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Information on EC 1.11.2.2 - myeloperoxidase

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EC Tree
     1 Oxidoreductases
         1.11 Acting on a peroxide as acceptor
             1.11.2 Peroxygenases
                1.11.2.2 myeloperoxidase
IUBMB Comments
Contains calcium and covalently bound heme (proximal ligand histidine). It is present in phagosomes of neutrophils and monocytes, where the hypochlorite produced is strongly bactericidal. It differs from EC 1.11.1.10 chloride peroxidase in its preference for formation of hypochlorite over the chlorination of organic substrates under physiological conditions (pH 5-8). Hypochlorite in turn forms a number of antimicrobial products (Cl2, chloramines, hydroxyl radical, singlet oxygen). MPO also oxidizes bromide, iodide and thiocyanate. In the absence of halides, it oxidizes phenols and has a moderate peroxygenase activity toward styrene.
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Word Map
The enzyme appears in viruses and cellular organisms
Reaction Schemes
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Synonyms
myeloperoxidase, tissue myeloperoxidase, peroxinectin, hemi-mpo, hemi-myeloperoxidase, rhmpo, properoxinectin, recombinant human mpo, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
Cl- + H2O2 + H+ = HClO + H2O
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PATHWAY SOURCE
PATHWAYS
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