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Information on EC 1.11.1.9 - glutathione peroxidase

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EC Tree
     1 Oxidoreductases
         1.11 Acting on a peroxide as acceptor
             1.11.1 Peroxidases
                1.11.1.9 glutathione peroxidase
IUBMB Comments
A protein containing a selenocysteine residue. Steroid and lipid hydroperoxides, but not the product of reaction of EC 1.13.11.12 lipoxygenase on phospholipids, can act as acceptor, but more slowly than H2O2 (cf. EC 1.11.1.12 phospholipid-hydroperoxide glutathione peroxidase).
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This record set is specific for:
UNIPROT: Q5XJZ8
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
glutathione peroxidase, gpx, gsh-px, ebselen, gshpx, gpx-1, gsh peroxidase, glutathione peroxidase 1, plasma glutathione peroxidase, selenium-dependent glutathione peroxidase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
c-GPx4
isoform, cytosolic GPx4
glutathione peroxidase 4
-
m-GPx4
isoform, mitochondrial GPx4
n-GPx4
isoform, nuclear GPx4
phospholipid hydroperoxide glutathione peroxidase
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6P229
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-
-
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ARMEP24
-
-
-
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AtGPX1
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-
-
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Cellular glutathione peroxidase
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Cuticular glycoprotein GP29
-
-
-
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DI29
-
-
-
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EGLP
-
-
-
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Epididymis-specific glutathione peroxidase-like protein
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-
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Extracellular glutathione peroxidase
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-
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Gastrointestinal glutathione peroxidase
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-
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GP30
-
-
-
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GPRP
-
-
-
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GPX
-
-
-
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GSH peroxidase
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-
-
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GSHPx-GI
-
-
-
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Major androgen-regulated protein
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-
-
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Major surface antigen GP29
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-
-
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Nt-SubC08
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-
-
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Odorant-metabolizing protein RY2D1
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-
-
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peroxidase, glutathione
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-
-
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reduced glutathione peroxidase
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-
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Salt-associated protein
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selenium-glutathione peroxidase
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
redox reaction
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oxidation
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-
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reduction
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-
-
-
SYSTEMATIC NAME
IUBMB Comments
glutathione:hydrogen-peroxide oxidoreductase
A protein containing a selenocysteine residue. Steroid and lipid hydroperoxides, but not the product of reaction of EC 1.13.11.12 lipoxygenase on phospholipids, can act as acceptor, but more slowly than H2O2 (cf. EC 1.11.1.12 phospholipid-hydroperoxide glutathione peroxidase).
CAS REGISTRY NUMBER
COMMENTARY hide
9013-66-5
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
glutathione + ROOH
glutathione disulfide + ROH + H2O
show the reaction diagram
-
-
-
?
H2O2 + GSH
H2O + GSSG
show the reaction diagram
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-
-
?
additional information
?
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does not accept thioredoxin as hydrogen donor
-
-
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
selenium
selenoprotein
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
fragment
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
isozyme n-GPx-4 is specifically expressed in late spermatocytes
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
Q5XJZ8_MOUSE
174
0
19865
TrEMBL
-
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
19000
isozyme c-GPx4, SDS-PAGE
34000
isozyme n-GPx4, SDS-PAGE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
monomer
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Savaskan, N.E.; Ufer, C.; Kuehn, H.; Borchert, A.
Molecular biology of glutathione peroxidase 4: from genomic structure to developmental expression and neural function
Biol. Chem.
388
1007-1017
2007
Mus musculus (Q5XJZ8)
Manually annotated by BRENDA team