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Information on EC 1.12.98.3 - Methanosarcina-phenazine hydrogenase and Organism(s) Methanosarcina mazei and UniProt Accession F1SVE4

for references in articles please use BRENDA:EC1.12.98.3
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IUBMB Comments
Contains nickel, iron-sulfur clusters and cytochrome b. The enzyme from some sources contains selenocysteine.
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Select one or more organisms in this record:
This record set is specific for:
Methanosarcina mazei
UNIPROT: F1SVE4 not found.
Word Map
The expected taxonomic range for this enzyme is: Methanosarcina
The taxonomic range for the selected organisms is: Methanosarcina mazei
Synonyms
F420 non-reducing hydrogenase, membrane-bound hydrogenase, methanophenazine hydrogenase, methanophenazine-reducing hydrogenase, methylviologen-reducing hydrogenase, Mph-reducing hydrogenase, VhoGAC, VhtGAC, VhxGAC, viologen-reducing hydrogenase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
F420 non-reducing hydrogenase
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membrane-bound hydrogenase
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methanophenazine hydrogenase
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methanophenazine-reducing hydrogenase
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methylviologen-reducing hydrogenase
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-
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Mph-reducing hydrogenase
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VhoGAC
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isoform
VhtGAC
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isoform
VhxGAC
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isoform
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
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redox reaction
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reduction
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SYSTEMATIC NAME
IUBMB Comments
hydrogen:2-(2,3-dihydropentaprenyloxy)phenazine oxidoreductase
Contains nickel, iron-sulfur clusters and cytochrome b. The enzyme from some sources contains selenocysteine.
CAS REGISTRY NUMBER
COMMENTARY hide
9027-05-8
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
H2 + 2-(2,3-dihydropentaprenyloxy)phenazine
2-dihydropentaprenyloxyphenazine
show the reaction diagram
H2 + 2-hydroxyphenazine
dihydro-2-hydroxyphenazine
show the reaction diagram
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
H2 + 2-(2,3-dihydropentaprenyloxy)phenazine
2-dihydropentaprenyloxyphenazine
show the reaction diagram
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
coenzyme F420
the reaction is dependent on the cofactor F420
cytochrome b
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[3Fe-4S]-center
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[4Fe-4S]-center
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Fe
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enzyme contains FeS clusters
Ni2+
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enzyme contains a redox-active Ni2+ ion
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
the enzyme is part of the energy conserving electron transport system of the methanogenic archaeon Methanosarcina mazei Gö1
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
40000
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x * 60000 + x * 40000
60000
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x * 60000 + x * 40000
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
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x * 60000 + x * 40000
CLONED/commentary
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Abken, H.J.; Tietze, M.; Brodersen, J.; Baumer, S.; Beifuss, U.; Deppenmeier, U.
Isolation and characterization of methanophenazine and function of phenazines in membrane-bound electron transport of Methanosarcina mazei Go1
J. Bacteriol.
180
2027-2032
1998
Methanosarcina mazei
Manually annotated by BRENDA team
Deppenmeier, U.; Lienard, T.; Gottschalk, G.
Novel reactions involved in energy conservation by methanogenic archaea
FEBS Lett.
457
291-297
1999
Methanosarcina barkeri, Methanosarcina mazei
Manually annotated by BRENDA team
Baumer, S.; Ide, T.; Jacobi, C.; Johann, A.; Gottschalk, G.; Deppenmeier, U.
The F420H2 dehydrogenase from Methanosarcina mazei is a Redox-driven proton pump closely related to NADH dehydrogenases
J. Biol. Chem.
275
17968-17973
2000
Methanosarcina mazei (Q8PU58 and F1SVL1 and Q8PZ67 and F1SVH7 and F1SVE4 and Q8PU59 and Q8PU60 and Q8PU61 and F1SVE0 and F1SVK0 and F1SVH9 and F1SVL2 and F1SVE1), Methanosarcina mazei DSM 3647 (Q8PU58 and F1SVL1 and Q8PZ67 and F1SVH7 and F1SVE4 and Q8PU59 and Q8PU60 and Q8PU61 and F1SVE0 and F1SVK0 and F1SVH9 and F1SVL2 and F1SVE1)
Manually annotated by BRENDA team
Welte, C.; Deppenmeier, U.
Bioenergetics and anaerobic respiratory chains of aceticlastic methanogens
Biochim. Biophys. Acta
1837
1130-1147
2014
Methanosarcina mazei
Manually annotated by BRENDA team
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