Disease on EC 1.13.11.12 - linoleate 13S-lipoxygenase
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Acidosis
TRPV1 and the gut: from a tasty receptor for a painful vanilloid to a key player in hyperalgesia.
Acne Vulgaris
Exploration of retinoid activity and the role of inflammation in acne: issues affecting future directions for acne therapy.
Acute Lung Injury
Cyclooxygenase and lipoxygenase inhibition by BW-755C reduces acrolein smoke-induced acute lung injury.
Acute Lung Injury
Effects of eicosapentaenoic and gamma-linolenic acid on lung permeability and alveolar macrophage eicosanoid synthesis in endotoxic rats.
Acute Lung Injury
Mediators of lung injury in mice following systemic activation of complement.
Adenocarcinoma
15-lipoxygenase-2 (15-LOX-2) is expressed in benign prostatic epithelium and reduced in prostate adenocarcinoma.
Adenocarcinoma
Concordant induction of 15-lipoxygenase-1 and mutant p53 expression in human prostate adenocarcinoma: correlation with Gleason staging.
Adenocarcinoma
Methyl jasmonate induced apoptosis in human prostate carcinoma cells via 5-lipoxygenase dependent pathway.
Adenocarcinoma
Novel 3-aryl-5-substituted-coumarin analogues: Synthesis and bioactivity profile.
Adenocarcinoma
The role of 15-lipoxygenase-1 expression and its potential role in the pathogenesis of endometrial hyperplasia and endometrial adenocarcinomas.
Adenocarcinoma, Bronchiolo-Alveolar
Dietary lipids modulate eicosanoid release and apoptosis of cells of a murine lung alveolar carcinoma.
Adenoma
HETEs enhance IL-1-mediated COX-2 expression via augmentation of message stability in human colonic myofibroblasts.
Agranulocytosis
Synergistic inhibition of complement induced granulocyte margination by BW755C and calcium channel blockers.
Airway Obstruction
Eicosanoids modulate hyperpnea-induced late phase airway obstruction and hyperreactivity in dogs.
Alkalosis
Involvement of lipoxygenase and cyclo-oxygenase pathways in hypoxia and metabolic alkalosis produced by canatoxin in rats.
Alzheimer Disease
Assessment of enzyme inhibitory and antioxidant activities of lignans from Taxus baccata L.
Alzheimer Disease
Blockade of 12-lipoxygenase expression protects cortical neurons from apoptosis induced by beta-amyloid peptide.
Alzheimer Disease
Brain uptake and utilization of fatty acids, lipids & lipoproteins: recommendations for future research.
Alzheimer Disease
Gene-environment interaction models to unmask susceptibility mechanisms in Parkinson's disease.
Alzheimer Disease
Phospholipase A2 is involved in muscarinic receptor-mediated sAPPalpha release independently of cyclooxygenase or lypoxygenase activity in SH-SY5Y cells.
Alzheimer Disease
Salvia officinalis L. Essential Oils from Spain: Determination of Composition, Antioxidant Capacity, Antienzymatic, and Antimicrobial Bioactivities.
Alzheimer Disease
Thymus mastichina L. essential oils from Murcia (Spain): Composition and antioxidant, antienzymatic and antimicrobial bioactivities.
Anaphylaxis
Bronchial anaphylaxis in actively sensitized Sprague Dawley rats: studies on mediators involved.
Anaphylaxis
Capsaicin inhibits airway hyperresponsiveness but not lipoxygenase activity or eosinophilia after repeated aerosolized antigen in guinea pigs.
Anaphylaxis
Cardiac anaphylaxis: Part II: The role of prostaglandins, thromboxanes and leukotrienes in C.A.
Anaphylaxis
Chronological relationships between mediator release and changes in airway dynamics during an ascaris response in sensitive cynomolgus monkeys.
Anaphylaxis
Effect of inhibition of synthesis and receptor antagonism of SRS-A in cardiac anaphylaxis.
Anaphylaxis
Effects of anaphylaxis mediators on partitioned pulmonary vascular resistance during ragweed shock in dogs.
Anaphylaxis
In vitro inhibition of the biosynthesis of slow reacting substance of anaphylaxis (SRS-A) and lipoxygenase activity by quercetin.
Anaphylaxis
In vitro testing for lung toxicity: a method for distinguishing between immune- and non-immune-mediated reactions to xenobiotics.
Anaphylaxis
Inhibition of the release of slow-reacting substance of anaphylaxis by inhibitors of lipoxygenase activity.
Anaphylaxis
Leukotrienes, thromboxane A2, and prostaglandins during systemic anaphylaxis in sheep.
Anaphylaxis
Mechanism of action of 6, 7, 8, 9, 10, 12-hexahydro-azepino-[2, 1-b] quinazolin-12-one-(RLX)--a novel bronchodilator.
Anaphylaxis
Ozone-induced bronchial hyperreactivity in guinea pigs is abolished by BW 755C or FPL 55712 but not by indomethacin.
Anaphylaxis
Pharmacological investigation of the mechanisms of platelet-activating factor induced mortality in the mouse.
Anaphylaxis
Prostaglandin-generating factor of anaphylaxis induces mucous glycoprotein release and the formation of lipoxygenase products of arachidonate from human airways.
Anaphylaxis
Release of slow-reacting substance of anaphylaxis from dispersed pig lung cells: effect of cyclo-oxygenase and lipoxygenase inhibitors.
Anaphylaxis
The effect of lipoxygenase inhibitors and diethylcarbamazine on the immunological release of slow reacting substance of anaphylaxis (SRS-A) from guinea-pig chopped lung.
Anaphylaxis
The effect of lipoxygenase inhibitors and leukotriene antagonists on anaphylaxis.
Anaphylaxis
[Brain tissue leukotrienes in cerebral ischemia and the effect of inhibitor of SRS-A release on postischemic cerebral edema]
Anaphylaxis
[Lipoxygenase catalyzation of arachidonic acid metabolism and the effect of its inhibition on anaphylactic reactions]
Anaphylaxis
[The effect of indomethacin on the changes in the hemodynamics and coronary vascular resistance during anaphylactic shock]
Anaphylaxis
[The mechanisms of the changes in coronary vascular resistance in anaphylactic shock]
Anemia
Evidence for the appearance of a reticulocyte population low in lipoxygenase mRNA during the recovery from a phenylhydrazine-induced anemia in rabbits.
Anemia
Occurrence of lipoxygenase products in membranes of rabbit reticulocytes. Evidence for a role of the reticulocyte lipoxygenase in the maturation of red cells.
Anemia
Synthesis of non-globin proteins in rabbit-erythroid cells. Synthesis of a lipoxygenase in reticulocytes.
Anemia
The biological dynamics of lipoxygenase in rabbit red cells in the course of an experimental bleeding anaemia. Unexpected effects of the calcium ionophore A 23187.
Anemia
The lipoxygenase of reticulocytes. Purification, characterization and biological dynamics of the lipoxygenase; its identity with the respiratory inhibitors of the reticulocyte.
Anemia
The share of lipoxygenase in the antimycin-resistant oxygen uptake of intact rabbit reticulocytes.
Anemia, Hypochromic
A role for oxidative stress in the Citrus limon/Phoma tracheiphila interaction
Anemia, Hypochromic
Deciphering the molecular mechanism behind stimulated co-uptake of arsenic and fluoride from soil, associated toxicity, defence and glyoxalase machineries in arsenic-tolerant rice.
Arrhythmias, Cardiac
Effects of a lipoxygenase inhibitor on digoxin-induced cardiac arrhythmias in the isolated perfused guinea-pig heart.
Arrhythmias, Cardiac
The effect of substances influencing the arachidonic acid cascade on experimental cardiac arrhythmias.
Arthritis
5-Lipoxygenase inhibitors attenuate TNF-?-induced inflammation in human synovial fibroblasts.
Arthritis
Changes in lipoxygenase products from synovial fluid in carrageenan induced arthritis in dogs.
Arthritis
Docking Studies and Molecular Dynamics Simulation of Ipomoea batatas L. Leaves Compounds as Lipoxygenase (LOX) Inhibitor.
Arthritis
Functional polymorphism in ALOX15 results in increased allele-specific transcription in macrophages through binding of the transcription factor SPI1.
Arthritis
Lipoxygenase products of arachidonic acid in psoriasis, atopic dermatitis, and experimental arthritis.
Arthritis
Role of transient receptor potential vanilloid 1 receptors in adjuvant-induced chronic arthritis: in vivo study using gene-deficient mice.
Arthritis
The c.-292C>T promoter polymorphism increases reticulocyte-type 15-lipoxygenase-1 activity and could be atheroprotective.
Arthritis
[Effects of methotrexate on leukotriene and derivated lipoxygenase synthesis in polynuclear neutrophils in rheumatoid polyarthritis]
Arthritis, Experimental
[Antiphlogistic effectiveness of combinations of inhibitors of phospholipase A2, cyclooxygenase and lipoxygenases of the arachidonic acid cascade]
Arthritis, Rheumatoid
5-Lipoxygenase inhibitors attenuate TNF-?-induced inflammation in human synovial fibroblasts.
Arthritis, Rheumatoid
Activation of inflammation and resolution pathways of lipid mediators in synovial fluid from patients with severe rheumatoid arthritis compared with severe osteoarthritis.
Arthritis, Rheumatoid
Effects of alumina and zirconium dioxide particles on arachidonic acid metabolism and proinflammatory interleukin production in osteoarthritis and rheumatoid synovial cells.
Arthritis, Rheumatoid
Esculetin reduces leukotriene B4 level in plasma of rats with adjuvant-induced arthritis.
Arthritis, Rheumatoid
Expression of 5-lipoxygenase and 15-lipoxygenase in rheumatoid arthritis synovium and effects of intraarticular glucocorticoids.
Arthritis, Rheumatoid
In-silico studies of isolated phytoalkaloid against Lipoxygenase: study based on possible correlation.
Arthritis, Rheumatoid
Inhibition of LOX by flavonoids: a structure-activity relationship study.
Arthritis, Rheumatoid
Leukotriene B4, a mediator of inflammation present in synovial fluid in rheumatoid arthritis.
Arthritis, Rheumatoid
Lipoxygenation of arachidonic acid as a source of polymorphonuclear leukocyte chemotactic factors in synovial fluid and tissue in rheumatoid arthritis and spondyloarthritis.
Arthritis, Rheumatoid
Multi-Target Cinnamic Acids for Oxidative Stress and Inflammation: Design, Synthesis, Biological Evaluation and Modeling Studies.
Arthritis, Rheumatoid
Proinflammatory lipoxygenase products from peripheral mononuclear cells in patients with rheumatoid arthritis.
Arthritis, Rheumatoid
Simultaneous profiling of eicosanoid metabolome in plasma by UPLC-MS/MS method: Application to identify potential makers for rheumatoid arthritis.
Arthritis, Rheumatoid
The effect of methotrexate on ex vivo lipoxygenase metabolism in neutrophils from patients with rheumatoid arthritis.
Arthus Reaction
Differential effects of anti-inflammatory drugs on lipoxygenase and cyclo-oxygenase activities of neutrophils from a reverse passive Arthus reaction.
Arthus Reaction
Ex vivo effects of nonsteroidal antiinflammatory drugs on arachidonic acid metabolism in neutrophils from a reverse passive Arthus reaction.
Arthus Reaction
Release of eicosanoids in rat peritoneal cavity during the Arthus reaction. Effect of the PAF-antagonist BN-52021 and indomethacin.
Asthma
12/15-Lipoxygenase deficiency protects mice from allergic airways inflammation and increases secretory IgA levels.
Asthma
12/15-lipoxygenase is an interleukin-13 and interferon-? counterregulated-mediator of allergic airway inflammation.
Asthma
15-lipoxygenase-1 induces expression and release of chemokines in cultured human lung epithelial cells.
Asthma
Airway lipoxin A4 generation and lipoxin A4 receptor expression are decreased in severe asthma.
Asthma
An agent that releases basophil and mast cell histamine but blocks cyclooxygenase and lipoxygenase metabolism of arachidonic acid inhibits immunoglobulin E-mediated asthma in rhesus monkeys.
Asthma
An inhibitor of the lipoxygenase and cyclooxygenase pathways of arachidonic acid, 5, 8, 11, 14-eicosatetraynoic acid, inhibits immunoglobulin E mediated antigen induced monkey asthma and skin reactions.
Asthma
Anti-Lipoxygenase Activity of Leaf Gall Extracts of Terminalia chebula (Gaertn.) Retz. (Combretaceae).
Asthma
Aryl-acetic and cinnamic acids as lipoxygenase inhibitors with antioxidant, anti-inflammatory, and anticancer activity.
Asthma
Aspirin-Intolerant Asthma: A Comprehensive Review of Biomarkers and Pathophysiology.
Asthma
Changes in urinary LTE4 and nasal functions following nasal provocation test with ASA in ASA-tolerant and -intolerant asthmatics.
Asthma
Development of novel peptide inhibitor of Lipoxygenase based on biochemical and BIAcore evidences.
Asthma
Effect of the lipoxygenase inhibitor N-hydroxy-N-(6-methoxy-3,4-dihydro-2-naphthylmethyl)urea on bronchoconstriction and lung vascular permeability in anaphylactic guinea pigs.
Asthma
Elevated plasma level of leukotrienes in bronchial asthma patients: a possible clinical relevance.
Asthma
Functional and phenotypic characteristics of bronchial epithelial cells obtained by brushing from asthmatic and normal subjects.
Asthma
Functional polymorphism in ALOX15 results in increased allele-specific transcription in macrophages through binding of the transcription factor SPI1.
Asthma
Glutathione peroxidase activity in blood cells from aspirin-induced asthma patients.
Asthma
Identification of 6-benzyloxysalicylates as a novel class of inhibitors of 15-lipoxygenase-1.
Asthma
In vivo anti-allergic and anti-inflammatory effects of drugs that inhibit lipoxygenase activity in vitro.
Asthma
In-silico studies of isolated phytoalkaloid against Lipoxygenase: study based on possible correlation.
Asthma
Lipoxygenase inhibitor-provoked acute asthma in a patient with asthma relieved by aspirin.
Asthma
Lipoxygenase inhibitory tetraketones: potential remedial source for inflammation and asthma.
Asthma
Metabolomics reveals a correlation between hydroxyeicosatetraenoic acids and allergic asthma: Evidence from three years' immunotherapy.
Asthma
Multi-Target Cinnamic Acids for Oxidative Stress and Inflammation: Design, Synthesis, Biological Evaluation and Modeling Studies.
Asthma
Oleyl sulfate reveals allosteric inhibition of soybean lipoxygenase-1 and human 15-lipoxygenase.
Asthma
PGE suppresses excessive anti-IgE induced cysteinyl leucotrienes production in mast cells of patients with aspirin exacerbated respiratory disease.
Asthma
Prominent release of lipoxygenase generated mediators in a murine house dust mite-induced asthma model.
Asthma
Rational Development of a Potent 15-Lipoxygenase-1 Inhibitor with in Vitro and ex Vivo Anti-inflammatory Properties.
Asthma
Specific enhancement of LTD4-induced contractions of isolated guinea pig trachea by 5-hydroxyeicosatetraenoic acid (5-HETE).
Asthma
Sputum macrophage diversity and activation in asthma: Role of severity and inflammatory phenotype.
Asthma
Structure-activity relationship studies of nordihydroguaiaretic acid inhibitors toward soybean, 12-human, and 15-human lipoxygenase.
Asthma
Targeted eicosanoid lipidomics of exhaled breath condensate provide a distinct pattern in the aspirin-intolerant asthma phenotype.
Asthma
Targeted quantitative analysis of eicosanoid lipids in biological samples using liquid chromatography-tandem mass spectrometry.
Asthma
The c.-292C>T promoter polymorphism increases reticulocyte-type 15-lipoxygenase-1 activity and could be atheroprotective.
Asthma
The pharmacology of benoxaprofen with particular to effects on lipoxygenase product formation.
Asthma
Urinary LTE4 is higher after nasal provocation test with L-ASA in bronchial than in only nasal responders.
Asthma
Zileuton, a 5-lipoxygenase inhibitor, increases production of thromboxane A2 and platelet aggregation in patients with asthma.
Asthma, Aspirin-Induced
Changes in urinary LTE4 and nasal functions following nasal provocation test with ASA in ASA-tolerant and -intolerant asthmatics.
Asthma, Aspirin-Induced
Lipoxygenase pathway and hydroperoxy acids: possible relevance to aspirin-induced asthma and hyperirritability of airways in asthmatics.
Asthma, Aspirin-Induced
Release of peptide leukotriene into nasal secretions after local instillation of aspirin in aspirin-sensitive asthmatic patients.
Asthma, Aspirin-Induced
Urinary LTE4 is higher after nasal provocation test with L-ASA in bronchial than in only nasal responders.
Asthma, Aspirin-Induced
[Asthma induced by aspirin and arachidonic acid metabolites. II. The role of leukotrienes (part four)]
Astrocytoma
mRNA levels of enzymes and receptors implicated in arachidonic acid metabolism in gliomas.
Atherosclerosis
15-lipoxygenase-1 induces expression and release of chemokines in cultured human lung epithelial cells.
Atherosclerosis
A leukocyte type of 12-lipoxygenase is expressed in human vascular and mononuclear cells. Evidence for upregulation by angiotensin II.
Atherosclerosis
Arachidonic Acid metabolites in the cardiovascular system: the role of lipoxygenase isoforms in atherogenesis with particular emphasis on vascular remodeling.
Atherosclerosis
Conditional expression of human 15-lipoxygenase-1 in mouse prostate induces prostatic intraepithelial neoplasia: the FLiMP mouse model.
Atherosclerosis
Development of novel peptide inhibitor of Lipoxygenase based on biochemical and BIAcore evidences.
Atherosclerosis
Differential recruitment of the coactivator proteins CREB-binding protein and steroid receptor coactivator-1 to peroxisome proliferator-activated receptor gamma/9-cis-retinoic acid receptor heterodimers by ligands present in oxidized low-density lipoprotein.
Atherosclerosis
Disruption of 12/15-lipoxygenase expression in peritoneal macrophages. Enhanced utilization of the 5-lipoxygenase pathway and diminished oxidation of low density lipoprotein.
Atherosclerosis
Effect of some biologically interesting substituted tetrahydro-1,4-oxazines on drug metabolising enzymes and on inflammation.
Atherosclerosis
Elevated glucose and angiotensin II increase 12-lipoxygenase activity and expression in porcine aortic smooth muscle cells.
Atherosclerosis
Expanding expression of the 5-lipoxygenase pathway within the arterial wall during human atherogenesis.
Atherosclerosis
Functional polymorphism in ALOX15 results in increased allele-specific transcription in macrophages through binding of the transcription factor SPI1.
Atherosclerosis
Human lipoxygenase pathway gene variation and association with markers of subclinical atherosclerosis in the diabetes heart study.
Atherosclerosis
Hydroxyoctadecadienoic acids: novel regulators of macrophage differentiation and atherogenesis.
Atherosclerosis
Inhibition of five lipoxygenase activating protein (FLAP) by MK-886 decreases atherosclerosis in apoE/LDLR-double knockout mice.
Atherosclerosis
Inhibition of mammalian 15-lipoxygenase-dependent lipid peroxidation in low-density lipoprotein by quercetin and quercetin monoglucosides.
Atherosclerosis
Inhibition of peroxisome proliferator-activated receptor (PPAR)-mediated keratinocyte differentiation by lipoxygenase inhibitors.
Atherosclerosis
Inhibitory effect of Chinese green tea on endothelial cell-induced LDL oxidation.
Atherosclerosis
Lipoxygenase pathways as mediators of early inflammatory events in atherosclerosis.
Atherosclerosis
Multi-Target Cinnamic Acids for Oxidative Stress and Inflammation: Design, Synthesis, Biological Evaluation and Modeling Studies.
Atherosclerosis
Nitric oxide, peroxynitrite and lipoxygenase in atherogenesis: mechanistic insights.
Atherosclerosis
Oleyl sulfate reveals allosteric inhibition of soybean lipoxygenase-1 and human 15-lipoxygenase.
Atherosclerosis
Review: Potential role of the lipoxygenase derived lipid mediators in atherosclerosis: leukotrienes, lipoxins and resolvins.
Atherosclerosis
Role of 12-lipoxygenase and oxidant stress in hyperglycaemia-induced acceleration of atherosclerosis in a diabetic pig model.
Atherosclerosis
Role of Sandhika: a polyherbal formulation on MC3T3-E1 osteoblast-like cells.
Atherosclerosis
Skeletal inflammation and attenuation of Wnt signaling, Wnt ligand expression, and bone formation in atherosclerotic ApoE-null mice.
Atherosclerosis
Specific inflammatory cytokines regulate the expression of human monocyte 15-lipoxygenase.
Atherosclerosis
Structure-activity relationship studies of nordihydroguaiaretic acid inhibitors toward soybean, 12-human, and 15-human lipoxygenase.
Atherosclerosis
The c.-292C>T promoter polymorphism increases reticulocyte-type 15-lipoxygenase-1 activity and could be atheroprotective.
Atherosclerosis
The effect of montelukast on atherogenesis in apoE/LDLR-double knockout mice.
Atherosclerosis
The inhibition of mammalian 15-lipoxygenases by the anti-inflammatory drug ebselen: dual-type mechanism involving covalent linkage and alteration of the iron ligand sphere.
Atherosclerosis
The specificity of lipoxygenase-catalyzed lipid peroxidation and the effects of radical-scavenging antioxidants.
Atherosclerosis
Transgenic rabbits with the integrated human 15-lipoxygenase gene driven by a lysozyme promoter: macrophage-specific expression and variable positional specificity of the transgenic enzyme.
Atherosclerosis
[Effects of modifications of lipoproteins by water soluble forms of lineoleic-hydroxamic acid on biochemical markers of development of atherosclerosis]
Atherosclerosis
[Selenium and the activities of cyclooxygenase and lipoxygenase in cells involved in atherogenesis]
Autoimmune Diseases
Augmentation of 12-lipoxygenase activity of lymph node and spleen T cells in autoimmune mice MRL/1.
Azotemia
High-calorie diet with moderate protein restriction prevents cachexia and ameliorates oxidative stress, inflammation and proteinuria in experimental chronic kidney disease.
Bacteremia
Indomethacin, dazoxiben and extravascular lung water after Escherichia coli infusion.
Blindness
Cytochrome P450 2C8 ?3-long-chain polyunsaturated fatty acid metabolites increase mouse retinal pathologic neovascularization--brief report.
Bone Resorption
First place--resident basic science award 1999. Effects of leukotriene and cyclo-oxygenase inhibition on adaptive bone remodeling in the middle ear.
Bone Resorption
Stimulation of bone resorption by lipoxygenase metabolites of arachidonic acid.
Bone Resorption
Transforming growth factor-beta modulates eicosanoid metabolism in osteogenic osteosarcoma cells.
Brain Edema
Alterations of the eicosanoid synthetic capacity of rat brain microvessels following ischemia: relevance to ischemic brain edema.
Brain Edema
Blocking of interleukin-1 activity is a beneficial approach to ischemia brain edema formation.
Brain Edema
Effects of cyclooxygenase and lipoxygenase inhibitors on cerebral edema induced by freezing lesions in rats.
Brain Edema
Effects of lipoxygenase inhibitor on cerebral edema induced by freezing lesion in rats.
Brain Edema
Identification and quantitative analysis of hydroxy-eicosatetraenoic acids in rat brains exposed to regional ischemia.
Brain Edema
Strong attenuation of ischemic and postischemic brain edema in rats by a novel free radical scavenger.
Brain Edema
[Identification of 11-HETE in the rat brain and its relevancy to ischemic cerebral edema]
Brain Edema
[Role of arachidonic acid metabolites on development of ischemic cerebral edema in rat middle cerebral artery occlusion]
Brain Injuries
Increased plasma PGE2, 6-keto-PGF1 alpha, and 12-HETE levels following experimental concussive brain injury.
Brain Injuries
Involvement of arachidonic acid metabolites in experimental brain injury. Identification of lipoxygenase products in brain. Clinical studies on prostacyclin infusion in acute cerebral ischemia.
Brain Injuries, Traumatic
Brain microvessel 12-hydroxyeicosatetraenoic acid is the (S) enantiomer and is lipoxygenase derived.
Brain Ischemia
Effects of ebselen on cerebral ischemia and reperfusion evaluated by microdialysis.
Brain Ischemia
Involvement of arachidonic acid metabolites in experimental brain injury. Identification of lipoxygenase products in brain. Clinical studies on prostacyclin infusion in acute cerebral ischemia.
Brain Ischemia
Phenidone attenuates oxygen/glucose deprivation-induced neurotoxicity by antioxidant and antiapoptotic action in mouse cortical cultures.
Brain Ischemia
[Brain tissue leukotrienes in cerebral ischemia and the effect of inhibitor of SRS-A release on postischemic cerebral edema]
Brain Ischemia
[Role of arachidonic acid metabolites on development of ischemic cerebral edema in rat middle cerebral artery occlusion]
Breast Neoplasms
ALOX12B promotes carcinogenesis in cervical cancer by regulating the PI3K/ERK1 signaling pathway.
Breast Neoplasms
Cyclooxygenase and lipoxygenase gene expression in the inflammogenesis of breast cancer.
Breast Neoplasms
Cytotoxic action of cis-unsaturated fatty acids on human cervical carcinoma (HeLa) cells: relationship to free radicals and lipid peroxidation and its modulation by calmodulin antagonists.
Breast Neoplasms
Cytotoxicity of arachidonic acid and of its lipoxygenase metabolite 15-hydroperoxyeicosatetraenoic acid on human breast cancer MCF-7 cells in culture.
Breast Neoplasms
Effects of eicosanoid synthesis inhibitors on the in vitro growth and prostaglandin E and leukotriene B secretion of a human breast cancer cell line.
Breast Neoplasms
Effects of linoleic acid and eicosanoid synthesis inhibitors on the growth and c-myc oncogene expression of human breast cancer cells.
Breast Neoplasms
In vitro effects of eicosanoid synthesis inhibitors in the presence of linoleic acid on MDA-MB-231 human breast cancer cells.
Breast Neoplasms
Increased 12-lipoxygenase expression in breast cancer tissues and cells. Regulation by epidermal growth factor.
Breast Neoplasms
Involvement of 15-lipoxygenase-1 in the regulation of breast cancer cell death induced by sodium butyrate.
Breast Neoplasms
Lipoxygenase catalyzed metabolites derived from docosahexaenoic acid are promising antitumor agents against breast cancer.
Breast Neoplasms
Lipoxygenase mediates invasion of intrametastatic lymphatic vessels and propagates lymph node metastasis of human mammary carcinoma xenografts in mouse.
Breast Neoplasms
Nordihydroguaiaretic acid suppression of rat mammary carcinogenesis induced by N-methyl-N-nitrosourea.
Breast Neoplasms
Proliferative responses of normal human mammary and MCF-7 breast cancer cells to linoleic acid, conjugated linoleic acid and eicosanoid synthesis inhibitors in culture.
Breast Neoplasms
Regulation of the adhesion of a human breast carcinoma cell line to type IV collagen and vitronectin: roles for lipoxygenase and protein kinase C.
Breast Neoplasms
Requirement for autologous cancer extracts and lipoxygenation of arachidonic acid for human T-cell responses in leukocyte adherence inhibition and transmembrane potential change assays.
Breast Neoplasms
Structure Based Design and Synthesis of Peptide Inhibitor of Human LOX-12: In Vitro and In Vivo Analysis of a Novel Therapeutic Agent for Breast Cancer.
Breast Neoplasms
Tetrahydrofurandiol stimulation of phospholipase A2, lipoxygenase, and cyclooxygenase gene expression and MCF-7 human breast cancer cell proliferation.
Breast Neoplasms
The mechanisms of lipoxygenase inhibitor-induced apoptosis in human breast cancer cells.
Bronchial Hyperreactivity
Role of arachidonic acid metabolites in allergen-induced late responses.
Bronchial Spasm
Alteration of drug responsiveness in guinea-pig lung anaphylaxis using different antigen challenge concentrations.
Bronchial Spasm
Dependency of the Paf-acether induced bronchospasm on the lipoxygenase pathway in the guinea-pig.
Bronchial Spasm
The effect of leukotriene antagonists, lipoxygenase inhibitors and selected standards on leukotriene-mediated allergic bronchospasm in guinea pigs.
Bronchial Spasm
The effects of antiallergic and bronchodilator drugs on platelet-activating factor (PAF-acether) induced bronchospasm and platelet aggregation.
Bronchial Spasm
The influence of misoprostol (synthetic analogue of prostaglandin E1) on aspirin-induced bronchoconstriction in aspirin-sensitive asthma.
Bronchial Spasm
[Role of arachidonic acid (ETE) and its metabolites in the pathogenesis of bronchial spasm. II. Metabolites formed under the effect of lipoxygenase]
Bronchitis
[Interrelationship between lipoxygenase metabolites of arachidonic acid and pulmonary blood flow and ventilation in acute pneumonia]
Bronchitis, Chronic
Identification of 6-benzyloxysalicylates as a novel class of inhibitors of 15-lipoxygenase-1.
Bronchitis, Chronic
Rational Development of a Potent 15-Lipoxygenase-1 Inhibitor with in Vitro and ex Vivo Anti-inflammatory Properties.
Carcinogenesis
15-lipoxygenase-1 induces expression and release of chemokines in cultured human lung epithelial cells.
Carcinogenesis
15-Lipoxygenase-1 induces lipid peroxidation and apoptosis, and improves survival in rat malignant glioma.
Carcinogenesis
15-Lipoxygenase-1 transcriptional silencing by DNA methyltransferase-1 independently of DNA methylation.
Carcinogenesis
15-LOX-1 inhibits p21 (Cip/WAF 1) expression by enhancing MEK-ERK 1/2 signaling in colon carcinoma cells.
Carcinogenesis
15-LOX-1 suppression of hypoxia-induced metastatic phenotype and HIF-1? expression in human colon cancer cells.
Carcinogenesis
3,5-Disubstituted Isoxazole Derivatives: Potential Inhibitors of Inflammation and Cancer.
Carcinogenesis
Anti-Cancer Activity of 2,4-Disubstituted Thiophene Derivatives: Dual Inhibitors of Lipoxygenase and Cyclooxygenase.
Carcinogenesis
Arachidonic acid pathway: A molecular target in human testicular cancer (Review).
Carcinogenesis
Aryl-acetic and cinnamic acids as lipoxygenase inhibitors with antioxidant, anti-inflammatory, and anticancer activity.
Carcinogenesis
Chemoprevention of colon carcinogenesis by dietary curcumin, a naturally occurring plant phenolic compound.
Carcinogenesis
Comparative effects of piroxicam and esculetin on incidence, proliferation, and cell kinetics of mammary carcinomas induced by 7,12-dimethylbenz[a]anthracene in rats on high- and low-fat diets.
Carcinogenesis
Conditional expression of human 15-lipoxygenase-1 in mouse prostate induces prostatic intraepithelial neoplasia: the FLiMP mouse model.
Carcinogenesis
Determination of endogenous tissue inflammation profiles by LC/MS/MS: COX- and LOX-derived bioactive lipids.
Carcinogenesis
Enhancing antitumor effects in pancreatic cancer cells by combined use of COX-2 and 5-LOX inhibitors.
Carcinogenesis
Expression of cysteinylLT1 receptor in human testicular cancer and growth reduction by its antagonist through apoptosis.
Carcinogenesis
Growth control of lung cancer by interruption of 5-lipoxygenase-mediated growth factor signaling.
Carcinogenesis
Honokiol inhibits gastric tumourigenesis by activation of 15-lipoxygenase-1 and consequent inhibition of peroxisome proliferator-activated receptor-gamma and COX-2-dependent signals.
Carcinogenesis
Identification of a Bromodomain-like Region in 15-Lipoxygenase-1 Explains Its Nuclear Localization.
Carcinogenesis
Influence of esculetin on incidence, proliferation, and cell kinetics of mammary carcinomas induced by 7,12-dimethylbenz[a]anthracene in rats on high- and low-fat diets.
Carcinogenesis
Inhibition of two-stage skin carcinogenesis as well as complete skin carcinogenesis by oral administration of TMK688, a potent lipoxygenase inhibitor.
Carcinogenesis
Inhibitory effect of caffeic acid esters on azoxymethane-induced biochemical changes and aberrant crypt foci formation in rat colon.
Carcinogenesis
Inhibitory effects of nabumetone, a cyclooxygenase-2 inhibitor, and esculetin, a lipoxygenase inhibitor, on N-methyl-N-nitrosourea-induced mammary carcinogenesis in rats.
Carcinogenesis
Lipoxygenase and cyclooxygenase metabolism: new insights in treatment and chemoprevention of pancreatic cancer.
Carcinogenesis
Lipoxygenase inhibitors prevent lung carcinogenesis and inhibit non-small cell lung cancer growth.
Carcinogenesis
Overexpression of 15-lipoxygenase-1 in PC-3 human prostate cancer cells increases tumorigenesis.
Carcinogenesis
Overexpression of cysteinyl LT1 receptor in prostate cancer and CysLT1R antagonist inhibits prostate cancer cell growth through apoptosis.
Carcinogenesis
PI3K/Akt Cooperates with Oncogenic Notch by Inducing Nitric Oxide-Dependent Inflammation.
Carcinogenesis
Profiling lipoxygenase metabolism in specific steps of colorectal tumorigenesis.
Carcinogenesis
Prostate cancer in native Japanese and Japanese-American men: effects of dietary differences on prostatic tissue.
Carcinogenesis
Relationship between cysteinyl-leukotriene-1 receptor and human transitional cell carcinoma in bladder.
Carcinogenesis
Serum 5-LOX: a progressive protein marker for breast cancer and new approach for therapeutic target.
Carcinogenesis
Some perspectives on dietary inhibition of carcinogenesis: studies with curcumin and tea.
Carcinogenesis
The 15-lipoxygenase-1 product 13-S-hydroxyoctadecadienoic acid down-regulates PPAR-delta to induce apoptosis in colorectal cancer cells.
Carcinogenesis
The Co-regulatory Role of 5-Lipoxygenase and Cyclooxygenase-2 in the Carcinogenesis and their Promotion by Cigarette Smoking in Colons.
Carcinogenesis
The critical role of 15-lipoxygenase-1 in colorectal epithelial cell terminal differentiation and tumorigenesis.
Carcinogenesis
The effect of leukotrienes B and selected HETEs on the proliferation of colon cancer cells.
Carcinogenesis
The inhibitory effect of vitamin E on arachidonic acid metabolism during the process of urethane-induced lung tumorigenesis in mice.
Carcinogenesis
The Investigation of Lipoxygenases as Therapeutic Targets in Malignant Pleural Mesothelioma.
Carcinogenesis
The role of fatty acids and eicosanoid synthesis inhibitors in breast carcinoma.
Carcinogenesis
What are cyclooxygenases and lipoxygenases doing in the driver's seat of carcinogenesis?
Carcinoma
?-Conotoxins Enhance both the In Vivo Suppression of Ehrlich carcinoma Growth and In Vitro Reduction in Cell Viability Elicited by Cyclooxygenase and Lipoxygenase Inhibitors.
Carcinoma
Alterations in lipoxygenase and cyclooxygenase-2 catalytic activity and mRNA expression in prostate carcinoma.
Carcinoma
Altered 1-14C arachidonic acid metabolism in arterial wall from patients with renal cell carcinoma.
Carcinoma
Arachidonic acid metabolism and cell proliferation in rat mammary carcinoma cells treated with indomethacin.
Carcinoma
Arachidonic acid metabolites in saliva of patients with squamous cell carcinoma of the head and neck.
Carcinoma
Characterization of the protein synthesis independent TNFalpha lytic mechanism in human ovarian and cervical carcinoma cell lines.
Carcinoma
Enhanced endothelial cell retraction mediated by 12(S)-HETE: a proposed mechanism for the role of platelets in tumor cell metastasis.
Carcinoma
Expression of 15-lipoxygenase-1 in Merkel cell carcinoma is linked to advanced disease.
Carcinoma
Expression of lipoxygenase in human bladder carcinoma and growth inhibition by its inhibitors.
Carcinoma
Inhibition of head and neck tumor cell growth with arachidonic acid metabolism inhibition.
Carcinoma
Letter to the Editor in reference to: Expression of 15-lipoxygenase-1 in Merkel cell carcinoma is linked to advanced disease.
Carcinoma
Lipoxygenase mediates invasion of intrametastatic lymphatic vessels and propagates lymph node metastasis of human mammary carcinoma xenografts in mouse.
Carcinoma
Overexpression of 12/15-lipoxygenase, an ortholog of human 15-lipoxygenase-1, in the prostate tumors of TRAMP mice.
Carcinoma
Tumor cell-derived 12(S)-hydroxyeicosatetraenoic acid induces microvascular endothelial cell retraction.
Carcinoma, Ehrlich Tumor
Leukotriene-D4 induced cell shrinkage in Ehrlich ascites tumor cells.
Carcinoma, Ehrlich Tumor
Regulation of the cellular content of the organic osmolyte taurine in mammalian cells.
Carcinoma, Hepatocellular
15-Lipoxygenase-1/15-hydroxyeicosatetraenoic acid promotes hepatocellular cancer cells growth through protein kinase B and heat shock protein 90 complex activation.
Carcinoma, Hepatocellular
Inhibitory effects of inhibitors of arachidonic acid metabolism on the evolution of rat liver preneoplastic foci into nodules and hepatocellular carcinomas with or without phenobarbital exposure.
Carcinoma, Hepatocellular
Nordihydroguaiaretic acid depletes ATP and inhibits a swelling-activated, ATP-sensitive taurine channel.
Carcinoma, Lewis Lung
Cyclooxygenase and lipoxygenase inhibitors as modulators of cancer therapies.
Carcinoma, Lewis Lung
Enhanced endothelial cell retraction mediated by 12(S)-HETE: a proposed mechanism for the role of platelets in tumor cell metastasis.
Carcinoma, Lewis Lung
Tumor cell-derived 12(S)-hydroxyeicosatetraenoic acid induces microvascular endothelial cell retraction.
Carcinoma, Merkel Cell
Expression of 15-lipoxygenase-1 in Merkel cell carcinoma is linked to advanced disease.
Carcinoma, Merkel Cell
Letter to the Editor in reference to: Expression of 15-lipoxygenase-1 in Merkel cell carcinoma is linked to advanced disease.
Carcinoma, Non-Small-Cell Lung
Lipoxygenase inhibitors prevent lung carcinogenesis and inhibit non-small cell lung cancer growth.
Carcinoma, Renal Cell
Altered 1-14C arachidonic acid metabolism in arterial wall from patients with renal cell carcinoma.
Carcinoma, Squamous Cell
Arachidonic acid metabolites in saliva of patients with squamous cell carcinoma of the head and neck.
Carcinoma, Squamous Cell
Biosynthesis of prostaglandins and hydroxy fatty acids in primary squamous carcinomas of head and neck in humans.
Carcinoma, Squamous Cell
Characterization and purification of a lipoxygenase inhibitor in human epidermoid carcinoma A431 cells.
Carcinoma, Squamous Cell
Identification of a lipoxygenase inhibitor in A431 cells as a phospholipid hydroperoxide glutathione peroxidase.
Carcinoma, Squamous Cell
Inhibition of head and neck tumor cell growth with arachidonic acid metabolism inhibition.
Carcinoma, Squamous Cell
Lipoxygenase pathway of arachidonic acid metabolism in growth control of tumor cells of different type.
Carcinosarcoma
Suppression of W256 carcinosarcoma cell apoptosis by arachidonic acid and other polyunsaturated fatty acids.
Cardiotoxicity
Effects of cyclooxygenase and lipoxygenase inhibitors on digoxin-induced arrhythmias and haemodynamics in guinea-pigs.
Cardiotoxicity
The peroxidase activity of ADM-Fe(3+) cooperates with lipid peroxidation: The participation of hydroperoxide and hydroxyl radicals in the damage to proteins and DNA.
Cardiovascular Diseases
Human lipoxygenase pathway gene variation and association with markers of subclinical atherosclerosis in the diabetes heart study.
Cardiovascular Diseases
Lipoxygenase and prostaglandin G/H synthase cascades in cardiovascular disease.
Cardiovascular Diseases
Targeted quantitative analysis of eicosanoid lipids in biological samples using liquid chromatography-tandem mass spectrometry.
Central Nervous System Diseases
5-Lipoxygenase inhibition reduces inflammation and neuronal apoptosis via AKT signaling after subarachnoid hemorrhage in rats.
Choriocarcinoma
Effect of lipoxygenase products on choriogonadotropin secretion by cultured human choriocarcinoma JEG-3 cells pre- and post-stimulation with epidermal growth factor and a phorbol ester.
Chronic Periodontitis
Effect of Alox-15 Polymorphism on GCF Levels of Lipoxin-A4 in Chronic Periodontitis: A Preliminary Study.
Colitis
Effects of cyclooxygenase and lipoxygenase inhibition on eicosanoids and healing of acetic acid colitis in rats.
Colitis
Fish oil fatty acid supplementation in active ulcerative colitis: a double-blind, placebo-controlled, crossover study.
Colitis
Metabolism of arachidonic acid in acetic acid colitis in rats. Similarity to human inflammatory bowel disease.
Colitis, Ulcerative
In vivo effects of orally administered prednisolone on prostaglandin and leucotriene production in ulcerative colitis.
Colitis, Ulcerative
In vivo profiles of eicosanoids in ulcerative colitis, Crohn's colitis, and Clostridium difficile colitis.
Colitis, Ulcerative
Inhibition of soybean lipoxygenase by sulfasalazine and 5-aminosalicylic acid: a possible mode of action in ulcerative colitis.
Colitis, Ulcerative
Lipoxygenase metabolites of arachidonic acid do not induce mucus secretion from rabbit intestinal goblet cells in vitro.
Colitis, Ulcerative
Modulation of human colonic arachidonic acid metabolism by sulfasalazine.
Colitis, Ulcerative
Multi-Target Cinnamic Acids for Oxidative Stress and Inflammation: Design, Synthesis, Biological Evaluation and Modeling Studies.
Colitis, Ulcerative
Soybean lipoxygenase inhibition: studies with the sulphasalazine metabolites N-acetylaminosalicylic acid, 5-aminosalicylic acid and sulphapyridine.
Colitis, Ulcerative
[Synthesis of eicosanoids in the colonic mucosa in patients with ulcerative colitis]
Colitis-Associated Neoplasms
15-Lipoxygenase-1 suppression of colitis-associated colon cancer through inhibition of the IL-6/STAT3 signaling pathway.
Colitis-Associated Neoplasms
The role of 15-LOX-1 in colitis and colitis-associated colorectal cancer.
Colonic Neoplasms
15-Lipoxygenase-1 as a tumor suppressor gene in colon cancer: is the verdict in?
Colonic Neoplasms
15-Lipoxygenase-1 mediates nonsteroidal anti-inflammatory drug-induced apoptosis independently of cyclooxygenase-2 in colon cancer cells.
Colonic Neoplasms
15-LOX-1 suppression of hypoxia-induced metastatic phenotype and HIF-1? expression in human colon cancer cells.
Colonic Neoplasms
Activation of protein kinase G up-regulates expression of 15-lipoxygenase-1 in human colon cancer cells.
Colonic Neoplasms
Arachidonate lipoxygenase (ALOX) and cyclooxygenase (COX) polymorphisms and colon cancer risk.
Colonic Neoplasms
Cellular proliferation and lipid metabolism: importance of lipoxygenases in modulating epidermal growth factor-dependent mitogenesis.
Colonic Neoplasms
Chromatin modification requirements for 15-lipoxygenase-1 transcriptional reactivation in colon cancer cells.
Colonic Neoplasms
Decreased 13-S-hydroxyoctadecadienoic acid levels and 15-lipoxygenase-1 expression in human colon cancers.
Colonic Neoplasms
Effect of fish oil on levels of R- and S-enantiomers of 5-, 12-, and 15-hydroxyeicosatetraenoic acids in mouse colonic mucosa.
Colonic Neoplasms
Effects of Cyclooxygenase and Lipoxygenase Inhibitors on the Proliferation of Colon Cancer Cells and Their Production of Eicosanoids.
Colonic Neoplasms
Effects of purified green and black tea polyphenols on cyclooxygenase- and lipoxygenase-dependent metabolism of arachidonic acid in human colon mucosa and colon tumor tissues.
Colonic Neoplasms
Novel dual cyclooxygenase and lipoxygenase inhibitors targeting hyaluronan-CD44v6 pathway and inducing cytotoxicity in colon cancer cells.
Colonic Neoplasms
Reversal of expression of 15-lipoxygenase-1 to cyclooxygenase-2 is associated with development of colonic cancer.
Colonic Neoplasms
The effect of leukotrienes B and selected HETEs on the proliferation of colon cancer cells.
Colorectal Neoplasms
15-lipoxygenase-1 exerts its tumor suppressive role by inhibiting nuclear factor-kappa B via activation of PPAR gamma.
Colorectal Neoplasms
15-Lipoxygenase-1 expression suppresses the invasive properties of colorectal carcinoma cell lines HCT-116 and HT-29.
Colorectal Neoplasms
15-Lipoxygenase-1 mediates nonsteroidal anti-inflammatory drug-induced apoptosis independently of cyclooxygenase-2 in colon cancer cells.
Colorectal Neoplasms
15-lipoxygenase-1 metabolites down-regulate peroxisome proliferator-activated receptor gamma via the MAPK signaling pathway.
Colorectal Neoplasms
15-Lipoxygenase-1 re-expression in colorectal cancer alters endothelial cell features through enhanced expression of TSP-1 and ICAM-1.
Colorectal Neoplasms
A GATA binding site is involved in the regulation of 15-lipoxygenase-1 expression in human colorectal carcinoma cell line, caco-2.
Colorectal Neoplasms
Arachidonic and linoleic acid metabolism in mouse intestinal tissue: evidence for novel lipoxygenase activity.
Colorectal Neoplasms
Evaluation of the activity and localization of 15-lipoxygenase-1 after introduction into human colorectal carcinoma Caco-2 cells.
Colorectal Neoplasms
Expression of 15-lipoxygenase-1 is regulated by histone acetylation in human colorectal carcinoma.
Colorectal Neoplasms
GATA-6 transcriptional regulation of 15-lipoxygenase-1 during NSAID-induced apoptosis in colorectal cancer cells.
Colorectal Neoplasms
Interplay between 15-lipoxygenase-1 and metastasis-associated antigen 1 in the metastatic potential of colorectal cancer.
Colorectal Neoplasms
Lipoxygenase and Cyclooxygenase Pathways and Colorectal Cancer Prevention.
Colorectal Neoplasms
Nonsteroidal anti-inflammatory drugs induce apoptosis in esophageal cancer cells by restoring 15-lipoxygenase-1 expression.
Colorectal Neoplasms
Overexpression of 15-lipoxygenase-1 induces growth arrest through phosphorylation of p53 in human colorectal cancer cells.
Colorectal Neoplasms
The 15-lipoxygenase-1 expression may enhance the sensitivity to non-steroidal anti-inflammatory drug-induced apoptosis in colorectal cancers from patients who are treated with the compounds.
Colorectal Neoplasms
The 15-lipoxygenase-1 product 13-S-hydroxyoctadecadienoic acid down-regulates PPAR-delta to induce apoptosis in colorectal cancer cells.
Colorectal Neoplasms
The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces apoptosis via induction of 15-lipoxygenase-1 in colorectal cancer cells.
Colorectal Neoplasms
The methyltransferase inhibitor 5-aza-2-deoxycytidine induces apoptosis via induction of 15-lipoxygenase-1 in colorectal cancer cells.
Colorectal Neoplasms
Tumor-associated down-regulation of 15-lipoxygenase-1 is reversed by celecoxib in colorectal cancer.
Common Variable Immunodeficiency
A novel arachidonic acid metabolite with stimulatory effect on PHA-induced mitogenesis of lymphocytes.
Common Variable Immunodeficiency
Improved in vitro antigen-specific antibody synthesis in two patients with common variable immunodeficiency taking an oral cyclooxygenase and lipoxygenase inhibitor (ketoprofen).
Confusion
Interaction between Mitochondrial Cytochromes and Linoleic Acid Hydroperoxide: POSSIBLE CONFUSION WITH LIPOXYGENASE AND ALTERNATIVE PATHWAY.
Conjunctivitis, Allergic
In-silico studies of isolated phytoalkaloid against Lipoxygenase: study based on possible correlation.
Corneal Edema
Antagonists and inhibitors of lipid mediators in experimental inflammation of the cornea.
Corneal Neovascularization
Effect of inhibitors of arachidonic acid metabolism on corneal neovascularization in the rat.
Coronary Occlusion
Modulation of arachidonic acid metabolites and vulnerability to ventricular fibrillation during myocardial ischemia in the cat.
Coronary Occlusion
The effects of lipoxygenase inhibitor and peptidoleukotriene antagonist on myocardial injury in a canine coronary occlusion-reperfusion model.
Crohn Disease
In vivo profiles of eicosanoids in ulcerative colitis, Crohn's colitis, and Clostridium difficile colitis.
Crohn Disease
Regulated spatial distribution of cyclooxygenases and lipoxygenases in Crohn's ulcer.
Crohn Disease
Release of leukotriene B4 and 5-hydroxyeicosatetraenoic acid during phagocytosis of artificial immune complexes by peripheral neutrophils in chronic inflammatory bowel disease.
Cystic Fibrosis
Expression of cyclooxygenase and lipoxygenase enzymes in sinonasal mucosa of patients with cystic fibrosis.
Cystic Fibrosis
Generation and metabolism of leukotrienes in granulocytes of patients with cystic fibrosis.
Deafness
Whole-exome sequencing identifies a novel missense variant within LOXHD1 causing rare hearing loss in a Chinese family.
Dehydration
Jasmonic acid regulates ascorbate and glutathione metabolism in Agropyron cristatum leaves under water stress
Dementia
Elevated central nervous system prostaglandins in human immunodeficiency virus-associated dementia.
Demyelinating Diseases
Leukotrienes and other lipoxygenase metabolites of arachidonic acid: their role in edema, ischemia and demyelination of the central nervous system.
Dental Pulp Calcification
Effect of olive stoning on the volatile and phenolic composition of virgin olive oil.
Dermatitis
Superoxide anion in polymorphonuclear leukocytes of hairless rats suffering from magnesium-deficiency dermatitis.
Dermatitis
The metabolic transformations of columbinic acid and the effect of topical application of the major metabolites on rat skin.
Dermatitis, Atopic
A double-blind, randomized, placebo-controlled trial of n-3 versus n-6 fatty acid-based lipid infusion in atopic dermatitis.
Dermatitis, Atopic
In-silico studies of isolated phytoalkaloid against Lipoxygenase: study based on possible correlation.
Dermatitis, Atopic
Lipoxygenase products of arachidonic acid in psoriasis, atopic dermatitis, and experimental arthritis.
Dermatitis, Atopic
Reduced lipoxygenase and cyclooxygenase mediated signaling in PBMC of atopic dermatitis patients.
Dermatitis, Contact
Arachidonic acid metabolism in skin: experimental contact dermatitis in guinea pigs.
Dermatitis, Exfoliative
Hepoxilin A3 (HXA3) synthase deficiency is causative of a novel ichthyosis form.
Dermatitis, Exfoliative
Lipoxygenase-3 (ALOXE3) and 12(R)-lipoxygenase (ALOX12B) are mutated in non-bullous congenital ichthyosiform erythroderma (NCIE) linked to chromosome 17p13.1.
Dermatitis, Exfoliative
Mutations associated with a congenital form of ichthyosis (NCIE) inactivate the epidermal lipoxygenases 12R-LOX and eLOX3.
Diabetes Complications
Inhibitory effect of polar oregano extracts on aldose reductase and soybean lipoxygenase in vitro.
Diabetes Mellitus
Assessment of association between lipoxygenase genes variants in elderly Greek population and type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
A 12-lipoxygenase product, 12-hydroxyeicosatetraenoic acid, is increased in diabetics with incipient and early renal disease.
Diabetes Mellitus, Type 2
Assessment of association between lipoxygenase genes variants in elderly Greek population and type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
Effect of masoprocol on glucose transport and lipolysis by isolated rat adipocytes.
Diabetes Mellitus, Type 2
Masoprocol (nordihydroguaiaretic acid): a new antihyperglycemic agent isolated from the creosote bush (Larrea tridentata).
Diabetic Nephropathies
Differential behavior of mesangial cells derived from 12/15-lipoxygenase knockout mice relative to control mice.
Diabetic Nephropathies
Increased lipoxygenase and decreased cytochrome P450s metabolites correlated with the incidence of diabetic nephropathy: Potential role of eicosanoids from metabolomics in type 2 diabetic patients.
Diabetic Nephropathies
Nordihydroguairetic acid, a lignin, prevents oxidative stress and the development of diabetic nephropathy in rats.
Diabetic Nephropathies
Oxidative stress and eicosanoids in the kidneys of hyperglycemic rats treated with dehydroepiandrosterone.
Diabetic Nephropathies
Targeting oxidative stress and anti-oxidant defence in diabetic kidney disease.
Diabetic Neuropathies
Molecular mechanism of diabetic neuropathy and its pharmacotherapeutic targets.
Encephalomalacia
Lipoxygenase and other enzymes of arachidonic acid metabolism in the brain of chicks affected by nutritional encephalomalacia.
Encephalomyelitis
Phenidone, a dual inhibitor of cyclooxygenases and lipoxygenases, ameliorates rat paralysis in experimental autoimmune encephalomyelitis by suppressing its target enzymes.
Encephalomyelitis, Autoimmune, Experimental
Phenidone, a dual inhibitor of cyclooxygenases and lipoxygenases, ameliorates rat paralysis in experimental autoimmune encephalomyelitis by suppressing its target enzymes.
Endometrial Hyperplasia
The role of 15-lipoxygenase-1 expression and its potential role in the pathogenesis of endometrial hyperplasia and endometrial adenocarcinomas.
Endotoxemia
Dexamethasone and indomethacin modify endotoxin-induced respiratory failure in pigs.
Endotoxemia
Endotoxemia in rats--influence of lipoxygenase blocker versus leukotriene receptor antagonist (BW755C vs LY171883).
Endotoxemia
Endotoxin-induced eicosanoid production by equine vascular endothelial cells and neutrophils.
Endotoxemia
Influence of steroidal and nonsteroidal anti-inflammatory agents on the accumulation of arachidonic acid metabolites in plasma and lung lymph after endotoxemia in awake sheep. Measurements of prostacyclin and thromboxane metabolites and 12-HETE.
Endotoxemia
Pulmonary dysfunction caused by diffuse lung inflammation. Roles of metabolites of arachidonic acid.
Endotoxemia
Pulmonary microvascular injury from lipoxygenase infusion: comparison with endotoxemia.
Enteritis
Unique regulation of Na-glutamine cotransporter SN2/SNAT5 in rabbit intestinal crypt cells during chronic enteritis.
Eosinophilia
Capsaicin inhibits airway hyperresponsiveness but not lipoxygenase activity or eosinophilia after repeated aerosolized antigen in guinea pigs.
Eosinophilia
Comparison of 5- and 15-lipoxygenase activities in blood and alveolar leukocyte preparations from normal subjects and patients with eosinophilia.
Eosinophilia
Experimental uterine eosinophilia in the rat. The role of some inhibitors of arachidonic acid metabolism.
Eosinophilia
Formation of oedema and accumulation of eosinophils in the guinea pig lung. Inhibition by inhaled beta-stimulants.
Eosinophilia
Insights into IgE-mediated lung inflammation derived from a study employing a 5-lipoxygenase inhibitor.
Eosinophilia
Pharmacological modulation of lipopolysaccharide-induced pleural eosinophilia in the rat; a role for a newly generated protein.
Epilepsy
The accumulation of free arachidonic acid, diacylglycerols, prostaglandins, and lipoxygenase reaction products in the brain during experimental epilepsy.
Epiretinal Membrane
Detection of eicosanoids in epiretinal membranes of patients suffering from proliferative vitreoretinal diseases.
Erythema
Eicosapentaenoic acid as a modulator of inflammation. Effect on prostaglandin and leukotriene synthesis.
Erythema
The pattern and kinetics in human skin of erythema and mediators during the acute and late-phase response (LPR).
Esophageal Neoplasms
15-Lipoxygenase-1 mediates cyclooxygenase-2 inhibitor-induced apoptosis in gastric cancer.
Esophageal Neoplasms
Nonsteroidal anti-inflammatory drugs induce apoptosis in esophageal cancer cells by restoring 15-lipoxygenase-1 expression.
Esophagitis
Leukotrienes in acetylcholine-induced contraction of esophageal circular smooth muscle in experimental esophagitis.
Esophagitis, Peptic
Effect of Perilla frutescens Fixed Oil on Experimental Esophagitis in Albino Wistar Rats.
Essential Hypertension
Masoprocol lowers blood pressure in rats with fructose-induced hypertension.
Exanthema
Dermatosis in magnesium-deficient hairless rats: effects of steroidal and non-steroidal anti-inflammatory drugs.
Eye Burns
Chemical and thermal injuries of the eyes. Surgical and medical treatment based on clinical and pathophysiological findings.
Fibrosarcoma
Identification of arachidonic acid pathways required for the invasive and metastatic activity of malignant tumor cells.
Fibrosarcoma
Inhibition of lipoxygenase pathway in macrophages co-cultivated with tumor cells.
Fibrosarcoma
Lipoxygenase inhibitors suppress proliferation of G5:113 fibrosarcoma cells in vitro but they have no anticancer activity in vivo.
Fusariosis
Characterization of Fusarium wilt resistant somaclonal variants of banana cv. Rasthali by cDNA-RAPD.
Glaucoma
Betalain exerts a protective effect against glaucoma is majorly through the association of inflammatory cytokines.
Glioblastoma
Down-regulation of vinculin upon MK886-induced apoptosis in LN18 glioblastoma cells.
Glioblastoma
mRNA levels of enzymes and receptors implicated in arachidonic acid metabolism in gliomas.
Glioblastoma
Nordy, a synthetic lipoxygenase inhibitor, inhibits the expression of formylpeptide receptor and induces differentiation of malignant glioma cells.
Glioblastoma
The 1,4 benzoquinone-featured 5-lipoxygenase inhibitor RF-Id induces apoptotic death through downregulation of IAPs in human glioblastoma cells.
Glioblastoma
Ultrastructural evidence for differentiation in a human glioblastoma cell line treated with inhibitors of eicosanoid metabolism.
Glioblastoma
[Effect of nordy on biological behaviors of malignant glioma cell line U87MG and the analysis of differential expression proteome]
Glioma
15-Lipoxygenase-1 induces lipid peroxidation and apoptosis, and improves survival in rat malignant glioma.
Glioma
?-Conotoxins and ?-Cobratoxin Promote, while Lipoxygenase and Cyclooxygenase Inhibitors Suppress the Proliferation of Glioma C6 Cells.
Glioma
A novel lipoxygenase inhibitor Nordy attenuates malignant human glioma cell responses to chemotactic and growth stimulating factors.
Glioma
Arachidonic acid promotes glutamate-induced cell death associated with necrosis by 12- lipoxygenase activation in glioma cells.
Glioma
Augmentation of chemotherapy-triggered glioma cell apoptosis by blockade of arachidonic acid metabolism-the potential role of ceramide accumulation.
Glioma
Effect of nordihydroguaiaretic acid on cultured rat and human glioma cell proliferation.
Glioma
Effective Combination Therapy for Malignant Glioma with TRAIL-Secreting Mesenchymal Stem Cells and Lipoxygenase Inhibitor MK886.
Glioma
Effects of the 5-lipoxygenase inhibitors AA-863 and U-60,257 on human glioma cell lines.
Glioma
Induction of Hsp68 by oxidative stress involves the lipoxygenase pathway in C6 rat glioma cells.
Glioma
Interferon entry through the blood-brain barrier in glioma and its effect on lipoxygenase activity.
Glioma
Ketoconazole blocks organic osmolyte efflux independently of its effect on arachidonic acid conversion.
Glioma
Lipoxygenase inhibitor MK886 potentiates TRAIL-induced apoptosis through CHOP- and p38 MAPK-mediated up-regulation of death receptor 5 in malignant glioma.
Glioma
Lipoxygenase inhibitors block CD95 ligand-mediated apoptosis of human malignant glioma cells.
Glioma
mRNA levels of enzymes and receptors implicated in arachidonic acid metabolism in gliomas.
Glioma
Nordy, a synthetic lipoxygenase inhibitor, inhibits the expression of formylpeptide receptor and induces differentiation of malignant glioma cells.
Glioma
Preferential expression of chemokine receptor CXCR4 by highly malignant human gliomas and its association with poor patient survival.
Glioma
[Nordy inhibits cell proliferation and angiogenic factor production of malignant human glioma cells mediated by formylpeptide receptor]
Glomerulonephritis
Glomerulonephritis: roles for lipoxygenase pathways in pathophysiology and therapy.
glutathione synthase deficiency
Impaired synthesis of lipoxygenase products in glutathione synthetase deficiency.
Granuloma
Macrophage function in the Schistosoma mansoni egg-induced pulmonary granuloma. Role of arachidonic acid metabolites in macrophage Ia antigen expression.
Granuloma
Substance P Upregulates LTB(4) in Rat Adherent Macrophages from Granuloma Induced by KMnO(4).
Granulomatous Disease, Chronic
Leukotriene biosynthesis by polymorphonuclear leukocytes from two patients with chronic granulomatous disease.
Graves Disease
Interleukin-4 induces 15-lipoxygenase-1 expression in human orbital fibroblasts from patients with Graves disease. Evidence for anatomic site-selective actions of Th2 cytokines.
Hearing Loss
Bioconversion of Scutellaria baicalensis extract can increase recovery of auditory function in a mouse model of noise-induced hearing loss.
Hearing Loss
Whole-exome sequencing identifies a novel missense variant within LOXHD1 causing rare hearing loss in a Chinese family.
Heart Failure
Activation of EP4 receptor limits transition of acute to chronic heart failure in lipoxygenase deficient mice.
Heart Failure
Lipoxygenase drives lipidomic and metabolic reprogramming in ischemic heart failure.
Heart Failure
Lipoxygenase inhibitor ML351 dysregulated an innate inflammatory response leading to impaired cardiac repair in acute heart failure.
Herpes Simplex
Immunomodulation of cellular cytotoxicity to herpes simplex virus infection in pregnancy by inhibition of eicosanoid metabolism.
Herpes Simplex
Lipoxygenase-inhibitory action of antiviral polymeric oxidation products of polyphenols.
Herpes Simplex
The effect of a new lipoxygenase inhibitor on the production of arachidonic acid metabolites during experimental herpes simplex keratitis.
Herpes Zoster
Role of arachidonic acid metabolism in ACTH-stimulated cortisol secretion by bovine adrenocortical cells.
Herpes Zoster
Role of the lipoxygenase pathway in angiotensin II-mediated aldosterone biosynthesis in human adrenal glomerulosa cells.
Hidradenitis Suppurativa
Lipidomics Profiling of Hidradenitis Suppurativa Skin Lesions Reveals Lipoxygenase Pathway Dysregulation and Accumulation of Proinflammatory Leukotriene B4.
HIV Infections
Induction of 15-lipoxygenase-1 impairs expression of HIV-1 receptors CD4 and CXCR4 in monocytic cells.
Hodgkin Disease
Biosynthesis of 14,15-Hepoxilins in Human L1236 Hodgkin Lymphoma Cells and Eosinophils.
Hodgkin Disease
Differential expression of cysteinyl leukotriene receptor 1 and 15-lipoxygenase-1 in non-Hodgkin lymphomas.
Hodgkin Disease
Epigenetic and transcriptional control of the 15-lipoxygenase-1 gene in a Hodgkin lymphoma cell line.
Hodgkin Disease
Hodgkin Reed-Sternberg cells express 15-lipoxygenase-1 and are putative producers of eoxins in vivo: novel insight into the inflammatory features of classical Hodgkin lymphoma.
Hodgkin Disease
On the biosynthesis and biological role of eoxins and 15-lipoxygenase-1 in airway inflammation and Hodgkin lymphoma.
Hydronephrosis
Eicosanoid synthesis by rabbit hydronephrotic cortical interstitial cells in culture.
Hyperalgesia
Acute thermal hyperalgesia in the rat is produced by activation of N-methyl-D-aspartate receptors and protein kinase C and production of nitric oxide.
Hyperalgesia
Anti-inflammatory effect of licofelone against various inflammatory challenges.
Hyperalgesia
Contribution of 5- and 12-lipoxygenase products to mechanical hyperalgesia induced by prostaglandin E(2) and epinephrine in the rat.
Hyperalgesia
Eicosapentaenoic acid as a modulator of inflammation. Effect on prostaglandin and leukotriene synthesis.
Hyperalgesia
Hyperalgesic and edematogenic effects of Secapin-2, a peptide isolated from Africanized honeybee (Apis mellifera) venom.
Hyperalgesia
Inflammatory mediators in the pronociceptive effects induced by Bothrops leucurus snake venom: The role of biogenic amines, nitric oxide, and eicosanoids.
Hyperalgesia
Involvement of spinal lipoxygenase metabolites in hyperalgesia and opioid tolerance.
Hyperalgesia
Mediation of primary afferent peripheral hyperalgesia by the cAMP second messenger system.
Hyperalgesia
Pharmacological evidence for a role of lipoxygenase products in platelet-activating factor (PAF)-induced hyperalgesia.
Hyperalgesia
Role of transient receptor potential vanilloid 1 receptors in adjuvant-induced chronic arthritis: in vivo study using gene-deficient mice.
Hyperalgesia
The VGF-derived peptide TLQP-21 contributes to inflammatory and nerve injury-induced hypersensitivity.
Hypercholesterolemia
Contribution of arachidonic acid metabolites to reduced norepinephrine-induced contractions in hypercholesterolemic rabbit aortas.
Hyperemia
Eicosanoid synthesis in human peritoneal macrophages stimulated with S. epidermidis.
Hyperemia
[The participation of humoral factors released by the endothelium in the development of reactive hyperemia]
Hyperglycemia
Amelioration of streptozotocin-induced type 2 diabetes mellitus in Wistar rats by arachidonic acid.
Hyperglycemia
Oxidative stress and eicosanoids in the kidneys of hyperglycemic rats treated with dehydroepiandrosterone.
Hyperinsulinism
Central interleukin 1-elicited hyperinsulinemia is mediated by prostaglandins but not autonomics.
Hypersensitivity
Activation of a 15-lipoxygenase/leukotriene pathway in human polymorphonuclear leukocytes by the anti-inflammatory agent ibuprofen.
Hypersensitivity
Leukotrienes and lipoxygenase factors: mediators and modulators of the allergic reaction.
Hypersensitivity
Lipoxygenase inhibitors as cancer chemopreventives: discovery, recent developments, and future perspectives.
Hypersensitivity
Platelet hypersensitivity induced by 1-chloro-2, 4-dinitrobenzene, hydroperoxides and inhibition of lipoxygenase.
Hypersensitivity
The role of leukotrienes in allergen-induced late responses in allergic sheep.
Hypersensitivity
[Blood platelets as one hemostatic indicator in patients with bronchial asthma]
Hypersensitivity
[Effect of tolmetin on responsiveness of isolated guinea pig tracheal smooth muscles]
Hypersensitivity, Delayed
Effects of cyclooxygenase and lipoxygenase inhibitors on inflammation associated with oxazolone-induced delayed hypersensitivity.
Hypersensitivity, Immediate
Prostaglandin-generating factor of anaphylaxis induces mucous glycoprotein release and the formation of lipoxygenase products of arachidonate from human airways.
Hypertension
12-Lipoxygenase products modulate calcium signals in vascular smooth muscle cells.
Hypertension
Functional significance of activation of calcium/calmodulin-dependent protein kinase II in angiotensin II--induced vascular hyperplasia and hypertension.
Hypertension
High-calorie diet with moderate protein restriction prevents cachexia and ameliorates oxidative stress, inflammation and proteinuria in experimental chronic kidney disease.
Hypertension
Hypotensive effects of the lipoxygenase inhibitor phenidone in two-kidney, one clip Goldblatt hypertension.
Hypertension
Indomethacin, dazoxiben and extravascular lung water after Escherichia coli infusion.
Hypertension
Inhibition of lipoxygenase pathway reduces blood pressure in renovascular hypertensive rats.
Hypertension
Pharmacological modulation of platelet activating factor (PAF)-induced bronchoconstriction and hypertension in anaesthetized guinea-pigs.
Hypertension
The Obligatory Role of the Acetylcholine-Induced Endothelium-Dependent Contraction in Hypertension: Can Arachidonic Acid Resolve this Inflammation?
Hypertension, Portal
Arachidonic acid metabolites and endothelial dysfunction of portal hypertension.
Hypertension, Pregnancy-Induced
Increased placental production of leukotriene B4 in gestational hypertension.
Hypertension, Pulmonary
Arachidonate raises vascular resistance but not permeability in lungs of awake sheep.
Hypertension, Pulmonary
Indomethacin, dazoxiben and extravascular lung water after Escherichia coli infusion.
Hypertension, Pulmonary
Lipoxygenase and cyclooxygenase blockade by BW755C does not prevent the secondary phase of septic pulmonary hypertension.
Hypertension, Pulmonary
Prevention of endotoxin-induced pulmonary hypertension in primates by the use of a selective thromboxane synthetase inhibitor, OKY 1581.
Hypertension, Renovascular
Hypotensive effects of the lipoxygenase inhibitor phenidone in two-kidney, one clip Goldblatt hypertension.
Hypertriglyceridemia
High dietary fructose induces a hepatic stress response resulting in cholesterol and lipid dysregulation.
Hypoalbuminemia
The influence of albumin and calcium on human platelet arachidonic acid metabolism.
Hypotension
Lipoxygenase and cyclooxygenase blockade by BW755C prevents endotoxin-induced hypotension but not changes in glucose metabolism.
Hypotension
The action of sevoflurane on vascular smooth muscle of isolated mesenteric resistance arteries (part 1): role of endothelium.
Hypotension
[The effect of indomethacin on the changes in the hemodynamics and coronary vascular resistance during anaphylactic shock]
Ichthyosiform Erythroderma, Congenital
Lipoxygenase-3 (ALOXE3) and 12(R)-lipoxygenase (ALOX12B) are mutated in non-bullous congenital ichthyosiform erythroderma (NCIE) linked to chromosome 17p13.1.
Ichthyosiform Erythroderma, Congenital
Mutations associated with a congenital form of ichthyosis (NCIE) inactivate the epidermal lipoxygenases 12R-LOX and eLOX3.
Ichthyosis
Aloxe3 Knockout Mice Reveal a Function of Epidermal Lipoxygenase-3 as Hepoxilin Synthase and Its Pivotal Role in Barrier Formation.
Ichthyosis
Epidermal lipoxygenase products of the hepoxilin pathway selectively activate the nuclear receptor PPARalpha.
Ichthyosis
Hepoxilin A3 (HXA3) synthase deficiency is causative of a novel ichthyosis form.
Ichthyosis
Novel mutations in ALOX12B in patients with autosomal recessive congenital ichthyosis and evidence for genetic heterogeneity on chromosome 17p13.
Ichthyosis
Report of a Novel ALOX12B Mutation in Self-Improving Collodion Ichthyosis with an Overview of the Genetic Background of the Collodion Baby Phenotype.
Ichthyosis
Unbound Corneocyte Lipid Envelopes in 12R-Lipoxygenase Deficiency Support A Specific Role in Lipid-Protein Crosslinking.
Ichthyosis, Lamellar
Hepoxilin A3 (HXA3) synthase deficiency is causative of a novel ichthyosis form.
Infarction, Middle Cerebral Artery
Arachidonic acid metabolite production following focal cerebral ischemia: time course and effect of meclofenamate.
Infarction, Middle Cerebral Artery
Protecting against cerebrovascular injury: contributions of 12/15-lipoxygenase to edema formation after transient focal ischemia.
Infections
?-Carrageenan Suppresses Tomato Chlorotic Dwarf Viroid (TCDVd) Replication and Symptom Expression in Tomatoes.
Infections
A 13-Lipoxygenase, GhLOX2, positively regulates cotton tolerance against Verticillium dahliae through JA-mediated pathway.
Infections
A Lipoxygenase Pathway Is Activated in Rice after Infection with the Rice Blast Fungus Magnaporthe grisea.
Infections
A novel lipoxygenase from rice. Primary structure and specific expression upon incompatible infection with rice blast fungus.
Infections
A novel plastidial lipoxygenase of maize (Zea mays) ZmLOX6 encodes for a fatty acid hydroperoxide lyase and is uniquely regulated by phytohormones and pathogen infection.
Infections
Arachidonate lipoxygenase metabolites in amniotic fluid of women with intra-amniotic infection and preterm labor.
Infections
Arachidonic Acid Derived Lipid Mediators Influence Kaposi's Sarcoma-Associated Herpesvirus Infection and Pathogenesis.
Infections
Arachidonic acid metabolism by murine peritoneal macrophages infected with Leishmania donovani: in vitro evidence for parasite-induced alterations in cyclooxygenase and lipoxygenase pathways.
Infections
Characterization of a novel resistance-related deoxycytidine deaminase from Brassica oleracea var. capitata.
Infections
Cryogenic induced ocular HSV-1 reactivation is enhanced by an inhibitor of the lipoxygenase pathway.
Infections
Differential formation of octadecadienoic acid and octadecatrienoic acid products in control and injured/infected potato tubers.
Infections
Differential modulation of the lipoxygenase cascade during typical and latent Pectobacterium atrosepticum infections.
Infections
Duplicate maize 13-lipoxygenase genes are differentially regulated by circadian rhythm, cold stress, wounding, pathogen infection, and hormonal treatments.
Infections
Effect of tebuconazole and trifloxystrobin on Ceratocystis fimbriata to control black rot of sweet potato: processes of reactive oxygen species generation and antioxidant defense responses.
Infections
Effect of the interaction between lipoxygenase pathway and progesterone on the regulation of hydroxysteroid 11-Beta dehydrogenase 2 in cultured human term placental trophoblasts.
Infections
Effects of enhanced UV-B radiation on the interaction between rice and Magnaporthe oryzae in Yuanyang terrace.
Infections
Enhancement by parainfluenza 3 infection of contractile responses to substance P and capsaicin in airway smooth muscle from the guinea pig.
Infections
Evaluation of the expression level of 12/15 lipoxygenase and the related inflammatory factors (CCL5, CCL3) in respiratory syncytial virus infection in mice model.
Infections
Exogenous application of methyl jasmonate induces defense response and develops tolerance against mungbean yellow mosaic India virus in Vigna mungo.
Infections
Green leaf volatiles and jasmonic acid enhance susceptibility to anthracnose diseases caused by Colletotrichum graminicola in maize.
Infections
Hydrophobic proteins secreted into the apoplast may contribute to resistance against Phytophthora infestans in potato.
Infections
Identification of lipoxygenase (LOX) genes from legumes and their responses in wild type and cultivated peanut upon Aspergillus flavus infection.
Infections
Immunomodulation of cellular cytotoxicity to herpes simplex virus infection in pregnancy by inhibition of eicosanoid metabolism.
Infections
Inhibitory effects of sulfated lentinan with different degree of sulfation against tobacco mosaic virus (TMV) in tobacco seedlings.
Infections
Involvement of epicatechin in the regulation of lipoxygenase activity during activation of quiescent Colletotrichum gloeosporioides infections of ripening avocado fruits.
Infections
Leaf rust induced volatile organic compounds signalling in willow during the infection.
Infections
Lipid profiling of the Arabidopsis hypersensitive response reveals specific lipid peroxidation and fragmentation processes: biogenesis of pimelic and azelaic Acid.
Infections
Lipoxygenase Activity Increment in Infected Tomato Leaves and Oxidation Product of Linolenic Acid by Its In Vitro Enzyme Reaction.
Infections
Lipoxygenase gene expression in the tobacco-Phytophthora parasitica nicotianae interaction.
Infections
Lipoxygenase metabolites of alpha-linolenic acid in the development of resistance in pigeonpea, Cajanus cajan (L.) Millsp, seedlings against Fusarium udum infection.
Infections
Long-term protection against tobacco mosaic virus induced by the marine alga oligo-sulphated-galactan Poly-Ga in tobacco plants.
Infections
Multiplex profiling of inflammation-related bioactive lipid mediators in Toxocara canis- and Toxocara cati-induced neurotoxocarosis.
Infections
Oak gall wasp infections of Quercus robur leaves lead to profound modifications in foliage photosynthetic and volatile emission characteristics.
Infections
Oak powdery mildew (Erysiphe alphitoides)-induced volatile emissions scale with the degree of infection in Quercus robur.
Infections
Overexpression of Camellia sinensis Thaumatin-Like Protein, CsTLP in Potato Confers Enhanced Resistance to Macrophomina phaseolina and Phytophthora infestans Infection.
Infections
Overexpression of hydroperoxide lyase, peroxygenase and epoxide hydrolase in tobacco for the biotechnological production of flavours and polymer precursors.
Infections
Oxylipin biosynthesis genes positively regulate PCD during compatible infections by the synergistic pair Potato virus X-Potato virus Y and by Tomato spotted wilt virus.
Infections
Polyamine metabolism and lipoxygenase activity during Fusarium oxysporum f. sp. ricini -Castor interaction.
Infections
Proteomics analysis reveals novel host molecular mechanisms associated with thermotherapy of 'Ca. Liberibacter asiaticus'-infected citrus plants.
Infections
Pseudomonas aeruginosa Lipoxygenase LoxA Contributes to Lung Infection by Altering the Host Immune Lipid Signaling.
Infections
Purification and properties of lipoxygenase induced in downy mildew resistant pearl millet seedlings due to infection with Sclerospora graminicola.
Infections
Role of pathogen-induced volatiles in the Nicotiana tabacum-Golovinomyces cichoracearum interaction.
Infections
Seed-Derived Ethylene Facilitates Colonization but Not Aflatoxin Production by Aspergillus flavus in Maize.
Infections
Serial Metabolome Changes in a Prospective Cohort of Subjects with Influenza Viral Infection and Comparison with Dengue Fever.
Infections
Silicon induced systemic defense responses in perennial ryegrass against infection by Magnaporthe oryzae.
Infections
Synchronised regulation of disease resistance in primed finger millet plants against the blast disease.
Infections
The effect of a new lipoxygenase inhibitor on the production of arachidonic acid metabolites during experimental herpes simplex keratitis.
Infections
Time-course of lipoxygenase, antioxidant enzyme activities and H?O? accumulation during the early stages of Rhizobium-legume symbiosis
Infections
Trichoderma harzianum ETS 323-mediated resistance in Brassica oleracea var. capitata to Rhizoctonia solani involves the novel expression of a glutathione S-transferase and a deoxycytidine deaminase.
Infections
Wounding and pathogen infection induce a chloroplast-targeted lipoxygenase in the common bean (Phaseolus vulgaris L.).
Infections
[Biochemical aspects of the interaction of the malarial parasite, Plasmodium berghei, with erythrocytes of the host]
Infections
[Effect of influenza virus infection on arachidonic acid cascade in mouse thrombocytes]
Infertility, Male
Cytoplasmic Male Sterility in Barley : VIII. LIPOXYGENASE ACTIVITY AND ANTHER AMINO NITROGEN IN THE msm1-Rfm1a SYSTEM.
Inflammatory Bowel Diseases
Biosynthesis of lipoxygenase and cyclo-oxygenase products from [14C]-arachidonic acid by human colonic mucosa.
Inflammatory Bowel Diseases
Fish oil fatty acid supplementation in active ulcerative colitis: a double-blind, placebo-controlled, crossover study.
Inflammatory Bowel Diseases
Human colonic (Na+ + K+)-ATPase and specific ouabain binding are not influenced by lipoxygenase products or superoxide radicals.
Inflammatory Bowel Diseases
Inhibition of LOX by flavonoids: a structure-activity relationship study.
Inflammatory Bowel Diseases
Mechanism of leukotriene D4 stimulation of Cl- secretion in rat distal colon in vitro.
Inflammatory Bowel Diseases
Metabolism of arachidonic acid in acetic acid colitis in rats. Similarity to human inflammatory bowel disease.
Inflammatory Bowel Diseases
New developments in the pharmacotherapy of inflammatory bowel disease.
Inflammatory Bowel Diseases
Release of leukotriene B4 and 5-hydroxyeicosatetraenoic acid during phagocytosis of artificial immune complexes by peripheral neutrophils in chronic inflammatory bowel disease.
Inflammatory Bowel Diseases
Source of endogenous arachidonate and 5-lipoxygenase products in human neutrophils stimulated by bradykinin and A23187.
Insulin Resistance
Baicalein protects against hypertension associated with diabetes: effect on vascular reactivity and stiffness.
Insulin Resistance
Protectin DX ameliorates hepatic steatosis by suppression of endoplasmic reticulum stress via AMPK-induced ORP150 expression.
Insulin Resistance
Protectin DX ameliorates palmitate- or high-fat diet-induced insulin resistance and inflammation through an AMPK-PPAR?-dependent pathway in mice.
Insulinoma
Hepoxilin A(3) protects ?-cells from apoptosis in contrast to its precursor, 12-hydroperoxyeicosatetraenoic acid.
Insulinoma
Protective action of arachidonic acid against alloxan-induced cytotoxicity and diabetes mellitus.
Intellectual Disability
Linking the Fragile X mental retardation protein to the lipoxygenase pathway.
Ischemic Attack, Transient
Development of cyclooxygenase and lipoxygenase metabolites of arachidonic acid after transient cerebral ischemia.
Joint Diseases
An exploration of the ability of tepoxalin to ameliorate the degradation of articular cartilage in a canine in vitro model.
Joint Diseases
Lipoxygenation of arachidonic acid as a source of polymorphonuclear leukocyte chemotactic factors in synovial fluid and tissue in rheumatoid arthritis and spondyloarthritis.
Joint Diseases
Modulation of arachidonic acid metabolism in experimental arthritis induced by Salmonella enteritidis. I. Effect of ibuprofen and flurbiprofen on experimental arthritis induced by Salmonella enteritidis.
Joint Diseases
[Levels of different metabolites of arachidonic acid in synovial fluid of patients with arthrosis or rheumatoid arthritis]
Keratitis
Anti-inflammatory therapy and outcome in a guinea pig model of Pseudomonas keratitis.
Keratitis
Modulation of immunogenic keratitis in rabbits by topical administration of inhibitors of lipoxygenase and cyclooxygenase.
Keratitis
Regulation of lipoxygenase-1 and Dectin-1 on interleukin-10 in mouse Aspergillus fumigatus keratitis.
Keratitis
The effect of a new lipoxygenase inhibitor on the production of arachidonic acid metabolites during experimental herpes simplex keratitis.
Keratitis
Treatment of experimental Pseudomonas keratitis with cyclo-oxygenase and lipoxygenase inhibitors.
Keratitis, Herpetic
The effect of a new lipoxygenase inhibitor on the production of arachidonic acid metabolites during experimental herpes simplex keratitis.
Leukemia
Anti-Lipoxygenase Activity of Leaf Gall Extracts of Terminalia chebula (Gaertn.) Retz. (Combretaceae).
Leukemia
Antiproliferative effects of lipoxygenase inhibitors on malignant human hematopoietic cell lines.
Leukemia
Arachidonate 15-lipoxygenase (omega-6 lipoxygenase) from human leukocytes. Purification and structural homology to other mammalian lipoxygenases.
Leukemia
Bioactive Potential of Several Actinobacteria Isolated from Microbiologically Barely Explored Desert Habitat, Saudi Arabia.
Leukemia
Effect of the 5-hydroperoxide of eicosatetraenoic acid and inhibitors of the lipoxygenase pathway on the formation of slow reacting substance by rat basophilic leukemia cells; direct evidence that slow reacting substance is a product of the lipoxygenase pathway.
Leukemia
Effects of lipoxygenase and glutathione pathway inhibitors on leukemic cell line growth.
Leukemia
Evidence that endogenous generation of leukotrienes does not regulate proliferation of malignant hemopoietic cell lines.
Leukemia
Inhibitors of lipoxygenase metabolism exert synergistic effects with retinoic acid on differentiation of human leukemia HL-60 cells.
Leukemia
Metabolism of cyclooxygenase and lipoxygenase products by 15-prostaglandin dehydrogenase from human HL-60 leukemia cells.
Leukemia
Preventive effect of MCI-186 on 15-HPETE induced vascular endothelial cell injury in vitro.
Leukemia
Selective inhibition of the lipoxygenase metabolic pathway of arachidonic acid by the SRS-A antagonist, FPL 55712.
Leukemia P388
Lipoxygenase Inhibitors Nordihydroguaiaretic Acid and Fungus Lecanicillum lecanii Extract Induce Death of Lymphoid Leukemia Cells.
Leukemia, Erythroblastic, Acute
15-Lipoxygenase products of arachidonate play a role in proliferation of transformed erythroid cells.
Leukemia, Erythroblastic, Acute
Activation of different lipoxygenase isozymes induces apoptosis in human erythroleukemia and neuroblastoma cells.
Leukemia, Erythroblastic, Acute
Changes in lipoxygenase activities in human erythroleukemia (HEL) cells during diosgenin-induced differentiation.
Leukemia, Erythroblastic, Acute
Comparison of the effect of lipoxygenase metabolites of arachidonic acid and eicosapentaenoic acid on human natural killer cell cytotoxicity.
Leukemia, Erythroblastic, Acute
Lipoxygenase products induce ultraweak light emission from human erythroleukemia cells.
Leukemia, Erythroblastic, Acute
Ribozyme-mediated suppression of platelet type 12 lipoxygenase in human erythroleukemia cells.
Leukemia, Lymphoid
Lipoxygenase Inhibitors Nordihydroguaiaretic Acid and Fungus Lecanicillum lecanii Extract Induce Death of Lymphoid Leukemia Cells.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Altered arachidonate metabolism by platelets in patients with myeloproliferative disorders.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Effect of 15-lipoxygenase metabolites, 15-(S)-HPETE and 15-(S)-HETE on chronic myelogenous leukemia cell line K-562: reactive oxygen species (ROS) mediate caspase-dependent apoptosis.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Leukotriene production by fresh human bone marrow cells: evidence of altered lipoxygenase activity in chronic myelocytic leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Lipoxygenase products in myeloproliferative disorders: increased leukotriene C4 and decreased lipoxin formation in chronic myeloid leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Platelet and leukocyte lipoxygenase products in a patient with chronic granulocytic leukemia undergoing syngeneic bone marrow transplantation.
Leukemia, Myeloid
Antiproliferative effects of lipoxygenase inhibitors on malignant human hematopoietic cell lines.
Leukemia, T-Cell
Lipoxygenase inhibitors induce death receptor 5/TRAIL-R2 expression and sensitize malignant tumor cells to TRAIL-induced apoptosis.
Leukopenia
Differential protective activities of site specific lipoxygenase inhibitors in endotoxic shock and production of tumor necrosis factor.
Leukopenia
Pharmacological modulation of the effects of N-formyl-L-methionyl-L-leucyl-L-phenylalanine in guinea-pigs: involvement of the arachidonic acid cascade.
linoleate 13s-lipoxygenase deficiency
Acquired von Willebrand disease and storage pool disease in chronic myelocytic leukemia.
linoleate 13s-lipoxygenase deficiency
Altered arachidonate metabolism by platelets in patients with myeloproliferative disorders.
linoleate 13s-lipoxygenase deficiency
Deficiency of platelet lipoxygenase activity in myeloproliferative disorders.
linoleate 13s-lipoxygenase deficiency
Lipoxygenase deficiency in primary thrombocythemia is not a true deficiency.
linoleate 13s-lipoxygenase deficiency
Primary thrombocythaemia in childhood: symptomatic episodes and their relationship to thromboxane A2, 6-keto-PGE1 and 12-hydroxy-eicosatetraenoic acid production: a case report.
Lipidoses
[Effects of modifications of lipoproteins by water soluble forms of lineoleic-hydroxamic acid on biochemical markers of development of atherosclerosis]
Liver Cirrhosis
Reduction of apparent indicators of liver cirrhosis in rats by the arachidonate lipoxygenase inhibitor BW755C.
Liver Cirrhosis
Synthesis of eicosanoids by circulating mononuclears in healthy people and in patients with liver cirrhosis.
Lung Diseases
A combinatorial approach for the discovery of drug-like inhibitors of 15-lipoxygenase-1.
Lung Diseases
Identification of leukotrienes in the sputum of patients with cystic fibrosis.
Lung Diseases
Rational Development of a Potent 15-Lipoxygenase-1 Inhibitor with in Vitro and ex Vivo Anti-inflammatory Properties.
Lung Injury
Effects of ONO-1078, a peptide leukotriene antagonist, on endotoxin-induced acute lung injury.
Lung Injury
Eicosanoids are involved in the permeability changes but not the pulmonary hypertension after systemic activation of complement.
Lung Injury
Increases in severity of lung damage and mortality by treatment with cyclo and lipoxygenase inhibitors in bleomycin and hyperoxia model of lung injury in hamsters.
Lung Injury
Influence of cyclooxygenase and lipoxygenase inhibitors on oxidative stress-induced lung injury.
Lung Injury
Inhibition of eicosanoids does not prevent neutrophil injury from phorbol in isolated rabbit lung.
Lung Injury
Insights into IgE-mediated lung inflammation derived from a study employing a 5-lipoxygenase inhibitor.
Lung Injury
Phospholipase A2-induced lung edema and its mechanism in isolated perfused guinea pig lung.
Lung Injury
The role of cyclooxygenase and lipoxygenase mediators in oxidant-induced lung injury.
Lung Injury
Vasoactive intestinal peptide and helodermin inhibit phospholipase A2 activity in vitro.
Lung Neoplasms
Lipoxygenase inhibitors prevent lung carcinogenesis and inhibit non-small cell lung cancer growth.
Lung Neoplasms
Synergistic effects of new chemopreventive agents and conventional cytotoxic agents against human lung cancer cell lines.
Lymphatic Metastasis
Expression of 15-lipoxygenase-1 in Merkel cell carcinoma is linked to advanced disease.
Lymphatic Metastasis
Lipoxygenase mediates invasion of intrametastatic lymphatic vessels and propagates lymph node metastasis of human mammary carcinoma xenografts in mouse.
Lymphoma
Anti-Lipoxygenase Activity of Leaf Gall Extracts of Terminalia chebula (Gaertn.) Retz. (Combretaceae).
Lymphoma
Differential expression of cysteinyl leukotriene receptor 1 and 15-lipoxygenase-1 in non-Hodgkin lymphomas.
Lymphoma
Glucocorticoid-induced lymphoma cell growth inhibition: the role of leukotriene B4.
Lymphoma
Modulation of cellular proliferation and induction of apoptosis in a human lymphoma cell line after treatment with selective lipoxygenase inhibitors.
Lymphoma, Non-Hodgkin
Hodgkin Reed-Sternberg cells express 15-lipoxygenase-1 and are putative producers of eoxins in vivo: novel insight into the inflammatory features of classical Hodgkin lymphoma.
Mastitis
The combined use of lipoxygenase and cyclooxygenase inhibitors in Klebsiella pneumoniae-induced bovine mastitis.
Mastocytoma
Effects of a novel fatty acid derivative [(7E)-8-(2-naphthyl)-5,6-trans-5,6-methano-7-octenoic acid] on arachidonic acid metabolism in cultured cells.
Mastocytoma
Inhibitors of lipoxygenase have antiproliferative effects on P815 murine mastocytoma cells.
Mastocytoma
Schistosoma mansoni: cercarial eicosanoid production and penetration response inhibited by esculetin and ibuprofen.
Mastocytoma
Tetraene and pentaene leukotrienes: selective production from murine mastocytoma cells after dietary manipulation.
Melanoma
Healing fats of the skin: the structural and immunologic roles of the omega-6 and omega-3 fatty acids.
Melanoma
Identification of arachidonic acid pathways required for the invasive and metastatic activity of malignant tumor cells.
Melanoma
In Vitro Effects of Selective COX and LOX Inhibitors and Their Combinations with Antineoplastic Drugs in the Mouse Melanoma Cell Line B16F10.
Melanoma
The lipoxygenase metabolite 12(S)-HETE induces a cytoskeleton-dependent increase in surface expression of integrin alpha IIb beta 3 on melanoma cells.
Melanoma, Amelanotic
Melanoma cell spreading on fibronectin induced by 12(S)-HETE involves both protein kinase C- and protein tyrosine kinase-dependent focal adhesion formation and tyrosine phosphorylation of focal adhesion kinase (pp125FAK).
Melanoma, Amelanotic
Role of protein kinase C and phosphatases in 12(S)-HETE-induced tumor cell cytoskeletal reorganization.
Melanoma, Experimental
Inhibition of lipoxygenase pathway in macrophages co-cultivated with tumor cells.
Melanoma, Experimental
Inhibition of radiation-enhanced expression of integrin and metastatic potential in B16 melanoma cells by a lipoxygenase inhibitor.
Mesothelioma
The Investigation of Lipoxygenases as Therapeutic Targets in Malignant Pleural Mesothelioma.
Metabolic Diseases
Brain uptake and utilization of fatty acids, lipids & lipoproteins: recommendations for future research.
Mite Infestations
Study of defense-related gene expression in grapevine infested by Colomerus vitis (Acari: Eriophyidae).
Mouth Neoplasms
Lipoxygenase products in human saliva: patients with oral cancer compared to controls.
Multiple Sclerosis
Effect of calcium ionophore A23187 and of leukotrienes B4 and C4 on the adherence of mononuclear leucocytes in multiple sclerosis.
Multiple Sclerosis
Ketogenic diets attenuate cyclooxygenase and lipoxygenase gene expression in multiple sclerosis.
Multiple Sclerosis
Measles virus-induced mononuclear leukocyte adherence inhibition: effect of some drugs influencing arachidonic acid metabolic pathways.
Myeloproliferative Disorders
Altered arachidonate metabolism by platelets in patients with myeloproliferative disorders.
Myeloproliferative Disorders
Deficiency of platelet lipoxygenase activity in myeloproliferative disorders.
Myeloproliferative Disorders
Deficient induction of leukotriene synthesis in human neutrophils by lipoxygenase-deficient platelets.
Myeloproliferative Disorders
Lipoxygenase products in myeloproliferative disorders: increased leukotriene C4 and decreased lipoxin formation in chronic myeloid leukemia.
Myeloproliferative Disorders
Primary thrombocythaemia in childhood: symptomatic episodes and their relationship to thromboxane A2, 6-keto-PGE1 and 12-hydroxy-eicosatetraenoic acid production: a case report.
Myocardial Infarction
Altered lipoxygenase metabolites and leukocyte involvement in an acute occlusion-reperfusion model of canine myocardial infarction.
Myocardial Infarction
Calcium overload and cardiac myocyte cell damage induced by arachidonate lipoxygenation.
Myocardial Infarction
Platelet lipoxygenase defect (Wien-Penzing defect) in two patients with myocardial infarction.
Myocardial Infarction
Protective effects of a thromboxane synthetase inhibitor, a thromboxane antagonist, a lipoxygenase inhibitor and a leukotriene C4, D4 antagonist on myocardial injury caused by acute myocardial infarction in the canine heart.
Myocardial Ischemia
Effects of BW755C, a mixed cyclo-oxygenase-lipoxygenase inhibitor, following traumatic spinal cord injury in rats.
Myocardial Ischemia
Protective actions of propyl gallate, a lipoxygenase inhibitor, on the ischemic myocardium.
Myocardial Ischemia
Role of leukocytes in acute myocardial infarction in anesthetized dogs: relationship to myocardial salvage by anti-inflammatory drugs.
Myocardial Ischemia
The Arachidonate 15-Lipoxygenase Enzyme Product 15-HETE Is Present in Heart Tissue from Patients with Ischemic Heart Disease and Enhances Clot Formation.
Myocardial Reperfusion Injury
Comparison of antioxidant and nonantioxidant lipoxygenase inhibitors on neutrophil function. Implications for pathogenesis of myocardial reperfusion injury.
Myocardial Reperfusion Injury
Effects of supplementation with iloprost on the cardioprotection by BW755C (a dual inhibitor of cyclooxygenase and lipoxygenase enzymes) in myocardial reperfusion injury.
Myocarditis
Antiinflammatory effect of a lipoxygenase inhibitor (FLM 5011) in severe active myocarditis.
Nasal Polyps
Changes in urinary LTE4 and nasal functions following nasal provocation test with ASA in ASA-tolerant and -intolerant asthmatics.
Nasal Polyps
Expression of cyclooxygenase and lipoxygenase enzymes in nasal polyps of aspirin-sensitive and aspirin-tolerant patients.
Nasal Polyps
Urinary LTE4 is higher after nasal provocation test with L-ASA in bronchial than in only nasal responders.
Neoplasm Metastasis
12(S)-hydroxyeicosatetraenoic acid increases the actin microfilament content in B16a melanoma cells: a protein kinase-dependent process.
Neoplasm Metastasis
12-Lipoxygenase and the regulation of hypoxia-inducible factor in prostate cancer cells.
Neoplasm Metastasis
15-Lipoxygenase-2 is differentially expressed in normal and neoplastic ovary.
Neoplasm Metastasis
Dietary linoleic acid-stimulated human breast cancer cell growth and metastasis in nude mice and their suppression by indomethacin, a cyclooxygenase inhibitor.
Neoplasm Metastasis
Effects of antiplatelet agents alone or in combinations on platelet aggregation and on liver metastases from a human pancreatic adenocarcinoma in the nude mouse.
Neoplasm Metastasis
Eicosanoids as mediators of linoleic acid-stimulated invasion and type IV collagenase production by a metastatic human breast cancer cell line.
Neoplasm Metastasis
Expression of 12-lipoxygenase in human renal cell carcinoma and growth prevention by its inhibitor.
Neoplasm Metastasis
Expression of 15-lipoxygenase-1 in Merkel cell carcinoma is linked to advanced disease.
Neoplasm Metastasis
Expression of lipoxygenase in human bladder carcinoma and growth inhibition by its inhibitors.
Neoplasm Metastasis
Inhibition of radiation-enhanced expression of integrin and metastatic potential in B16 melanoma cells by a lipoxygenase inhibitor.
Neoplasm Metastasis
Interplay between 15-lipoxygenase-1 and metastasis-associated antigen 1 in the metastatic potential of colorectal cancer.
Neoplasm Metastasis
Lipoxygenase mediates invasion of intrametastatic lymphatic vessels and propagates lymph node metastasis of human mammary carcinoma xenografts in mouse.
Neoplasm Metastasis
Lipoxygenase metabolites of arachidonic and linoleic acids modulate the adhesion of tumor cells to endothelium via regulation of protein kinase C.
Neoplasm Metastasis
Lipoxygenase regulation of membrane expression of tumor cell glycoproteins and subsequent metastasis.
Neoplasm Metastasis
Molecular modeling of the non-covalent binding of the dietary tomato carotenoids lycopene and lycophyll, and selected oxidative metabolites with 5-lipoxygenase.
Neoplasm Metastasis
Molecular signature of nitric oxide on major cancer hallmarks of colorectal carcinoma.
Neoplasm Metastasis
Tumor cell-endothelial cell interactions: evidence for roles for lipoxygenase products of arachidonic acid in metastasis.
Neoplasms
12(S)-HETE enhancement of prostate tumor cell invasion: selective role of PKC alpha.
Neoplasms
12(S)-HETE increases the motility of prostate tumor cells through selective activation of PKC alpha.
Neoplasms
12(S)-hydroxyeicosatetraenoic acid increases the actin microfilament content in B16a melanoma cells: a protein kinase-dependent process.
Neoplasms
13-Hydroxyoctadecadienoic acid is the mitogenic signal for linoleic acid-dependent growth in rat hepatoma 7288CTC in vivo.
Neoplasms
15-lipoxygenase 2 (15-LOX2) is a functional tumor suppressor that regulates human prostate epithelial cell differentiation, senescence, and growth (size).
Neoplasms
15-Lipoxygenase-1 activates tumor suppressor p53 independent of enzymatic activity.
Neoplasms
15-lipoxygenase-1 exerts its tumor suppressive role by inhibiting nuclear factor-kappa B via activation of PPAR gamma.
Neoplasms
15-Lipoxygenase-1 induced by interleukin-4 mediates apoptosis in oral cavity cancer cells.
Neoplasms
15-Lipoxygenase-1 mediates cyclooxygenase-2 inhibitor-induced apoptosis in gastric cancer.
Neoplasms
15-Lipoxygenase-1 mediates nonsteroidal anti-inflammatory drug-induced apoptosis independently of cyclooxygenase-2 in colon cancer cells.
Neoplasms
15-lipoxygenase-1 metabolites down-regulate peroxisome proliferator-activated receptor gamma via the MAPK signaling pathway.
Neoplasms
15-lipoxygenase-1 production is lost in pancreatic cancer and overexpression of the gene inhibits tumor cell growth.
Neoplasms
15-Lipoxygenase-1/15-hydroxyeicosatetraenoic acid promotes hepatocellular cancer cells growth through protein kinase B and heat shock protein 90 complex activation.
Neoplasms
15-LOX-1 inhibits p21 (Cip/WAF 1) expression by enhancing MEK-ERK 1/2 signaling in colon carcinoma cells.
Neoplasms
15-LOX-1 suppression of hypoxia-induced metastatic phenotype and HIF-1? expression in human colon cancer cells.
Neoplasms
15-LOX-1 transcription suppression through the NuRD complex in colon cancer cells.
Neoplasms
4 Beta- and 4 alpha-12-O-tetradecanoylphorbol-13-acetate elicit arachidonate release from epidermal cells through different mechanisms.
Neoplasms
5-Lipoxygenase inhibitors attenuate growth of human renal cell carcinoma and induce apoptosis through arachidonic acid pathway.
Neoplasms
7-Farnesyloxycoumarin Exerts Anti-cancer Effects on a Prostate Cancer Cell Line by 15-LOX-1 Inhibition.
Neoplasms
?-3 Polyunsaturated fatty acids-derived lipid metabolites on angiogenesis, inflammation and cancer.
Neoplasms
Ability of okadaic acid and other protein phosphatase inhibitors to mimic the stimulatory effects of 12-O-tetradecanoylphorbol-13-acetate on hydroperoxide production in mouse epidermis in vivo.
Neoplasms
Activity of the lipoxygenase inhibitor 1-phenyl-3-pyrazolidinone (phenidone) and derivatives on the inhibition of adhesion molecule expression on human umbilical vascular endothelial cells.
Neoplasms
Anti-inflammatory effects and antioxidant activity of dihydroasparagusic acid in lipopolysaccharide-activated microglial cells.
Neoplasms
Anti-Lipoxygenase Activity of Leaf Gall Extracts of Terminalia chebula (Gaertn.) Retz. (Combretaceae).
Neoplasms
Anti-proliferative effects of lichen-derived lipoxygenase inhibitors on twelve human cancer cell lines of different tissue origin in vitro.
Neoplasms
Anti-tumor activities of lipids and lipid analogues and their development as potential anticancer drugs.
Neoplasms
Antitumor effects of inhibitors of arachidonic acid cascade on experimentally induced intestinal tumors.
Neoplasms
Arachidonate has protumor-promoting action that is inhibited by linoleate in mouse skin carcinogenesis.
Neoplasms
Arachidonic acid metabolism in growth control of A549 human lung adenocarcinoma cells.
Neoplasms
Arachidonic acid metabolites in cutaneous carcinomas. Evidence suggesting that elevated levels of prostaglandins in basal cell carcinomas are associated with an aggressive growth pattern.
Neoplasms
Arachidonic acid metabolites in saliva of patients with squamous cell carcinoma of the head and neck.
Neoplasms
Arachidonic acid potentiates superoxide anion radical production by murine peritoneal macrophages stimulated with tumor promoters.
Neoplasms
Attenuation of atherosclerotic complications by modulating inflammatory responses in hypercholesterolemic rats with dietary Njavara rice bran oil.
Neoplasms
Bidirectional control of membrane expression and/or activation of the tumor cell IRGpIIb/IIIa receptor and tumor cell adhesion by lipoxygenase products of arachidonic acid and linoleic acid.
Neoplasms
Binding of 13-HODE and 5-, 12- and 15-HETE to endothelial cells and subsequent platelet, neutrophil and tumor cell adhesion.
Neoplasms
Bioactive Potential of Several Actinobacteria Isolated from Microbiologically Barely Explored Desert Habitat, Saudi Arabia.
Neoplasms
Biosynthesis of 12(S)-hydroxyeicosatetraenoic acid by B16 amelanotic melanoma cells is a determinant of their metastatic potential.
Neoplasms
Breaking the cycle: the role of omega-3 polyunsaturated fatty acids in inflammation-driven cancers.
Neoplasms
Cell killing and induction of manganous superoxide dismutase by tumor necrosis factor-alpha is mediated by lipoxygenase metabolites of arachidonic acid.
Neoplasms
Characterization of integrin expression and regulation on SW-480 human colon adenocarcinoma cells and the effect of rhodostomin on basal and upregulated tumor cell adhesion.
Neoplasms
Chemoprevention by lipoxygenase and leukotriene pathway inhibitors of vinyl carbamate-induced lung tumors in mice.
Neoplasms
Chemoprevention of colon carcinogenesis by dietary curcumin, a naturally occurring plant phenolic compound.
Neoplasms
Chemoprevention of colon carcinogenesis by sulindac, a nonsteroidal anti-inflammatory agent.
Neoplasms
Comparative effect of horse gram and black gram on inflammatory mediators and antioxidant status.
Neoplasms
Comparison of the effects of ketoprofen and flunixin meglumine on the in vitro response of equine peripheral blood monocytes to bacterial endotoxin.
Neoplasms
Comparison of the gene expression profiles of resistant and non-resistant Japanese black pine inoculated with pine wood nematode using a modified LongSAGE technique
Neoplasms
Computational and pharmacological investigation of novel 1,5-diaryl-1,4-pentadien-3-one derivatives for analgesic, anti-inflammatory and anticancer potential.
Neoplasms
Conditional expression of human 15-lipoxygenase-1 in mouse prostate induces prostatic intraepithelial neoplasia: the FLiMP mouse model.
Neoplasms
Conjugated linoleic acid reduction of murine mammary tumor cell growth through 5-hydroxyeicosatetraenoic acid.
Neoplasms
COX and LOX eicosanoids modulate platelet activation and procoagulation induced by two murine cancer cells.
Neoplasms
Design, synthesis, and computational studies on dihydropyrimidine scaffolds as potential lipoxygenase inhibitors and cancer chemopreventive agents.
Neoplasms
Development of novel peptide inhibitor of Lipoxygenase based on biochemical and BIAcore evidences.
Neoplasms
Dietary linoleic acid-stimulated human breast cancer cell growth and metastasis in nude mice and their suppression by indomethacin, a cyclooxygenase inhibitor.
Neoplasms
Differential protective activities of site specific lipoxygenase inhibitors in endotoxic shock and production of tumor necrosis factor.
Neoplasms
Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries.
Neoplasms
DNA methylation paradigm shift: 15-lipoxygenase-1 upregulation in prostatic intraepithelial neoplasia and prostate cancer by atypical promoter hypermethylation.
Neoplasms
Docking Studies and Molecular Dynamics Simulation of Ipomoea batatas L. Leaves Compounds as Lipoxygenase (LOX) Inhibitor.
Neoplasms
Downregulation of ubiquitin-dependent proteolysis by eicosapentaenoic acid in acute starvation.
Neoplasms
Drugs that target lipoxygenases and leukotrienes as emerging therapies for asthma and cancer.
Neoplasms
Ectopic alphaIIbbeta3 integrin signaling involves 12-lipoxygenase- and PKC-mediated serine phosphorylation events in melanoma cells.
Neoplasms
Effect of ?-3 and ?-9 fatty acid rich oils on lipoxygenases and cyclooxygenases enzymes and on the growth of a mammary adenocarcinoma model.
Neoplasms
Effects of antihistamines on phorbol ester tumor promotion and vascular permeability changes.
Neoplasms
Effects of antiplatelet agents alone or in combinations on platelet aggregation and on liver metastases from a human pancreatic adenocarcinoma in the nude mouse.
Neoplasms
Effects of arachidonic acid metabolites in a murine model of squamous cell carcinoma.
Neoplasms
Effects of endothelial cell treatment on 13-HODE and prostacyclin synthesis and its correlation with tumor cell-vascular endothelial cell adhesion.
Neoplasms
Effects of flavonoids and antioxidants on 12-O-tetradecanoyl-phorbol-13-acetate-caused epidermal ornithine decarboxylase induction and tumor promotion in relation to lipoxygenase inhibition by these compounds.
Neoplasms
Effects of gut-targeted 15-LOX-1 transgene expression on colonic tumorigenesis in mice.
Neoplasms
Effects of systemic complement activation and neutrophil-mediated pulmonary injury on the retention and metastasis of circulating cancer cells in mouse lungs.
Neoplasms
Effects of various inhibitors of arachidonic acid oxygenation on macrophage superoxide release and tumoricidal activity.
Neoplasms
Efficacy of a Standardized Turmeric Extract Comprised of 70% Bisdemothoxy-Curcumin (REVERC3) Against LPS-Induced Inflammation in RAW264.7 Cells and Carrageenan-Induced Paw Edema.
Neoplasms
Eicosanoid profile in cultured human pulmonary artery smooth muscle cells treated with IL-1 beta and TNF alpha.
Neoplasms
Eicosanoid profiling in an orthotopic model of lung cancer progression by mass spectrometry demonstrates selective production of leukotrienes by inflammatory cells of the microenvironment.
Neoplasms
Eicosanoid synthesis by alveolar macrophages in rats with malignant mammary tumors: differences in rats treated with and without carrageenan implants.
Neoplasms
Eicosanoids as mediators of linoleic acid-stimulated invasion and type IV collagenase production by a metastatic human breast cancer cell line.
Neoplasms
Endogenous lipoxygenase metabolites mediate A23187 induced macrophage cytostasis towards P815 tumor cells in vitro.
Neoplasms
Enhanced 15-lipoxygenase activity and elevated eicosanoid production in kidney tumor microenvironment contribute to the inflammation and immune suppression.
Neoplasms
Enhanced endothelial cell retraction mediated by 12(S)-HETE: a proposed mechanism for the role of platelets in tumor cell metastasis.
Neoplasms
Enhanced tumor cell adhesion to the subendothelial matrix resulting from 12(S)-HETE-induced endothelial cell retraction.
Neoplasms
Enhancement of experimental colon carcinogenesis by dietary 6-phenylhexyl isothiocyanate.
Neoplasms
Evaluation of targeted arterial delivery of the branched chain fatty acid 12-methyltetradecanoic acid as a novel therapy for solid tumors.
Neoplasms
Expression of 12-lipoxygenase in human renal cell carcinoma and growth prevention by its inhibitor.
Neoplasms
Expression of 15-lipoxygenase-1 in Merkel cell carcinoma is linked to advanced disease.
Neoplasms
Expression of enzymes and receptors of the leukotriene pathway in human neuroblastoma promotes tumor survival and provides a target for therapy.
Neoplasms
Expression of lipoxygenase in human bladder carcinoma and growth inhibition by its inhibitors.
Neoplasms
Expression of lipoxygenase in human prostate cancer and growth reduction by its inhibitors.
Neoplasms
Expression profile of NF-?B regulated genes in sporadic colorectal cancer patients.
Neoplasms
Fish oil supplementation inhibits NNK-induced lung carcinogenesis in the A/J mouse.
Neoplasms
Gamma-linolenic acid therapy of human glioma-a review of in vitro, in vivo, and clinical studies.
Neoplasms
Generation of leukotrienes and hydroxyeicosatetraenoic acids in peritoneal macrophages of tumor-bearing mice.
Neoplasms
Ginkgolic Acid is a Multi-Target Inhibitor of Key Enzymes in Pro-Inflammatory Lipid Mediator Biosynthesis.
Neoplasms
Hodgkin Reed-Sternberg cells express 15-lipoxygenase-1 and are putative producers of eoxins in vivo: novel insight into the inflammatory features of classical Hodgkin lymphoma.
Neoplasms
Human 5-, 12- and 15-lipoxygenase-1 coexist in kidney but show opposite trends and their balance changes in cancer.
Neoplasms
Impairment of testicular function in electronic cigarette (e-cig, e-cigs) exposed rats under low-voltage and nicotine-free conditions.
Neoplasms
In Silico Screening for Anti-Inflammatory Bioactive Molecules from Ayurvedic Decoction, Balaguluchyadi Kashayam.
Neoplasms
Increased invasion of malignant gliomas after 15-LO-1 and HSV-tk/ganciclovir combination gene therapy.
Neoplasms
Indomethacin stimulation of macrophage cytostasis against MOPC-315 tumor cells is enhanced by endogenous metabolites of lipoxygenase and counteracted by prostaglandin E2.
Neoplasms
Indomethacin stimulation of macrophage cytostasis against MOPC-315 tumor cells is inhibited by both prostaglandin E2 and nordihydroguaiaretic acid, a lipoxygenase inhibitor.
Neoplasms
Induction of apoptosis by Trichostatin A in human breast cancer cell lines: involvement of 15-Lox-1.
Neoplasms
Induction of cyclooxygenase expression and enhancement of malignant cell transformation by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Neoplasms
Influence of maternal diet enrichment with conjugated linoleic acids on lipoxygenase metabolites of polyunsaturated fatty acids in serum of their offspring with 7,12-dimethylbenz[a]anthracene induced mammary tumors.
Neoplasms
Inhibition by lipoxygenase inhibitors of 7-bromomethylbenz[a]anthracene-caused epidermal ornithine decarboxylase induction and skin tumor promotion in mice.
Neoplasms
Inhibition of 12-O-tetradecanoyl-phorbol-13-acetate-induced tumor promotion by nordihydroguaiaretic acid, a lipoxygenase inhibitor, and p-bromophenacyl bromide, a phospholipase A2 inhibitor.
Neoplasms
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-caused tumor promotion in 7,12-dimethylbenz[a]anthracene-initiated SENCAR mouse skin by a polyphenolic fraction isolated from green tea.
Neoplasms
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced epidermal ornithine decarboxylase activity by lipoxygenase inhibitors: possible role of product(s) of lipoxygenase pathway.
Neoplasms
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion and ornithine decarboxylase activity by quercetin: possible involvement of lipoxygenase inhibition.
Neoplasms
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-mediated epidermal ornithine decarboxylase induction and skin tumor promotion by new lipoxygenase inhibitors lacking protein kinase C inhibitory effects.
Neoplasms
Inhibition of human malignant neuroblastoma cell DNA synthesis by lipoxygenase metabolites of arachidonic acid.
Neoplasms
Inhibition of lipoxygenase pathway in macrophages co-cultivated with tumor cells.
Neoplasms
Inhibition of peroxisome proliferator-activated receptor (PPAR)-mediated keratinocyte differentiation by lipoxygenase inhibitors.
Neoplasms
Inhibition of radiation-enhanced expression of integrin and metastatic potential in B16 melanoma cells by a lipoxygenase inhibitor.
Neoplasms
Inhibition of soybean lipoxygenase and mouse skin tumor promotion by onion and garlic components.
Neoplasms
Inhibition of steroid production in Leydig cells by non-steroidal anti-inflammatory and related compounds: evidence for the involvement of lipoxygenase products in steroidogenesis.
Neoplasms
Inhibition of TPA and 12(S)-HETE-stimulated tumor cell adhesion by prostacyclin and its stable analogs: rationale for their antimetastatic effects.
Neoplasms
Inhibition of tumor promotion in SENCAR mouse skin by ethanol extract of Zingiber officinale rhizome.
Neoplasms
Inhibitory effect of curcumin and some related dietary compounds on tumor promotion and arachidonic acid metabolism in mouse skin.
Neoplasms
Inhibitory effects of curcumin on in vitro lipoxygenase and cyclooxygenase activities in mouse epidermis.
Neoplasms
Intestinal secretory factor released by macrophages stimulated with Clostridium difficile toxin A: role of interleukin 1beta.
Neoplasms
Intracellular Ca2+ mediates lipoxygenase-induced proliferation of U-373 MG human astrocytoma cells.
Neoplasms
Intravitreal adenoviral 15-lipoxygenase-1 gene transfer prevents vascular endothelial growth factor A induced neovascularization in rabbit eyes.
Neoplasms
Involvement of 15-lipoxygenase-1 in the regulation of breast cancer cell death induced by sodium butyrate.
Neoplasms
Jasonia glutinosa (L.) DC., a traditional herbal medicine, reduces inflammation, oxidative stress and protects the intestinal barrier in a murine model of colitis.
Neoplasms
Lentinan augments skin reaction induced by bradykinin: its correlation with vascular dilatation and hemorrhage responses and antitumor activities.
Neoplasms
Lipoxygenase inhibitors as cancer chemopreventives: discovery, recent developments, and future perspectives.
Neoplasms
Lipoxygenase inhibitors but not site specific 5-lipoxygenase blockers protect against endotoxic shock and inhibit production of tumor necrosis factor.
Neoplasms
Lipoxygenase inhibitors enhance tumor suppressive effects of jun proteins on v-myb-transformed monoblasts BM2.
Neoplasms
Lipoxygenase inhibitors induce arrest of tumor cells in S-phase of the cell cycle.
Neoplasms
Lipoxygenase inhibitors induce death receptor 5/TRAIL-R2 expression and sensitize malignant tumor cells to TRAIL-induced apoptosis.
Neoplasms
Lipoxygenase inhibitors suppress formation of tumor necrosis factor in vitro and in vivo.
Neoplasms
Lipoxygenase mediates invasion of intrametastatic lymphatic vessels and propagates lymph node metastasis of human mammary carcinoma xenografts in mouse.
Neoplasms
Lipoxygenase metabolites of arachidonic and linoleic acids modulate the adhesion of tumor cells to endothelium via regulation of protein kinase C.
Neoplasms
Lipoxygenase pathway of arachidonic acid metabolism in growth control of tumor cells of different type.
Neoplasms
Lipoxygenase products regulate IRGpIIb/IIIa receptor mediated adhesion of tumor cells to endothelial cells, subendothelial matrix and fibronectin.
Neoplasms
Lipoxygenase regulation of membrane expression of tumor cell glycoproteins and subsequent metastasis.
Neoplasms
Lung cancer cell lines inhibit leukotriene B4 production by human polymorphonuclear leukocytes at the level of phospholipase A2.
Neoplasms
Mechanism of the anti-tumour effect of 2,3,5-trimethyl-6-(3-pyridylmethyl) 1,4-benzoquinone (CV-6504).
Neoplasms
Mechanisms of nordihydroguaiaretic acid-induced growth inhibition and apoptosis in human cancer cells.
Neoplasms
Mechanistic contribution of ubiquitous 15-lipoxygenase-1 expression loss in cancer cells to terminal cell differentiation evasion.
Neoplasms
Methyl jasmonate induced apoptosis in human prostate carcinoma cells via 5-lipoxygenase dependent pathway.
Neoplasms
MK886-induced apoptosis depends on the 5-LO expression level in human malignant glioma cells.
Neoplasms
Molecular modeling of the non-covalent binding of the dietary tomato carotenoids lycopene and lycophyll, and selected oxidative metabolites with 5-lipoxygenase.
Neoplasms
Molecular signature of nitric oxide on major cancer hallmarks of colorectal carcinoma.
Neoplasms
Morusinol extracted from Morus alba inhibits arterial thrombosis and modulates platelet activation for the treatment of cardiovascular disease.
Neoplasms
Multi-Target Cinnamic Acids for Oxidative Stress and Inflammation: Design, Synthesis, Biological Evaluation and Modeling Studies.
Neoplasms
Multifactorial anticancer effects of digalloyl-resveratrol encompass apoptosis, cell-cycle arrest, and inhibition of lymphendothelial gap formation in vitro.
Neoplasms
Nafazatrom (Bay g 6575) inhibition of tumor cell lipoxygenase activity and cellular proliferation.
Neoplasms
Natural Products as Anticancerous Therapeutic Molecules with Special Reference to Enzymatic Targets Topoisomerase, COX, LOX and Aromatase.
Neoplasms
Nordihydroguaiaretic acid suppression of rat mammary carcinogenesis induced by N-methyl-N-nitrosourea.
Neoplasms
Nutritional and botanical modulation of the inflammatory cascade--eicosanoids, cyclooxygenases, and lipoxygenases--as an adjunct in cancer therapy.
Neoplasms
Oleyl sulfate reveals allosteric inhibition of soybean lipoxygenase-1 and human 15-lipoxygenase.
Neoplasms
Opposing effects of 15-lipoxygenase-1 and -2 metabolites on MAPK signaling in prostate. Alteration in peroxisome proliferator-activated receptor gamma.
Neoplasms
Overexpression of 12/15-lipoxygenase, an ortholog of human 15-lipoxygenase-1, in the prostate tumors of TRAMP mice.
Neoplasms
Photoactivation provides a mechanistic explanation for pan-assay interference behaviour of 2-aminopyrroles in lipoxygenase inhibition.
Neoplasms
Pitfalls in the use of arachidonic acid oxidation products to assign lipoxygenase activity in cancer cells.
Neoplasms
Platelet-activating factor (PAF) enhances tumor necrosis factor production by alveolar macrophages. Prevention by PAF receptor antagonists and lipoxygenase inhibitors.
Neoplasms
Pre-treatment of HT-29 cells with 5-LOX inhibitor (MK-886) induces changes in cell cycle and increases apoptosis after photodynamic therapy with hypericin.
Neoplasms
Products of arachidonic acid metabolism and the effects of cyclooxygenase inhibition on ongoing cutaneous allergic reactions in human beings.
Neoplasms
Prostaglandin production by murine tumors as a predictor for therapeutic response to indomethacin.
Neoplasms
Prostate cancer vs hyperplasia: relationships with prostatic and adipose tissue fatty acid composition.
Neoplasms
Prostate Tumor Growth and Recurrence Can Be Modulated by the omega-6:omega-3 Ratio in Diet: Athymic Mouse Xenograft Model Simulating Radical Prostatectomy.
Neoplasms
Prostate tumor growth can be modulated by dietarily targeting the 15-lipoxygenase-1 and cyclooxygenase-2 enzymes.
Neoplasms
Protective Effect of Ginkgolic Acid in Attenuating LDL Induced Inflammation Human Peripheral Blood Mononuclear Cells via Altering the NF-?B Signaling Pathway.
Neoplasms
Regulation of proliferation of rat mammary tumor cells by inhibitors of cyclooxygenase and lipoxygenase.
Neoplasms
Regulation of the cellular content of the organic osmolyte taurine in mammalian cells.
Neoplasms
Requirement for autologous cancer extracts and lipoxygenation of arachidonic acid for human T-cell responses in leukocyte adherence inhibition and transmembrane potential change assays.
Neoplasms
Role of arachidonic acid metabolites in tumor growth inhibition by nonsteroidal antiinflammatory drugs.
Neoplasms
Role of lipoxins, resolvins, and other bioactive lipids in colon and pancreatic cancer.
Neoplasms
Ruthenium(ii) arene NSAID complexes: inhibition of cyclooxygenase and antiproliferative activity against cancer cell lines.
Neoplasms
Sensitization of colon cancer cell lines to butyrate-mediated proliferation inhibition by combined application of indomethacin and nordihydroguaiaretic acid.
Neoplasms
Specific lipoxygenase inhibition reverses macrophage cytotasis towards P815 tumor cells in vitro induced by the calcium ionophore A23187.
Neoplasms
Structure of curcumin in complex with lipoxygenase and its significance in cancer.
Neoplasms
Structure-activity relationship studies of nordihydroguaiaretic acid inhibitors toward soybean, 12-human, and 15-human lipoxygenase.
Neoplasms
Studies of synergistic and antagonistic combinations of conventional cytotoxic agents with the multiple eicosanoid pathway modulator LY 293111.
Neoplasms
Studies of synthetic chalcone derivatives as potential inhibitors of secretory phospholipase A2, cyclooxygenases, lipoxygenase and pro-inflammatory cytokines.
Neoplasms
Studies on the role of platelet eicosanoid metabolism and integrin alpha IIb beta 3 in tumor-cell-induced platelet aggregation.
Neoplasms
Stylosin and some of its synthetic derivatives induce apoptosis in prostate cancer cells as 15-lipoxygenase enzyme inhibitors.
Neoplasms
Suppression of endotoxin mitogenicity of spleen cells by lipoxygenase inhibitors and its reversal by 13-hydroxyoctadecadienoic acid.
Neoplasms
Suppression of human cancer cell proliferation by lipoxygenase inhibitors and gamma-radiation in vitro.
Neoplasms
Suppression of tumor promoter-induced chemiluminescence in mouse epidermal cells by several inhibitors of arachidonic acid metabolism.
Neoplasms
Synergistic anti-tumor effects of melatonin and PUFAs from walnuts in a murine mammary adenocarcinoma model.
Neoplasms
Targeted quantitative analysis of eicosanoid lipids in biological samples using liquid chromatography-tandem mass spectrometry.
Neoplasms
The 1,4 benzoquinone-featured 5-lipoxygenase inhibitor RF-Id induces apoptotic death through downregulation of IAPs in human glioblastoma cells.
Neoplasms
The differentiation-inducing effect of Nordy on HPV-16 subgenes-immortalized human endocervical cells H8.
Neoplasms
The Effect of Diet Supplementation with Pomegranate and Bitter Melon on Lipidomic Profile of Serum and Cancerous Tissues of Rats with Mammary Tumours.
Neoplasms
The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces apoptosis via induction of 15-lipoxygenase-1 in colorectal cancer cells.
Neoplasms
The in vitro development of cytotoxicity in response to granulocyte/macrophage-colony-stimulating factor or interferon gamma in the peripheral blood monocytes of patients with solid tumors: modulation by arachidonic acid metabolic inhibitors.
Neoplasms
The induction of ornithine decarboxylase caused by 12-O-tetradecanoylphorbol-13-acetate in isolated epidermal cells is inhibited by lipoxygenase inhibitors but not by cyclooxygenase inhibitors.
Neoplasms
The influence of arachidonic acid metabolites on cell division in the intestinal epithelium and in colonic tumors.
Neoplasms
The involvement of macrophage-derived tumour necrosis factor and lipoxygenase products on the neutrophil recruitment induced by Clostridium difficile toxin B.
Neoplasms
The linoleic acid metabolite, 13-HpODE augments the phosphorylation of EGF receptor and SHP-2 leading to their increased association.
Neoplasms
The lipoxygenase metabolite 12(S)-HETE induces a cytoskeleton-dependent increase in surface expression of integrin alpha IIb beta 3 on melanoma cells.
Neoplasms
The lipoxygenase metabolite, 12(S)-HETE, induces a protein kinase C-dependent cytoskeletal rearrangement and retraction of microvascular endothelial cells.
Neoplasms
The mechanism of skin tumor promotion caused by phorbol esters: possible involvement of arachidonic acid cascade/lipoxygenase, protein kinase C and calcium/calmodulin systems.
Neoplasms
The photoreceptor protector zeaxanthin induces cell death in neuroblastoma cells.
Neoplasms
The role of platelet cyclooxygenase and lipoxygenase pathways in tumor cell induced platelet aggregation.
Neoplasms
Toxoplasma gondii-induced immune suppression by human peripheral blood monocytes: role of gamma interferon.
Neoplasms
Tumor cell-derived 12(S)-hydroxyeicosatetraenoic acid induces microvascular endothelial cell retraction.
Neoplasms
Tumor cell-endothelial cell interactions: evidence for roles for lipoxygenase products of arachidonic acid in metastasis.
Neoplasms
Tumor-cell-induced platelet aggregation is a glycoprotein-dependent and lipoxygenase-associated process.
Neoplasms
[Effect of lysine clonixinate and indomethacin on lipoxygenase and cyclooxygenase activity in colon isolated from cancer patients]
Neoplasms
[Effect of nonsteroidal antiinflammatory drugs on colonic lipoxygenase and cyclooxygenase activities from patients with colonic neoplasia]
Neoplasms
[Growth inhibition and induction of tumor cell death by phospholipase A2 and lipoxygenase inhibitors]
Neoplasms
[Relationship between the gene polymorphisms of oxidative metabolism enzyme of exogenous chemicals and the susceptibility to neoplasms].
Neoplasms
[Synthesis of arachidonic acid cascade eicosanoids in tumors of various histogenesis in mice]
Nephritis
Mechanisms underlying the anti-inflammatory effects of essential fatty acid deficiency in experimental glomerulonephritis. Inhibited release of a monocyte chemoattractant by glomeruli.
Nephrotic Syndrome
Structure-activity relationship for two lipoxygenase inhibitors and their potential for inducing nephrotic syndrome.
Nervous System Diseases
Docking Studies and Molecular Dynamics Simulation of Ipomoea batatas L. Leaves Compounds as Lipoxygenase (LOX) Inhibitor.
Neuralgia
Thymus algeriensis and Thymus fontanesii exert neuroprotective effect against chronic constriction injury-induced neuropathic pain in rats.
Neuroblastoma
Activation of cyclic nucleotide formation in murine neuroblastoma N1E-115 cells by modified human thrombins.
Neuroblastoma
Activation of different lipoxygenase isozymes induces apoptosis in human erythroleukemia and neuroblastoma cells.
Neuroblastoma
Analysis of chromatin changes associated with the expression of globin and non-globin genes in cell hybrids between erythroid and other cells.
Neuroblastoma
Conversion of arachidonic acid to cyclooxygenase and lipoxygenase products, and incorporation into phospholipids in the mouse neuroblastoma clone, Neuro-2A.
Neuroblastoma
Cytosolic phospholipase A2 and lipoxygenase are involved in cell cycle progression in neuroblastoma cells.
Neuroblastoma
Effect of inhibitors of eicosanoid metabolism on release of [3H]noradrenaline from the human neuroblastoma, SH-SY5Y.
Neuroblastoma
Effects of delta 9-tetrahydrocannabinol and cannabidiol on phospholipase and other enzymes regulating arachidonate metabolism.
Neuroblastoma
Inhibition of human malignant neuroblastoma cell DNA synthesis by lipoxygenase metabolites of arachidonic acid.
Neuroblastoma
Novel 3-aryl-5-substituted-coumarin analogues: Synthesis and bioactivity profile.
Neuroblastoma
Zinc Oxide Nanoparticles Exhibit Both Cyclooxygenase- and Lipoxygenase-Mediated Apoptosis in Human Bone Marrow-Derived Mesenchymal Stem Cells.
Neurodegenerative Diseases
Characterization of novel furan compounds on the basis of their radical scavenging activity and cytoprotective effects against glutamate- and lipopolysaccharide-induced insults.
Neurodegenerative Diseases
Evolutionary aspects of lipoxygenases and genetic diversity of human leukotriene signaling.
Neurodegenerative Diseases
Galantamine potentiates the protective effect of rofecoxib and caffeic acid against intrahippocampal Kainic acid-induced cognitive dysfunction in rat.
Neurodegenerative Diseases
Gene-environment interaction models to unmask susceptibility mechanisms in Parkinson's disease.
Neurodegenerative Diseases
Role of LOX/COX pathways in 3-nitropropionic acid-induced HD like symptoms in rats: Protective role of Licofelone.
Neuroinflammatory Diseases
Modulation of LOX and COX pathways via inhibition of amyloidogenesis contributes to mitoprotection against ?-amyloid oligomer-induced toxicity in an animal model of Alzheimer's disease in rats.
Obesity
Antioxidant supplementation and obesity have independent effects on hepatic oxylipin profiles in insulin-resistant, obesity-prone rats.
Obesity
Lipidomic profiling of high-fat diet-induced obesity in mice: Importance of cytochrome P450-derived fatty acid epoxides.
Obstetric Labor, Premature
Action of immunoregulatory agents on 5-HETE production by cultured human amnion cells.
Obstetric Labor, Premature
Amniotic fluid arachidonate lipoxygenase metabolites in preterm labor.
Obstetric Labor, Premature
Arachidonate lipoxygenase metabolites in amniotic fluid of women with intra-amniotic infection and preterm labor.
Obstetric Labor, Premature
Effect of the interaction between lipoxygenase pathway and progesterone on the regulation of hydroxysteroid 11-Beta dehydrogenase 2 in cultured human term placental trophoblasts.
Oligodendroglioma
mRNA levels of enzymes and receptors implicated in arachidonic acid metabolism in gliomas.
Osteoarthritis
15-Lipoxygenase-1 in osteoblasts promotes TGF-?1 expression via inhibiting autophagy in human osteoarthritis.
Osteoarthritis
An exploration of the ability of tepoxalin to ameliorate the degradation of articular cartilage in a canine in vitro model.
Osteoarthritis
Effects of alumina and zirconium dioxide particles on arachidonic acid metabolism and proinflammatory interleukin production in osteoarthritis and rheumatoid synovial cells.
Osteoarthritis
Elevated levels of 15-lipoxygenase-1 contribute to the abnormal phenotypes of osteoblasts in human osteoarthritis.
Osteoarthritis
Human articular chondrocytes express 15-lipoxygenase-1 and -2: potential role in osteoarthritis.
Osteoarthritis
In vivo dual inhibition of cyclooxygenase and lipoxygenase by ML-3000 reduces the progression of experimental osteoarthritis: suppression of collagenase 1 and interleukin-1beta synthesis.
Osteoarthritis
In vivo effects of tepoxalin, an inhibitor of cyclooxygenase and lipoxygenase, on prostanoid and leukotriene production in dogs with chronic osteoarthritis.
Osteoarthritis
Increased 15-lipoxygenase-1 expression in chondrocytes contributes to the pathogenesis of osteoarthritis.
Osteoarthritis
Interactions of hydroxyapatite and fluorapatite particles on human osteoarthritis type B synoviocytes: effects on interleukin-1 alpha levels and lipoxygenase pathways.
Osteoarthritis
Synthesis of interleukin 1beta, tumor necrosis factor-alpha, and interstitial collagenase (MMP-1) is eicosanoid dependent in human osteoarthritis synovial membrane explants: interactions with antiinflammatory cytokines.
Osteoarthritis
The inhibition of subchondral bone resorption in the early phase of experimental dog osteoarthritis by licofelone is associated with a reduction in the synthesis of MMP-13 and cathepsin K.
Osteosarcoma
Purification of Soluble Membrane-Bound Ambystoma mexicanum Epidermal Lipoxygenase from E. coli and Its Growth Effect on Human Fetal Foreskin Fibroblast.
Osteosarcoma
Transforming growth factor-beta 1 inhibits lipoxygenase and epoxygenase eicosanoid production by osteosarcoma cells.
Otitis
Arabinogalactan- and dextran-induced ear inflammation in mice: differential inhibition by H1-antihistamines, 5-HT-serotonin antagonists and lipoxygenase blockers.
Otitis
Inhibitory effect of curcumin and some related dietary compounds on tumor promotion and arachidonic acid metabolism in mouse skin.
Otitis Media
Arachidonic acid metabolites in experimental otitis media and effects of anti-inflammatory drugs.
Otitis Media with Effusion
Experimental otitis media with effusion induced by platelet activating factor.
Ovarian Neoplasms
15-Lipoxygenase-2 is differentially expressed in normal and neoplastic ovary.
Ovarian Neoplasms
Role of 12-lipoxygenase in regulation of ovarian cancer cell proliferation and survival.
Overweight
[Isomeric specific analysis of hydroxyeicosatetraenoic acid in blood samples from obese patients with non-alcoholic and alcoholic steatohepatitis].
Pancreatic Neoplasms
15-lipoxygenase-1 production is lost in pancreatic cancer and overexpression of the gene inhibits tumor cell growth.
Pancreatic Neoplasms
A phase II study of the 5-lipoxygenase inhibitor, CV6504, in advanced pancreatic cancer: correlation of clinical data with pharmacokinetic and pharmacodynamic endpoints.
Pancreatic Neoplasms
Enhancing antitumor effects in pancreatic cancer cells by combined use of COX-2 and 5-LOX inhibitors.
Pancreatic Neoplasms
Hydroxyeicosatetraenoic acids in patients with pancreatic cancer: a preliminary report.
Pancreatic Neoplasms
Lipoxygenase and cyclooxygenase metabolism: new insights in treatment and chemoprevention of pancreatic cancer.
Pancreatic Neoplasms
Lipoxygenase inhibition induced apoptosis, morphological changes, and carbonic anhydrase expression in human pancreatic cancer cells.
Pancreatic Neoplasms
Lipoxygenase inhibitors abolish proliferation of human pancreatic cancer cells.
Pancreatic Neoplasms
Lipoxygenase inhibitors attenuate growth of human pancreatic cancer xenografts and induce apoptosis through the mitochondrial pathway.
Pancreatic Neoplasms
Mitochondrial DNA stress triggers autophagy-dependent ferroptotic death.
Pancreatitis
Cyclooxygenase and lipoxygenase metabolism in sodium taurocholate induced acute hemorrhagic pancreatitis in rats.
Pancreatitis, Acute Hemorrhagic
Cyclooxygenase and lipoxygenase metabolism in sodium taurocholate induced acute hemorrhagic pancreatitis in rats.
Papilloma
Effects of antihistamines on phorbol ester tumor promotion and vascular permeability changes.
Paralysis
Lipoxin-mediated inhibition of IL-12 production by DCs: a mechanism for regulation of microbial immunity.
Parasitemia
Effects of eicosanoid biosynthesis inhibitors on the prophenoloxidase-activating system and microaggregation reactions in the hemolymph of Rhodnius prolixus infected with Trypanosoma rangeli.
Parkinson Disease
Gene-environment interaction models to unmask susceptibility mechanisms in Parkinson's disease.
Pemphigoid, Bullous
12/15-Lipoxygenase choreographs the resolution of IgG-mediated skin inflammation.
Periapical Periodontitis
Influence of cigarette smoking on synthesis of eicosanoids, isoprostanes and lipoxygenase metabolites in apical periodontitis.
Periodontal Diseases
Levels of leukotriene B4 in gingival crevicular fluid and gingival tissue in specific periodontal diseases.
Periodontal Diseases
Relative conversion of arachidonic acid through lipoxygenase and cyclooxygenase pathways by homogenates of diseased periodontal tissues.
Periodontal Diseases
[Evaluation of the biosynthesis of mono-HETES and leukotrienes in diseased periodontal tissues]
Periodontal Diseases
[The role of arachidonic and eicosapentaenoic acid lipoxygenase products in the pathogenesis of generalized parodontosis]
Peripheral Nervous System Diseases
Characterization of Mice Ubiquitously Overexpressing Human 15-Lipoxygenase-1: Effect of Diabetes on Peripheral Neuropathy and Treatment with Menhaden Oil.
Peritonitis
Eicosanoid synthesis in human peritoneal macrophages stimulated with S. epidermidis.
Peritonitis
Exogenous pathogen and plant 15-lipoxygenase initiate endogenous lipoxin A4 biosynthesis.
Pituitary Neoplasms
Somatostatin stimulates BKCa channels in rat pituitary tumor cells through lipoxygenase metabolites of arachidonic acid.
Pleural Effusion
Quantitation of arachidonic acid lipoxygenase products in malignant and nonmalignant effusions.
Pleurisy
Involvement of leukotrienes in allergic pleurisy in actively sensitized rats: inhibition by the lipoxygenase inhibitor T-0757 of the increase in vascular permeability and leukotriene E4 production.
Pleurisy
Pharmacological modulation of Paf-induced rat pleurisy and its role in inflammation by zymosan.
Pleurisy
Pharmacological studies on zymosan inflammation in rats and mice. 2: Zymosan-induced pleurisy in rats.
Pneumonia
Human alveolar macrophages have 15-lipoxygenase and generate 15(S)-hydroxy-5,8,11-cis-13-trans-eicosatetraenoic acid and lipoxins.
Pneumonia
[Interrelationship between lipoxygenase metabolites of arachidonic acid and pulmonary blood flow and ventilation in acute pneumonia]
Pneumoperitoneum
Comparison of peritoneal oxidative stress during laparoscopy and laparotomy.
Polycystic Kidney Diseases
Cyclooxygenase product inhibition with acetylsalicylic acid slows disease progression in the Han:SPRD-Cy rat model of polycystic kidney disease.
Polycystic Kidney Diseases
Distinct oxylipin alterations in diverse models of cystic kidney diseases.
Polycystic Kidney Diseases
Renal cyclooxygenase and lipoxygenase products are altered in polycystic kidneys and by dietary soy protein and fish oil treatment in the Han:SPRD-Cy rat.
Polycystic Kidney, Autosomal Dominant
Bioactive lipid mediators in polycystic kidney disease.
Polycystic Kidney, Autosomal Recessive
Distinct oxylipin alterations in diverse models of cystic kidney diseases.
Polycythemia
[Defects in the prostaglandin system. IX. Lipoxygenase defect of thrombocytes in a patient with polycythemia vera]
Polycythemia Vera
Altered arachidonate metabolism by platelets in patients with myeloproliferative disorders.
Polycythemia Vera
[Defects in the prostaglandin system. IX. Lipoxygenase defect of thrombocytes in a patient with polycythemia vera]
Pre-Eclampsia
Lipoxygenase activity in human uterine and intrauterine tissues: new prospects for control of prostacyclin production in pre-eclampsia.
Pre-Eclampsia
[Significance of prostaglandins and other eicosanoids in the physiology and physiopathology of pregnancy]
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Lipoxygenase inhibitors protect acute lymphoblastic leukemia cells from ferroptotic cell death.
Premature Birth
Prediction and associations of preterm birth and its subtypes with eicosanoid enzymatic pathways and inflammatory markers.
Primary Myelofibrosis
Altered arachidonate metabolism by platelets in patients with myeloproliferative disorders.
Prostatic Intraepithelial Neoplasia
Conditional expression of human 15-lipoxygenase-1 in mouse prostate induces prostatic intraepithelial neoplasia: the FLiMP mouse model.
Prostatic Intraepithelial Neoplasia
DNA methylation paradigm shift: 15-lipoxygenase-1 upregulation in prostatic intraepithelial neoplasia and prostate cancer by atypical promoter hypermethylation.
Prostatic Neoplasms
12-Lipoxygenase and the regulation of hypoxia-inducible factor in prostate cancer cells.
Prostatic Neoplasms
15-lipoxygenase 2 (15-LOX2) is a functional tumor suppressor that regulates human prostate epithelial cell differentiation, senescence, and growth (size).
Prostatic Neoplasms
15-lipoxygenase-1 expression upregulates and activates insulin-like growth factor-1 receptor in prostate cancer cells.
Prostatic Neoplasms
7-Farnesyloxycoumarin Exerts Anti-cancer Effects on a Prostate Cancer Cell Line by 15-LOX-1 Inhibition.
Prostatic Neoplasms
8-Farnesyloxycoumarin induces apoptosis in PC-3 prostate cancer cells by inhibition of 15-lipoxygenase-1 enzymatic activity.
Prostatic Neoplasms
DNA methylation paradigm shift: 15-lipoxygenase-1 upregulation in prostatic intraepithelial neoplasia and prostate cancer by atypical promoter hypermethylation.
Prostatic Neoplasms
Expression of lipoxygenase in human prostate cancer and growth reduction by its inhibitors.
Prostatic Neoplasms
Inhibition of lipoxygenase activity: implications for the treatment and chemoprevention of prostate cancer.
Prostatic Neoplasms
Investigating the effects of two novel 4-MMPB analogs as potent lipoxygenase inhibitors for prostate cancer treatment.
Prostatic Neoplasms
Kinetic and structural investigations of the allosteric site in human epithelial 15-lipoxygenase-2.
Prostatic Neoplasms
Methyl jasmonate induced apoptosis in human prostate carcinoma cells via 5-lipoxygenase dependent pathway.
Prostatic Neoplasms
Opposing effects of 15-lipoxygenase-1 and -2 metabolites on MAPK signaling in prostate. Alteration in peroxisome proliferator-activated receptor gamma.
Prostatic Neoplasms
Overexpression of 15-lipoxygenase-1 in PC-3 human prostate cancer cells increases tumorigenesis.
Prostatic Neoplasms
The arachidonic Acid pathway and its role in prostate cancer development and progression.
Proteinuria
High-calorie diet with moderate protein restriction prevents cachexia and ameliorates oxidative stress, inflammation and proteinuria in experimental chronic kidney disease.
Proteinuria
The lipoxygenase inhibitor phenidone protects against proteinuria and stroke in stroke-prone spontaneously hypertensive rats.
Pruritus
Supplementation with n-3 and n-6 polyunsaturated fatty acids: effects on lipoxygenase activity and clinical symptoms of pruritus in hemodialysis patients.
Psoriasis
Clinical and biochemical effects of an oral leukotriene biosynthesis inhibitor (MK886) in psoriasis.
Psoriasis
Effect of dithranol treatment on arachidonic acid and its lipoxygenase products in psoriasis.
Psoriasis
Identification of chemotactic lipoxygenase products of arachidonate metabolism in psoriatic skin.
Psoriasis
Leukotrienes and other lipoxygenase products in the pathogenesis and therapy of psoriasis and other dermatoses.
Psoriasis
Lipoxygenase inhibition and antioxidant properties of bisbenzylisoqunoline alkaloids isolated from Mahonia aquifolium.
Psoriasis
Lipoxygenase inhibition and antioxidant properties of protoberberine and aporphine alkaloids isolated from Mahonia aquifolium.
Psoriasis
Lipoxygenase products of arachidonic acid in psoriasis, atopic dermatitis, and experimental arthritis.
Psoriasis
Multi-Target Cinnamic Acids for Oxidative Stress and Inflammation: Design, Synthesis, Biological Evaluation and Modeling Studies.
Psoriasis
Novel thiazolyl, thiazolinyl and benzothiazolyl Schiff bases as possible lipoxygenase's inhibitors and anti-inflammatory agents.
Psoriasis
Pharmacology and significance of nonsteroidal anti-inflammatory drugs in the treatment of skin diseases.
Psoriasis
Testing of lipoxygenase inhibitors, cyclooxygenase inhibitors, drugs with immunomodulating properties and some reference antipsoriatic drugs in the modified mouse tail test, an animal model of psoriasis.
Psoriasis
The chemokinetic response of psoriatic and normal polymorphonuclear leukocytes to arachidonic acid lipoxygenase products.
Psoriasis
The role of chemo-attractant lipoxygenase products in the pathogenesis of psoriasis.
Psoriasis
Thiazolyl and benzothiazolyl Schiff bases as novel possible lipoxygenase inhibitors and anti inflammatory agents. Synthesis and biological evaluation.
Pulmonary Atelectasis
Lipoxygenase and cyclooxygenase blockade by BW 755C enhances pulmonary hypoxic vasoconstriction.
Pulmonary Disease, Chronic Obstructive
Chronic bronchitis: reflex on the pulmonary circulation.
Pulmonary Disease, Chronic Obstructive
Eicosanoids metabolized through LOX distinguish asthma-COPD overlap from COPD by metabolomics study.
Pulmonary Disease, Chronic Obstructive
Identification of 6-benzyloxysalicylates as a novel class of inhibitors of 15-lipoxygenase-1.
Pulmonary Disease, Chronic Obstructive
In-silico studies of isolated phytoalkaloid against Lipoxygenase: study based on possible correlation.
Pulmonary Disease, Chronic Obstructive
Linoleic acid-derived lipid mediators increase in a female-dominated subphenotype of COPD.
Pulmonary Disease, Chronic Obstructive
Rational Development of a Potent 15-Lipoxygenase-1 Inhibitor with in Vitro and ex Vivo Anti-inflammatory Properties.
Pulmonary Edema
Elevated concentrations of leukotriene D4 in pulmonary edema fluid of patients with the adult respiratory distress syndrome.
Pulmonary Edema
Salutary effects of prostaglandin E1 in perfused rat lungs injured with hydrogen peroxide.
Pulmonary Fibrosis
Inhibition of bleomycin-induced pulmonary fibrosis by nordihydroguaiaretic acid. The role of alveolar macrophage activation and mediator production.
Radiation Pneumonitis
Effects of some nonsteroidal anti-inflammatory agents on experimental radiation pneumonitis.
Renal Artery Obstruction
New insights into the pathophysiology of renovascular hypertension.
Renal Insufficiency, Chronic
Elevated lipoxygenase and cytochrome P450 products predict progression of chronic kidney disease.
Reperfusion Injury
Comparison of antioxidant and nonantioxidant lipoxygenase inhibitors on neutrophil function. Implications for pathogenesis of myocardial reperfusion injury.
Reperfusion Injury
Lipoxygenase inhibitor FLM 5011, an effective protectant of myocardial microvessels against ischemia-reperfusion injury? An ultrastructural-morphometric study.
Reperfusion Injury
Protease-activated receptor 2 protects against myocardial ischemia-reperfusion injury through the lipoxygenase pathway and TRPV1 channels.
Reperfusion Injury
The effects of lipoxygenase inhibitor and peptidoleukotriene antagonist on myocardial injury in a canine coronary occlusion-reperfusion model.
Respiratory Distress Syndrome
Elevated concentrations of leukotriene D4 in pulmonary edema fluid of patients with the adult respiratory distress syndrome.
Respiratory Distress Syndrome
Therapeutic intervention in a rat model of adult respiratory distress syndrome: II. Lipoxygenase pathway inhibition.
Respiratory Insufficiency
Dexamethasone and indomethacin modify endotoxin-induced respiratory failure in pigs.
Respiratory Insufficiency
Hydroxyeicosatetraenoic acids are increased in bronchoalveolar lavage fluid of endotoxemic pigs.
Retinal Detachment
Eicosanoid Profiles in the Vitreous Humor of Patients with Proliferative Diabetic Retinopathy.
Retinal Neovascularization
Cytochrome P450 2C8 ?3-long-chain polyunsaturated fatty acid metabolites increase mouse retinal pathologic neovascularization--brief report.
Retinal Neovascularization
Inhibition of Oxygen-Induced Ischemic Retinal Neovascularization with Adenoviral 15-Lipoxygenase-1 Gene Transfer via Up-Regulation of PPAR-? and Down-Regulation of VEGFR-2 Expression.
Retinal Neovascularization
Overexpression of 15-lipoxygenase-1 in oxygen-induced ischemic retinopathy inhibits retinal neovascularization via downregulation of vascular endothelial growth factor-A expression.
Retinal Neovascularization
[Overexpression of 15-lipoxygenase-1 inhibits oxygen-induced retinal neovascularization in mice].
Rhinitis
Release of peptide leukotriene into nasal secretions after local instillation of aspirin in aspirin-sensitive asthmatic patients.
Rhinitis, Allergic
In-silico studies of isolated phytoalkaloid against Lipoxygenase: study based on possible correlation.
Rhinitis, Allergic
Inhibition of LOX by flavonoids: a structure-activity relationship study.
Rhinitis, Allergic
Mast cell stabilization, lipoxygenase inhibition, hyaluronidase inhibition, antihistaminic and antispasmodic activities of Aller-7, a novel botanical formulation for allergic rhinitis.
Sarcoma
Human sensory neuron-specific Mas-related G protein-coupled receptors-X1 sensitize and directly activate transient receptor potential cation channel V1 via distinct signaling pathways.
Seizures
Brain microvessel 12-hydroxyeicosatetraenoic acid is the (S) enantiomer and is lipoxygenase derived.
Seizures
Involvement of the arachidonic acid cascade in the hypersusceptibility to pentylenetetrazole-induced seizure during diazepam withdrawal.
Seizures
Leukotriene C4 and prostaglandin E2 activities in the serum and cerebrospinal fluid during acute cerebral ischemia.
Seizures
The accumulation of free arachidonic acid, diacylglycerols, prostaglandins, and lipoxygenase reaction products in the brain during experimental epilepsy.
Seizures
The ALOXE3 gene variants from patients with Dravet syndrome decrease gene expression and enzyme activity.
Seizures
The cyclooxygenase and lipoxygenase inhibitor BW755C protects rats against kainic acid-induced seizures and neurotoxicity.
Sepsis
Activity of the lipoxygenase inhibitor 1-phenyl-3-pyrazolidinone (phenidone) and derivatives on the inhibition of adhesion molecule expression on human umbilical vascular endothelial cells.
Sepsis
Effect of cyclooxygenase and lipoxygenase products on pulmonary function in group B streptococcal sepsis.
Sepsis
Effect of methylprednisolone, indomethacin, and diethylcarbamazine on survival rate following trauma and sepsis in rats.
Sepsis
Inhibition of eicosanoid production by BW755C does not attenuate sepsis-induced alterations in glucose kinetics.
Sepsis
Phospholipids and their inhibitors: a critical evaluation of their role in the treatment of sepsis.
Sepsis
Secreted lipoxygenase from Pseudomonas aeruginosa exhibits biomembrane oxygenase activity and induces hemolysis in human red blood cells.
Shock, Septic
Beneficial effects of a leukotriene antagonist on endotoxin-induced acute hemodynamic alterations.
Shock, Septic
Differential protective activities of site specific lipoxygenase inhibitors in endotoxic shock and production of tumor necrosis factor.
Shock, Septic
Effect of methylprednisolone, indomethacin, and diethylcarbamazine on survival rate following trauma and sepsis in rats.
Shock, Septic
Effects of two different inhibitors of the arachidonic acid metabolism on platelet sequestration in endotoxic shock.
Shock, Septic
Inhibition of lipoxygenase (LOX) or of cyclooxygenase (COX) improves survival of rats in endotoxin shock.
Skin Diseases
Effects of chronic intracutaneous administration of arachidonic acid and its metabolites. Induction of leukocytoclastic vasculitis by leukotriene B4 and 12-hydroxyeicosatetraenoic acid and its prevention by prostaglandin E2.
Skin Diseases
Inhibitory effects of sulfonated shale oils (ammonium bituminosulphonates, Ichthyols) on enzymes of polyenoic fatty acid metabolism.
Skin Diseases
Interferon-gamma-induced 15-lipoxygenase-2 expression in normal human epidermal keratinocytes and a pathogenic link to psoriasis vulgaris.
Skin Diseases
Leukotrienes and other lipoxygenase products in the pathogenesis and therapy of psoriasis and other dermatoses.
Skin Diseases
Pharmacology and significance of nonsteroidal anti-inflammatory drugs in the treatment of skin diseases.
Spasm
[The effect of indomethacin on the changes in the hemodynamics and coronary vascular resistance during anaphylactic shock]
Starvation
Downregulation of ubiquitin-dependent proteolysis by eicosapentaenoic acid in acute starvation.
Starvation
The potassium-dependent transcriptome of Arabidopsis reveals a prominent role of jasmonic acid in nutrient signaling.
Status Epilepticus
Effect of bicuculline-induced status epilepticus on prostaglandins and hydroxyeicosatetraenoic acids in rat brain subcellular fractions.
Status Epilepticus
The accumulation of free arachidonic acid, diacylglycerols, prostaglandins, and lipoxygenase reaction products in the brain during experimental epilepsy.
Stomach Neoplasms
15-Lipoxygenase-1 mediates cyclooxygenase-2 inhibitor-induced apoptosis in gastric cancer.
Stomach Ulcer
Methanolic Extract of Distemonanthus benthamianus (Caesalpiniaceae) Stem Bark Suppresses Ethanol/Indomethacin-Induced Chronic Gastric Injury in Rats.
Stroke
Brain microvessel 12-hydroxyeicosatetraenoic acid is the (S) enantiomer and is lipoxygenase derived.
Stroke
Brain uptake and utilization of fatty acids, lipids & lipoproteins: recommendations for future research.
Stroke
The lipoxygenase inhibitor phenidone protects against proteinuria and stroke in stroke-prone spontaneously hypertensive rats.
Subarachnoid Hemorrhage
Cerebral arteries can generate 5- and 15-hydroxyeicosatetraenoic acid from arachidonic acid.
Subarachnoid Hemorrhage
Effect of high-dose methylprednisolone and U74006F on eicosanoid synthesis after subarachnoid hemorrhage in rats.
Subarachnoid Hemorrhage
Participation of lipoxygenase products from arachidonic acid in the pathogenesis of cerebral vasospasm.
Sunburn
Healing fats of the skin: the structural and immunologic roles of the omega-6 and omega-3 fatty acids.
Tetanus
Nordihydroguaiaretic acid blocks the synaptic component of long-term potentiation and the associated increases in release of glutamate and arachidonate: an in vivo study in the dentate gyrus of the rat.
Thrombocythemia, Essential
Altered arachidonate metabolism by platelets in patients with myeloproliferative disorders.
Thrombocythemia, Essential
Aspirin increases the bleeding side effects in essential thrombocythemia independent of the cyclooxygenase pathway: role of the lipoxygenase pathway.
Thrombocythemia, Essential
Lipoxygenase deficiency in primary thrombocythemia is not a true deficiency.
Thrombocytosis
Deficiency of platelet lipoxygenase activity in myeloproliferative disorders.
Thrombosis
Deficient induction of leukotriene synthesis in human neutrophils by lipoxygenase-deficient platelets.
Thrombosis
Leukocyte mediated vein injury and thrombosis is reduced by a lipoxygenase inhibitor.
Thrombosis
Platelet adhesivity to subendothelium is influenced by polymorphonuclear leukocytes: studies with aspirin and salicylate.
Thymoma
Incorporation of 5,8,11,14-eicosatetraynoic acid (ETYA) into cell lipids: competition with arachidonic acid for esterification.
Thyroid Cancer, Papillary
Arachidonate 5 lipoxygenase expression in papillary thyroid carcinoma promotes invasion via MMP-9 induction.
Uremia
[The level of thromboxane A2 and prostacyclin in patients with chronic kidney failure undergoing hemodialysis]
Urinary Bladder Neoplasms
Antitumor effects of lipoxygenase inhibitors on murine bladder cancer cell line (MBT-2).
Urinary Bladder Neoplasms
Expression of lipoxygenase in human bladder carcinoma and growth inhibition by its inhibitors.
Urinary Bladder Neoplasms
Polyunsaturated fatty acid metabolizing 15-Lipoxygenase-1 (15-LO-1) expression in normal and tumorigenic human bladder tissues.
Uveitis
Anti-inflammatory effects of betamethasone phosphate, dexamethasone phosphate and indomethacin on rabbit ocular inflammation induced by bovine serum albumin.
Uveitis
Treatment of experimental granulomatous uveitis by lipoxygenase and cyclo-oxygenase inhibitors.
Uveitis
[Effect of topical pranoprofen on the lipoxygenase metabolism of the arachidonic and in endotoxin-induced uveitis]
Vaccinia
Site-directed mutagenesis studies on a putative fifth iron ligand of mouse 8S-lipoxygenase: retention of catalytic activity on mutation of serine-558 to asparagine, histidine, or alanine.
Vascular Calcification
[Arachidonic acid Alox15/12-HETE signaling inhibits vascular calcification].
Vascular Ring
Platelets enhance anoxic contraction of rat aortic rings through platelet-activating factor-dependent mechanism.
Vascular System Injuries
Influence of steroidal and nonsteroidal anti-inflammatory agents on the accumulation of arachidonic acid metabolites in plasma and lung lymph after endotoxemia in awake sheep. Measurements of prostacyclin and thromboxane metabolites and 12-HETE.
Vascular System Injuries
Lipoxygenase inhibition decreases neointimal formation following vascular injury.
Vasculitis
Effects of chronic intracutaneous administration of arachidonic acid and its metabolites. Induction of leukocytoclastic vasculitis by leukotriene B4 and 12-hydroxyeicosatetraenoic acid and its prevention by prostaglandin E2.
Vasospasm, Intracranial
Cerebral arteries can generate 5- and 15-hydroxyeicosatetraenoic acid from arachidonic acid.
Vasospasm, Intracranial
Ebselen (DR3305) ameliorates delayed cerebral vasospasm in a canine two-hemorrhage model.
Vasospasm, Intracranial
Participation of lipoxygenase products from arachidonic acid in the pathogenesis of cerebral vasospasm.
Ventricular Dysfunction
Lipoxygenase inhibitor nafazatrom fails to attenuate postischaemic ventricular dysfunction.
Ventricular Fibrillation
Modulation of arachidonic acid metabolites and vulnerability to ventricular fibrillation during myocardial ischemia in the cat.
Virus Diseases
Antisense expression of a omega-3 fatty acid desaturase gene in tobacco plants enhances susceptibility against pathogens.
Virus Diseases
Evaluation of the expression level of 12/15 lipoxygenase and the related inflammatory factors (CCL5, CCL3) in respiratory syncytial virus infection in mice model.
Vitamin E Deficiency
In vitro and in vivo effects of vitamin E on arachidonic acid metabolism in rat platelets.
Vitamin E Deficiency
[Activation of lipoxygenase, neuraminidase and phospholipase A in cellular and subcellular membranes in carbon tetrachloride poisoning and vitamin E deficiency]
Whooping Cough
Arachidonic acid metabolites as intracellular modulators of the G protein-gated cardiac K+ channel.
Whooping Cough
Epinephrine impairs insulin release by a mechanism distal to calcium mobilization. Similarity to lipoxygenase inhibitors.
Whooping Cough
Intestinal secretory factor released by macrophages stimulated with Clostridium difficile toxin A: role of interleukin 1beta.
Whooping Cough
Pertussis toxin and H-7 distinguish mechanisms involved in eicosanoid release from lipopolysaccharide-primed macrophages. Eicosanoid release from lipopolysaccharide-primed macrophages.
Whooping Cough
Signal pathways that transduce growth factor-stimulated mitogenesis in bone cells.
Whooping Cough
Somatostatin stimulates BKCa channels in rat pituitary tumor cells through lipoxygenase metabolites of arachidonic acid.
Whooping Cough
The bradykinin receptor--a putative receptor-operated channel in PC12 cells: studies of neurotransmitter release and inositol phosphate accumulation.
Wiskott-Aldrich Syndrome
A novel arachidonic acid metabolite with stimulatory effect on PHA-induced mitogenesis of lymphocytes.
Zellweger Syndrome
Lipoxygenase metabolites in amniotic fluid of patients with Zellweger syndrome.
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