.
Breast Neoplasms
The mechanisms of lipoxygenase inhibitor-induced apoptosis in human breast cancer cells.
Bronchitis
Environment Changes Genetic Effects on Respiratory Conditions and Allergic Phenotypes.
Bronchitis, Chronic
15(S)-HETE modulates LTB(4) production and neutrophil chemotaxis in chronic bronchitis.
Bronchitis, Chronic
Gene expression and immunolocalization of 15-lipoxygenase isozymes in the airway mucosa of smokers with chronic bronchitis.
Bronchitis, Chronic
Histochemical evidence for induction of arachidonate 15-lipoxygenase in airway disease.
Bronchitis, Chronic
Substituted (E)-2-(2-benzylidenehydrazinyl)-4-methylthiazole-5-carboxylates as dual inhibitors of 15-lipoxygenase & carbonic anhydrase II: synthesis, biochemical evaluation and docking studies.
Carcinogenesis
12-Lipoxygenase promotes invasion and metastasis of human gastric cancer cells via epithelial-mesenchymal transition.
Carcinogenesis
12/15 lipoxygenase regulation of colorectal tumorigenesis is determined by the relative tumor levels of its metabolite 12-HETE and 13-HODE in animal models.
Carcinogenesis
15-lipoxygenase metabolites of gamma-linolenic acid/eicosapentaenoic acid suppress growth and arachidonic acid metabolism in human prostatic adenocarcinoma cells: possible implications of dietary fatty acids.
Carcinogenesis
15-lipoxygenase-1 production is lost in pancreatic cancer and overexpression of the gene inhibits tumor cell growth.
Carcinogenesis
15-Lipoxygenase-1 suppression of colitis-associated colon cancer through inhibition of the IL-6/STAT3 signaling pathway.
Carcinogenesis
15-LOX-1 suppression of hypoxia-induced metastatic phenotype and HIF-1? expression in human colon cancer cells.
Carcinogenesis
15-LOX-1: a novel molecular target of nonsteroidal anti-inflammatory drug-induced apoptosis in colorectal cancer cells.
Carcinogenesis
5-Lipoxygenase is a direct p53 target gene in humans.
Carcinogenesis
5-Lipoxygenase is Coexpressed with Cox-2 in Sporadic Colorectal Cancer: A Correlation with Advanced Stage.
Carcinogenesis
A Sucrose-Enriched Diet Promotes Tumorigenesis in Mammary Gland in Part through the 12-Lipoxygenase Pathway.
Carcinogenesis
Activation of peroxisome proliferator-activated receptor (PPAR)-gamma by 15S-hydroxyeicosatrienoic acid parallels growth suppression of androgen-dependent prostatic adenocarcinoma cells.
Carcinogenesis
ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway.
Carcinogenesis
ALOX12B promotes carcinogenesis in cervical cancer by regulating the PI3K/ERK1 signaling pathway.
Carcinogenesis
ALOX15 as a suppressor of inflammation and cancer: Lost in the link.
Carcinogenesis
Antitumor Activities of Ethyl Acetate Extracts from Selaginella doederleinii Hieron In Vitro and In Vivo and Its Possible Mechanism.
Carcinogenesis
Associations of functional polymorphisms in cyclooxygenase-2 and platelet 12-lipoxygenase with risk of occurrence and advanced disease status of colorectal cancer.
Carcinogenesis
Deletions linked to TP53 loss drive cancer through p53-independent mechanisms.
Carcinogenesis
Effects of gut-targeted 15-LOX-1 transgene expression on colonic tumorigenesis in mice.
Carcinogenesis
Eicosanoid profiling in colon cancer: Emergence of a pattern.
Carcinogenesis
Expression of 12-lipoxygenase as a biomarker for melanoma carcinogenesis.
Carcinogenesis
Expression of 15-lipoxygenase-1 in human colorectal cancer.
Carcinogenesis
Expression of cyclooxygenase-2, 12-lipoxygenase, and inducible nitric oxide synthase in head and neck squamous cell carcinoma.
Carcinogenesis
Honokiol inhibits gastric tumourigenesis by activation of 15-lipoxygenase-1 and consequent inhibition of peroxisome proliferator-activated receptor-gamma and COX-2-dependent signals.
Carcinogenesis
Inhibition of carcinogenesis in transgenic mouse models over-expressing 15-lipoxygenase in the vascular wall under the control of murine preproendothelin-1 promoter.
Carcinogenesis
Lipoxygenase metabolism: roles in tumor progression and survival.
Carcinogenesis
Lipoxygenase modulation to reverse carcinogenesis.
Carcinogenesis
Mechanisms regulating tumor angiogenesis by 12-lipoxygenase in prostate cancer cells.
Carcinogenesis
Mechanistic contribution of ubiquitous 15-lipoxygenase-1 expression loss in cancer cells to terminal cell differentiation evasion.
Carcinogenesis
Metabolic suppression of platelet-type 12-lipoxygenase in human uterine cervix with invasive carcinoma.
Carcinogenesis
Orthotopic expression of human 15-lipoxygenase (LO)-1 in the dorsolateral prostate of normal wild-type C57BL/6 mouse causes PIN-like lesions.
Carcinogenesis
Platelet 12-lipoxygenase Arg261Gln polymorphism: functional characterization and association with risk of esophageal squamous cell carcinoma in combination with COX-2 polymorphisms.
Carcinogenesis
Platelet-type 12-lipoxygenase accelerates tumor promotion of mouse epidermal cells through enhancement of cloning efficiency.
Carcinogenesis
Polymorphisms in arachidonic acid metabolism-related genes and the risk and prognosis of colorectal cancer.
Carcinogenesis
Profiling lipoxygenase metabolism in specific steps of colorectal tumorigenesis.
Carcinogenesis
Radiotherapy Increases 12-LOX and CCL5 Levels in Esophageal Cancer Cells and Promotes Cancer Metastasis via THP-1-Derived Macrophages.
Carcinogenesis
Role of 'platelet-type' 12-lipoxygenase in skin carcinogenesis.
Carcinogenesis
Suppression of Membranous LRP5 Recycling, Wnt/?-Catenin Signaling, and Colon Carcinogenesis by 15-LOX-1 Peroxidation of Linoleic Acid in PI3P.
Carcinogenesis
The critical role of 15-lipoxygenase-1 in colorectal epithelial cell terminal differentiation and tumorigenesis.
Carcinogenesis
The Investigation of Lipoxygenases as Therapeutic Targets in Malignant Pleural Mesothelioma.
Carcinogenesis
The possible involvement of 15-lipoxygenase/leukocyte type 12-lipoxygenase in colorectal carcinogenesis.
Carcinogenesis
The role of 15-lipoxygenase-1 expression and its potential role in the pathogenesis of endometrial hyperplasia and endometrial adenocarcinomas.
Carcinogenesis
The role of lipoxygenases in pathophysiology; new insights and future perspectives.
Carcinogenesis
The transcription factor GATA-6 is overexpressed in vivo and contributes to silencing 15-LOX-1 in vitro in human colon cancer.
Carcinogenesis
Therapeutic molecular targeting of 15-lipoxygenase-1 in colon cancer.
Carcinogenesis
Therapeutic Molecular Targetingof 15-Lipoxygenase-1 in Colon Cancer.
Carcinogenesis
What are cyclooxygenases and lipoxygenases doing in the driver's seat of carcinogenesis?
Carcinoma
12(S)-HETE enhancement of prostate tumor cell invasion: selective role of PKC alpha.
Carcinoma
12-HETE facilitates cell survival by activating the integrin-linked kinase/NF-?B pathway in ovarian cancer.
Carcinoma
12-Lipoxygenase in Lewis lung carcinoma cells: molecular identity, intracellular distribution of activity and protein, and Ca(2+)-dependent translocation from cytosol to membranes.
Carcinoma
12-lipoxygenase promotes tumor progress by TGF-?1-mediated epithelial to mesenchymal transition and predicts poor prognosis in esophageal squamous cell carcinoma.
Carcinoma
15-Lipoxygenase-1 activates tumor suppressor p53 independent of enzymatic activity.
Carcinoma
15-LOX-1 inhibits p21 (Cip/WAF 1) expression by enhancing MEK-ERK 1/2 signaling in colon carcinoma cells.
Carcinoma
5-Lipoxygenase inhibitors attenuate growth of human renal cell carcinoma and induce apoptosis through arachidonic acid pathway.
Carcinoma
?-Conotoxins Enhance both the In Vivo Suppression of Ehrlich carcinoma Growth and In Vitro Reduction in Cell Viability Elicited by Cyclooxygenase and Lipoxygenase Inhibitors.
Carcinoma
Diverse roles of 2-arachidonoylglycerol in invasion of prostate carcinoma cells: Location, hydrolysis and 12-lipoxygenase metabolism.
Carcinoma
Eicosanoid regulation of angiogenesis in tumors.
Carcinoma
Elevated expression of 12/15-lipoxygenase and cyclooxygenase-2 in a transgenic mouse model of prostate carcinoma.
Carcinoma
Endogenous 12(S)-HETE production by tumor cells and its role in metastasis.
Carcinoma
Evaluation of 12-lipoxygenase (12-LOX) and plasminogen activator inhibitor 1 (PAI-1) as prognostic markers in prostate cancer.
Carcinoma
Expression of 12-lipoxygenase in human renal cell carcinoma and growth prevention by its inhibitor.
Carcinoma
Expression of cyclooxygenase-2, 12-lipoxygenase, and inducible nitric oxide synthase in head and neck squamous cell carcinoma.
Carcinoma
Expression, subcellular localization and putative function of platelet-type 12-lipoxygenase in human prostate cancer cell lines of different metastatic potential.
Carcinoma
Increased metastatic potential in human prostate carcinoma cells by overexpression of arachidonate 12-lipoxygenase.
Carcinoma
Inhibition of 12-lipoxygenase during baicalein-induced human lung nonsmall carcinoma H460 cell apoptosis.
Carcinoma
Interleukin-4-mediated 15-lipoxygenase-1 trans-activation requires UTX recruitment and H3K27me3 demethylation at the promoter in A549 cells.
Carcinoma
Inverse regulation of lipid-peroxidizing and hydroperoxyl lipid-reducing enzymes by interleukins 4 and 13.
Carcinoma
Mechanisms regulating tumor angiogenesis by 12-lipoxygenase in prostate cancer cells.
Carcinoma
Metabolic suppression of platelet-type 12-lipoxygenase in human uterine cervix with invasive carcinoma.
Carcinoma
Multiple use of a signal transduction pathway in tumor cell invasion.
Carcinoma
Nonsteroidal anti-inflammatory drugs induce apoptosis in esophageal cancer cells by restoring 15-lipoxygenase-1 expression.
Carcinoma
Opposing effects of 15-lipoxygenase-1 and -2 metabolites on MAPK signaling in prostate. Alteration in peroxisome proliferator-activated receptor gamma.
Carcinoma
Overexpression of 12/15-lipoxygenase, an ortholog of human 15-lipoxygenase-1, in the prostate tumors of TRAMP mice.
Carcinoma
Phospho-?Np63? regulates AQP3, ALOX12B, CASP14 and CLDN1 expression through transcription and microRNA modulation.
Carcinoma
Platelet 12-lipoxygenase Arg261Gln polymorphism: functional characterization and association with risk of esophageal squamous cell carcinoma in combination with COX-2 polymorphisms.
Carcinoma
Platelet-type 12- lipoxygenase induces MMP9 expression and cellular invasion via activation of PI3K/AKT/NF-?B.
Carcinoma
Platelet-type 12-lipoxygenase in a human prostate carcinoma stimulates angiogenesis and tumor growth.
Carcinoma
Platelet-type 12-lipoxygenase regulates angiogenesis in human prostate carcinoma.
Carcinoma
Radiotherapy Increases 12-LOX and CCL5 Levels in Esophageal Cancer Cells and Promotes Cancer Metastasis via THP-1-Derived Macrophages.
Carcinoma
Reduced expression of 15-lipoxygenase 2 in human head and neck carcinomas.
Carcinoma
Regulation of 15-lipoxygenase expression in lung epithelial cells by interleukin-4.
Carcinoma
Regulation of apoptosis through arachidonate cascade in mammalian cells.
Carcinoma
Regulation of monoamine oxidase A (MAO-A) expression, activity, and function in IL-13-stimulated monocytes and A549 lung carcinoma cells.
Carcinoma
Role of 12-lipoxygenase in regulation of ovarian cancer cell proliferation and survival.
Carcinoma
Specific overexpression of 15-lipoxygenase in endothelial cells promotes cancer cell death in an in vivo Lewis lung carcinoma mouse model.
Carcinoma
Tumor-associated down-regulation of 15-lipoxygenase-1 is reversed by celecoxib in colorectal cancer.
Carcinoma
[Association of genetic variant in 12-lipoxygenase and risk of hepatic carcinoma].
Carcinoma, Ductal
Levels of expression of lipoxygenases and cyclooxygenase-2 in human breast cancer.
Carcinoma, Hepatocellular
15-Lipoxygenase-1/15-hydroxyeicosatetraenoic acid promotes hepatocellular cancer cells growth through protein kinase B and heat shock protein 90 complex activation.
Carcinoma, Hepatocellular
Genetic ablation and short-duration inhibition of lipoxygenase results in increased macroautophagy.
Carcinoma, Hepatocellular
Inhibition of 12-lipoxygenase reduces proliferation and induces apoptosis of hepatocellular carcinoma cells in vitro and in vivo.
Carcinoma, Lewis Lung
12-Lipoxygenase in Lewis lung carcinoma cells: molecular identity, intracellular distribution of activity and protein, and Ca(2+)-dependent translocation from cytosol to membranes.
Carcinoma, Lewis Lung
Specific overexpression of 15-lipoxygenase in endothelial cells promotes cancer cell death in an in vivo Lewis lung carcinoma mouse model.
Carcinoma, Lobular
Levels of expression of lipoxygenases and cyclooxygenase-2 in human breast cancer.
Carcinoma, Non-Small-Cell Lung
Regulation of monoamine oxidase A (MAO-A) expression, activity, and function in IL-13-stimulated monocytes and A549 lung carcinoma cells.
Carcinoma, Ovarian Epithelial
Role of 12-lipoxygenase in regulation of ovarian cancer cell proliferation and survival.
Carcinoma, Renal Cell
5-Lipoxygenase inhibitors attenuate growth of human renal cell carcinoma and induce apoptosis through arachidonic acid pathway.
Carcinoma, Renal Cell
Expression of 12-lipoxygenase in human renal cell carcinoma and growth prevention by its inhibitor.
Carcinoma, Squamous Cell
12-Lipoxygenase in A431 cells: genetic identity, modulation of expression, and intracellular localization.
Carcinoma, Squamous Cell
ALOX12B promotes carcinogenesis in cervical cancer by regulating the PI3K/ERK1 signaling pathway.
Carcinoma, Squamous Cell
Attenuation of c-Jun and Sp1 expression and p300 recruitment to gene promoter confers the trichostatin A-induced inhibition of 12(S)-lipoxygenase expression in EGF-treated A431 cells.
Carcinoma, Squamous Cell
Depletion of phospholipid hydroperoxide glutathione peroxidase up-regulates arachidonate metabolism by 12S-lipoxygenase and cyclooxygenase 1 in human epidermoid carcinoma A431 cells.
Carcinoma, Squamous Cell
Down-regulation of epidermal growth factor-induced 12-lipoxygenase expression by glucocorticoids in human epidermoid carcinoma A431 cells.
Carcinoma, Squamous Cell
Epidermal growth factor enhances transcription of human arachidonate 12-lipoxygenase in A431 cells.
Carcinoma, Squamous Cell
Essential role of mitogen-activated protein kinase pathway and c-Jun induction in epidermal growth factor-induced gene expression of human 12-lipoxygenase.
Carcinoma, Squamous Cell
Expression of cyclooxygenase-2, 12-lipoxygenase, and inducible nitric oxide synthase in head and neck squamous cell carcinoma.
Carcinoma, Squamous Cell
Functional interaction between c-Jun and promoter factor Sp1 in epidermal growth factor-induced gene expression of human 12(S)-lipoxygenase.
Carcinoma, Squamous Cell
Functional role of extracellular signal-regulated kinase activation and c-Jun induction in phorbol ester-induced promoter activation of human 12(S)-lipoxygenase gene.
Carcinoma, Squamous Cell
Identification of 12-lipoxygenase interaction with cellular proteins by yeast two-hybrid screening.
Carcinoma, Squamous Cell
Induction of 12-lipoxygenase expression by epidermal growth factor is mediated by protein kinase C in A431 cells.
Carcinoma, Squamous Cell
Induction of 12-lipoxygenase expression by phorbol 12-myristate 13-acetate in human epidermoid carcinoma A431 cells.
Carcinoma, Squamous Cell
Induction of 12-lipoxygenase expression by transforming growth factor-alpha in human epidermoid carcinoma A431 cells.
Carcinoma, Squamous Cell
Induction of arachidonate 12-lipoxygenase mRNA by epidermal growth factor in A431 cells.
Carcinoma, Squamous Cell
Inhibition of 12-LOX and COX-2 reduces the proliferation of human epidermoid carcinoma cells (A431) by modulating the ERK and PI3K-Akt signalling pathways.
Carcinoma, Squamous Cell
Lipoxygenase pathway of arachidonic acid metabolism in growth control of tumor cells of different type.
Carcinoma, Squamous Cell
Overexpression of c-Fos enhances the transcription of human arachidonate 12-lipoxygenase in A431 cells.
Carcinoma, Squamous Cell
Overexpression of Ha-ras enhances the transcription of human arachidonate 12-lipoxygenase promoter in A431 cells.
Carcinoma, Squamous Cell
Phospho-?Np63? regulates AQP3, ALOX12B, CASP14 and CLDN1 expression through transcription and microRNA modulation.
Carcinoma, Squamous Cell
Regulation of 12-lipoxygenase expression by epidermal growth factor in human epidermoid carcinoma A431 cells.
Carcinoma, Squamous Cell
Requirement for epidermal growth factor receptor tyrosine kinase and for 12-lipoxygenase activity in the expression of 12-lipoxygenase in human epidermoid carcinoma cells.
Carcinoma, Squamous Cell
Transcription factor Sp1 functions as an anchor protein in gene transcription of human 12(S)-lipoxygenase.
Carcinoma, Squamous Cell
Transcriptional activation of human 12-lipoxygenase gene promoter is mediated through Sp1 consensus sites in A431 cells.
Carcinosarcoma
Apoptosis of W256 carcinosarcoma cells of the monocytoid origin induced by NDGA involves lipid peroxidation and depletion of GSH: role of 12-lipoxygenase in regulating tumor cell survival.
Carcinosarcoma
Arachidonate lipoxygenases as essential regulators of cell survival and apoptosis.
Carcinosarcoma
Overexpression of leukocyte-type 12-lipoxygenase promotes W256 tumor cell survival by enhancing alphavbeta5 expression.
Cardiovascular Diseases
12-Lipoxygenase metabolism in mouse distal convoluted tubule cells.
Cardiovascular Diseases
A Cell-based Assay for Screening Lipoxygenase Inhibitors.
Cardiovascular Diseases
A coding polymorphism in the 12-lipoxygenase gene is associated to essential hypertension and urinary 12(S)-HETE.
Cardiovascular Diseases
Distinctive Under-Expression Profile of Inflammatory and Redox Genes in the Blood of Elderly Patients with Cardiovascular Disease.
Cardiovascular Diseases
Impact of Age, Menopause, and Obesity on Oxylipins Linked to Vascular Health.
Cardiovascular Diseases
The biological role of arachidonic acid 12-lipoxygenase (ALOX12) in various human diseases.
Carotid Stenosis
Arachidonate 15-lipoxygenase enzyme products increase platelet aggregation and thrombin generation.
Cataract
A role for 12(S)-HETE in the response of human lens epithelial cells to epidermal growth factor and insulin.
Cerebral Hemorrhage
A Promoter polymorphism (rs17222919, -1316T/G) of ALOX5AP is associated with intracerebral hemorrhage in Korean population.
Cerebral Hemorrhage
Activation of peroxisome proliferator-activated receptor-? by a 12/15-lipoxygenase product of arachidonic acid: a possible neuroprotective effect in the brain after experimental intracerebral hemorrhage.
Cerebral Infarction
Key role of 15-LO/15-HETE in angiogenesis and functional recovery in later stages of post-stroke mice.
Cholangiocarcinoma
Zileuton suppresses cholangiocarcinoma cell proliferation and migration through inhibition of the Akt signaling pathway.
Cholesteatoma
Quantitative measurement of m-RNA levels to assess expression of cyclooxygenase-II, inducible nitric oxide synthase and 12-lipoxygenase genes in middle ear cholesteatoma.
Cholesteatoma, Middle Ear
Quantitative measurement of m-RNA levels to assess expression of cyclooxygenase-II, inducible nitric oxide synthase and 12-lipoxygenase genes in middle ear cholesteatoma.
Chronic Periodontitis
Effect of Alox-15 Polymorphism on GCF Levels of Lipoxin-A4 in Chronic Periodontitis: A Preliminary Study.
Chronic Periodontitis
Impaired polymorphonuclear leukocyte 15-lipoxygenase activity in juvenile and rapidly progressive periodontitis.
Colitis
ALOX15 as a suppressor of inflammation and cancer: Lost in the link.
Colitis
Female mice carrying a defective Alox15 gene are protected from experimental colitis via sustained maintenance of the intestinal epithelial barrier function.
Colitis
Lipoxin biosynthesis in inflammatory bowel disease.
Colitis
Omega-3 fatty acids protect from colitis via an Alox15-derived eicosanoid.
Colitis
Protectin D1n-3 DPA and resolvin D5n-3 DPA are effectors of intestinal protection.
Colitis
The role of 15-LOX-1 in colitis and colitis-associated colorectal cancer.
Colitis, Ulcerative
Induction of epithelial arachidonate 12-lipoxygenase at active sites of inflammatory bowel disease.
Colitis-Associated Neoplasms
The role of 15-LOX-1 in colitis and colitis-associated colorectal cancer.
Colonic Neoplasms
12/15 lipoxygenase regulation of colorectal tumorigenesis is determined by the relative tumor levels of its metabolite 12-HETE and 13-HODE in animal models.
Colonic Neoplasms
15-Lipoxygenase-1 as a tumor suppressor gene in colon cancer: is the verdict in?
Colonic Neoplasms
15-Lipoxygenase-1 mediates nonsteroidal anti-inflammatory drug-induced apoptosis independently of cyclooxygenase-2 in colon cancer cells.
Colonic Neoplasms
15-Lipoxygenase-1 suppression of colitis-associated colon cancer through inhibition of the IL-6/STAT3 signaling pathway.
Colonic Neoplasms
15-Lipoxygenase-1 transcriptional silencing by DNA methyltransferase-1 independently of DNA methylation.
Colonic Neoplasms
15-LOX-1 suppression of hypoxia-induced metastatic phenotype and HIF-1? expression in human colon cancer cells.
Colonic Neoplasms
15-LOX-1 transcription suppression through the NuRD complex in colon cancer cells.
Colonic Neoplasms
Activation of protein kinase G up-regulates expression of 15-lipoxygenase-1 in human colon cancer cells.
Colonic Neoplasms
Arachidonate lipoxygenase (ALOX) and cyclooxygenase (COX) polymorphisms and colon cancer risk.
Colonic Neoplasms
Chromatin modification requirements for 15-lipoxygenase-1 transcriptional reactivation in colon cancer cells.
Colonic Neoplasms
Colon cancer: genomics and apoptotic events.
Colonic Neoplasms
Decreased 13-S-hydroxyoctadecadienoic acid levels and 15-lipoxygenase-1 expression in human colon cancers.
Colonic Neoplasms
Eicosapentaenoic acid's metabolism of 15-LOX-1 promotes the expression of miR-101 thus inhibits Cox2 pathway in colon cancer.
Colonic Neoplasms
Mechanistic contribution of ubiquitous 15-lipoxygenase-1 expression loss in cancer cells to terminal cell differentiation evasion.
Colonic Neoplasms
Modulation of hypericin photodynamic therapy by pretreatment with 12 various inhibitors of arachidonic acid metabolism in colon adenocarcinoma HT-29 cells.
Colonic Neoplasms
Nox1 downstream of 12-lipoxygenase controls cell proliferation but not cell spreading of colon cancer cells.
Colonic Neoplasms
Oxidative metabolism of linoleic acid modulates PPAR-beta/delta suppression of PPAR-gamma activity.
Colonic Neoplasms
Platelets induce free and phospholipid-esterified 12-hydroxyeicosatetraenoic acid generation in colon cancer cells by delivering 12-lipoxygenase.
Colonic Neoplasms
PTGS1, PTGS2, ALOX5, ALOX12, ALOX15, and FLAP SNPs: interaction with fatty acids in colon cancer and rectal cancer.
Colonic Neoplasms
The polymorphism (Gln261Arg) of 12-lipoxygenase and cancer risk: a meta-analysis.
Colonic Neoplasms
The transcription factor GATA-6 is overexpressed in vivo and contributes to silencing 15-LOX-1 in vitro in human colon cancer.
Colonic Neoplasms
Therapeutic molecular targeting of 15-lipoxygenase-1 in colon cancer.
Colonic Neoplasms
Therapeutic Molecular Targetingof 15-Lipoxygenase-1 in Colon Cancer.
Colorectal Neoplasms
15-hydroxy-eicosatetraenoic acid arrests growth of colorectal cancer cells via a peroxisome proliferator-activated receptor gamma-dependent pathway.
Colorectal Neoplasms
15-Lipoxygenase-1 activates tumor suppressor p53 independent of enzymatic activity.
Colorectal Neoplasms
15-lipoxygenase-1 in colorectal cancer: a review.
Colorectal Neoplasms
15-Lipoxygenase-1 mediates nonsteroidal anti-inflammatory drug-induced apoptosis independently of cyclooxygenase-2 in colon cancer cells.
Colorectal Neoplasms
15-Lipoxygenase-1 re-expression in colorectal cancer alters endothelial cell features through enhanced expression of TSP-1 and ICAM-1.
Colorectal Neoplasms
15-Lipoxygenase-1 transcriptional silencing by DNA methyltransferase-1 independently of DNA methylation.
Colorectal Neoplasms
15-LOX-1 inhibits p21 (Cip/WAF 1) expression by enhancing MEK-ERK 1/2 signaling in colon carcinoma cells.
Colorectal Neoplasms
15-LOX-1 transcription suppression through the NuRD complex in colon cancer cells.
Colorectal Neoplasms
15-LOX-1: a novel molecular target of nonsteroidal anti-inflammatory drug-induced apoptosis in colorectal cancer cells.
Colorectal Neoplasms
ALOX15 as a suppressor of inflammation and cancer: Lost in the link.
Colorectal Neoplasms
Assessing 12(S)-lipoxygenase inhibitory activity using colorectal cancer cells overexpressing the enzyme.
Colorectal Neoplasms
Associations of functional polymorphisms in cyclooxygenase-2 and platelet 12-lipoxygenase with risk of occurrence and advanced disease status of colorectal cancer.
Colorectal Neoplasms
Deficiency of 15-LOX-1 Induces Radioresistance through Downregulation of MacroH2A2 in Colorectal Cancer.
Colorectal Neoplasms
Evaluation of eicosanoids and NSAIDs as PPARgamma ligands in colorectal carcinoma cells.
Colorectal Neoplasms
Expression of 15-lipoxygenase by human colorectal carcinoma Caco-2 cells during apoptosis and cell differentiation.
Colorectal Neoplasms
Expression of 15-lipoxygenase-1 in human colorectal cancer.
Colorectal Neoplasms
GATA-6 transcriptional regulation of 15-lipoxygenase-1 during NSAID-induced apoptosis in colorectal cancer cells.
Colorectal Neoplasms
Genetic variation in the lipoxygenase pathway and risk of colorectal neoplasia.
Colorectal Neoplasms
Lipoxygenase modulation to reverse carcinogenesis.
Colorectal Neoplasms
MiR-216a-3p inhibits colorectal cancer cell proliferation through direct targeting COX-2 and ALOX5.
Colorectal Neoplasms
Non-synonymous polymorphism (Gln261Arg) of 12-lipoxygenase in colorectal and thyroid cancers.
Colorectal Neoplasms
Nonsteroidal anti-inflammatory drugs induce apoptosis in esophageal cancer cells by restoring 15-lipoxygenase-1 expression.
Colorectal Neoplasms
Opposing effects of 15-lipoxygenase-1 and -2 metabolites on MAPK signaling in prostate. Alteration in peroxisome proliferator-activated receptor gamma.
Colorectal Neoplasms
Overexpression of 15-lipoxygenase-1 induces growth arrest through phosphorylation of p53 in human colorectal cancer cells.
Colorectal Neoplasms
Polymorphisms in arachidonic acid metabolism-related genes and the risk and prognosis of colorectal cancer.
Colorectal Neoplasms
The 15-lipoxygenase-1 product 13-S-hydroxyoctadecadienoic acid down-regulates PPAR-delta to induce apoptosis in colorectal cancer cells.
Colorectal Neoplasms
The methyltransferase inhibitor 5-aza-2-deoxycytidine induces apoptosis via induction of 15-lipoxygenase-1 in colorectal cancer cells.
Colorectal Neoplasms
The role of 15-LOX-1 in colitis and colitis-associated colorectal cancer.
Colorectal Neoplasms
The transcription factor GATA-6 is overexpressed in vivo and contributes to silencing 15-LOX-1 in vitro in human colon cancer.
Colorectal Neoplasms
Therapeutic molecular targeting of 15-lipoxygenase-1 in colon cancer.
Colorectal Neoplasms
Therapeutic Molecular Targetingof 15-Lipoxygenase-1 in Colon Cancer.
Colorectal Neoplasms
Tumor-associated down-regulation of 15-lipoxygenase-1 is reversed by celecoxib in colorectal cancer.
Colorectal Neoplasms
Up-regulation of 12(S)-lipoxygenase induces a migratory phenotype in colorectal cancer cells.
Coronary Artery Disease
A near null variant of 12/15-LOX encoded by a novel SNP in ALOX15 and the risk of coronary artery disease.
Coronary Artery Disease
Association of polymorphisms in the ALOX15B gene with coronary artery disease.
Coronary Artery Disease
Association of Sp1 tandem repeat polymorphism of ALOX5 with coronary artery disease in Indian subjects.
Coronary Artery Disease
Common polymorphisms of ALOX5 and ALOX5AP and risk of coronary artery disease.
Coronary Artery Disease
Expression of 15-lipoxygenase in transplant coronary artery disease.
Coronary Artery Disease
Genome-Wide Association Meta-Analysis of Single-Nucleotide Polymorphisms and Symptomatic Venous Thromboembolism during Therapy for Acute Lymphoblastic Leukemia and Lymphoma in Caucasian Children.
Coronary Artery Disease
Immunohistochemical demonstration of 15-lipoxygenase in transplant coronary artery disease.
Coronary Artery Disease
Interaction between ALOX15 polymorphisms and coronary artery disease in North Indian population.
Coronary Artery Disease
Lipoxygenase pathways in atherogenesis.
Coronary Artery Disease
Molecular basis for the reduced catalytic activity of the naturally occurring T560M mutant of human 12/15-lipoxygenase that has been implicated in coronary artery disease.
Coronary Artery Disease
No association of two functional polymorphisms in human ALOX15 with myocardial infarction.
Coronary Artery Disease
Normal high density lipoprotein inhibits three steps in the formation of mildly oxidized low density lipoprotein: steps 2 and 3.
Coronary Artery Disease
Replacement of an Indole Scaffold Targeting Human 15-Lipoxygenase-1 Using Combinatorial Chemistry.
Coronary Artery Disease
Two single nucleotide polymorphisms in ALOX15 are associated with risk of coronary artery disease in a Chinese Han population.
Coronary Disease
5-Lipoxygenase Gene Variants Are Not Associated With Atherosclerosis or Incident Coronary Heart Disease in the Multi-Ethnic Study of Atherosclerosis Cohort.
Coronary Disease
Inhibitory effect of flavonoids on low-density lipoprotein peroxidation catalyzed by mammalian 15-lipoxygenase.
Cough
Bradykinin sensitizes the cough reflex via a B2 receptor dependent activation of TRPV1 and TRPA1 channels through metabolites of cyclooxygenase and 12-lipoxygenase.
COVID-19
LTB4-Driven Inflammation and Increased Expression of ALOX5/ACE2 During Severe COVID-19 in Individuals With Diabetes.
Crohn Disease
Induction of epithelial arachidonate 12-lipoxygenase at active sites of inflammatory bowel disease.
Cystic Fibrosis
Effect of allergy and inflammation on eicosanoid gene expression in CFTR deficiency.
Cystic Fibrosis
Eicosanoid mediator expression in mononuclear and polymorphonuclear cells in normal subjects and patients with atopic asthma and cystic fibrosis.
Cystic Fibrosis
Reverse transcription-polymerase chain reaction (RT-PCR) phenotypic analysis of cell cultures of human tracheal epithelium, tracheobronchial glands, and lung carcinomas.
Cystitis
Expression of lipoxygenase in human bladder carcinoma and growth inhibition by its inhibitors.
Dementia
Benefits of neuropsychiatric phenomics: example of the 5-lipoxygenase-leptin-Alzheimer connection.
Dermatitis
Environment Changes Genetic Effects on Respiratory Conditions and Allergic Phenotypes.
Dermatitis, Contact
Human 15-lipoxygenase-1 is a regulator of dendritic-cell spreading and podosome formation.
Dermatitis, Exfoliative
A novel mutation in the 12(R)-lipoxygenase (ALOX12B) gene underlies nonbullous congenital ichthyosiform erythroderma.
Dermatitis, Exfoliative
Congenital ichthyosiform erythroderma with a novel variant in ABCA12 in a Chinese patient.
Dermatitis, Exfoliative
Different TGM1 mutation spectra in Italian and Portuguese patients with autosomal recessive congenital ichthyosis: evidence of founder effects in Portugal.
Dermatitis, Exfoliative
Hepoxilin A3 (HXA3) synthase deficiency is causative of a novel ichthyosis form.
Dermatitis, Exfoliative
Lipoxygenase-3 (ALOXE3) and 12(R)-lipoxygenase (ALOX12B) are mutated in non-bullous congenital ichthyosiform erythroderma (NCIE) linked to chromosome 17p13.1.
Dermatitis, Exfoliative
Mutation spectrum and functional analysis of epidermis-type lipoxygenases in patients with autosomal recessive congenital ichthyosis.
Dermatitis, Exfoliative
Mutations associated with a congenital form of ichthyosis (NCIE) inactivate the epidermal lipoxygenases 12R-LOX and eLOX3.
Dermatitis, Exfoliative
Novel mutations in ALOX12B in patients with autosomal recessive congenital ichthyosis and evidence for genetic heterogeneity on chromosome 17p13.
Dermatitis, Exfoliative
Partially disturbed lamellar granule secretion in mild congenital ichthyosiform erythroderma with ALOX12B mutations.
Dermatitis, Exfoliative
Self-healing collodion membrane and mild nonbullous congenital ichthyosiform erythroderma due to 2 novel mutations in the ALOX12B gene.
Diabetes Complications
Role of the 12-lipoxygenase pathway in diabetes pathogenesis and complications.
Diabetes Mellitus
12(S)-HETE impairs vascular endothelial permeability by altering adherens junction phosphorylation levels and affecting the binding and dissociation of its components in high glucose-induced vascular injury.
Diabetes Mellitus
12/15-lipoxygenase inhibitors in diabetic nephropathy in the rat.
Diabetes Mellitus
Association of genetic variants with myocardial infarction in individuals with or without hypertension or diabetes mellitus.
Diabetes Mellitus
Baicalein Alleviates Erectile Dysfunction Associated With Streptozotocin-Induced Type I Diabetes by Ameliorating Endothelial Nitric Oxide Synthase Dysfunction, Inhibiting Oxidative Stress and Fibrosis.
Diabetes Mellitus
Elevated glucose and angiotensin II increase 12-lipoxygenase activity and expression in porcine aortic smooth muscle cells.
Diabetes Mellitus
Evaluation of the oxidative stress-related genes ALOX5, ALOX5AP, GPX1, GPX3 and MPO for contribution to the risk of type 2 diabetes mellitus in the Han Chinese population.
Diabetes Mellitus
Increased 12/15-Lipoxygenase Enhances Cell Growth, Fibronectin Deposition, and Neointimal Formation in Response to Carotid Injury.
Diabetes Mellitus
RAGE and CYBA polymorphisms are associated with microalbuminuria and end-stage renal disease onset in a cohort of type 1 diabetes mellitus patients over a 20-year follow-up.
Diabetes Mellitus
Role of the lipoxygenase pathway in phenylephrine-induced vascular smooth muscle cell proliferation and migration.
Diabetes Mellitus
The ALOXA5AP gene (rs38022789) is associated with diabetic nephropathy in Slovenian patients with type 2 diabetes mellitus.
Diabetes Mellitus
The association between the rs4987105 of 5-lipoxygenase (ALOX5) gene and gestational glucose metabolism in Chinese population.
Diabetes Mellitus, Type 1
12(S)-HETE impairs vascular endothelial permeability by altering adherens junction phosphorylation levels and affecting the binding and dissociation of its components in high glucose-induced vascular injury.
Diabetes Mellitus, Type 1
12-Lipoxygenase governs the innate immune pathogenesis of islet inflammation and autoimmune diabetes.
Diabetes Mellitus, Type 1
Deletion of 12/15-Lipoxygenase Alters Macrophage and Islet Function in NOD-Alox15(null) Mice, Leading to Protection against Type 1 Diabetes Development.
Diabetes Mellitus, Type 1
Effects of cholesterol-tagged small interfering RNAs targeting 12/15-lipoxygenase on parameters of diabetic nephropathy in a mouse model of type 1 diabetes.
Diabetes Mellitus, Type 1
Expression pattern of 12-lipoxygenase in human islets with type 1 diabetes and type 2 diabetes.
Diabetes Mellitus, Type 1
Inhibition of 12/15-Lipoxygenase Protects Against ? Cell Oxidative Stress and Glycemic Deterioration in Mouse Models of Type 1 Diabetes.
Diabetes Mellitus, Type 1
Leukotriene Pathway Activation Associates with Poor Glycemic Control and with Cardiovascular Autonomic Neuropathy in Type 1 Diabetes.
Diabetes Mellitus, Type 1
Lipids and immunoinflammatory pathways of beta cell destruction.
Diabetes Mellitus, Type 1
Nonobese diabetic (NOD) mice congenic for a targeted deletion of 12/15-lipoxygenase are protected from autoimmune diabetes.
Diabetes Mellitus, Type 1
RAGE and CYBA polymorphisms are associated with microalbuminuria and end-stage renal disease onset in a cohort of type 1 diabetes mellitus patients over a 20-year follow-up.
Diabetes Mellitus, Type 1
Resistance to type 1 diabetes induction in 12-lipoxygenase knockout mice.
Diabetes Mellitus, Type 1
The Four-Way Stop Sign: Viruses, 12-Lipoxygenase, Islets, and Natural Killer Cells in Type 1 Diabetes Progression.
Diabetes Mellitus, Type 2
12-Lipoxygenase Inhibitor Improves Functions of Cytokine-Treated Human Islets and Type 2 Diabetic Islets.
Diabetes Mellitus, Type 2
5-Lipoxygenase (ALOX5): Genetic susceptibility to type 2 diabetes and vitamin D effects on monocytes.
Diabetes Mellitus, Type 2
Activation of the 12/15 lipoxygenase pathway accompanies metabolic decline in db/db pre-diabetic mice.
Diabetes Mellitus, Type 2
Adipose tissue-specific deletion of 12/15-lipoxygenase protects mice from the consequences of a high-fat diet.
Diabetes Mellitus, Type 2
Association of arachidonate 12-lipoxygenase genotype variation and glycemic control with albuminuria in type 2 diabetes.
Diabetes Mellitus, Type 2
Decreased activity of arachidonate 12-lipoxygenase in platelets of Japanese patients with non-insulin-dependent diabetes mellitus.
Diabetes Mellitus, Type 2
Evaluation of the oxidative stress-related genes ALOX5, ALOX5AP, GPX1, GPX3 and MPO for contribution to the risk of type 2 diabetes mellitus in the Han Chinese population.
Diabetes Mellitus, Type 2
Expression pattern of 12-lipoxygenase in human islets with type 1 diabetes and type 2 diabetes.
Diabetes Mellitus, Type 2
Human lipoxygenase pathway gene variation and association with markers of subclinical atherosclerosis in the diabetes heart study.
Diabetes Mellitus, Type 2
Interaction between cytokines and inflammatory cells in islet dysfunction, insulin resistance and vascular disease.
Diabetes Mellitus, Type 2
Role of 12/15-lipoxygenase in nitrosative stress and peripheral prediabetic and diabetic neuropathies.
Diabetes Mellitus, Type 2
Role of the 12-lipoxygenase pathway in diabetes pathogenesis and complications.
Diabetes Mellitus, Type 2
The association between the rs4987105 of 5-lipoxygenase (ALOX5) gene and gestational glucose metabolism in Chinese population.
Diabetes Mellitus, Type 2
The role of 12-lipoxygenase in pancreatic -cells (Review).
Diabetic Angiopathies
Inhibition of 12/15-Lipoxygenase Reduces Renal Inflammation and Injury in Streptozotocin-Induced Diabetic Mice.
Diabetic Angiopathies
Lipid inflammatory mediators in diabetic vascular disease.
Diabetic Cardiomyopathies
Arachidonate 12/15-lipoxygenase-induced inflammation and oxidative stress are involved in the development of diabetic cardiomyopathy.
Diabetic Nephropathies
12-Lipoxygenase as a key pharmacological target in the pathogenesis of diabetic nephropathy.
Diabetic Nephropathies
12-Lipoxygenase Inhibition on Microalbuminuria in Type-1 and Type-2 Diabetes Is Associated with Changes of Glomerular Angiotensin II Type 1 Receptor Related to Insulin Resistance.
Diabetic Nephropathies
12-lipoxygenase is increased in glucose-stimulated mesangial cells and in experimental diabetic nephropathy.
Diabetic Nephropathies
12/15-lipoxygenase inhibitors in diabetic nephropathy in the rat.
Diabetic Nephropathies
7-Ketocholesterol induces ROS-mediated mRNA expression of 12-lipoxygenase, cyclooxygenase-2 and pro-inflammatory cytokines in human mesangial cells: Potential role in diabetic nephropathy.
Diabetic Nephropathies
Association of ALOX12 gene polymorphism with all-cause and cardiovascular mortality in diabetic nephropathy.
Diabetic Nephropathies
Differential behavior of mesangial cells derived from 12/15-lipoxygenase knockout mice relative to control mice.
Diabetic Nephropathies
Effect of angiotensin II type 1 receptor blocker on 12-lipoxygenase activity and slit diaphragm protein expression in type 2 diabetic rat glomeruli.
Diabetic Nephropathies
Effects of cholesterol-tagged small interfering RNAs targeting 12/15-lipoxygenase on parameters of diabetic nephropathy in a mouse model of type 1 diabetes.
Diabetic Nephropathies
Effects of pravastatin or 12/15 lipoxygenase pathway inhibitors on indices of diabetic nephropathy in an experimental model of diabetic renal disease.
Diabetic Nephropathies
Epigenetic Histone Modifications Involved in Profibrotic Gene Regulation by 12/15-Lipoxygenase and Its Oxidized Lipid Products in Diabetic Nephropathy.
Diabetic Nephropathies
p16ink4a Expression Is Increased through 12-Lipoxygenase in High Glucose-Stimulated Glomerular Mesangial Cells and Type 2 Diabetic Glomeruli.
Diabetic Nephropathies
Products of 12/15-lipoxygenase upregulate the angiotensin II receptor.
Diabetic Nephropathies
Relationship between 12/15-lipoxygenase and COX-2 in mesangial cells: potential role in diabetic nephropathy.
Diabetic Nephropathies
Role of 12-lipoxygenase in decreasing P-cadherin and increasing angiotensin II type 1 receptor expression according to glomerular size in type 2 diabetic rats.
Diabetic Nephropathies
Role of 12-lipoxygenase in the stimulation of p38 mitogen-activated protein kinase and collagen alpha5(IV) in experimental diabetic nephropathy and in glucose-stimulated podocytes.
Diabetic Nephropathies
Roles of 12-Lipoxygenase and Its Interaction with Angiotensin II on p21 and p27 Expression in Diabetic Nephropathy.
Diabetic Neuropathies
Different roles of 12/15-lipoxygenase in diabetic large and small fiber peripheral and autonomic neuropathies.
Diabetic Neuropathies
Role of 12/15-lipoxygenase in nitrosative stress and peripheral prediabetic and diabetic neuropathies.
Diabetic Retinopathy
5-Lipoxygenase, but not 12/15-lipoxygenase, contributes to degeneration of retinal capillaries in a mouse model of diabetic retinopathy.
Diabetic Retinopathy
A lipidomic screen of hyperglycemia-treated HRECs links 12/15-Lipoxygenase to microvascular dysfunction during diabetic retinopathy via NADPH oxidase.
Diabetic Retinopathy
Increased expression and activity of 12-lipoxygenase in oxygen-induced ischemic retinopathy and proliferative diabetic retinopathy: implications in retinal neovascularization.
Diabetic Retinopathy
Pigment epithelium-derived factor inhibits retinal microvascular dysfunction induced by 12/15-lipoxygenase-derived eicosanoids.
Diabetic Retinopathy
Role of endoplasmic reticulum stress in 12/15-lipoxygenase-induced retinal microvascular dysfunction in a mouse model of diabetic retinopathy.
Diabetic Retinopathy
Targeting of 12/15-Lipoxygenase in retinal endothelial cells, but not in monocytes/macrophages, attenuates high glucose-induced retinal leukostasis.
Dyslipidemias
Cyclocarya paliurus Leaves Tea Improves Dyslipidemia in Diabetic Mice: A Lipidomics-Based Network Pharmacology Study.
Embolic Stroke
Baicalein, an antioxidant 12/15-lipoxygenase inhibitor improves clinical rating scores following multiple infarct embolic strokes.
Encephalitis
12/15-lipoxygenase-dependent myeloid production of interleukin-12 is essential for resistance to chronic toxoplasmosis.
Encephalomyelitis
12/15-Lipoxygenase-mediated enzymatic lipid oxidation regulates DC maturation and function.
Encephalomyelitis
Inhibition of 12/15-lipoxygenase by baicalein induces microglia PPAR?/?: a potential therapeutic role for CNS autoimmune disease.
Encephalomyelitis, Autoimmune, Experimental
12/15-Lipoxygenase-mediated enzymatic lipid oxidation regulates DC maturation and function.
Encephalomyelitis, Autoimmune, Experimental
Experimental allergic encephalomyelitis is exacerbated in mice deficient for 12/15-lipoxygenase or 5-lipoxygenase.
Encephalomyelitis, Autoimmune, Experimental
Inhibition of 12/15-lipoxygenase by baicalein induces microglia PPAR?/?: a potential therapeutic role for CNS autoimmune disease.
Endocarditis
Monocyte responses in the context of q Fever: from a static polarized model to a kinetic model of activation.
Endometrial Hyperplasia
The role of 15-lipoxygenase-1 expression and its potential role in the pathogenesis of endometrial hyperplasia and endometrial adenocarcinomas.
Endometrial Neoplasms
The role of 15-lipoxygenase-1 expression and its potential role in the pathogenesis of endometrial hyperplasia and endometrial adenocarcinomas.
Endometriosis
Absence of association between a functional polymorphism of ALOX15 gene and infertility in endometriosis.
Endometriosis
Omega-3 polyunsaturated Fatty acids suppress the cystic lesion formation of peritoneal endometriosis in transgenic mouse models.
Endotoxemia
Hydroxyeicosatetraenoic acids are increased in bronchoalveolar lavage fluid of endotoxemic pigs.
Enteritis
hucMSCs Attenuate IBD through Releasing miR148b-5p to Inhibit the Expression of 15-lox-1 in Macrophages.
Enterocolitis
Arachidonate 5-lipoxygenase establishes adaptive humoral immunity by controlling primary B cells and their cognate T-cell help.
Eosinophilia
Comparison of 5- and 15-lipoxygenase activities in blood and alveolar leukocyte preparations from normal subjects and patients with eosinophilia.
Eosinophilia
Comparison of arachidonic acid metabolism in nasal polyps and eosinophils.
Eosinophilia
Correlation of ALOX15 expression with eosinophilic or reflux esophagitis in a cohort of pediatric patients with esophageal eosinophilia.
Eosinophilic Esophagitis
ALOX15 Immunohistochemistry Aids in the Diagnosis of Eosinophilic Esophagitis on Pauci-Eosinophilic Biopsies in Children.
Eosinophilic Esophagitis
ALOX15 Immunohistochemistry Aids in the Diagnosis of Eosinophilic Esophagitis on Pauci-eosinophilic Biopsies in Children.
Eosinophilic Esophagitis
Expression microarray analysis identifies novel epithelial-derived protein markers in eosinophilic esophagitis.
Epilepsy
5-lipoxygenase pathway and its downstream cysteinyl leukotrienes as potential therapeutic targets for Alzheimer's disease.
Epilepsy
Targeting ferroptosis: A novel therapeutic strategy for the treatment of mitochondrial disease-related epilepsy.
Erectile Dysfunction
Baicalein Alleviates Erectile Dysfunction Associated With Streptozotocin-Induced Type I Diabetes by Ameliorating Endothelial Nitric Oxide Synthase Dysfunction, Inhibiting Oxidative Stress and Fibrosis.
Erythema
The eicosanoid response to high dose UVR exposure of individuals prone and resistant to sunburn.
Erythema
The sunburn response in human skin is characterized by sequential eicosanoid profiles that may mediate its early and late phases.
Esophageal Neoplasms
15-Lipoxygenase-1 mediates cyclooxygenase-2 inhibitor-induced apoptosis in gastric cancer.
Esophageal Neoplasms
Nonsteroidal anti-inflammatory drugs induce apoptosis in esophageal cancer cells by restoring 15-lipoxygenase-1 expression.
Esophageal Neoplasms
Radiotherapy Increases 12-LOX and CCL5 Levels in Esophageal Cancer Cells and Promotes Cancer Metastasis via THP-1-Derived Macrophages.
Esophageal Neoplasms
The deregulation of arachidonic acid metabolism-related genes in human esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
12-lipoxygenase promotes tumor progress by TGF-?1-mediated epithelial to mesenchymal transition and predicts poor prognosis in esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
Platelet 12-lipoxygenase Arg261Gln polymorphism: functional characterization and association with risk of esophageal squamous cell carcinoma in combination with COX-2 polymorphisms.
Esophageal Squamous Cell Carcinoma
Radiotherapy Increases 12-LOX and CCL5 Levels in Esophageal Cancer Cells and Promotes Cancer Metastasis via THP-1-Derived Macrophages.
Esophagitis
Correlation of ALOX15 expression with eosinophilic or reflux esophagitis in a cohort of pediatric patients with esophageal eosinophilia.
Esophagitis, Peptic
Correlation of ALOX15 expression with eosinophilic or reflux esophagitis in a cohort of pediatric patients with esophageal eosinophilia.
Essential Hypertension
A coding polymorphism in the 12-lipoxygenase gene is associated to essential hypertension and urinary 12(S)-HETE.
Essential Hypertension
Increased levels of 12(S)-HETE in patients with essential hypertension.
Fatty Liver
Fatty acids modulate the expression of pyruvate kinase and arachidonate-lipoxygenase through PPAR?/CYP2C45 pathway: a link to goose fatty liver.
Fatty Liver
Reduced dietary omega-6 to omega-3 fatty acid ratio and 12/15-lipoxygenase deficiency are protective against chronic high fat diet-induced steatohepatitis.
Fibrosarcoma
In vitro proliferation of fibrosarcoma cells depends on intact functions of lipoxygenases and cytochrome P-450-monooxygenase.
Gastroesophageal Reflux
Correlation of ALOX15 expression with eosinophilic or reflux esophagitis in a cohort of pediatric patients with esophageal eosinophilia.
Gastrointestinal Diseases
Systems pharmacology to decipher the combinational anti-migraine effects of Tianshu formula.
Glioblastoma
Association of polymorphisms in FLT3, EGFR, ALOX5, and NEIL3 with glioblastoma in the Han Chinese population.
Glioma
12-Lipoxygenase overexpression in rodent NG108-15 cells enhances membrane excitability by inhibiting M-type K+ channels.
Glomerulonephritis
15-Lipoxygenase products as leukotriene antagonists: therapeutic potential in glomerulonephritis.
Glomerulonephritis
Co-regulated expression of glomerular 12/15-lipoxygenase and interleukin-4 mRNAs in rat nephrotoxic nephritis.
Glomerulonephritis
Elevated expressions of 15-lipoxygenase and lipoxin A4 in children with acute poststreptococcal glomerulonephritis.
Glomerulonephritis
Leukotrienes and 15-lipoxygenase products in glomerulonephritis.
Glomerulonephritis
Lipoxygenase product formation and cell adhesion during neutrophil-glomerular endothelial cell interaction.
Glomerulonephritis
Transfection of rat kidney with human 15-lipoxygenase suppresses inflammation and preserves function in experimental glomerulonephritis.
Glucose Intolerance
Disruption of the 12/15-lipoxygenase gene (Alox15) protects hyperlipidemic mice from nonalcoholic fatty liver disease.
Granuloma
Mice deficient for 5-lipoxygenase, but not leukocyte-type 12-lipoxygenase, display altered immune responses during infection with Schistosoma mansoni.
Granulomatous Disease, Chronic
Activation of NADPH oxidase required for macrophage-mediated oxidation of low-density lipoprotein.
Heart Arrest
Increased 12/15-Lipoxygenase Leads to Widespread Brain Injury Following Global Cerebral Ischemia.
Heart Failure
Arachidonate 12/15-lipoxygenase-induced inflammation and oxidative stress are involved in the development of diabetic cardiomyopathy.
Heart Failure
Cardiac 12/15 lipoxygenase-induced inflammation is involved in heart failure.
Heart Failure
Hypoxic cardiac fibroblasts from failing human hearts decrease cardiomyocyte beating frequency in an ALOX15 dependent manner.
Heart Failure
Inhibition of 12/15 lipoxygenase by baicalein reduces myocardial ischemia/reperfusion injury via modulation of multiple signaling pathways.
Heart Failure
Inhibition of 12/15-LO ameliorates CVB3-induced myocarditis by activating Nrf2.
Herpes Zoster
Characterization and application of Raman labels for confocal Raman microspectroscopic detection of cellular proteins in single cells.
Herpes Zoster
Evidence that a leukocyte type of 12-lipoxygenase is expressed and regulated by angiotensin II in human adrenal glomerulosa cells.
Hodgkin Disease
Interleukin-4-mediated 15-lipoxygenase-1 trans-activation requires UTX recruitment and H3K27me3 demethylation at the promoter in A549 cells.
Hodgkin Disease
Transcriptional regulation of 15-lipoxygenase expression by histone h3 lysine 4 methylation/demethylation.
hydroperoxy icosatetraenoate dehydratase deficiency
Diminished protein-bound ?-hydroxylated ceramides in the skin of patients with ichthyosis with 12R-lipoxygenase (LOX) or eLOX-3 deficiency.
Hyperalgesia
Contribution of 5- and 12-lipoxygenase products to mechanical hyperalgesia induced by prostaglandin E(2) and epinephrine in the rat.
Hyperalgesia
Different roles of 12/15-lipoxygenase in diabetic large and small fiber peripheral and autonomic neuropathies.
Hyperalgesia
Effect of high-fat diet on peripheral neuropathy in C57BL/6 mice.
Hyperalgesia
Inflammatory hyperalgesia induces essential bioactive lipid production in the spinal cord.
Hyperalgesia
Inhibition of spinal 15-LOX-1 attenuates TLR4-dependent, nonsteroidal anti-inflammatory drug-unresponsive hyperalgesia in male rats.
Hyperalgesia
Spinal 12-lipoxygenase-derived hepoxilin A3 contributes to inflammatory hyperalgesia via activation of TRPV1 and TRPA1 receptors.
Hyperalgesia
Systematic analysis of rat 12/15-lipoxygenase enzymes reveals critical role for spinal eLOX3 hepoxilin synthase activity in inflammatory hyperalgesia.
Hypercholesterolemia
Effect of gestational hypercholesterolemia and maternal immunization on offspring plasma eicosanoids.
Hypercholesterolemia
Inducible Endothelium-derived Hyperpolarizing Factor: Role of the 15-Lipoxygenase-EDHF Pathway.
Hypercholesterolemia
Membrane-dependent Activities of Human 15-LOX-2 and Its Murine Counterpart: IMPLICATIONS FOR MURINE MODELS OF ATHEROSCLEROSIS.
Hypercholesterolemia
Relationship of vascular 15-lipoxygenase induction to atherosclerotic plaque formation in rabbits.
Hypercholesterolemia
Systemic activation of 15-lipoxygenase in heart, lung, and vascular tissues by hypercholesterolemia: relationship to lipoprotein oxidation and atherogenesis.
Hypereosinophilic Syndrome
Arachidonic acid metabolism in normal and hypereosinophilic syndrome human eosinophils: generation of leukotrienes B4, C4, D4 and 15-lipoxygenase products.
Hyperglycemia
12-Lipoxygenase products increase monocyte:endothelial interactions.
Hyperglycemia
Decreased activity of arachidonate 12-lipoxygenase in platelets of Japanese patients with non-insulin-dependent diabetes mellitus.
Hyperglycemia
Evaluation of PMI-5011, an ethanolic extract of Artemisia dracunculus L., on peripheral neuropathy in streptozotocin-diabetic mice.
Hyperglycemia
High-fat diet induced neuropathy of pre-diabetes and obesity: effects of "healthy" diet and aldose reductase inhibition.
Hyperglycemia
Lipids and immunoinflammatory pathways of beta cell destruction.
Hyperlipidemias
Disruption of the 12/15-lipoxygenase gene (Alox15) protects hyperlipidemic mice from nonalcoholic fatty liver disease.
Hyperlipidemias
Nutrigenetic Disruption of Inflammation-Resolution Homeostasis and Atherogenesis.
Hyperlipidemias
Role of 12-lipoxygenase and oxidant stress in hyperglycaemia-induced acceleration of atherosclerosis in a diabetic pig model.
Hyperlipoproteinemia Type II
Selective interleukin-12 synthesis defect in 12/15-lipoxygenase-deficient macrophages associated with reduced atherosclerosis in a mouse model of familial hypercholesterolemia.
Hypertension
12-Lipoxygenase metabolism in mouse distal convoluted tubule cells.
Hypertension
15-Lipoxygenase Promotes Chronic Hypoxia-Induced Phenotype Changes of PASMCs via Positive Feedback-Loop of BMP4.
Hypertension
15-Lipoxygenase Promotes Chronic Hypoxia-Induced Pulmonary Artery Inflammation via Positive Interaction With Nuclear Factor-?B.
Hypertension
A coding polymorphism in the 12-lipoxygenase gene is associated to essential hypertension and urinary 12(S)-HETE.
Hypertension
Association of genetic variants with myocardial infarction in individuals with or without hypertension or diabetes mellitus.
Hypertension
Catalytic consumption of nitric oxide by 12/15- lipoxygenase: inhibition of monocyte soluble guanylate cyclase activation.
Hypertension
Comparison of 12-lipoxygenase expression in vascular smooth muscle cells from old normotensive Wistar-Kyoto rats with spontaneously hypertensive rats.
Hypertension
Deactivation of 12(S)-HETE through (?-1)-hydroxylation and ?-oxidation in alternatively activated macrophages.
Hypertension
Effects of silencing leukocyte-type 12/15-lipoxygenase using short interfering RNAs.
Hypertension
Elevated endothelial nitric oxide bioactivity and resistance to angiotensin-dependent hypertension in 12/15-lipoxygenase knockout mice.
Hypertension
Elk-1-mediated 15-Lipoxygenase Expression is Required for Hypoxia-induced Pulmonary Vascular Adventitial Fibroblast Dynamics.
Hypertension
Heme oxygenase-1 induces 15-lipoxygenase expression during hypoxia-induced pulmonary hypertension.
Hypertension
Increase in 12-lipoxygenase activity in platelets of spontaneously hypertensive rats.
Hypertension
Increased levels of 12(S)-HETE in patients with essential hypertension.
Hypertension
Inflammation and immune regulation by 12/15-lipoxygenases.
Hypertension
Inhibition of 12/15 lipoxygenase by baicalein reduces myocardial ischemia/reperfusion injury via modulation of multiple signaling pathways.
Hypertension
Key Role of ROS in the Process of 15-Lipoxygenase/15-Hydroxyeicosatetraenoiccid-Induced Pulmonary Vascular Remodeling in Hypoxia Pulmonary Hypertension.
Hypertension
Mice lacking macrophage 12/15-lipoxygenase are resistant to experimental hypertension.
Hypertension
Reciprocal regulation of HIF-1? and 15-LO/15-HETE promotes anti-apoptosis process in pulmonary artery smooth muscle cells during hypoxia.
Hypertension
Reduced growth factor responses in vascular smooth muscle cells derived from 12/15-lipoxygenase-deficient mice.
Hypertension
Regulation of monocyte chemoattractant protein-1 by the oxidized lipid, 13-hydroperoxyoctadecadienoic acid, in vascular smooth muscle cells via nuclear factor-kappa B (NF-kappa B).
Hypertension
ROCK pathway participates in the processes that 15-hydroxyeicosatetraenoic acid (15-HETE) mediated the pulmonary vascular remodeling induced by hypoxia in rat.
Hypertension
Role of macrophage PPAR? in experimental hypertension.
Hypertension
Role of the lipoxygenase pathway in phenylephrine-induced vascular smooth muscle cell proliferation and migration.
Hypertension
The key role of transforming growth factor-beta receptor I and 15-lipoxygenase in hypoxia-induced proliferation of pulmonary artery smooth muscle cells.
Hypertension
The role of ERK1/2 in 15-HETE-inhibited apoptosis in pulmonary arterial smooth muscle cells.
Hypertension
[Lipoxygenase inhibition and protection of cardiovascular system]
Hypertension, Pulmonary
15-Lipoxygenase and 15-hydroxyeicosatetraenoic acid regulate intravascular thrombosis in pulmonary hypertension.
Hypertension, Pulmonary
Heme oxygenase-1 induces 15-lipoxygenase expression during hypoxia-induced pulmonary hypertension.
Hypertension, Pulmonary
Key Role of ROS in the Process of 15-Lipoxygenase/15-Hydroxyeicosatetraenoiccid-Induced Pulmonary Vascular Remodeling in Hypoxia Pulmonary Hypertension.
Hypertension, Pulmonary
NFATc3 pathway participates in the process that 15-LO/15-HETE protects pulmonary artery smooth muscle cells against apoptosis during hypoxia.
Hypertension, Pulmonary
Placenta growth factor mediates angiogenesis in hypoxic pulmonary hypertension.
Hypertension, Pulmonary
Platelet-derived growth factor (PDGF) induces pulmonary vascular remodeling through 15-LO/15-HETE pathway under hypoxic condition.
Hypertension, Pulmonary
Positive feedback-loop of telomerase reverse transcriptase and 15-lipoxygenase-2 promotes pulmonary hypertension.
Hypertension, Pulmonary
Role of 12-lipoxygenase in hypoxia-induced rat pulmonary artery smooth muscle cell proliferation.
Hypotension
15-Lipoxygenase metabolites contribute to age-related reduction in acetylcholine-induced hypotension in rabbits.
Ichthyosiform Erythroderma, Congenital
Congenital ichthyosiform erythroderma with a novel variant in ABCA12 in a Chinese patient.
Ichthyosiform Erythroderma, Congenital
Different TGM1 mutation spectra in Italian and Portuguese patients with autosomal recessive congenital ichthyosis: evidence of founder effects in Portugal.
Ichthyosiform Erythroderma, Congenital
Lipoxygenase-3 (ALOXE3) and 12(R)-lipoxygenase (ALOX12B) are mutated in non-bullous congenital ichthyosiform erythroderma (NCIE) linked to chromosome 17p13.1.
Ichthyosiform Erythroderma, Congenital
Mutations associated with a congenital form of ichthyosis (NCIE) inactivate the epidermal lipoxygenases 12R-LOX and eLOX3.
Ichthyosiform Erythroderma, Congenital
Novel mutations in ALOX12B in patients with autosomal recessive congenital ichthyosis and evidence for genetic heterogeneity on chromosome 17p13.
Ichthyosiform Erythroderma, Congenital
Partially disturbed lamellar granule secretion in mild congenital ichthyosiform erythroderma with ALOX12B mutations.
Ichthyosis
12R-lipoxygenase deficiency disrupts epidermal barrier function.
Ichthyosis
A novel deletion mutation in the ALOX12B gene in a Kurdish family with autosomal recessive congenital ichthyosis.
Ichthyosis
Aloxe3 Knockout Mice Reveal a Function of Epidermal Lipoxygenase-3 as Hepoxilin Synthase and Its Pivotal Role in Barrier Formation.
Ichthyosis
An update on molecular aspects of the non-syndromic ichthyoses.
Ichthyosis
Analysis of TGM1, ALOX12B, ALOXE3, NIPAL4 and CYP4F22 in autosomal recessive congenital ichthyosis from Galicia (NW Spain): evidence of founder effects.
Ichthyosis
Characterization of Epidermal Lipoxygenase Expression in Normal Human Skin and Tissue-Engineered Skin Substitutes.
Ichthyosis
Conditional Alox12b Knockout: Degradation of the Corneocyte Lipid Envelope in a Mouse Model of Autosomal Recessive Congenital Ichthyoses.
Ichthyosis
Development of an ichthyosiform phenotype in Alox12b-deficient mouse skin transplants.
Ichthyosis
Diminished protein-bound ?-hydroxylated ceramides in the skin of patients with ichthyosis with 12R-lipoxygenase (LOX) or eLOX-3 deficiency.
Ichthyosis
Genotype-phenotype correlation in a large English cohort of patients with autosomal recessive ichthyosis.
Ichthyosis
Genotypic and clinical spectrum of self-improving collodion ichthyosis: ALOX12B, ALOXE3, and TGM1 mutations in Scandinavian patients.
Ichthyosis
Hepoxilin A3 (HXA3) synthase deficiency is causative of a novel ichthyosis form.
Ichthyosis
Identification of a novel PNPLA1 mutation in a Spanish family with autosomal recessive congenital ichthyosis.
Ichthyosis
Identification of Mutations in SDR9C7 in 6 Families with Autosomal Recessive Congenital Ichthyosis.
Ichthyosis
Molecular analysis of 250 patients with autosomal recessive congenital ichthyosis: evidence for mutation hotspots in ALOXE3 and allelic heterogeneity in ALOX12B.
Ichthyosis
Mutation in ALOX12B likely cause of POI and also ichthyosis in a large Iranian pedigree.
Ichthyosis
Mutation spectrum and functional analysis of epidermis-type lipoxygenases in patients with autosomal recessive congenital ichthyosis.
Ichthyosis
Mutations associated with a congenital form of ichthyosis (NCIE) inactivate the epidermal lipoxygenases 12R-LOX and eLOX3.
Ichthyosis
Nonsense mutation in the ALOX12B gene leads to autosomal recessive congenital ichthyosis in a Lebanese family.
Ichthyosis
Novel ALOX12B Mutation Identified in Parents following Single Nucleotide Polymorphism Microarray Testing of Banked DNA from a Fatal Case of Congenital Ichthyosis.
Ichthyosis
Novel mutations in ALOX12B in patients with autosomal recessive congenital ichthyosis and evidence for genetic heterogeneity on chromosome 17p13.
Ichthyosis
Partially disturbed lamellar granule secretion in mild congenital ichthyosiform erythroderma with ALOX12B mutations.
Ichthyosis
Pseudodominant inheritance of self-improving collodion ichthyosis with homozygous mutation in the ALOX12B gene.
Ichthyosis
Report of a Novel ALOX12B Mutation in Self-Improving Collodion Ichthyosis with an Overview of the Genetic Background of the Collodion Baby Phenotype.
Ichthyosis
The hepoxilin connection in the epidermis.
Ichthyosis
The role of lipoxygenases in epidermis.
Ichthyosis
The role of lipoxygenases in pathophysiology; new insights and future perspectives.
Ichthyosis
Updated molecular genetics and pathogenesis of ichthiyoses.
Ichthyosis, Lamellar
A novel mutation in the 12(R)-lipoxygenase (ALOX12B) gene underlies nonbullous congenital ichthyosiform erythroderma.
Ichthyosis, Lamellar
Different TGM1 mutation spectra in Italian and Portuguese patients with autosomal recessive congenital ichthyosis: evidence of founder effects in Portugal.
Ichthyosis, Lamellar
Hepoxilin A3 (HXA3) synthase deficiency is causative of a novel ichthyosis form.
Ichthyosis, Lamellar
Lamellar Ichthyosis Due to ALOX12B Mutation.
Ichthyosis, Lamellar
Self-healing collodion membrane and mild nonbullous congenital ichthyosiform erythroderma due to 2 novel mutations in the ALOX12B gene.
Ileus
A role for 12/15-lipoxygenase-derived proresolving mediators in postoperative ileus: protectin DX-regulated neutrophil extravasation.
Immune System Diseases
5-Lipoxygenase is a direct p53 target gene in humans.
Infarction, Middle Cerebral Artery
12/15-Lipoxygenase Inhibition or Knockout Reduces Warfarin-Associated Hemorrhagic Transformation After Experimental Stroke.
Infarction, Middle Cerebral Artery
Baicalein and 12/15-lipoxygenase in the ischemic brain.
Infarction, Middle Cerebral Artery
Following experimental stroke, the recovering brain is vulnerable to lipoxygenase-dependent semaphorin signaling.
Infarction, Middle Cerebral Artery
Increased nuclear apoptosis-inducing factor after transient focal ischemia: a 12/15-lipoxygenase-dependent organelle damage pathway.
Infarction, Middle Cerebral Artery
Inhibiting 12/15-lipoxygenase to treat acute stroke in permanent and tPA induced thrombolysis models.
Infarction, Middle Cerebral Artery
Neuroprotection of taurine through inhibition of 12/15 lipoxygenase pathway in cerebral ischemia of rats.
Infarction, Middle Cerebral Artery
Protecting against cerebrovascular injury: contributions of 12/15-lipoxygenase to edema formation after transient focal ischemia.
Infections
ALOX12 In Human Toxoplasmosis.
Infections
Characterization of arachidonate 12-lipoxygenase found in the liver of mongrel dog and its immunohistochemical localization in neutrophils.
Infections
Cyclooxygenase-2 Generates the Endogenous Mutagen trans-4-Hydroxy-2-nonenal in Enterococcus faecalis-Infected Macrophages.
Infections
Cytosolic phospholipase A2? promotes pulmonary inflammation and systemic disease during Streptococcus pneumoniae infection.
Infections
Distinct isoforms of phospholipase A2 mediate the ability of Salmonella enterica serotype typhimurium and Shigella flexneri to induce the transepithelial migration of neutrophils.
Infections
Enteroaggregative Escherichia coli promotes transepithelial migration of neutrophils through a conserved 12-lipoxygenase pathway.
Infections
Evaluation of the expression level of 12/15 lipoxygenase and the related inflammatory factors (CCL5, CCL3) in respiratory syncytial virus infection in mice model.
Infections
Exogenous pathogen and plant 15-lipoxygenase initiate endogenous lipoxin A4 biosynthesis.
Infections
Hepoxilin A(3) facilitates neutrophilic breach of lipoxygenase-expressing airway epithelial barriers.
Infections
Immunoregulatory role of 15-lipoxygenase in the pathogenesis of bacterial keratitis.
Infections
Lipidomic profiling of influenza infection identifies mediators that induce and resolve inflammation.
Infections
Mice deficient for 5-lipoxygenase, but not leukocyte-type 12-lipoxygenase, display altered immune responses during infection with Schistosoma mansoni.
Infections
On the biosynthesis of 15-HETE and eoxin C4 by human airway epithelial cells.
Infections
Peripheral blood leukocytes show differential expression of tumour progression-related genes in colorectal cancer patients who have a postoperative intra-abdominal infection: a prospective matched cohort study.
Infections
Pneumolysin Induces 12-Lipoxygenase-Dependent Neutrophil Migration during Streptococcus pneumoniae Infection.
Infections
Reactive oxygen species and 12/15-lipoxygenase contribute to the antiproliferative capacity of alternatively activated myeloid cells elicited during helminth infection.
Infections
Systemic Disease during Streptococcus pneumoniae Acute Lung Infection Requires 12-Lipoxygenase-Dependent Inflammation.
Infections
The biological role of arachidonic acid 12-lipoxygenase (ALOX12) in various human diseases.
Infections
The oxido-reductase enzyme glutathione peroxidase 4 (GPX4) governs Salmonella Typhimurium-induced neutrophil transepithelial migration.
Infertility
Absence of association between a functional polymorphism of ALOX15 gene and infertility in endometriosis.
Infertility, Male
Male subfertility induced by heterozygous expression of catalytically inactive glutathione peroxidase 4 is rescued in vivo by systemic inactivation of the Alox15 gene.
Infertility, Male
Mechanistic Insight into the Regulation of Lipoxygenase-Driven Lipid Peroxidation Events in Human Spermatozoa and Their Impact on Male Fertility.
Inflammatory Bowel Diseases
Human umbilical cord mesenchymal stem cells alleviate inflammatory bowel disease through the regulation of 15-LOX-1 in macrophages.
Inflammatory Bowel Diseases
Induction of epithelial arachidonate 12-lipoxygenase at active sites of inflammatory bowel disease.
Inflammatory Bowel Diseases
Milk Fermented with a 15-Lipoxygenase-1-Producing Lactococcus Lactis Alleviates Symptoms of colitis in a Murine Model.
Influenza, Human
Role of omega-3 PUFA-derived mediators, the protectins, in influenza virus infection.
Insulin Resistance
12- and 15-lipoxygenases in adipose tissue inflammation.
Insulin Resistance
12-Lipoxygenase Inhibition on Microalbuminuria in Type-1 and Type-2 Diabetes Is Associated with Changes of Glomerular Angiotensin II Type 1 Receptor Related to Insulin Resistance.
Insulin Resistance
12-Lipoxygenase-knockout mice are resistant to inflammatory effects of obesity induced by Western diet.
Insulin Resistance
12/15-lipoxygenase is required for the early onset of high fat diet-induced adipose tissue inflammation and insulin resistance in mice.
Insulin Resistance
12/15-Lipoxygenase Products Induce Inflammation and Impair Insulin Signaling in 3T3-L1 Adipocytes.
Insulin Resistance
12/15-Lipoxygenase signaling in the endoplasmic reticulum stress response.
Insulin Resistance
Activation of the 12/15 lipoxygenase pathway accompanies metabolic decline in db/db pre-diabetic mice.
Insulin Resistance
Adipose tissue 12/15 lipoxygenase pathway in human obesity and diabetes.
Insulin Resistance
Adipose tissue-specific deletion of 12/15-lipoxygenase protects mice from the consequences of a high-fat diet.
Insulin Resistance
ALOX5AP Overexpression in Adipose Tissue Leads to LXA4 Production and Protection Against Diet-Induced Obesity and Insulin Resistance.
Insulin Resistance
Disruption of the 12/15-lipoxygenase gene (Alox15) protects hyperlipidemic mice from nonalcoholic fatty liver disease.
Insulin Resistance
Evidence for Activation of Inflammatory Lipoxygenase Pathways in Visceral Adipose Tissue of Obese Zucker Rats.
Insulin Resistance
Identification of ALOX5 as a gene regulating adiposity and pancreatic function.
Insulin Resistance
Interaction between cytokines and inflammatory cells in islet dysfunction, insulin resistance and vascular disease.
Insulin Resistance
Lipocalin-2 deficiency attenuates insulin resistance associated with aging and obesity.
Insulin Resistance
Molecular mechanisms of nonalcoholic fatty liver disease: Potential role for 12-lipoxygenase.
Insulin Resistance
Reduced dietary omega-6 to omega-3 fatty acid ratio and 12/15-lipoxygenase deficiency are protective against chronic high fat diet-induced steatohepatitis.
Insulinoma
Hepoxilin A3 synthase.
Insulinoma
The rat leukocyte-type 12-lipoxygenase exhibits an intrinsic hepoxilin A3 synthase activity.
Iron Deficiencies
Induction of arachidonate 12-lipoxygenase (Alox15) in intestine of iron-deficient rats correlates with the production of biologically active lipid mediators.
Iron Deficiencies
Microarray analysis of rat pancreas reveals altered expression of alox15 and regenerating islet-derived genes in response to iron deficiency and overload.
Ischemic Attack, Transient
12- and 15-lipoxygenases in human carotid atherosclerotic lesions: Associations with cerebrovascular symptoms.
Ischemic Stroke
15-oxo-ETE-induced internal carotid artery constriction in hypoxic rats is mediated by potassium channels.
Ischemic Stroke
A Promoter polymorphism (rs17222919, -1316T/G) of ALOX5AP is associated with intracerebral hemorrhage in Korean population.
Ischemic Stroke
Association of ALOX15 Gene Polymorphism with Ischemic Stroke in Northern Chinese Han Population.
Ischemic Stroke
Association of ALOX5, LTA4H and LTC4S gene polymorphisms with ischemic stroke risk in a cohort of Chinese in east China.
Ischemic Stroke
Contributions of 12/15-Lipoxygenase to Bleeding in the Brain Following Ischemic Stroke.
Ischemic Stroke
Genetic Variations of Oxidative Stress Related Genes ALOX5, ALOX5AP and MPO Modulate Ischemic Stroke Susceptibility Through Main Effects and Epistatic Interactions in a Chinese Population.
Ischemic Stroke
Genome-Wide Association Meta-Analysis of Single-Nucleotide Polymorphisms and Symptomatic Venous Thromboembolism during Therapy for Acute Lymphoblastic Leukemia and Lymphoma in Caucasian Children.
Ischemic Stroke
Impact of 12/15-Lipoxygenase on Brain Injury After Subarachnoid Hemorrhage.
Ischemic Stroke
Lipoxygenase inhibitor ML351 dysregulated an innate inflammatory response leading to impaired cardiac repair in acute heart failure.
Ischemic Stroke
Stroke: 12/15-lipoxygenase inhibitor shows promise as a first-line therapy for ischaemic stroke.
Ischemic Stroke
Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke.
Keratitis
Immunoregulatory role of 15-lipoxygenase in the pathogenesis of bacterial keratitis.
Kidney Diseases
Differential behavior of mesangial cells derived from 12/15-lipoxygenase knockout mice relative to control mice.
Kidney Diseases
Leukotriene Pathway Activation Associates with Poor Glycemic Control and with Cardiovascular Autonomic Neuropathy in Type 1 Diabetes.
Kidney Diseases
Prediabetic nephropathy as an early consequence of the high-calorie/high-fat diet: relation to oxidative stress.
Kidney Failure, Chronic
Contribution of impaired Nrf2-Keap1 pathway to oxidative stress and inflammation in chronic renal failure.
Leukemia
12-Lipoxygenase from rat basophilic leukemia cells, an oxygenase with leukotriene A4-synthase activity.
Leukemia
12-Lipoxygenase from rat basophilic leukemia cells: separation from 5-lipoxygenase and temperature-dependent inactivation by hydroperoxy fatty acid.
Leukemia
12-Lipoxygenase in Lewis lung carcinoma cells: molecular identity, intracellular distribution of activity and protein, and Ca(2+)-dependent translocation from cytosol to membranes.
Leukemia
A tumor suppressor function of the Msr1 gene in leukemia stem cells of chronic myeloid leukemia.
Leukemia
ALOX5 exhibits anti-tumor and drug-sensitizing effects in MLL-rearranged leukemia.
Leukemia
Calcium stimulation of a novel 12-lipoxygenase from rat basophilic leukemia (RBL-1) cells.
Leukemia
Cooperation between RUNX1-ETO9a and novel transcriptional partner KLF6 in upregulation of Alox5 in acute myeloid leukemia.
Leukemia
Identification of 12/15-lipoxygenase as a suppressor of myeloproliferative disease.
Leukemia
Improved purification of 12-lipoxygenase from rat basophilic leukemia cells and conditions for optimal enzyme activity.
Leukemia
Inhibition of adenylyl cyclases by 12(S)-hydroxyeicosatetraenoic acid.
Leukemia
Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia.
Leukemia
LSK derived LSK- cells have a high apoptotic rate related to survival regulation of hematopoietic and leukemic stem cells.
Leukemia
Oxygenation of phosphatidylcholine by human polymorphonuclear leukocyte 15-lipoxygenase.
Leukemia
Tumor microenvironment determines drug efficacy in vitro - apoptotic and anti-inflammatory effects of 15-lipoxygenase metabolite, 13-HpOTrE.
Leukemia
Zinc and other divalent cations inhibit purified leukotriene A4 hydrolase and leukotriene B4 biosynthesis in human polymorphonuclear leukocytes.
Leukemia
[Apoptosis in P388 leukemia cells induced by specific inhibitors of 5- and 12-lipoxygenase and the product of cyclooxygenase, prostaglandin E2]
Leukemia, Erythroblastic, Acute
15-Lipoxygenase products affect protein phosphorylation in Friend erythroleukemia cells.
Leukemia, Erythroblastic, Acute
A novel form of platelet-type 12-lipoxygenase mRNA in human vascular smooth muscle cells.
Leukemia, Erythroblastic, Acute
Actions of lipoxins A4 and B4 on signal transduction events in Friend erythroleukemia cells.
Leukemia, Erythroblastic, Acute
Activity and protein distribution of 12-lipoxygenase in HEL cells: induction of membrane-association by phorbol ester TPA, modulation of activity by glutathione and 13-HPODE, and Ca(2+)-dependent translocation to membranes.
Leukemia, Erythroblastic, Acute
Characterization of human 12-lipoxygenase genes.
Leukemia, Erythroblastic, Acute
Cloning of the cDNA for human 12-lipoxygenase.
Leukemia, Erythroblastic, Acute
Evidence that a leukocyte type of 12-lipoxygenase is expressed and regulated by angiotensin II in human adrenal glomerulosa cells.
Leukemia, Erythroblastic, Acute
Induction of 12-lipoxygenase expression by epidermal growth factor is mediated by protein kinase C in A431 cells.
Leukemia, Erythroblastic, Acute
Induction of cyclooxygenase and suppression of 12-lipoxygenase in human erythroleukemia cells upon phorbol ester-induced differentiation.
Leukemia, Erythroblastic, Acute
Molecular cloning and expression of human arachidonate 12-lipoxygenase.
Leukemia, Erythroblastic, Acute
Molecular cloning, primary structure, and expression of the human platelet/erythroleukemia cell 12-lipoxygenase.
Leukemia, Erythroblastic, Acute
Purification and characterization of recombinant histidine-tagged human platelet 12-lipoxygenase expressed in a baculovirus/insect cell system.
Leukemia, Erythroblastic, Acute
Relation between ABCB1 overexpression and COX2 and ALOX5 genes in human erythroleukemia cell lines.
Leukemia, Erythroblastic, Acute
Ribozyme-mediated suppression of platelet type 12 lipoxygenase in human erythroleukemia cells.
Leukemia, Erythroblastic, Acute
Suppression of platelet-type 12-lipoxygenase activity in human erythroleukemia cells by an RNA-cleaving DNAzyme.
Leukemia, Erythroblastic, Acute
The transcriptional regulation of human arachidonate 12-lipoxygenase gene by NF kappa B/Rel.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
A tumor suppressor function of the Msr1 gene in leukemia stem cells of chronic myeloid leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Cooperation between RUNX1-ETO9a and novel transcriptional partner KLF6 in upregulation of Alox5 in acute myeloid leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Effect of 15-lipoxygenase metabolites, 15-(S)-HPETE and 15-(S)-HETE on chronic myelogenous leukemia cell line K-562: reactive oxygen species (ROS) mediate caspase-dependent apoptosis.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Leukotriene signaling via ALOX5 and cysteinyl leukotriene receptor 1 is dispensable for in vitro growth of CD34(+)CD38(-) stem and progenitor cells in chronic myeloid leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Low leukotriene B4 receptor 1 leads to ALOX5 downregulation at diagnosis of chronic myeloid leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
The Alox5 gene is a novel therapeutic target in cancer stem cells of chronic myeloid leukemia.
Leukemia, Myeloid
[Relationship between Polymorphism in ALOX5, ALOX5AP and Susceptibility to Myeloid Leukemia].
Leukemia, Myeloid, Acute
Cooperation between RUNX1-ETO9a and novel transcriptional partner KLF6 in upregulation of Alox5 in acute myeloid leukemia.
Leukomalacia, Periventricular
12/15-lipoxygenase expression is increased in oligodendrocytes and microglia of periventricular leukomalacia.
Leukostasis
Targeting of 12/15-Lipoxygenase in retinal endothelial cells, but not in monocytes/macrophages, attenuates high glucose-induced retinal leukostasis.
Liver Cirrhosis
Arachidonate 12S-lipoxygenase of platelet-type in hepatic stellate cells of methionine and choline-deficient diet-fed mice.
Liver Cirrhosis
Melatonin suppresses activation of hepatic stellate cells through ROR?-mediated inhibition of 5-lipoxygenase.
Liver Diseases
Disruption of the 12/15-lipoxygenase gene (Alox15) protects hyperlipidemic mice from nonalcoholic fatty liver disease.
Liver Diseases
Molecular mechanisms of nonalcoholic fatty liver disease: Potential role for 12-lipoxygenase.
Liver Diseases
Protection from hepatic lipid accumulation and inflammation by genetic ablation of 5-lipoxygenase.
Lung Diseases
Interleukin-4 enhances 15-lipoxygenase activity and incorporation of 15(S)-HETE into cellular phospholipids in cultured pulmonary epithelial cells.
Lung Diseases
Substituted (E)-2-(2-benzylidenehydrazinyl)-4-methylthiazole-5-carboxylates as dual inhibitors of 15-lipoxygenase & carbonic anhydrase II: synthesis, biochemical evaluation and docking studies.
Lung Injury
12-Lipoxygenase is a Critical Mediator of Type II Pneumocyte Senescence, Macrophage Polarization and Pulmonary Fibrosis after Irradiation.
Lung Injury
Altered expression of cyclooxygenase-2, 12-lipoxygenase, inducible nitric oxide synthase-2 and surfactant protein D in lungs of patients with pulmonary injury caused by sulfur mustard.
Lung Injury
Collagenase-3 induction in rat lung fibroblasts requires the combined effects of tumor necrosis factor-alpha and 12-lipoxygenase metabolites: a model of macrophage-induced, fibroblast-driven extracellular matrix remodeling during inflammatory lung injury.
Lung Injury
Trauma and hemorrhagic shock activate molecular association of 5-lipoxygenase and 5-lipoxygenase-Activating protein in lung tissue.
Lung Neoplasms
Effects of ALOX5, IL6R and SFTPD gene polymorphisms on the risk of lung cancer: A case-control study in China.
Lung Neoplasms
Inhibition of arachidonate lipoxygenase12 targets lung cancer through inhibiting EMT and suppressing RhoA and NF-?B activity.
Lung Neoplasms
Mechanistic contribution of ubiquitous 15-lipoxygenase-1 expression loss in cancer cells to terminal cell differentiation evasion.
Lung Neoplasms
Synergistic effects of new chemopreventive agents and conventional cytotoxic agents against human lung cancer cell lines.
Lung Neoplasms
The future of cyclooxygenase-2 inhibitors and other inhibitors of the eicosanoid signal pathway in the prevention and therapy of lung cancer.
Lymphatic Metastasis
15-lipoxygenase-1 production is lost in pancreatic cancer and overexpression of the gene inhibits tumor cell growth.
Lymphatic Metastasis
Expression of 15-lipoxygenase-1 in Merkel cell carcinoma is linked to advanced disease.
Lymphatic Metastasis
Lipoxygenase mediates invasion of intrametastatic lymphatic vessels and propagates lymph node metastasis of human mammary carcinoma xenografts in mouse.
Lymphatic Metastasis
[Comparative proteomics of the serum in patients with nasopharyngeal carcinoma: a study with two-dimensional electrophoresis and MALDI-TOF-MS]
Lymphoma
ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway.
Lymphoma
Arachidonate 5-lipoxygenase establishes adaptive humoral immunity by controlling primary B cells and their cognate T-cell help.
Lymphoma
Transcriptional regulation of 15-lipoxygenase expression by promoter methylation.
Lymphoma, B-Cell
Autophagy as a Regulatory Component of Erythropoiesis.
Lymphoma, Mantle-Cell
Arachidonate 5-lipoxygenase establishes adaptive humoral immunity by controlling primary B cells and their cognate T-cell help.
Melanoma
12-lipoxygenase expression in human melanoma cell lines.
Melanoma
Autocrine motility factor induces differential 12-lipoxygenase expression and activity in high- and low-metastatic K1735 melanoma cell variants.
Melanoma
Baicalein induces proliferation inhibition in B16F10 melanoma cells by generating reactive oxygen species via 12-lipoxygenase.
Melanoma
Endogenous 12(S)-HETE production by tumor cells and its role in metastasis.
Melanoma
Enhancement role of host 12/15-lipoxygenase in melanoma progression.
Melanoma
Expression of 12-lipoxygenase as a biomarker for melanoma carcinogenesis.
Melanoma
Molecular identification, localization and function of platelet-type 12-lipoxygenase in human melanoma progression, under experimental and clinical conditions.
Melanoma, Amelanotic
Activation of microvascular endothelium by eicosanoid 12(S)-hydroxyeicosatetraenoic acid leads to enhanced tumor cell adhesion via up-regulation of surface expression of alpha v beta 3 integrin: a posttranscriptional, protein kinase C- and cytoskeleton-dependent process.
Melanoma, Experimental
Expression of 12-lipoxygenase as a biomarker for melanoma carcinogenesis.
Memory Disorders
Absence of ALOX5 gene prevents stress-induced memory deficits, synaptic dysfunction and tauopathy in a mouse model of Alzheimer's disease.
Memory Disorders
Pharmacologic blockade of 12/15-lipoxygenase ameliorates memory deficits, A? and tau neuropathology in the triple-transgenic mice.
Mesothelioma
The Investigation of Lipoxygenases as Therapeutic Targets in Malignant Pleural Mesothelioma.
Metabolic Diseases
Minireview: 12-Lipoxygenase and Islet ?-Cell Dysfunction in Diabetes.
Metabolic Syndrome
Activation of the 12-lipoxygenase and signal transducer and activator of transcription pathway during neointima formation in a model of the metabolic syndrome.
Metabolic Syndrome
Increased 12/15-Lipoxygenase Enhances Cell Growth, Fibronectin Deposition, and Neointimal Formation in Response to Carotid Injury.
Migraine Disorders
Systems pharmacology to decipher the combinational anti-migraine effects of Tianshu formula.
Mouth Neoplasms
Overexpression of cyclooxygenase-2 in rat oral cancers and prevention of oral carcinogenesis in rats by selective and nonselective COX inhibitors.
Multiple Sclerosis
5-lipoxygenase pathway and its downstream cysteinyl leukotrienes as potential therapeutic targets for Alzheimer's disease.
Multiple Sclerosis
Inhibition of 12/15-lipoxygenase by baicalein induces microglia PPAR?/?: a potential therapeutic role for CNS autoimmune disease.
Multiple Sclerosis
The role of expression and activity of 15-Lipoxygenase isoforms and related cytokines in patients with Multiple Sclerosis and healthy controls.
Muscular Atrophy
Genetic ablation of 12/15-lipoxygenase but not 5-lipoxygenase protects against denervation-induced muscle atrophy.
Myeloproliferative Disorders
Decreased messenger RNA of arachidonate 12-lipoxygenase in platelets of patients with myeloproliferative disorders.
Myeloproliferative Disorders
Identification of 12/15-lipoxygenase as a suppressor of myeloproliferative disease.
Myeloproliferative Disorders
Qualitative platelet 12-lipoxygenase abnormality in a patient with essential thrombocythemia.
Myeloproliferative Disorders
Reduced 12-lipoxygenase activity in platelets of patients with myeloproliferative disorders.
Myocardial Infarction
A functional Sp1/Egr1-tandem repeat polymorphism in the 5-lipoxygenase gene is not associated with myocardial infarction.
Myocardial Infarction
Genetic deletion of 12/15 lipoxygenase promotes effective resolution of inflammation following myocardial infarction.
Myocardial Infarction
Inhibition of 12/15 lipoxygenase by baicalein reduces myocardial ischemia/reperfusion injury via modulation of multiple signaling pathways.
Myocardial Infarction
No association of two functional polymorphisms in human ALOX15 with myocardial infarction.
Myocardial Infarction
Protease-activated receptor 2 protects against myocardial ischemia-reperfusion injury through the lipoxygenase pathway and TRPV1 channels.
Myocardial Infarction
Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke.
Myocardial Reperfusion Injury
Pharmacological inhibition of arachidonate 12-lipoxygenase ameliorates myocardial ischemia-reperfusion injury in multiple species.
Myocarditis
Inhibition of 12/15-LO ameliorates CVB3-induced myocarditis by activating Nrf2.
nad(p)h oxidase (h2o2-forming) deficiency
Novel effect of oxidized low-density lipoprotein: cellular ATP depletion via downregulation of glyceraldehyde-3-phosphate dehydrogenase.
Nasal Polyps
A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis.
Nasal Polyps
Arachidonic Acid 15-Lipoxygenase: Effects of Its Expression, Metabolites, and Genetic and Epigenetic Variations on Airway Inflammation.
Nasal Polyps
Comparison of arachidonic acid metabolism in nasal polyps and eosinophils.
Nasal Polyps
Enhanced 15-Lipoxygenase 1 Production is Related to Periostin Expression and Eosinophil Recruitment in Eosinophilic Chronic Rhinosinusitis.
Nasal Polyps
Expression of cyclooxygenase and lipoxygenase enzymes in nasal polyps of aspirin-sensitive and aspirin-tolerant patients.
Nasal Polyps
Oxidative metabolism of N-phenyllinoleamide by human nasal polyps.
Neoplasm Metastasis
12-Lipoxygenase and the regulation of hypoxia-inducible factor in prostate cancer cells.
Neoplasm Metastasis
12-lipoxygenase expression in human melanoma cell lines.
Neoplasm Metastasis
12-Lipoxygenase promotes epithelial-mesenchymal transition via the Wnt/?-catenin signaling pathway in gastric cancer cells.
Neoplasm Metastasis
12-Lipoxygenase promotes invasion and metastasis of human gastric cancer cells via epithelial-mesenchymal transition.
Neoplasm Metastasis
12-Lipoxygenase, 12(S)-HETE, and cancer metastasis.
Neoplasm Metastasis
12-lipoxygenases and 12(S)-HETE: role in cancer metastasis.
Neoplasm Metastasis
15-Lipoxygenase-1 as a tumor suppressor gene in colon cancer: is the verdict in?
Neoplasm Metastasis
15-lipoxygenase-1 production is lost in pancreatic cancer and overexpression of the gene inhibits tumor cell growth.
Neoplasm Metastasis
15-Lipoxygenases in cancer: A double-edged sword?
Neoplasm Metastasis
15-LOX-1 suppression of hypoxia-induced metastatic phenotype and HIF-1? expression in human colon cancer cells.
Neoplasm Metastasis
A Sucrose-Enriched Diet Promotes Tumorigenesis in Mammary Gland in Part through the 12-Lipoxygenase Pathway.
Neoplasm Metastasis
Biosynthesis, biological effects, and receptors of hydroxyeicosatetraenoic acids (HETEs) and oxoeicosatetraenoic acids (oxo-ETEs) derived from arachidonic acid.
Neoplasm Metastasis
Brachmann-Cornelia de Lange syndrome with a papilloma of the choroid plexus: analyses of molecular genetic characteristics of the patient and the tumor. A single-case study.
Neoplasm Metastasis
Convergence of eicosanoid and integrin biology: Role of Src in 12-LOX activation.
Neoplasm Metastasis
Cyclooxygenase and lipoxygenase gene expression in the inflammogenesis of breast cancer.
Neoplasm Metastasis
Elevated 12-lipoxygenase mRNA expression correlates with advanced stage and poor differentiation of human prostate cancer.
Neoplasm Metastasis
Exploring the chemopreventive properties and perspectives of baicalin and its aglycone baicalein in solid tumors.
Neoplasm Metastasis
Expression of 12-lipoxygenase as a biomarker for melanoma carcinogenesis.
Neoplasm Metastasis
Expression of 12-lipoxygenase in human renal cell carcinoma and growth prevention by its inhibitor.
Neoplasm Metastasis
Expression of 15-lipoxygenase-1 in Merkel cell carcinoma is linked to advanced disease.
Neoplasm Metastasis
Expression, subcellular localization and putative function of platelet-type 12-lipoxygenase in human prostate cancer cell lines of different metastatic potential.
Neoplasm Metastasis
Identification of 12-lipoxygenase interaction with cellular proteins by yeast two-hybrid screening.
Neoplasm Metastasis
In vitro 12(S)-HETE inhibitory activities of naphthoquinones isolated from the root bark of Euclea racemosa ssp. schimperi.
Neoplasm Metastasis
Increased metastatic potential in human prostate carcinoma cells by overexpression of arachidonate 12-lipoxygenase.
Neoplasm Metastasis
Inhibition of 12-lipoxygenase reduces proliferation and induces apoptosis of hepatocellular carcinoma cells in vitro and in vivo.
Neoplasm Metastasis
Inhibition of radiation-enhanced expression of integrin and metastatic potential in B16 melanoma cells by a lipoxygenase inhibitor.
Neoplasm Metastasis
Interplay between 15-lipoxygenase-1 and metastasis-associated antigen 1 in the metastatic potential of colorectal cancer.
Neoplasm Metastasis
Lipoxygenase mediates invasion of intrametastatic lymphatic vessels and propagates lymph node metastasis of human mammary carcinoma xenografts in mouse.
Neoplasm Metastasis
Mechanisms controlling cell cycle arrest and induction of apoptosis after 12-lipoxygenase inhibition in prostate cancer cells.
Neoplasm Metastasis
Mechanisms regulating tumor angiogenesis by 12-lipoxygenase in prostate cancer cells.
Neoplasm Metastasis
Molecular identification, localization and function of platelet-type 12-lipoxygenase in human melanoma progression, under experimental and clinical conditions.
Neoplasm Metastasis
Platelets induce free and phospholipid-esterified 12-hydroxyeicosatetraenoic acid generation in colon cancer cells by delivering 12-lipoxygenase.
Neoplasm Metastasis
Radiotherapy Increases 12-LOX and CCL5 Levels in Esophageal Cancer Cells and Promotes Cancer Metastasis via THP-1-Derived Macrophages.
Neoplasm Metastasis
Reduction of isoforms of 15-lipoxygenase (15-LOX)-1 and 15-LOX-2 in human breast cancer.
Neoplasm Metastasis
Role of 12-lipoxygenase in hypoxia-induced rat pulmonary artery smooth muscle cell proliferation.
Neoplasm Metastasis
Role of lipoxygenases in breast cancer.
Neoplasm Metastasis
Synthetic curcuminoids modulate the arachidonic acid metabolism of human platelet 12-lipoxygenase and reduce sprout formation of human endothelial cells.
Neoplasm Metastasis
[Comparative proteomics of the serum in patients with nasopharyngeal carcinoma: a study with two-dimensional electrophoresis and MALDI-TOF-MS]
Neoplasms
12-HETE facilitates cell survival by activating the integrin-linked kinase/NF-?B pathway in ovarian cancer.
Neoplasms
12-Lipoxygenase and the regulation of hypoxia-inducible factor in prostate cancer cells.
Neoplasms
12-lipoxygenase expression in human melanoma cell lines.
Neoplasms
12-Lipoxygenase in Lewis lung carcinoma cells: molecular identity, intracellular distribution of activity and protein, and Ca(2+)-dependent translocation from cytosol to membranes.
Neoplasms
12-lipoxygenase induces apoptosis of human gastric cancer AGS cells via the ERK1/2 signal pathway.
Neoplasms
12-Lipoxygenase inhibition induced apoptosis in human gastric cancer cells.
Neoplasms
12-Lipoxygenase isoenzymes in mouse skin tumor development.
Neoplasms
12-Lipoxygenase promotes epithelial-mesenchymal transition via the Wnt/?-catenin signaling pathway in gastric cancer cells.
Neoplasms
12-Lipoxygenase promotes invasion and metastasis of human gastric cancer cells via epithelial-mesenchymal transition.
Neoplasms
12-lipoxygenase promotes tumor progress by TGF-?1-mediated epithelial to mesenchymal transition and predicts poor prognosis in esophageal squamous cell carcinoma.
Neoplasms
12-Lipoxygenase, 12(S)-HETE, and cancer metastasis.
Neoplasms
12-Lipoxygenase: classification, possible therapeutic benefits from inhibition, and inhibitors.
Neoplasms
12-lipoxygenases and 12(S)-HETE: role in cancer metastasis.
Neoplasms
12/15 lipoxygenase regulation of colorectal tumorigenesis is determined by the relative tumor levels of its metabolite 12-HETE and 13-HODE in animal models.
Neoplasms
12/15-Lipoxygenase Products Induce Inflammation and Impair Insulin Signaling in 3T3-L1 Adipocytes.
Neoplasms
15-Lipoxygenase-1 activates tumor suppressor p53 independent of enzymatic activity.
Neoplasms
15-Lipoxygenase-1 as a tumor suppressor gene in colon cancer: is the verdict in?
Neoplasms
15-lipoxygenase-1 in colorectal cancer: a review.
Neoplasms
15-Lipoxygenase-1 mediates cyclooxygenase-2 inhibitor-induced apoptosis in gastric cancer.
Neoplasms
15-Lipoxygenase-1 mediates nonsteroidal anti-inflammatory drug-induced apoptosis independently of cyclooxygenase-2 in colon cancer cells.
Neoplasms
15-lipoxygenase-1 production is lost in pancreatic cancer and overexpression of the gene inhibits tumor cell growth.
Neoplasms
15-Lipoxygenase-1 suppression of colitis-associated colon cancer through inhibition of the IL-6/STAT3 signaling pathway.
Neoplasms
15-Lipoxygenase-1 transcriptional silencing by DNA methyltransferase-1 independently of DNA methylation.
Neoplasms
15-Lipoxygenases and its metabolites 15(S)-HETE and 13(S)-HODE in the development of non-small cell lung cancer.
Neoplasms
15-Lipoxygenases in cancer: A double-edged sword?
Neoplasms
15-LOX-1 has diverse roles in the resensitization of resistant cancer cell lines to doxorubicin.
Neoplasms
15-LOX-1 suppression of hypoxia-induced metastatic phenotype and HIF-1? expression in human colon cancer cells.
Neoplasms
15-LOX-1 transcription suppression through the NuRD complex in colon cancer cells.
Neoplasms
15S-Lipoxygenase-2 mediates arachidonic acid-stimulated adhesion of human breast carcinoma cells through the activation of TAK1, MKK6, and p38 MAPK.
Neoplasms
5-Lipoxygenase is a direct p53 target gene in humans.
Neoplasms
A Cell-based Assay for Screening Lipoxygenase Inhibitors.
Neoplasms
A dual role of 12/15-lipoxygenase in LPS-induced acute renal inflammation and injury.
Neoplasms
A lipoxygenase metabolite, 12-(S)-HETE, stimulates protein kinase C-mediated release of cathepsin B from malignant cells.
Neoplasms
A novel hydroxamic acid compound, BMD188, demonstrates anti-prostate cancer effects by inducing apoptosis. I: In vitro studies.
Neoplasms
Absence of glutathione peroxidase 4 affects tumor angiogenesis through increased 12/15-lipoxygenase activity.
Neoplasms
ALOX12 In Human Toxoplasmosis.
Neoplasms
ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway.
Neoplasms
ALOX12B promotes carcinogenesis in cervical cancer by regulating the PI3K/ERK1 signaling pathway.
Neoplasms
ALOX15 as a suppressor of inflammation and cancer: Lost in the link.
Neoplasms
Alox5 Blockade Eradicates JAK2V617F-Induced Polycythemia Vera in Mice.
Neoplasms
Alterations in eicosanoid levels during U937 bcl-xL tumour growth suppression and recovery in NU/NU mice in vivo-Involvement of phospholipase A2.
Neoplasms
An integrated expression phenotype mapping approach defines common variants in LEP, ALOX15 and CAPNS1 associated with induction of IL-6.
Neoplasms
Analysis of transcripts from 17p13.3 in medulloblastoma suggests ROX/MNT as a potential tumour suppressor gene.
Neoplasms
Anti-cancer effects of baicalein in non-small cell lung cancer in-vitro and in-vivo.
Neoplasms
Anti-proliferative and pro-apoptotic effects of lichen-derived compound protolichesterinic acid are not mediated by its lipoxygenase-inhibitory activity.
Neoplasms
Anti-proliferative effects of lichen-derived lipoxygenase inhibitors on twelve human cancer cell lines of different tissue origin in vitro.
Neoplasms
Antineoplastic effects of 15(S)-hydroxyeicosatetraenoic acid and 13-S-hydroxyoctadecadienoic acid in non-small cell lung cancer.
Neoplasms
Apoptosis Induced by 13-S-hydroxyoctadecadienoic acid in the Breast Cancer Cell Lines, MCF-7 and MDA-MB-231.
Neoplasms
Apoptosis of W256 carcinosarcoma cells of the monocytoid origin induced by NDGA involves lipid peroxidation and depletion of GSH: role of 12-lipoxygenase in regulating tumor cell survival.
Neoplasms
Arachidonate 12-lipoxygenase and 12-hydroxyeicosatetraenoic acid contribute to stromal aging-induced progression of pancreatic cancer.
Neoplasms
Arachidonate 12/15-lipoxygenase-induced inflammation and oxidative stress are involved in the development of diabetic cardiomyopathy.
Neoplasms
Arachidonate 15-lipoxygenase is required for chronic myeloid leukemia stem cell survival.
Neoplasms
Arachidonate 5 lipoxygenase expression in papillary thyroid carcinoma promotes invasion via MMP-9 induction.
Neoplasms
Aspirin-Triggered Resolvin D1 Reduces Proliferation and the Neutrophil to Lymphocyte Ratio in a Mutant KRAS-Driven Lung Adenocarcinoma Model.
Neoplasms
Assessing 12(S)-lipoxygenase inhibitory activity using colorectal cancer cells overexpressing the enzyme.
Neoplasms
Biosynthesis, biological effects, and receptors of hydroxyeicosatetraenoic acids (HETEs) and oxoeicosatetraenoic acids (oxo-ETEs) derived from arachidonic acid.
Neoplasms
Brachmann-Cornelia de Lange syndrome with a papilloma of the choroid plexus: analyses of molecular genetic characteristics of the patient and the tumor. A single-case study.
Neoplasms
CAF secreted miR-522 suppresses ferroptosis and promotes acquired chemo-resistance in gastric cancer.
Neoplasms
Ceramide elevates 12-hydroxyeicosatetraenoic acid levels and upregulates 12-lipoxygenase in rat primary hippocampal cell cultures containing predominantly astrocytes.
Neoplasms
Characterization of an 8-lipoxygenase activity induced by the phorbol ester tumor promoter 12-O-tetradecanoylphorbol-13-acetate in mouse skin in vivo.
Neoplasms
Chromatin modification requirements for 15-lipoxygenase-1 transcriptional reactivation in colon cancer cells.
Neoplasms
Collagenase-3 induction in rat lung fibroblasts requires the combined effects of tumor necrosis factor-alpha and 12-lipoxygenase metabolites: a model of macrophage-induced, fibroblast-driven extracellular matrix remodeling during inflammatory lung injury.
Neoplasms
Colon cancer: genomics and apoptotic events.
Neoplasms
Convergence of eicosanoid and integrin biology: 12-lipoxygenase seeks a partner.
Neoplasms
Convergence of eicosanoid and integrin biology: Role of Src in 12-LOX activation.
Neoplasms
Cyclooxygenase and lipoxygenase gene expression in the inflammogenesis of breast cancer.
Neoplasms
Cyclooxygenase, lipoxygenase and tumor angiogenesis.
Neoplasms
Decreased 13-S-hydroxyoctadecadienoic acid levels and 15-lipoxygenase-1 expression in human colon cancers.
Neoplasms
Dietary n-3 polyunsaturated fatty acids enhance hormone ablation therapy in androgen-dependent prostate cancer.
Neoplasms
Differential Expression of Prostaglandin I2 Synthase Associated with Arachidonic Acid Pathway in the Oral Squamous Cell Carcinoma.
Neoplasms
Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries.
Neoplasms
Distinct effects of annexin A7 and p53 on arachidonate lipoxygenation in prostate cancer cells involve 5-lipoxygenase transcription.
Neoplasms
Ectopic alphaIIbbeta3 integrin signaling involves 12-lipoxygenase- and PKC-mediated serine phosphorylation events in melanoma cells.
Neoplasms
Effect of catechol derivatives on cell growth and lipoxygenase activity.
Neoplasms
Effects of gut-targeted 15-LOX-1 transgene expression on colonic tumorigenesis in mice.
Neoplasms
Effects of mutant p53 expression on human 15-lipoxygenase-promoter activity and murine 12/15-lipoxygenase gene expression: evidence that 15-lipoxygenase is a mutator gene.
Neoplasms
EGF-receptor tyrosine kinase and 12-lipoxygenase activity regulate expression of 12-lipoxygenase in human tumor cells.
Neoplasms
Eicosanoid activation of extracellular signal-regulated kinase1/2 in human epidermoid carcinoma cells.
Neoplasms
Eicosanoid regulation of angiogenesis in human prostate carcinoma and its therapeutic implications.
Neoplasms
Eicosanoid regulation of angiogenesis in tumors.
Neoplasms
Elevated 12-lipoxygenase mRNA expression correlates with advanced stage and poor differentiation of human prostate cancer.
Neoplasms
Elevated expression of 12/15-lipoxygenase and cyclooxygenase-2 in a transgenic mouse model of prostate carcinoma.
Neoplasms
Emerging cellular functions of the lipid metabolizing enzyme 15-Lipoxygenase-1.
Neoplasms
Endogenous 12(S)-HETE production by tumor cells and its role in metastasis.
Neoplasms
Enhanced 15-lipoxygenase activity and elevated eicosanoid production in kidney tumor microenvironment contribute to the inflammation and immune suppression.
Neoplasms
Enhanced tumor cell adhesion to the subendothelial matrix resulting from 12(S)-HETE-induced endothelial cell retraction.
Neoplasms
Evaluation of 12-lipoxygenase (12-LOX) and plasminogen activator inhibitor 1 (PAI-1) as prognostic markers in prostate cancer.
Neoplasms
Expression microarray analysis identifies novel epithelial-derived protein markers in eosinophilic esophagitis.
Neoplasms
Expression of 12-lipoxygenase as a biomarker for melanoma carcinogenesis.
Neoplasms
Expression of 12-lipoxygenase in human renal cell carcinoma and growth prevention by its inhibitor.
Neoplasms
Expression of 15-lipoxygenase-1 in human colorectal cancer.
Neoplasms
Expression of 15-lipoxygenase-1 in Merkel cell carcinoma is linked to advanced disease.
Neoplasms
Expression of lipoxygenase in human prostate cancer and growth reduction by its inhibitors.
Neoplasms
Expression, subcellular localization and putative function of platelet-type 12-lipoxygenase in human prostate cancer cell lines of different metastatic potential.
Neoplasms
Ferroptosis-Related Genes in Lung Adenocarcinoma: Prognostic Signature and Immune, Drug Resistance, Mutation Analysis.
Neoplasms
GADD153 and 12-lipoxygenase mediate fenretinide-induced apoptosis of neuroblastoma.
Neoplasms
Genetic Variants in COX2 and ALOX Genes and Breast Cancer Risk in White and Black Women.
Neoplasms
Genetic variation in the lipoxygenase pathway and risk of colorectal neoplasia.
Neoplasms
Growth inhibitory effect of polyunsaturated fatty acids (PUFAs) on colon cancer cells via their growth inhibitory metabolites and fatty acid composition changes.
Neoplasms
High expression of human 15-lipoxygenase induces NF-kappaB-mediated expression of vascular cell adhesion molecule 1, intercellular adhesion molecule 1, and T-cell adhesion on human endothelial cells.
Neoplasms
Honokiol inhibits gastric tumourigenesis by activation of 15-lipoxygenase-1 and consequent inhibition of peroxisome proliferator-activated receptor-gamma and COX-2-dependent signals.
Neoplasms
Human 5-, 12- and 15-lipoxygenase-1 coexist in kidney but show opposite trends and their balance changes in cancer.
Neoplasms
Human platelet 12-lipoxygenase, new findings about its activity, membrane binding and low-resolution structure.
Neoplasms
Identification of 12-lipoxygenase interaction with cellular proteins by yeast two-hybrid screening.
Neoplasms
Identification of the key genes and pathways involved in the tumorigenesis and prognosis of kidney renal clear cell carcinoma.
Neoplasms
In vitro 12(S)-HETE inhibitory activities of naphthoquinones isolated from the root bark of Euclea racemosa ssp. schimperi.
Neoplasms
Increased metastatic potential in human prostate carcinoma cells by overexpression of arachidonate 12-lipoxygenase.
Neoplasms
Inflammation and immune regulation by 12/15-lipoxygenases.
Neoplasms
Inhibition of 12-lipoxygenase during baicalein-induced human lung nonsmall carcinoma H460 cell apoptosis.
Neoplasms
Inhibition of 12-lipoxygenase reduces proliferation and induces apoptosis of hepatocellular carcinoma cells in vitro and in vivo.
Neoplasms
Inhibition of arachidonate lipoxygenase12 targets lung cancer through inhibiting EMT and suppressing RhoA and NF-?B activity.
Neoplasms
Inhibition of imiquimod-induced psoriasis-like dermatitis in mice by herbal extracts from some Indian medicinal plants.
Neoplasms
Inhibition of tumour growth by lipoxygenase inhibitors.
Neoplasms
Integrative Genomic and Transcriptomic Analyses of Tumor Suppressor Genes and Their Role on Tumor Microenvironment and Immunity in Lung Squamous Cell Carcinoma.
Neoplasms
Interplay between 15-lipoxygenase-1 and metastasis-associated antigen 1 in the metastatic potential of colorectal cancer.
Neoplasms
Intracellular distribution, activity, and Ca(2+)-dependent translocation of 12-lipoxygenase in Lewis lung tumor cells.
Neoplasms
Involvement of the multiple tumor suppressor genes and 12-lipoxygenase in human prostate cancer. Therapeutic implications.
Neoplasms
Is 15-LOX-1 a tumor suppressor?
Neoplasms
Knockout of ALOX12 protects against spinal cord injury-mediated nerve injury by inhibition of inflammation and apoptosis.
Neoplasms
Levels of expression of lipoxygenases and cyclooxygenase-2 in human breast cancer.
Neoplasms
Lipocalin-2 deficiency attenuates insulin resistance associated with aging and obesity.
Neoplasms
Lipoxygenase in Human Tumor Cells.
Neoplasms
Lipoxygenase inhibitors from natural plant sources. Part 2: medicinal plants with inhibitory activity on arachidonate 12-lipoxygenase, 15-lipoxygenase and leukotriene receptor antagonists.
Neoplasms
Lipoxygenase mediates invasion of intrametastatic lymphatic vessels and propagates lymph node metastasis of human mammary carcinoma xenografts in mouse.
Neoplasms
Lipoxygenase modulation to reverse carcinogenesis.
Neoplasms
Loss of heterozygosity of 17p13, with possible involvement of ACADVL and ALOX15B, in the pathogenesis of adrenocortical tumors.
Neoplasms
Mechanisms of free-radical induction in relation to fenretinide-induced apoptosis of neuroblastoma.
Neoplasms
Mechanisms regulating tumor angiogenesis by 12-lipoxygenase in prostate cancer cells.
Neoplasms
Mechanistic contribution of ubiquitous 15-lipoxygenase-1 expression loss in cancer cells to terminal cell differentiation evasion.
Neoplasms
MGST1 is a redox-sensitive repressor of ferroptosis in pancreatic cancer cells.
Neoplasms
MiR-216a-3p inhibits colorectal cancer cell proliferation through direct targeting COX-2 and ALOX5.
Neoplasms
Modulation of epidermal tumor development caused by targeted overexpression of epidermis-type 12S-lipoxygenase.
Neoplasms
Molecular identification, localization and function of platelet-type 12-lipoxygenase in human melanoma progression, under experimental and clinical conditions.
Neoplasms
Multiple use of a signal transduction pathway in tumor cell invasion.
Neoplasms
Neuroprotection of taurine through inhibition of 12/15 lipoxygenase pathway in cerebral ischemia of rats.
Neoplasms
Neutrophils support lung colonization of metastasis-initiating breast cancer cells.
Neoplasms
Non-synonymous polymorphism (Gln261Arg) of 12-lipoxygenase in colorectal and thyroid cancers.
Neoplasms
Nonsteroidal anti-inflammatory drugs induce apoptosis in esophageal cancer cells by restoring 15-lipoxygenase-1 expression.
Neoplasms
Opposing effects of 15-lipoxygenase-1 and -2 metabolites on MAPK signaling in prostate. Alteration in peroxisome proliferator-activated receptor gamma.
Neoplasms
Overexpression of 12/15-lipoxygenase, an ortholog of human 15-lipoxygenase-1, in the prostate tumors of TRAMP mice.
Neoplasms
Overexpression of leukocyte-type 12-lipoxygenase promotes W256 tumor cell survival by enhancing alphavbeta5 expression.
Neoplasms
Overexpression of lipid metabolism genes and PBX1 in the contralateral breasts of women with estrogen receptor-negative breast cancer.
Neoplasms
Overexpression of platelet-type 12-lipoxygenase promotes tumor cell survival by enhancing alpha(v)beta(3) and alpha(v)beta(5) integrin expression.
Neoplasms
Platelet 12-lipoxygenase Arg261Gln polymorphism: functional characterization and association with risk of esophageal squamous cell carcinoma in combination with COX-2 polymorphisms.
Neoplasms
Platelet-12 lipoxygenase targeting via a newly synthesized curcumin derivative radiolabeled with technetium-99m.
Neoplasms
Platelet-type 12-lipoxygenase accelerates tumor promotion of mouse epidermal cells through enhancement of cloning efficiency.
Neoplasms
Platelet-type 12-lipoxygenase activates NF-kappaB in prostate cancer cells.
Neoplasms
Platelet-type 12-lipoxygenase in a human prostate carcinoma stimulates angiogenesis and tumor growth.
Neoplasms
Platelets and cancer metastasis: a causal relationship?
Neoplasms
Platelets induce free and phospholipid-esterified 12-hydroxyeicosatetraenoic acid generation in colon cancer cells by delivering 12-lipoxygenase.
Neoplasms
Polyunsaturated Fatty Acid Diet and Upregulation of Lipoxin A4 Reduce the Inflammatory Response of Preeclampsia.
Neoplasms
Predominant synthesis of 5-hydroxyeicosatetraenoic acid by a cloned mastocytoma P-815 line, 2-E-6 cells.
Neoplasms
RAD001 targeted HUVECs reverses 12-lipoxygenase-induced angiogenesis in oesophageal squamous cell carcinoma.
Neoplasms
Radiotherapy Increases 12-LOX and CCL5 Levels in Esophageal Cancer Cells and Promotes Cancer Metastasis via THP-1-Derived Macrophages.
Neoplasms
Reduction of isoforms of 15-lipoxygenase (15-LOX)-1 and 15-LOX-2 in human breast cancer.
Neoplasms
Regulation of 15-lipoxygenase expression and mucus secretion by IL-4 in human bronchial epithelial cells.
Neoplasms
Replacement of an Indole Scaffold Targeting Human 15-Lipoxygenase-1 Using Combinatorial Chemistry.
Neoplasms
Requirement for epidermal growth factor receptor tyrosine kinase and for 12-lipoxygenase activity in the expression of 12-lipoxygenase in human epidermoid carcinoma cells.
Neoplasms
Ribozyme-mediated suppression of platelet type 12 lipoxygenase in human erythroleukemia cells.
Neoplasms
Role of 'platelet-type' 12-lipoxygenase in skin carcinogenesis.
Neoplasms
Role of 12-lipoxygenase and protein kinase C in modulating the activation state of the integrin alpha IIb beta 3 on human tumor cells.
Neoplasms
Role of 12-lipoxygenase in hypoxia-induced rat pulmonary artery smooth muscle cell proliferation.
Neoplasms
Role of eicosanoids in prostate cancer progression.
Neoplasms
Role of lipoxygenases in breast cancer.
Neoplasms
Search of factors that intermediate cytokine-induced group IIA phospholipase A2 expression through the cytosolic phospholipase A2- and 12/15-lipoxygenase-dependent pathway.
Neoplasms
Silencing IL-13R?2 promotes glioblastoma cell death via endogenous signaling.
Neoplasms
Specific overexpression of 15-lipoxygenase in endothelial cells promotes cancer cell death in an in vivo Lewis lung carcinoma mouse model.
Neoplasms
Suppression of platelet-type 12-lipoxygenase activity in human erythroleukemia cells by an RNA-cleaving DNAzyme.
Neoplasms
Synthetic curcuminoids modulate the arachidonic acid metabolism of human platelet 12-lipoxygenase and reduce sprout formation of human endothelial cells.
Neoplasms
Targeting Lipid Peroxidation for Cancer Treatment.
Neoplasms
The Alox5 gene is a novel therapeutic target in cancer stem cells of chronic myeloid leukemia.
Neoplasms
The biological role of arachidonic acid 12-lipoxygenase (ALOX12) in various human diseases.
Neoplasms
The concentration of 12-lipoxygenase in platelet rich plasma as an indication of cancer of the prostate.
Neoplasms
The future of cyclooxygenase-2 inhibitors and other inhibitors of the eicosanoid signal pathway in the prevention and therapy of lung cancer.
Neoplasms
The importance of 15-lipoxygenase inhibitors in cancer treatment.
Neoplasms
The methyltransferase inhibitor 5-aza-2-deoxycytidine induces apoptosis via induction of 15-lipoxygenase-1 in colorectal cancer cells.
Neoplasms
The modulatory properties of Si Jun Zi Tang enhancing anticancer of gefitinib by an integrating approach.
Neoplasms
The polymorphism (Gln261Arg) of 12-lipoxygenase and cancer risk: a meta-analysis.
Neoplasms
The role of 12/15-lipoxygenase in the expression of interleukin-6 and tumor necrosis factor-alpha in macrophages.
Neoplasms
The role of lipoxygenases in pathophysiology; new insights and future perspectives.
Neoplasms
The transcription factor GATA-6 is overexpressed in vivo and contributes to silencing 15-LOX-1 in vitro in human colon cancer.
Neoplasms
Therapeutic molecular targeting of 15-lipoxygenase-1 in colon cancer.
Neoplasms
Therapeutic Molecular Targetingof 15-Lipoxygenase-1 in Colon Cancer.
Neoplasms
Thrombin causes pseudopod detachment via a pathway involving cytosolic phospholipase A2 and 12/15-lipoxygenase products.
Neoplasms
Transcriptional regulation of 15-lipoxygenase expression by promoter methylation.
Neoplasms
Transient overexpression of human 15-lipoxygenase in aortic endothelial cells enhances tumor necrosis factor-induced vascular cell adhesion molecule-1 gene expression.
Neoplasms
Tumor cell-derived 12(S)-hydroxyeicosatetraenoic acid induces microvascular endothelial cell retraction.
Neoplasms
Tumor microenvironment determines drug efficacy in vitro - apoptotic and anti-inflammatory effects of 15-lipoxygenase metabolite, 13-HpOTrE.
Neoplasms
Up-regulation of 12(S)-lipoxygenase induces a migratory phenotype in colorectal cancer cells.
Neoplasms
Up-regulation of 15-lipoxygenase enzymes and products in functional and non-functional pituitary adenomas.
Neoplasms
Valsartan protects pancreatic islets and adipose tissue from the inflammatory and metabolic consequences of a high-fat diet in mice.
Neoplasms
Vascular endothelial growth factor production in human prostate cancer cells is stimulated by overexpression of platelet 12-lipoxygenase.
Neoplasms
Zyflamend-mediated inhibition of human prostate cancer PC3 cell proliferation: effects on 12-LOX and Rb protein phosphorylation.
Neoplasms
[Selective 12-lipoxygenase inhibition potentiates the effect of radiation on human prostate cancer cells in vitro and in vivo].
Nephritis
Co-regulated expression of glomerular 12/15-lipoxygenase and interleukin-4 mRNAs in rat nephrotoxic nephritis.
Nephritis
Elevated expressions of 15-lipoxygenase and lipoxin A4 in children with acute poststreptococcal glomerulonephritis.
Nephritis
Inverse temporal changes of lipoxin A(4) and leukotrienes in children with Henoch-Schönlein purpura.
Nephritis
NZB/NZW F1 mouse nephritis and immune response are not changed by treatment with a 15-lipoxygenase derivative.
Nephritis
Transfection of rat kidney with human 15-lipoxygenase suppresses inflammation and preserves function in experimental glomerulonephritis.
Nervous System Diseases
12/15 lipoxygenase: A crucial enzyme in diverse types of cell death.
Neuroblastoma
12-Lipoxygenase overexpression in rodent NG108-15 cells enhances membrane excitability by inhibiting M-type K+ channels.
Neuroblastoma
Docosahexaenoic acid metabolome in neural tumors: identification of cytotoxic intermediates.
Neuroblastoma
Expression of DHA-Metabolizing Enzyme Alox15 is Regulated by Selective Histone Acetylation in Neuroblastoma Cells.
Neuroblastoma
GADD153 and 12-lipoxygenase mediate fenretinide-induced apoptosis of neuroblastoma.
Neuroblastoma
Genetic ablation and short-duration inhibition of lipoxygenase results in increased macroautophagy.
Neuroblastoma
Mechanisms of free-radical induction in relation to fenretinide-induced apoptosis of neuroblastoma.
Neuroblastoma
Molecular mechanisms of fenretinide-induced apoptosis of neuroblastoma cells.
Neuroblastoma
Omega-3 fatty acid supplementation delays the progression of neuroblastoma in vivo.
Neuroblastoma
The NF-kappaB pathway mediates fenretinide-induced apoptosis in SH-SY5Y neuroblastoma cells.
Neuroblastoma
The role of gangliosides in fenretinide-induced apoptosis of neuroblastoma.
Neurodegenerative Diseases
12/15-lipoxygenase is increased in Alzheimer's disease: possible involvement in brain oxidative stress.
Neurodegenerative Diseases
Ceramide elevates 12-hydroxyeicosatetraenoic acid levels and upregulates 12-lipoxygenase in rat primary hippocampal cell cultures containing predominantly astrocytes.
Neurodegenerative Diseases
Effects of anti-inflammatory and adaptogenic herbal extracts on gene expression of eicosanoids signaling pathways in isolated brain cells.
Neurodegenerative Diseases
Inhibition of 12/15 LOX ameliorates cognitive and cholinergic dysfunction in mouse model of hypobaric hypoxia via. attenuation of oxidative/nitrosative stress.
Neurodegenerative Diseases
Novel lipoxygenase inhibitors as neuroprotective reagents.
Neurodegenerative Diseases
Peroxynitrite-induced neuronal apoptosis is mediated by intracellular zinc release and 12-lipoxygenase activation.
Neurodegenerative Diseases
The biological role of arachidonic acid 12-lipoxygenase (ALOX12) in various human diseases.
Neuroinflammatory Diseases
Genetic absence of ALOX5 protects from homocysteine-induced memory impairment, tau phosphorylation and synaptic pathology.
Neuroinflammatory Diseases
Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase.
Non-alcoholic Fatty Liver Disease
Arachidonate 12S-lipoxygenase of platelet-type in hepatic stellate cells of methionine and choline-deficient diet-fed mice.
Non-alcoholic Fatty Liver Disease
Disruption of the 12/15-lipoxygenase gene (Alox15) protects hyperlipidemic mice from nonalcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
Molecular mechanisms of nonalcoholic fatty liver disease: Potential role for 12-lipoxygenase.
Obesity
12- and 15-lipoxygenases in adipose tissue inflammation.
Obesity
12-Lipoxygenase-knockout mice are resistant to inflammatory effects of obesity induced by Western diet.
Obesity
12/15-Lipoxygenase Products Induce Inflammation and Impair Insulin Signaling in 3T3-L1 Adipocytes.
Obesity
12/15-Lipoxygenase signaling in the endoplasmic reticulum stress response.
Obesity
15-Lipoxygenase inhibitors: a patent review.
Obesity
A high-fat diet induces bone loss in mice lacking the Alox5 gene.
Obesity
Adipose tissue 12/15 lipoxygenase pathway in human obesity and diabetes.
Obesity
ALOX12 polymorphisms are associated with fat mass but not peak bone mineral density in Chinese nuclear families.
Obesity
ALOX5AP Overexpression in Adipose Tissue Leads to LXA4 Production and Protection Against Diet-Induced Obesity and Insulin Resistance.
Obesity
Evidence for Activation of Inflammatory Lipoxygenase Pathways in Visceral Adipose Tissue of Obese Zucker Rats.
Obesity
Fish Oil Supplementation in Overweight/Obese Patients with Uncontrolled Asthma: A Randomized Trial.
Obesity
Interaction between cytokines and inflammatory cells in islet dysfunction, insulin resistance and vascular disease.
Obesity
Prediabetic nephropathy as an early consequence of the high-calorie/high-fat diet: relation to oxidative stress.
Obesity
Proliferation and differentiation of adipose tissue in prolonged lean and obese critically ill patients.
Optic Nerve Injuries
Neuroprotectin D1 inhibits retinal ganglion cell death following axotomy.
Osteoarthritis
Deletion of 12/15-lipoxygenase accelerates the development of aging-associated and instability-induced osteoarthritis.
Osteoporosis
ALOX12 gene polymorphisms and serum selenium status in elderly osteoporotic patients.
Osteoporosis
Genetic epidemiology of osteoporosis: past, present, and future.
Osteoporosis
Inflammation and immune regulation by 12/15-lipoxygenases.
Osteoporosis
Polymorphisms in the ALOX12 gene and osteoporosis.
Osteoporosis
Regulation of bone mass in mice by the lipoxygenase gene Alox15.
Osteoporosis
The 12/15-lipoxygenase pathway promotes osteoclast development and differentiation.
Osteoporosis
Understanding our drugs and our diseases.
Osteoporosis, Postmenopausal
Association of a single nucleotide polymorphism in the lipoxygenase ALOX15 5'-flanking region (-5229G/A) with bone mineral density.
Osteosarcoma
Cloning and expression of human leukocyte 5-lipoxygenase.
Osteosarcoma
Expression of cloned human reticulocyte 15-lipoxygenase and immunological evidence that 15-lipoxygenases of different cell types are related.
Ovarian Neoplasms
Ovarian Cancer Risk Associated with Inherited Inflammation-Related Variants.
Ovarian Neoplasms
Role of 12-lipoxygenase in regulation of ovarian cancer cell proliferation and survival.
Pancreatic Neoplasms
12-lipoxygenase metabolite 12(S)-HETE stimulates human pancreatic cancer cell proliferation via protein tyrosine phosphorylation and ERK activation.
Pancreatic Neoplasms
15-lipoxygenase-1 production is lost in pancreatic cancer and overexpression of the gene inhibits tumor cell growth.
Pancreatic Neoplasms
Arachidonate 12-lipoxygenase and 12-hydroxyeicosatetraenoic acid contribute to stromal aging-induced progression of pancreatic cancer.
Pancreatic Neoplasms
Cyclooxygenases and lipoxygenases as potential targets for treatment of pancreatic cancer.
Pancreatic Neoplasms
Lipoxygenase inhibition induced apoptosis, morphological changes, and carbonic anhydrase expression in human pancreatic cancer cells.
Pancreatic Neoplasms
Lipoxygenase inhibitors abolish proliferation of human pancreatic cancer cells.
Pancreatic Neoplasms
Lipoxygenase inhibitors attenuate growth of human pancreatic cancer xenografts and induce apoptosis through the mitochondrial pathway.
Papilloma
c-Src-mediated phosphorylation of hnRNP K drives translational activation of specifically silenced mRNAs.
Parkinson Disease
5-lipoxygenase pathway and its downstream cysteinyl leukotrienes as potential therapeutic targets for Alzheimer's disease.
Pemphigoid, Bullous
12/15-Lipoxygenase choreographs the resolution of IgG-mediated skin inflammation.
Perinatal Death
The role of lipoxygenases in epidermis.
Periodontal Diseases
Effect of Alox-15 Polymorphism on GCF Levels of Lipoxin-A4 in Chronic Periodontitis: A Preliminary Study.
Periodontitis
Expression profile of lipoxygenases in gingival tissues of human periodontitis.
Periodontitis
Impaired polymorphonuclear leukocyte 15-lipoxygenase activity in juvenile and rapidly progressive periodontitis.
Periodontitis
Reduced inflammation and tissue damage in transgenic rabbits overexpressing 15-lipoxygenase and endogenous anti-inflammatory lipid mediators.
Peripheral Nervous System Diseases
12/15-Lipoxygenase inhibition counteracts MAPK phosphorylation in mouse and cell culture models of diabetic peripheral neuropathy.
Peripheral Nervous System Diseases
Interplay of sorbitol pathway of glucose metabolism, 12/15-lipoxygenase, and mitogen-activated protein kinases in the pathogenesis of diabetic peripheral neuropathy.
Peripheral Nervous System Diseases
Leukotriene Pathway Activation Associates with Poor Glycemic Control and with Cardiovascular Autonomic Neuropathy in Type 1 Diabetes.
Peripheral Nervous System Diseases
Role of 12/15-lipoxygenase in nitrosative stress and peripheral prediabetic and diabetic neuropathies.
Peritonitis
Eosinophils control the resolution of inflammation and draining lymph node hypertrophy through the proresolving mediators and CXCL13 pathway in mice.
Peritonitis
Exogenous pathogen and plant 15-lipoxygenase initiate endogenous lipoxin A4 biosynthesis.
Pituitary Neoplasms
Inhibition of adenylyl cyclases by 12(S)-hydroxyeicosatetraenoic acid.
Pituitary Neoplasms
Up-regulation of 15-lipoxygenase enzymes and products in functional and non-functional pituitary adenomas.
Pleurisy
In vivo anti-allergic and anti-inflammatory effects of drugs that inhibit lipoxygenase activity in vitro.
Pneumonia
12/15-Lipoxygenase Regulates IL-33-Induced Eosinophilic Airway Inflammation in Mice.
Pneumonia
Cytosolic phospholipase A2? promotes pulmonary inflammation and systemic disease during Streptococcus pneumoniae infection.
Pneumonia
Eliminating or blocking 12/15-lipoxygenase reduces neutrophil recruitment in mouse models of acute lung injury.
Pneumonia
Improved survival and reduced vascular permeability by eliminating or blocking 12/15-lipoxygenase in mouse models of acute lung injury (ALI).
Pneumonia
Leukotriene B4 receptors contribute to house dust mite-induced eosinophilic airway inflammation via TH2 cytokine production.
Pneumonia
Specialized pro-resolving lipid mediators regulate ozone-induced pulmonary and systemic inflammation.
Pneumonia
Systemic Disease during Streptococcus pneumoniae Acute Lung Infection Requires 12-Lipoxygenase-Dependent Inflammation.
Polycystic Kidney, Autosomal Dominant
Bioactive lipid mediators in polycystic kidney disease.
Polycythemia Vera
Alox5 Blockade Eradicates JAK2V617F-Induced Polycythemia Vera in Mice.
Pre-Eclampsia
Preeclampsia activates 15-lipoxygenase and its metabolite 15-hydroxyeicosatetraenoic acid enhances constriction in umbilical arteries.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Identification of genetic variants associated with skeletal muscle function deficit in childhood acute lymphoblastic leukemia survivors.
Prediabetic State
Prediabetic nephropathy as an early consequence of the high-calorie/high-fat diet: relation to oxidative stress.
Prostatic Hyperplasia
Expression of lipoxygenase in human prostate cancer and growth reduction by its inhibitors.
Prostatic Intraepithelial Neoplasia
Expression of lipoxygenase in human prostate cancer and growth reduction by its inhibitors.
Prostatic Neoplasms
12(S)-HETE enhancement of prostate tumor cell invasion: selective role of PKC alpha.
Prostatic Neoplasms
12-Lipoxygenase and the regulation of hypoxia-inducible factor in prostate cancer cells.
Prostatic Neoplasms
15-lipoxygenase metabolites of docosahexaenoic acid inhibit prostate cancer cell proliferation and survival.
Prostatic Neoplasms
15-lipoxygenase metabolites of gamma-linolenic acid/eicosapentaenoic acid suppress growth and arachidonic acid metabolism in human prostatic adenocarcinoma cells: possible implications of dietary fatty acids.
Prostatic Neoplasms
15-Lipoxygenase-1 re-expression in colorectal cancer alters endothelial cell features through enhanced expression of TSP-1 and ICAM-1.
Prostatic Neoplasms
15-Lipoxygenase-1-mediated metabolism of docosahexaenoic acid is required for syndecan-1 signaling and apoptosis in prostate cancer cells.
Prostatic Neoplasms
7-Farnesyloxycoumarin Exerts Anti-cancer Effects on a Prostate Cancer Cell Line by 15-LOX-1 Inhibition.
Prostatic Neoplasms
8-Farnesyloxycoumarin induces apoptosis in PC-3 prostate cancer cells by inhibition of 15-lipoxygenase-1 enzymatic activity.
Prostatic Neoplasms
Apoptosis induction by a novel anti-prostate cancer compound, BMD188 (a fatty acid-containing hydroxamic acid), requires the mitochondrial respiratory chain.
Prostatic Neoplasms
Arachidonate 12-lipoxygenase may serve as a potential marker and therapeutic target for prostate cancer stem cells.
Prostatic Neoplasms
Associations between arachidonic acid metabolism gene polymorphisms and prostate cancer risk.
Prostatic Neoplasms
Convergence of eicosanoid and integrin biology: 12-lipoxygenase seeks a partner.
Prostatic Neoplasms
Eicosanoid regulation of angiogenesis in human prostate carcinoma and its therapeutic implications.
Prostatic Neoplasms
Elevated 12-lipoxygenase mRNA expression correlates with advanced stage and poor differentiation of human prostate cancer.
Prostatic Neoplasms
Evaluation of 12-lipoxygenase (12-LOX) and plasminogen activator inhibitor 1 (PAI-1) as prognostic markers in prostate cancer.
Prostatic Neoplasms
Expression of lipoxygenase in human prostate cancer and growth reduction by its inhibitors.
Prostatic Neoplasms
Expression, subcellular localization and putative function of platelet-type 12-lipoxygenase in human prostate cancer cell lines of different metastatic potential.
Prostatic Neoplasms
Increased metastatic potential in human prostate carcinoma cells by overexpression of arachidonate 12-lipoxygenase.
Prostatic Neoplasms
Involvement of the multiple tumor suppressor genes and 12-lipoxygenase in human prostate cancer. Therapeutic implications.
Prostatic Neoplasms
Mechanisms controlling cell cycle arrest and induction of apoptosis after 12-lipoxygenase inhibition in prostate cancer cells.
Prostatic Neoplasms
Mechanisms regulating tumor angiogenesis by 12-lipoxygenase in prostate cancer cells.
Prostatic Neoplasms
Opposing effects of 15-lipoxygenase-1 and -2 metabolites on MAPK signaling in prostate. Alteration in peroxisome proliferator-activated receptor gamma.
Prostatic Neoplasms
Overexpression of platelet-type 12-lipoxygenase promotes tumor cell survival by enhancing alpha(v)beta(3) and alpha(v)beta(5) integrin expression.
Prostatic Neoplasms
Platelet-type 12- lipoxygenase induces MMP9 expression and cellular invasion via activation of PI3K/AKT/NF-?B.
Prostatic Neoplasms
Platelet-type 12-lipoxygenase activates NF-kappaB in prostate cancer cells.
Prostatic Neoplasms
Prostate Cancer - Old Problems and New Approaches. (Part II. Diagnostic and Prognostic Markers, Pathology and Biological Aspects).
Prostatic Neoplasms
Proteomic Profiling of Two Distinct Populations of Extracellular Vesicles Isolated from Human Seminal Plasma.
Prostatic Neoplasms
Radiosensitivity of human prostate cancer cells can be modulated by inhibition of 12-lipoxygenase.
Prostatic Neoplasms
Rapid induction of apoptosis in prostate cancer cells by selenium: reversal by metabolites of arachidonate 5-lipoxygenase.
Prostatic Neoplasms
Replacement of an Indole Scaffold Targeting Human 15-Lipoxygenase-1 Using Combinatorial Chemistry.
Prostatic Neoplasms
Role of eicosanoids in prostate cancer progression.
Prostatic Neoplasms
Silencing IL-13R?2 promotes glioblastoma cell death via endogenous signaling.
Prostatic Neoplasms
Stylosin and some of its synthetic derivatives induce apoptosis in prostate cancer cells as 15-lipoxygenase enzyme inhibitors.
Prostatic Neoplasms
Synthetic curcuminoids modulate the arachidonic acid metabolism of human platelet 12-lipoxygenase and reduce sprout formation of human endothelial cells.
Prostatic Neoplasms
The concentration of 12-lipoxygenase in platelet rich plasma as an indication of cancer of the prostate.
Prostatic Neoplasms
Transcriptional regulation of 15-lipoxygenase expression by histone h3 lysine 4 methylation/demethylation.
Prostatic Neoplasms
Vascular endothelial growth factor production in human prostate cancer cells is stimulated by overexpression of platelet 12-lipoxygenase.
Prostatic Neoplasms
Zyflamend-mediated inhibition of human prostate cancer PC3 cell proliferation: effects on 12-LOX and Rb protein phosphorylation.
Prostatic Neoplasms
[Leukotriene-lipoxygenase pathway and drug discovery]
Prostatic Neoplasms
[Selective 12-lipoxygenase inhibition potentiates the effect of radiation on human prostate cancer cells in vitro and in vivo].
Proteinuria
Inhibition of 12/15-Lipoxygenase Reduces Renal Inflammation and Injury in Streptozotocin-Induced Diabetic Mice.
Proteinuria
Inverse temporal changes of lipoxin A(4) and leukotrienes in children with Henoch-Schönlein purpura.
Proteinuria
Role of 12-lipoxygenase in decreasing P-cadherin and increasing angiotensin II type 1 receptor expression according to glomerular size in type 2 diabetic rats.
Pruritus
TRPV1 mediates histamine-induced itching via the activation of phospholipase A2 and 12-lipoxygenase.
Psoriasis
Epidermis contains platelet-type 12-lipoxygenase that is overexpressed in germinal layer keratinocytes in psoriasis.
Psoriasis
In vitro 12(S)-HETE inhibitory activities of naphthoquinones isolated from the root bark of Euclea racemosa ssp. schimperi.
Psoriasis
Inhibition of imiquimod-induced psoriasis-like dermatitis in mice by herbal extracts from some Indian medicinal plants.
Psoriasis
Insulin-like growth factor-II regulates the 12-lipoxygenase gene expression and promotes cell proliferation in human keratinocytes via the extracellular regulatory kinase and phosphatidylinositol 3-kinase pathways.
Psoriasis
Lack of association of ALOX12 and ALOX15B polymorphisms with psoriasis despite altered urinary excretion of 12(S)-HETE.
Psoriasis
Lipoxygenase inhibitors from natural plant sources. Part 2: medicinal plants with inhibitory activity on arachidonate 12-lipoxygenase, 15-lipoxygenase and leukotriene receptor antagonists.
Psoriasis
Lipoxygenase-catalyzed formation of R-configuration hydroperoxides.
Psoriasis
Reciprocal regulation of 12- and 15-lipoxygenases by UV-irradiation in human keratinocytes.
Psoriasis
Selective decrease of 15-hydroxyeicosatetraenoic acid (15-HETE) formation in uninvolved psoriatic dermis.
Psoriasis
Upregulation of 8-lipoxygenase in the dermatitis of IkappaB-alpha-deficient mice.
Pulmonary Arterial Hypertension
15-Lipoxygenase Promotes Chronic Hypoxia-Induced Phenotype Changes of PASMCs via Positive Feedback-Loop of BMP4.
Pulmonary Arterial Hypertension
15-Lipoxygenase Promotes Chronic Hypoxia-Induced Pulmonary Artery Inflammation via Positive Interaction With Nuclear Factor-?B.
Pulmonary Arterial Hypertension
Heme oxygenase-1 induces 15-lipoxygenase expression during hypoxia-induced pulmonary hypertension.
Pulmonary Arterial Hypertension
Reciprocal regulation of HIF-1? and 15-LO/15-HETE promotes anti-apoptosis process in pulmonary artery smooth muscle cells during hypoxia.
Pulmonary Arterial Hypertension
ROCK pathway participates in the processes that 15-hydroxyeicosatetraenoic acid (15-HETE) mediated the pulmonary vascular remodeling induced by hypoxia in rat.
Pulmonary Arterial Hypertension
The key role of transforming growth factor-beta receptor I and 15-lipoxygenase in hypoxia-induced proliferation of pulmonary artery smooth muscle cells.
Pulmonary Arterial Hypertension
The role of ERK1/2 in 15-HETE-inhibited apoptosis in pulmonary arterial smooth muscle cells.
Pulmonary Disease, Chronic Obstructive
15-lipoxygenase-1 induces expression and release of chemokines in cultured human lung epithelial cells.
Pulmonary Disease, Chronic Obstructive
Arachidonic Acid 15-Lipoxygenase: Effects of Its Expression, Metabolites, and Genetic and Epigenetic Variations on Airway Inflammation.
Pulmonary Disease, Chronic Obstructive
Development and Clinical Validation of a Novel 4-Gene Prognostic Signature Predicting Survival in Colorectal Cancer.
Pulmonary Disease, Chronic Obstructive
Expression of 15-lipoxygenase and evidence for apoptosis in the lungs from patients with COPD
Pulmonary Disease, Chronic Obstructive
Substituted (E)-2-(2-benzylidenehydrazinyl)-4-methylthiazole-5-carboxylates as dual inhibitors of 15-lipoxygenase & carbonic anhydrase II: synthesis, biochemical evaluation and docking studies.
Pulmonary Disease, Chronic Obstructive
The Perspective of Diagnostic and Prognostic Values of Lipoxygenases mRNA Expression in Colon Adenocarcinoma.
Pulmonary Fibrosis
12-Lipoxygenase is a Critical Mediator of Type II Pneumocyte Senescence, Macrophage Polarization and Pulmonary Fibrosis after Irradiation.
Q Fever
Monocyte responses in the context of q Fever: from a static polarized model to a kinetic model of activation.
Rectal Neoplasms
Genetic variation in prostaglandin synthesis and related pathways, NSAID use and colorectal cancer risk in the Colon Cancer Family Registry.
Rectal Neoplasms
Genetic variation in the lipoxygenase pathway and risk of colorectal neoplasia.
Rectal Neoplasms
Polymorphisms in arachidonic acid metabolism-related genes and the risk and prognosis of colorectal cancer.
Rectal Neoplasms
PTGS1, PTGS2, ALOX5, ALOX12, ALOX15, and FLAP SNPs: interaction with fatty acids in colon cancer and rectal cancer.
Rectal Neoplasms
The polymorphism (Gln261Arg) of 12-lipoxygenase and cancer risk: a meta-analysis.
Reperfusion Injury
Activation of PPAR? by 12/15-lipoxygenase during cerebral ischemia-reperfusion injury.
Reperfusion Injury
Pharmacological inhibition of arachidonate 12-lipoxygenase ameliorates myocardial ischemia-reperfusion injury in multiple species.
Respiratory Syncytial Virus Infections
Evaluation of the expression level of 12/15 lipoxygenase and the related inflammatory factors (CCL5, CCL3) in respiratory syncytial virus infection in mice model.
Retinal Neovascularization
Increased expression and activity of 12-lipoxygenase in oxygen-induced ischemic retinopathy and proliferative diabetic retinopathy: implications in retinal neovascularization.
Retinal Neovascularization
Inhibition of Oxygen-Induced Ischemic Retinal Neovascularization with Adenoviral 15-Lipoxygenase-1 Gene Transfer via Up-Regulation of PPAR-? and Down-Regulation of VEGFR-2 Expression.
Retinal Neovascularization
Overexpression of 15-lipoxygenase-1 in oxygen-induced ischemic retinopathy inhibits retinal neovascularization via downregulation of vascular endothelial growth factor-A expression.
Rett Syndrome
13-HODE, 9-HODE and ALOX15 as potential players in Rett syndrome OxInflammation.
Rhinitis
Environment Changes Genetic Effects on Respiratory Conditions and Allergic Phenotypes.
Rhinitis, Allergic
5-lipoxygenase pathway and its downstream cysteinyl leukotrienes as potential therapeutic targets for Alzheimer's disease.
Schistosomiasis
Mice deficient for 5-lipoxygenase, but not leukocyte-type 12-lipoxygenase, display altered immune responses during infection with Schistosoma mansoni.
Seizures
Baicalein Exerts Neuroprotective Effects in FeCl3-Induced Posttraumatic Epileptic Seizures via Suppressing Ferroptosis.
Seizures
Targeting ferroptosis: A novel therapeutic strategy for the treatment of mitochondrial disease-related epilepsy.
Sepsis
Constructing a 10-core genes panel for diagnosis of pediatric sepsis.
Sepsis
Dual role of lipoxin A4 in pneumosepsis pathogenesis.
Sepsis
Identification of key pathogenic genes of sepsis based on the Gene Expression Omnibus database.
Sepsis
Pneumolysin Induces 12-Lipoxygenase-Dependent Neutrophil Migration during Streptococcus pneumoniae Infection.
Skin Diseases
Control of somatic tissue differentiation by the long non-coding RNA TINCR.
Skin Diseases
Epidermal fatty acid oxygenases are activated in non-psoriatic dermatoses.
Skin Diseases
Lipoxygenase-catalyzed formation of R-configuration hydroperoxides.
Skin Diseases
Reciprocal regulation of 12- and 15-lipoxygenases by UV-irradiation in human keratinocytes.
Skin Diseases
Upregulation of 8-lipoxygenase in the dermatitis of IkappaB-alpha-deficient mice.
Skin Diseases
ZNF750 Is Expressed in Differentiated Keratinocytes and Regulates Epidermal Late Differentiation Genes.
Squamous Cell Carcinoma of Head and Neck
Expression of cyclooxygenase-2, 12-lipoxygenase, and inducible nitric oxide synthase in head and neck squamous cell carcinoma.
Starvation
12-Lipoxygenase in A431 cells: genetic identity, modulation of expression, and intracellular localization.
Stomach Neoplasms
12-lipoxygenase induces apoptosis of human gastric cancer AGS cells via the ERK1/2 signal pathway.
Stomach Neoplasms
12-Lipoxygenase inhibition induced apoptosis in human gastric cancer cells.
Stomach Neoplasms
12-Lipoxygenase promotes epithelial-mesenchymal transition via the Wnt/?-catenin signaling pathway in gastric cancer cells.
Stomach Neoplasms
12-Lipoxygenase promotes invasion and metastasis of human gastric cancer cells via epithelial-mesenchymal transition.
Stomach Neoplasms
15-Lipoxygenase-1 mediates cyclooxygenase-2 inhibitor-induced apoptosis in gastric cancer.
Stomach Neoplasms
ALOX5-5-HETE promotes gastric cancer growth and alleviates chemotherapy toxicity via MEK/ERK activation.
Stomach Neoplasms
CAF secreted miR-522 suppresses ferroptosis and promotes acquired chemo-resistance in gastric cancer.
Stroke
12/15 Lipoxygenase as a Therapeutic Target in Brain Disorders.
Stroke
12/15-Lipoxygenase Inhibition or Knockout Reduces Warfarin-Associated Hemorrhagic Transformation After Experimental Stroke.
Stroke
12/15-Lipoxygenase targets neuronal mitochondria under oxidative stress.
Stroke
Arachidonate 5-lipoxygenase (ALOX5) gene polymorphism is associated with Alzheimer's disease and body mass index.
Stroke
Contributions of 12/15-Lipoxygenase to Bleeding in the Brain Following Ischemic Stroke.
Stroke
Effects of ML351 and tissue plasminogen activator combination therapy in a rat model of focal embolic stroke.
Stroke
Following experimental stroke, the recovering brain is vulnerable to lipoxygenase-dependent semaphorin signaling.
Stroke
Genetic ablation and short-duration inhibition of lipoxygenase results in increased macroautophagy.
Stroke
Increased 12/15-Lipoxygenase Leads to Widespread Brain Injury Following Global Cerebral Ischemia.
Stroke
Inhibiting 12/15-lipoxygenase to treat acute stroke in permanent and tPA induced thrombolysis models.
Stroke
Inhibition of 12/15-lipoxygenase as therapeutic strategy to treat stroke.
Stroke
Key role of 15-LO/15-HETE in angiogenesis and functional recovery in later stages of post-stroke mice.
Stroke
Loss of miR-29b following acute ischemic stroke contributes to neural cell death and infarct size.
Stroke
Mice deficient in L-12/15 lipoxygenase show increased vulnerability to 3-nitropropionic acid neurotoxicity.
Stroke
Neuroprotective properties of the natural vitamin E alpha-tocotrienol.
Stroke
Novel lipoxygenase inhibitors as neuroprotective reagents.
Stroke
Peroxynitrite-induced neuronal apoptosis is mediated by intracellular zinc release and 12-lipoxygenase activation.
Stroke
Potent and Selective Inhibitors of Human Reticulocyte 12/15- Lipoxygenase as Anti-Stroke Therapies.
Stroke
Pseudoperoxidase investigations of hydroperoxides and inhibitors with human lipoxygenases.
Stroke
Rosiglitazone-induced CD36 up-regulation resolves inflammation by PPAR? and 5-LO-dependent pathways.
Stroke
STAT-dependent upregulation of 12/15-lipoxygenase contributes to neuronal injury after stroke.
Stroke
Stroke: 12/15-lipoxygenase inhibitor shows promise as a first-line therapy for ischaemic stroke.
Stroke
The potential of 12/15-lipoxygenase inhibitors in stroke therapy.
Subarachnoid Hemorrhage
Impact of 12/15-Lipoxygenase on Brain Injury After Subarachnoid Hemorrhage.
Tauopathies
Absence of ALOX5 gene prevents stress-induced memory deficits, synaptic dysfunction and tauopathy in a mouse model of Alzheimer's disease.
Testicular Neoplasms
Relationship between lipoxygenase and human testicular cancer.
Thrombocythemia, Essential
Qualitative platelet 12-lipoxygenase abnormality in a patient with essential thrombocythemia.
Thrombocytopenia
Dissolution of arterial platelet thrombi in vivo with a bifunctional platelet GPIIIa49-66 ligand which specifically targets the platelet thrombus.
Thrombocytopenia
Role of molecular mimicry to HIV-1 peptides in HIV-1-related immunologic thrombocytopenia.
Thromboembolism
Cigarette smoking stimulates lipoxygenase but not cyclooxygenase pathway in platelets.
Thrombosis
12-HETrE inhibits platelet reactivity and thrombosis in part through the prostacyclin receptor.
Thrombosis
12-HETrE, a 12-Lipoxygenase Oxylipin of Dihomo-?-Linolenic Acid, Inhibits Thrombosis via G?s Signaling in Platelets.
Thrombosis
12-lipoxygenase activity plays an important role in PAR4 and GPVI-mediated platelet reactivity.
Thrombosis
15-Lipoxygenase and 15-hydroxyeicosatetraenoic acid regulate intravascular thrombosis in pulmonary hypertension.
Thrombosis
Arachidonate 15-lipoxygenase enzyme products increase platelet aggregation and thrombin generation.
Thrombosis
DHA 12-LOX-derived oxylipins regulate platelet activation and thrombus formation through a PKA-dependent signaling pathway.
Thrombosis
Docking and mutagenesis studies lead to improved inhibitor development of ML355 for human platelet 12-lipoxygenase.
Thrombosis
First Selective 12-LOX Inhibitor, ML355, Impairs Thrombus Formation and Vessel Occlusion In Vivo With Minimal Effects on Hemostasis.
Thrombosis
Lipid Receptor GPR31 (G-Protein-Coupled Receptor 31) Regulates Platelet Reactivity and Thrombosis Without Affecting Hemostasis.
Thrombosis
Platelet 12-LOX is essential for Fc?RIIa-mediated platelet activation.
Thrombosis
Platelet activation triggered by Chlamydia pneumoniae is antagonized by 12-lipoxygenase inhibitors but not cyclooxygenase inhibitors.
Thrombosis
Synthetic high-density lipoproteins loaded with an antiplatelet drug for efficient inhibition of thrombosis in mice.
Thrombosis
Targeting 12-Lipoxygenase As a Potential Novel Antiplatelet Therapy.
Thrombosis
The Arachidonate 15-Lipoxygenase Enzyme Product 15-HETE Is Present in Heart Tissue from Patients with Ischemic Heart Disease and Enhances Clot Formation.
Thyroid Neoplasms
Non-synonymous polymorphism (Gln261Arg) of 12-lipoxygenase in colorectal and thyroid cancers.
Toxoplasmosis
12/15-lipoxygenase-dependent myeloid production of interleukin-12 is essential for resistance to chronic toxoplasmosis.
Toxoplasmosis
ALOX12 In Human Toxoplasmosis.
Toxoplasmosis, Congenital
ALOX12 In Human Toxoplasmosis.
Tuberculosis
ALOX5 Is Associated with Tuberculosis in a Subset of the Pediatric Population of North China.
Tuberculosis
Nitric oxide prevents a pathogen-permissive granulocytic inflammation during tuberculosis.
Tuberculosis, Pulmonary
ALOX5 variants associated with susceptibility to human pulmonary tuberculosis.
Urinary Bladder Neoplasms
Antitumor effects of lipoxygenase inhibitors on murine bladder cancer cell line (MBT-2).
Urinary Bladder Neoplasms
Expression of lipoxygenase in human bladder carcinoma and growth inhibition by its inhibitors.
Urticaria
Copy number variation in ALOX5 and PTGER1 is associated with NSAIDs-induced urticaria and/or angioedema.
Urticaria
Leukotriene-related gene polymorphisms in patients with aspirin-intolerant urticaria and aspirin-intolerant asthma: differing contributions of ALOX5 polymorphism in Korean population.
Uterine Cervical Neoplasms
ALOX12B promotes carcinogenesis in cervical cancer by regulating the PI3K/ERK1 signaling pathway.
Uterine Cervical Neoplasms
Itraconazole Increases Resolvin E3 Concentration and 12/15-lipoxygenase Inhibitor Attenuates Itraconazole Cytotoxicity in Cervical Cancer Cells.
Uterine Cervical Neoplasms
Metabolic suppression of platelet-type 12-lipoxygenase in human uterine cervix with invasive carcinoma.
Uterine Cervical Neoplasms
Zileuton inhibits arachidonate-5-lipoxygenase to exert antitumor effects in preclinical cervical cancer models.
Vascular Diseases
12-Lipoxygenase and vascular disease.
Vascular Diseases
15-Lipoxygenase and its inhibition: a novel therapeutic target for vascular disease.
Vascular Diseases
A leukocyte type of 12-lipoxygenase is expressed in human vascular and mononuclear cells. Evidence for upregulation by angiotensin II.
Vascular Diseases
Catalytic consumption of nitric oxide by 12/15- lipoxygenase: inhibition of monocyte soluble guanylate cyclase activation.
Vascular Diseases
Elevated endothelial nitric oxide bioactivity and resistance to angiotensin-dependent hypertension in 12/15-lipoxygenase knockout mice.
Vascular Diseases
Elevated glucose and angiotensin II increase 12-lipoxygenase activity and expression in porcine aortic smooth muscle cells.
Vascular Diseases
Role of the lipoxygenase pathway in phenylephrine-induced vascular smooth muscle cell proliferation and migration.
Vascular Diseases
TagSNP evaluation for the association of 42 inflammation loci and vascular disease: evidence of IL6, FGB, ALOX5, NFKBIA, and IL4R loci effects.
Vascular Diseases
The effects of leukocyte-type 12/15-lipoxygenase on Id3-mediated vascular smooth muscle cell growth.
Vascular System Injuries
Increased 12/15-Lipoxygenase Leads to Widespread Brain Injury Following Global Cerebral Ischemia.
Vascular System Injuries
Lipoxygenase: An Emerging Target for Stroke Therapy.
Vascular System Injuries
Protecting against cerebrovascular injury: contributions of 12/15-lipoxygenase to edema formation after transient focal ischemia.
Vertigo
Systems pharmacology to decipher the combinational anti-migraine effects of Tianshu formula.
Virus Diseases
Evaluation of the expression level of 12/15 lipoxygenase and the related inflammatory factors (CCL5, CCL3) in respiratory syncytial virus infection in mice model.
Virus Diseases
Original research article Parainfluenza virus infection enhances NSAIDs-induced inhibition of PGE2 generation and COX-2 expression in human airway epithelial cells.
Vitamin E Deficiency
The effect of dietary vitamin E and beta-carotene on oxidation processes in the rat testis.
Vitiligo
Network pharmacological mechanisms of Vernonia anthelmintica (L.) in the treatment of vitiligo: Isorhamnetin induction of melanogenesis via up-regulation of melanin-biosynthetic genes.
Whooping Cough
Activation of the human neutrophil 5-lipoxygenase by exogenous arachidonic acid: involvement of pertussis toxin-sensitive guanine nucleotide-binding proteins.
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1.13.11.31 arachidonate 12-lipoxygenase
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The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). 
