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Information on EC 1.11.1.6 - catalase and Organism(s) Homo sapiens and UniProt Accession P04040

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EC Tree
     1 Oxidoreductases
         1.11 Acting on a peroxide as acceptor
             1.11.1 Peroxidases
                1.11.1.6 catalase
IUBMB Comments
A hemoprotein. A manganese protein containing MnIII in the resting state, which also belongs here, is often called pseudocatalase. The enzymes from some organisms, such as Penicillium simplicissimum, can also act as a peroxidase (EC 1.11.1.7) for which several organic substances, especially ethanol, can act as a hydrogen donor. Enzymes that exhibit both catalase and peroxidase activity belong under EC 1.11.1.21, catalase-peroxidase.
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Select one or more organisms in this record:
This record set is specific for:
Homo sapiens
UNIPROT: P04040
Word Map
The taxonomic range for the selected organisms is: Homo sapiens
The enzyme appears in selected viruses and cellular organisms
Synonyms
Ab-catalase, BNC, caperase, CAT, CAT-1, CAT-A, CAT-P, Cat1.4, CatA, catalase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
caperase
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catalase-peroxidase
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equilase
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H2O2:H2O2 oxidoreductase
247
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optidase
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polyethylene glycol-catalase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
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redox reaction
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reduction
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SYSTEMATIC NAME
IUBMB Comments
hydrogen-peroxide:hydrogen-peroxide oxidoreductase
A hemoprotein. A manganese protein containing MnIII in the resting state, which also belongs here, is often called pseudocatalase. The enzymes from some organisms, such as Penicillium simplicissimum, can also act as a peroxidase (EC 1.11.1.7) for which several organic substances, especially ethanol, can act as a hydrogen donor. Enzymes that exhibit both catalase and peroxidase activity belong under EC 1.11.1.21, catalase-peroxidase.
CAS REGISTRY NUMBER
COMMENTARY hide
9001-05-2
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
H2O2
O2 + H2O
show the reaction diagram
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?
ethanol + H2O2
acetaldehyde + ?
show the reaction diagram
formic acid + H2O2
?
show the reaction diagram
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?
H2O2
O2 + H2O
show the reaction diagram
methanol + H2O2
formaldehyde + ?
show the reaction diagram
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
H2O2
O2 + H2O
show the reaction diagram
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one
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2-mercaptoethanol
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3-Amino-1,2,4-triazole
3-amino-1H-1,2,4-triazole
acetic acid
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in vitro inhibitor
ascorbate
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in vitro inhibitor
azide
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very strong inhibitor of erythrocytic CAT but a relatively weak CAT inhibitor in human hemolysates
BrCN
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acting in vitro
CAS 1609
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eicosapentaenoic acid
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the incubation of Jurkat cells with 0.1 mM eicosapentaenoic acid causes a significant decrease of catalase activity but not of protein or mRNA content
ethanol
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in vitro inhibitor
F-
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in vitro inhibitor
formic acid
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in vitro inhibitor
gamma-linolenic acid
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the incubation of Jurkat cells with 0.05 mM gamma-linolenic acid causes a significant decrease of catalase activity but not of protein or mRNA content
glycerol trinitrate
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H2O2
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rapid inactivation above 0.1 M
hydroxylamine
isosorbide dinitrate
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linoleic acid
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the incubation of Jurkat cells with 0.1 mM linoleic acid causes a significant decrease of catalase activity but not of protein or mRNA content
methanol
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in vitro inhibitor
NaCN
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50% inhibition at 20 mM
nitrite
oleic acid
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the incubation of Jurkat cells with 0.2 mM oleic acid causes a significant decrease of catalase activity but not of protein or mRNA content
palmitic acid
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the incubation of Jurkat cells with 0.2 mM palmitic acid causes a significant decrease of catalase activity but not of protein or mRNA content
pentaerythritol tetranitrate
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pyocyanin
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may decrease cellular catalase activity via both transcriptional regulation and direct inactivation of the enzyme
S-nitrosoglutathione
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sodium nitroprusside
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stearic acid
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the incubation of Jurkat cells with 0.2 mM stearic acid causes a significant decrease of catalase activity but not of protein or mRNA content
additional information
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
progesterone receptor isoform B
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additional information
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