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Synonyms
glutathione peroxidase, gpx, gsh-px, ebselen, gshpx, gpx-1, gsh peroxidase, glutathione peroxidase 1, plasma glutathione peroxidase, selenium-dependent glutathione peroxidase,
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H2O2 + GSH
H2O + GSSG
-
-
-
?
1-linoleoyl lysophosphatidylcholine hydroperoxide + GSH
?
-
-
-
-
?
glutathione + ROOH
glutathione disulfide + ROH + H2O
H2O2 + GSH
H2O + GSSG
-
-
-
-
?
linoleic acid hydroperoxide + GSH
?
-
-
-
-
?
tert-butyl hydroperoxide + GSH
tert-butyl alcohol + GSSG + H2O
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-
-
-
?
additional information
?
-
-
major antioxidant enzyme
-
-
?
glutathione + ROOH
glutathione disulfide + ROH + H2O
-
-
-
-
?
glutathione + ROOH
glutathione disulfide + ROH + H2O
-
cumene hydroperoxide
-
-
?
glutathione + ROOH
glutathione disulfide + ROH + H2O
-
ethyl hydroperoxide
-
-
?
glutathione + ROOH
glutathione disulfide + ROH + H2O
-
cholesterol 7beta-hydroperoxide
-
-
?
glutathione + ROOH
glutathione disulfide + ROH + H2O
-
specificity for donor-substrate: free amino group near the SH group inhibits the reaction, free alpha-carboxylic group of glutamic acid residue in glutathione analogs increases reaction rate
-
-
?
glutathione + ROOH
glutathione disulfide + ROH + H2O
-
peroxidized DNA
-
-
?
glutathione + ROOH
glutathione disulfide + ROH + H2O
-
pregnenolone 17alpha-hydroperoxide
-
-
?
glutathione + ROOH
glutathione disulfide + ROH + H2O
-
thymine hydroperoxide
-
-
?
glutathione + ROOH
glutathione disulfide + ROH + H2O
-
gamma-glutamyl-L-cysteine-methyl ester has 26% of glutathione activity
-
-
?
glutathione + ROOH
glutathione disulfide + ROH + H2O
-
highly specific for glutathione
-
-
?
glutathione + ROOH
glutathione disulfide + ROH + H2O
-
linoleic acid hydroperoxide
-
-
?
glutathione + ROOH
glutathione disulfide + ROH + H2O
-
gamma-glutamyl-L-cysteine-methylester has 26% of glutathione activity
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
1-linoleoyl lysophosphatidylcholine hydroperoxide + GSH
?
-
-
-
-
?
glutathione + ROOH
glutathione disulfide + ROH + H2O
H2O2 + GSH
H2O + GSSG
-
-
-
-
?
additional information
?
-
-
major antioxidant enzyme
-
-
?
glutathione + ROOH
glutathione disulfide + ROH + H2O
-
-
-
-
?
glutathione + ROOH
glutathione disulfide + ROH + H2O
-
cumene hydroperoxide
-
-
?
glutathione + ROOH
glutathione disulfide + ROH + H2O
-
ethyl hydroperoxide
-
-
?
glutathione + ROOH
glutathione disulfide + ROH + H2O
-
cholesterol 7beta-hydroperoxide
-
-
?
glutathione + ROOH
glutathione disulfide + ROH + H2O
-
specificity for donor-substrate: free amino group near the SH group inhibits the reaction, free alpha-carboxylic group of glutamic acid residue in glutathione analogs increases reaction rate
-
-
?
glutathione + ROOH
glutathione disulfide + ROH + H2O
-
peroxidized DNA
-
-
?
glutathione + ROOH
glutathione disulfide + ROH + H2O
-
pregnenolone 17alpha-hydroperoxide
-
-
?
glutathione + ROOH
glutathione disulfide + ROH + H2O
-
thymine hydroperoxide
-
-
?
glutathione + ROOH
glutathione disulfide + ROH + H2O
-
highly specific for glutathione
-
-
?
glutathione + ROOH
glutathione disulfide + ROH + H2O
-
linoleic acid hydroperoxide
-
-
?
glutathione + ROOH
glutathione disulfide + ROH + H2O
-
gamma-glutamyl-L-cysteine-methylester has 26% of glutathione activity
-
-
?
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Wendel, A.
Glutathione peroxidase
Methods Enzymol.
77
325-333
1981
Bos taurus, Mammalia, no activity in plants
brenda
Ladenstein, R.; Epp, O.; Bartels, K.; Jones, A.; Huber, R.
Structure analysis and molecular model of the selenoenzyme glutathione peroxidase at 2.8 A resolution
J. Mol. Biol.
134
199-218
1979
Bos taurus
brenda
Gunzler, W.A.; Steffens, G.J.; Grossmann, A.; Kim, S.M.A.; tting, F.; Wendel, A.; Flohe, L.
The amino-acid sequence of bovine glutathione peroxidase
Hoppe-Seyler's Z. Physiol. Chem.
365
195-212
1984
Bos taurus
brenda
Epp, O.; Ladenstein, R.; Wendel, A.
The refined structure of the selenoenzyme glutathione peroxidase at 0.2-nm resolution
Eur. J. Biochem.
133
51-69
1983
Bos taurus
brenda
Flohe, L.; Eisele, B.; Wendel, A.
Glutathione peroxidase. I. Isolation and determinations of molecular weight
Hoppe-Seyler's Z. Physiol. Chem.
352
151-158
1971
Bos taurus
brenda
Flohe, L.; Gunzler, W.; Jung, G.; Schaich, E.; Schneider, F.
Glutathione peroxidase. II. Substrate specificity and inhibitory effects of substrate analogues
Hoppe-Seyler's Z. Physiol. Chem.
352
159-169
1971
Bos taurus
brenda
Asahi, M.; Fujii, J.; Suzuki, K.; Seo, H.G.; Kuzuya, T.; Hori, M.; Tada, M.; Fujii, S.; Taniguchi, N.
Inactivation of glutathione peroxidase by nitric oxide. Implication for cytotoxicity
J. Biol. Chem.
270
21035-21039
1995
Bos taurus
brenda
Marinho, H.S.; Antunes, F.; Pinto, R.E.
Role of glutathione peroxidase and phospholipid hydroperoxide glutathione peroxidase in the reduction of lysophospholipid hydroperoxides
Free Radic. Biol. Med.
22
871-883
1997
Bos taurus, Rattus norvegicus
brenda
Park, Y.S.; Koh, Y.H.; Takahashi, M.; Miyamoto, Y.; Suzuki, K.; Dohmae, N.; Takio, K.; Honke, K.; Taniguchi, N.
Identification of the binding site of methylglyoxal on glutathione peroxidase: methylglyoxal inhibits glutathione peroxidase activity via binding to glutathione binding sites Arg 184 and 185
Free Radic. Res.
37
205-211
2003
Bos taurus
brenda
Yamasaki, T.; Tahara, K.; Takano, S.; Inoue-Murayama, M.; Rose, M.T.; Minashima, T.; Aso, H.; Ito, S.
Mechanism of plasma glutathione peroxidase production in bovine adipocytes
Cell Tissue Res.
326
139-147
2006
Bos taurus
brenda
Drevet, J.R.
The antioxidant glutathione peroxidase family and spermatozoa: a complex story
Mol. Cell. Endocrinol.
250
70-79
2006
Bos taurus, Canis lupus familiaris, Oryctolagus cuniculus, Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa
brenda
Vaisberg, C.N.; Jelezarsky, L.V.; Dishlianova, B.; Chaushev, T.A.
Activity, substrate detection and immunolocalization of glutathione peroxidase (GPx) in bovine reproductive organs and semen
Theriogenology
64
416-428
2005
Bos taurus
brenda
Ballihaut, G.; Mounicou, S.; Lobinski, R.
Multitechnique mass-spectrometric approach for the detection of bovine glutathione peroxidase selenoprotein: focus on the selenopeptide
Anal. Bioanal. Chem.
388
585-591
2007
Bos taurus (P00435), Bos taurus
brenda
Durmaz, A.; Dikmen, N.
Homocysteine effects on cellular glutathione peroxidase (GPx-1) activity under in vitro conditions
J. Enzyme Inhib. Med. Chem.
22
733-738
2007
Bos taurus
brenda
Pilarczyk, B.; Jankowiak, D.; Tomza-Marciniak, A.; Pilarczyk, R.; Sablik, P.; Drozd, R.; Tylkowska, A.; Skolmowska, M.
Selenium concentration and glutathione peroxidase (GSH-Px) activity in serum of cows at different stages of lactation
Biol. Trace Elem. Res.
147
91-96
2012
Bos taurus
brenda