show all | hide all No of entries

Information on EC 1.11.2.1 - unspecific peroxygenase

for references in articles please use BRENDA:EC1.11.2.1
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
     1 Oxidoreductases
         1.11 Acting on a peroxide as acceptor
             1.11.2 Peroxygenases
                1.11.2.1 unspecific peroxygenase
IUBMB Comments
A heme-thiolate protein (P-450). Enzymes of this type include glycoproteins secreted by agaric basidiomycetes. They catalyse the insertion of an oxygen atom from H2O2 into a wide variety of substrates, including aromatic rings such as naphthalene, toluene, phenanthrene, pyrene and p-nitrophenol, recalcitrant heterocycles such as pyridine, dibenzofuran, various ethers (resulting in O-dealkylation) and alkanes such as propane, hexane and cyclohexane. Reactions catalysed include hydroxylation, epoxidation, N-oxidation, sulfooxidation, O- and N-dealkylation, bromination and one-electron oxidations. They have little or no activity toward chloride. Mechanistically, the catalytic cycle of unspecific (mono)-peroxygenases combines elements of the "shunt" pathway of cytochrome P-450s (a side activity that utilizes a peroxide in place of dioxygen and NAD[P]H) and the classic heme peroxidase cycle.
Specify your search results
Select one or more organisms in this record:
Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Archaea
Reaction Schemes
+
=
+
Synonyms
45 kDa peroxygenase/peroxidase, Agrocybe aegerita peroxidase, Agrocybe aegerita peroxidase/peroxygenase, Agrocybe aegerita peroxygenase, APO, aromatic peroxygenase, extracellular peroxygenase, haloperoxidase, haloperoxidase-peroxygenase, heme-thiolate peroxygenase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
RH + H2O2 = ROH + H2O
show the reaction diagram
Select items on the left to see more content.