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Information on EC 1.11.1.24 - thioredoxin-dependent peroxiredoxin
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1.11.1.24 thioredoxin-dependent peroxiredoxinIUBMB Comments
Peroxiredoxins (Prxs) are a ubiquitous family of antioxidant proteins. They can be divided into three classes: typical 2-Cys, atypical 2-Cys and 1-Cys peroxiredoxins . The peroxidase reaction comprises two steps centred around a redox-active cysteine called the peroxidatic cysteine. All three peroxiredoxin classes have the first step in common, in which the peroxidatic cysteine attacks the peroxide substrate and is oxidized to S-hydroxycysteine (a sulfenic acid) (see {single/111115a::mechanism}). The second step of the peroxidase reaction, the regeneration of cysteine from S-hydroxycysteine, distinguishes the three peroxiredoxin classes. For typical 2-Cys Prxs, in the second step, the peroxidatic S-hydroxycysteine from one subunit is attacked by the 'resolving' cysteine located in the C-terminus of the second subunit, to form an intersubunit disulfide bond, which is then reduced by one of several cell-specific thiol-containing reductants completing the catalytic cycle. In the atypical 2-Cys Prxs, both the peroxidatic cysteine and its resolving cysteine are in the same polypeptide, so their reaction forms an intrachain disulfide bond. The 1-Cys Prxs conserve only the peroxidatic cysteine, so its regeneration involves direct interaction with a reductant molecule. Thioredoxin-dependent peroxiredoxins are the most common. They have been reported from archaea, bacteria, fungi, plants, and animals.
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Word Map
- 1.11.1.24
- catalase
- dismutase
- peroxidases
- s-transferase
- chloroplast
-
peroxidatic
-
hyperoxidation
- gsh
-
anti-oxidant
- glutaredoxins
-
detoxify
-
annexin
- ascorbate
-
thiol-dependent
-
neuroprotective
- leishmania
- cumene
-
sulfenic
-
redox-sensitive
- trx1
-
tert-butyl
-
redox-active
-
h2o2-induced
-
decameric
- mnsod
- trypanothione
-
t-butyl
-
nitrosative
- paraquat
-
glutathionylation
-
h2o2-mediated
- sod2
-
redox-dependent
- cyclophilin
-
2d-dige
- hepatica
- selenocysteine
-
thioredoxin-like
-
peroxide-mediated
-
peroxide-induced
-
peroxidase-like
-
redox-regulated
- ask1
- catalase-peroxidase
- auranofin
- fasciola
-
thiol-based
-
excretory-secretory
-
metal-catalyzed
- thioredoxin-1
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Reaction Schemes
Synonyms
peroxiredoxin, prdx2, prx i, peroxiredoxin 1, prx ii, peroxiredoxin 2, prdx5, alkyl hydroperoxide reductase, thioredoxin peroxidase, 2-cys prx, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
BCP
-
-
-
-
PrxQ
-
-
-
-
thioredoxin peroxidase
-
-
-
-
Tpx
-
-
-
-
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SYSTEMATIC NAME
IUBMB Comments
thioredoxin:hydroperoxide oxidoreductase
Peroxiredoxins (Prxs) are a ubiquitous family of antioxidant proteins. They can be divided into three classes: typical 2-Cys, atypical 2-Cys and 1-Cys peroxiredoxins [4]. The peroxidase reaction comprises two steps centred around a redox-active cysteine called the peroxidatic cysteine. All three peroxiredoxin classes have the first step in common, in which the peroxidatic cysteine attacks the peroxide substrate and is oxidized to S-hydroxycysteine (a sulfenic acid) (see {single/111115a::mechanism}). The second step of the peroxidase reaction, the regeneration of cysteine from S-hydroxycysteine, distinguishes the three peroxiredoxin classes. For typical 2-Cys Prxs, in the second step, the peroxidatic S-hydroxycysteine from one subunit is attacked by the 'resolving' cysteine located in the C-terminus of the second subunit, to form an intersubunit disulfide bond, which is then reduced by one of several cell-specific thiol-containing reductants completing the catalytic cycle. In the atypical 2-Cys Prxs, both the peroxidatic cysteine and its resolving cysteine are in the same polypeptide, so their reaction forms an intrachain disulfide bond. The 1-Cys Prxs conserve only the peroxidatic cysteine, so its regeneration involves direct interaction with a reductant molecule. Thioredoxin-dependent peroxiredoxins are the most common. They have been reported from archaea, bacteria, fungi, plants, and animals.
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
tert-butyl hydroperoxide + reduced dithiothreitol
tert-butanol + oxidized dithiothreitol
-
-
-
?
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
imidazole
approximately 70% of the Prx activity is lost in the presence of 0.4 M imidazole or higher. The presence of 1.6 M imidazole seems to promote protein degradation
SDS
activity is lost completely in the presence of 1% SDS or higher
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Abortion, Habitual
Association of glutamate cystein ligase (GCL) activity Peroxiredoxin 4 (prxR4) and apelin levels in women with preeclampsia.
Abortion, Habitual
Role of peroxiredoxin2 downregulation in recurrent miscarriage through regulation of trophoblast proliferation and apoptosis.
Abortion, Spontaneous
Preoxiredoxin family members (Prx3 and Prx4) and pregnancy disorder (recurrent pregnancy loss).
Abortion, Spontaneous
Proteomic analysis on the alteration of protein expression in the placental villous tissue of early pregnancy loss.
Acquired Immunodeficiency Syndrome
Attenuation of hydrogen peroxide-mediated oxidative stress by Brassica juncea annexin-3 counteracts thiol-specific antioxidant (TSA1) deficiency in Saccharomyces cerevisiae.
Acquired Immunodeficiency Syndrome
MicroRNA-383 promotes reactive oxygen species-induced autophagy via downregulating peroxiredoxin 3 in human glioma U87 cells.
Acute Lung Injury
Peroxiredoxin 1 inhibits lipopolysaccharide-induced oxidative stress in lung tissue by regulating P38/JNK signaling pathway.
Acute Lung Injury
Peroxiredoxin 6 knockout aggravates cecal ligation and puncture-induced acute lung injury.
Acute Lung Injury
[Roles of peroxiredoxin 6 in the regulation of oxidative stress to lipopolysaccharide-induced acute lung injury].
Adenocarcinoma
Bicarbonate is essential for protein-tyrosine phosphatase 1B (PTP1B) oxidation and cellular signaling through EGF-triggered phosphorylation cascades.
Adenocarcinoma
Downregulation of peroxiredoxin II suppresses the proliferation and metastasis of gastric cancer cells.
Adenocarcinoma
Elucidation of the AGR2 Interactome in Esophageal Adenocarcinoma Cells Identifies a Redox-Sensitive Chaperone Hub for the Quality Control of MUC-5AC.
Adenocarcinoma
ILK and PRDX1 are prognostic markers in squamous cell/adenosquamous carcinomas and adenocarcinoma of gallbladder.
Adenocarcinoma
Loss of Peroxiredoxin Expression Is Associated with an Aggressive Phenotype in Pancreatic Adenocarcinoma.
Adenocarcinoma
Peroxiredoxin 1 Promotes Pancreatic Cancer Cell Invasion by Modulating p38 MAPK Activity.
Adenocarcinoma
Peroxiredoxin 4 as an independent prognostic marker for survival in patients with early-stage lung squamous cell carcinoma.
Adenocarcinoma
Peroxiredoxin V Inhibits Emodin-induced Gastric Cancer Cell Apoptosis via the ROS/Bcl2 Pathway.
Adenocarcinoma
Peroxiredoxin V Silencing Elevates Susceptibility to Doxorubicin-induced Cell Apoptosis via ROS-dependent Mitochondrial Dysfunction in AGS Gastric Cancer Cells.
Adenocarcinoma
PRDX2 Promotes the Proliferation and Metastasis of Non-Small Cell Lung Cancer In Vitro and In Vivo.
Adenocarcinoma
Prx I suppresses K-ras-driven lung tumorigenesis by opposing redox-sensitive ERK/cyclin D1 pathway.
Adenocarcinoma of Lung
DACH1 inhibits the proliferation and invasion of lung adenocarcinoma through the downregulation of peroxiredoxin 3.
Adenocarcinoma of Lung
Downregulation of peroxiredoxin-1 by ?-elemene enhances the radiosensitivity of lung adenocarcinoma xenografts.
Adenocarcinoma of Lung
Inhibitory effect of novel internalized fully human phage antibody fragments on proliferation of lung adenocarcinoma cell line overexpressing peroxiredoxin I.
Adenocarcinoma of Lung
Production and radioimmunoimaging of novel fully human phage display recombinant antibodies and growth inhibition of lung adenocarcinoma cell line overexpressing Prx I.
Adenocarcinoma of Lung
Prognostic roles of mRNA expression of peroxiredoxins in lung cancer.
Adenocarcinoma of Lung
The impact of PRDX4 and the EGFR mutation status on cellular proliferation in lung adenocarcinoma.
Adenocarcinoma of Lung
[Preparation and characterization of human phage display antibody against peroxiredoxin I of lung adenocarcinoma]
Adenoma
Membrane bound Peroxiredoxin-1 serves as a biomarker for in vivo detection of sessile serrated adenomas.
Adenoma, Oxyphilic
Adult rhabdomyoma with oncocytic changes affecting the floor of the mouth: optical, immunohistochemical, and ultrastructural study.
Adenoma, Pleomorphic
Peroxiredoxin I, platelet-derived growth factor A, and platelet-derived growth factor receptor alpha are overexpressed in carcinoma ex pleomorphic adenoma: association with malignant transformation.
Adenomatous Polyposis Coli
Interaction of tankyrase and peroxiredoxin II is indispensable for the survival of colorectal cancer cells.
Adenoviridae Infections
Luteolin ameliorates rat myocardial ischaemia-reperfusion injury through activation of peroxiredoxin II.
Alzheimer Disease
Interaction of amyloid binding alcohol dehydrogenase/Abeta mediates up-regulation of peroxiredoxin II in the brains of Alzheimer's disease patients and a transgenic Alzheimer's disease mouse model.
Alzheimer Disease
Oxidative Stress and Decreased Mitochondrial Superoxide Dismutase 2 and Peroxiredoxin 1 and 4 Based Mechanism of Concurrent Activation of AMPK and mTOR in Alzheimer's disease.
Alzheimer Disease
Peroxiredoxin I regulates the component expression of ?-secretase complex causing the Alzheimer's disease.
Alzheimer Disease
Protein levels of human peroxiredoxin subtypes in brains of patients with Alzheimer's disease and Down syndrome.
Anemia
Active hematopoiesis triggers exosomal release of PRDX2 that promotes osteoclast formation.
Anemia
Calpromotin, a cytoplasmic protein, is associated with the formation of dense cells in sickle cell anemia.
Anemia
Peroxiredoxin II is essential for preventing hemolytic anemia from oxidative stress through maintaining hemoglobin stability.
Anemia, Hemolytic
Gene expression profiling related to the enhanced erythropoiesis in mouse bone marrow cells.
Anemia, Hemolytic
Global analysis of erythroid cells redox status reveals the involvement of Prdx1 and Prdx2 in the severity of beta thalassemia.
Anemia, Hemolytic
Interactions between peroxiredoxin 2, hemichrome and the erythrocyte membrane.
Anemia, Hemolytic
Peroxiredoxin 2 functions as a noncatalytic scavenger of low-level hydrogen peroxide in the erythrocyte.
Anemia, Hemolytic
Peroxiredoxin I deficiency attenuates phagocytic capacity of macrophage in clearance of the red blood cells damaged by oxidative stress.
Anemia, Hemolytic
Peroxiredoxin II is essential for preventing hemolytic anemia from oxidative stress through maintaining hemoglobin stability.
Anemia, Hemolytic
Peroxiredoxin II is essential for sustaining life span of erythrocytes in mice.
Anemia, Hypochromic
NTRC and Chloroplast-Generated Reactive Oxygen Species Regulate Pseudomonas syringae pv. tomato Disease Development in Tomato and Arabidopsis.
Anemia, Sickle Cell
Calpromotin, a cytoplasmic protein, is associated with the formation of dense cells in sickle cell anemia.
Anemia, Sickle Cell
Peroxiredoxin II is essential for preventing hemolytic anemia from oxidative stress through maintaining hemoglobin stability.
Anthrax
Immunoproteomically identified GBAA_0345, alkyl hydroperoxide reductase subunit C is a potential target for multivalent anthrax vaccine.
Anthrax
S-nitrosylation of peroxiredoxin 1 contributes to viability of lung epithelial cells during Bacillus anthracis infection.
Aortic Aneurysm
Hyperhomocysteinemia during aortic aneurysm, a plausible role of epigenetics.
Aortic Aneurysm, Abdominal
Deficiency of peroxiredoxin 2 exacerbates angiotensin II-induced abdominal aortic aneurysm.
Aortic Aneurysm, Abdominal
Identification of peroxiredoxin-1 as a novel biomarker of abdominal aortic aneurysm.
Aortic Aneurysm, Abdominal
Role of proinflammatory CD68(+) mannose receptor(-) macrophages in peroxiredoxin-1 expression and in abdominal aortic aneurysms in humans.
Aortic Aneurysm, Thoracic
Hyperhomocysteinemia during aortic aneurysm, a plausible role of epigenetics.
Arrhythmias, Cardiac
Programmable VT detection enhancements in implantable cardioverter defibrillator therapy.
Arteritis
Vasculitis induced by immunization with Bacillus Calmette-Guérin followed by atypical mycobacterium antigen: a new mouse model for Kawasaki disease.
Arthritis
Exacerbation of collagen antibody-induced arthritis in transgenic mice overexpressing peroxiredoxin 6.
Arthritis, Rheumatoid
Autoantibodies to peroxiredoxin I and IV in patients with systemic autoimmune diseases.
Arthritis, Rheumatoid
Lymphocytes from rheumatoid arthritis patients have elevated levels of intracellular peroxiredoxin 2, and a greater frequency of cells with exofacial peroxiredoxin 2, compared with healthy human lymphocytes.
Arthritis, Rheumatoid
Monocyte activation drives preservation of membrane thiols by promoting release of oxidised membrane moieties via extracellular vesicles.
Asthenozoospermia
TAT-peroxiredoxin 2 Fusion Protein Supplementation Improves Sperm Motility and DNA Integrity in Sperm Samples from Asthenozoospermic Men.
Asthenozoospermia
[Peroxiredoxin I in sperm and reactive oxygen species in seminal plasma in patients with idiopathic asthenozoospermia].
Asthma
Differential role of peroxiredoxin II (PrxII) on the expression of toll-like receptor 4 (TLR4) and B-cell activating factor (BAFF) in ovalbumin (OVA)-induced mouse asthma.
Asthma
Hyperoxidized peroxiredoxins in peripheral blood mononuclear cells of asthma patients is associated with asthma severity.
Astrocytoma
Integrated proteomic platforms for the comparative characterization of medulloblastoma and pilocytic astrocytoma pediatric brain tumors: a preliminary study.
Astrocytoma
[Expressions of peroxiredoxin 1, peroxiredoxin 6 and GFAP in human brain astrocytoma and their clinical significance].
Atherosclerosis
Deficiency of TDAG51 protects against atherosclerosis by modulating apoptosis, cholesterol efflux, and peroxiredoxin-1 expression.
Atherosclerosis
Overexpression of peroxiredoxin 4 attenuates atherosclerosis in apolipoprotein e knockout mice.
Atherosclerosis
Peroxiredoxin 2 Deficiency Exacerbates Atherosclerosis in Apolipoprotein E-Deficient Mice.
Atherosclerosis
Peroxiredoxin 4 (PRDX4): Its critical in vivo roles in animal models of metabolic syndrome ranging from atherosclerosis to nonalcoholic fatty liver disease.
Atherosclerosis
PRDX2 Protects Against Atherosclerosis by Regulating the Phenotype and Function of the Vascular Smooth Muscle Cell.
Autoimmune Diseases
A novel anti-peroxiredoxin autoantibody in patients with Kawasaki disease.
Autoimmune Diseases
Autoantibodies to peroxiredoxin I and IV in patients with systemic autoimmune diseases.
Bacterial Infections
Characterization of 2-Cys peroxiredoxin 3 and 4 in common carp and the immune response against bacterial infection.
Bacterial Infections
Molecular characterization and functional activity of Prx1 in grass carp (Ctenopharyngodon idella).
Barrett Esophagus
Elucidation of the AGR2 Interactome in Esophageal Adenocarcinoma Cells Identifies a Redox-Sensitive Chaperone Hub for the Quality Control of MUC-5AC.
Behcet Syndrome
Autoantibodies to peroxiredoxin I and IV in patients with systemic autoimmune diseases.
beta-Thalassemia
Global analysis of erythroid cells redox status reveals the involvement of Prdx1 and Prdx2 in the severity of beta thalassemia.
beta-Thalassemia
Thalassemia major patients using iron chelators showed a reduced plasma thioredoxin level and reduced thioredoxin reductase activity, despite elevated oxidative stress.
beta-Thalassemia
Thalassemic erythrocytes release microparticles loaded with hemichromes by redox activation of p72Syk kinase.
Bone Neoplasms
Recombinant protein transduction domain-Cu/Zn superoxide dismutase alleviates bone cancer pain via peroxiredoxin 4 modulation and antioxidation.
Bradycardia
Initial single-center experience with an advanced third-generation investigational defibrillator.
Brain Edema
Role of lipocalin-2 in extracellular peroxiredoxin 2-induced brain swelling, inflammation and neuronal death.
Brain Injuries
Correction to: Intracerebral Hemorrhage-Induced Brain Injury in Rats: the Role of Extracellular Peroxiredoxin 2.
Brain Injuries
Intracerebral Hemorrhage-Induced Brain Injury in Rats: the Role of Extracellular Peroxiredoxin 2.
Brain Injuries
Neuroprotective effect of a novel gastrodin derivative against ischemic brain injury: involvement of peroxiredoxin and TLR4 signaling inhibition.
Brain Injuries, Traumatic
Peroxiredoxin 2 activates microglia by interacting with Toll-like receptor 4 after subarachnoid hemorrhage.
Brain Ischemia
Differences in the protein expression levels of Trx2 and Prx3 in the hippocampal CA1 region between adult and aged gerbils following transient global cerebral ischemia.
Brain Ischemia
Peroxiredoxin 2 overexpression protects cortical neuronal cultures from ischemic and oxidative injury but not glutamate excitotoxicity, whereas Cu/Zn superoxide dismutase 1 overexpression protects only against oxidative injury.
Brain Ischemia
Role of Peroxiredoxin 2 in the Protection Against Ferrous Sulfate-Induced Oxidative and Inflammatory Injury in PC12 Cells.
Breast Neoplasms
Autoantibodies to tailor-made panels of tumor-associated antigens in breast carcinoma.
Breast Neoplasms
Expression of peroxiredoxin 1, 2, 3, and 6 genes in cancer cells during drug resistance formation.
Breast Neoplasms
Expression of thioredoxin system and related peroxiredoxin proteins is associated with clinical outcome in radiotherapy treated early stage breast cancer.
Breast Neoplasms
GATA-binding protein 1 is a novel transcription regulator of peroxiredoxin 5 in human breast cancer cells.
Breast Neoplasms
Identification of a new panel of serum autoantibodies associated with the presence of in situ carcinoma of the breast in younger women.
Breast Neoplasms
Identification of the functional role of peroxiredoxin 6 in the progression of breast cancer.
Breast Neoplasms
Involvement of peroxiredoxin IV in the 16alpha-hydroxyestrone-induced proliferation of human MCF-7 breast cancer cells.
Breast Neoplasms
Overexpression of peroxiredoxin I and thioredoxin1 in human breast carcinoma.
Breast Neoplasms
Peroxiredoxin 2 specifically regulates the oxidative and metabolic stress response of human metastatic breast cancer cells in lungs.
Breast Neoplasms
Peroxiredoxin I and II inhibit H(2)O(2)-induced cell death in MCF-7 cell lines.
Breast Neoplasms
Peroxiredoxin I and II inhibit H2O2-induced cell death in MCF-7 cell lines.
Breast Neoplasms
Peroxiredoxin overexpression in MCF-7 breast cancer cells and regulation by cell proliferation and oxidative stress.
Breast Neoplasms
Peroxiredoxin proteins protect MCF-7 breast cancer cells from doxorubicin-induced toxicity.
Breast Neoplasms
Peroxiredoxin V: A candidate breast tumor marker of population specificity.
Breast Neoplasms
Peroxiredoxin-1 protects estrogen receptor alpha from oxidative stress-induced suppression and is a protein biomarker of favorable prognosis in breast cancer.
Breast Neoplasms
Peroxiredoxin-1 Tyr194 phosphorylation regulates LOX-dependent extracellular matrix remodelling in breast cancer.
Breast Neoplasms
Protein Signatures in Human MDA-MB-231 Breast Cancer Cells Indicating a More Invasive Phenotype Following Knockdown of Human Endometase/Matrilysin-2 by siRNA.
Breast Neoplasms
Redox modifications of cysteine-containing proteins, cell cycle arrest and translation inhibition: Involvement in vitamin C-induced breast cancer cell death.
Breast Neoplasms
Selective association of peroxiredoxin 1 with genomic DNA and COX-2 upstream promoter elements in estrogen receptor negative breast cancer cells.
Breast Neoplasms
Silencing the Peroxiredoxin III gene inhibits cell proliferation in breast cancer.
Breast Neoplasms
SIRT2 Deacetylates and Inhibits the Peroxidase Activity of Peroxiredoxin-1 to Sensitize Breast Cancer Cells to Oxidant Stress-Inducing Agents.
Breast Neoplasms
Targeting peroxiredoxin 1 impairs growth of breast cancer cells and potently sensitises these cells to prooxidant agents.
Breast Neoplasms
The role of enoyl-CoA hydratase short chain 1 and peroxiredoxin 3 in PP2-induced apoptosis in human breast cancer MCF-7 cells.
Breast Neoplasms
The role of peroxiredoxin II in radiation-resistant MCF-7 breast cancer cells.
Breast Neoplasms
Thioredoxin peroxidase-1 (peroxiredoxin-1) is increased in thioredoxin-1 transfected cells and results in enhanced protection against apoptosis caused by hydrogen peroxide but not by other agents including dexamethasone, etoposide, and doxorubicin.
Breast Neoplasms
Thioredoxin system-mediated regulation of mutant Kras associated pancreatic neoplasia and cancer.
Breast Neoplasms
[Effect of peroxiredoxin I gene silencing on the radiosensitivity of breast carcinoma MCF-7 cell xenograft in nude mice].
Brucellosis
Brucella infection regulates peroxiredoxin-5 protein expression to facilitate intracellular survival by reducing the production of nitric oxide and reactive oxygen species.
Carcinogenesis
Atrazine affects phosphoprotein and protein expression in MCF-10A human breast epithelial cells.
Carcinogenesis
Characterization and Expression Analysis of Peroxiredoxin Genes in NNK-induced V79 Cells.
Carcinogenesis
Development and molecular characterization of HCT-116 cell lines resistant to the tumor promoter and multiple stress-inducer, deoxycholate.
Carcinogenesis
Differential expression of ANXA6, HSP27, PRDX2, NCF2, and TPM4 during uterine cervix carcinogenesis: diagnostic and prognostic value.
Carcinogenesis
Differential expression of peroxiredoxin 3 in laryngeal squamous cell carcinoma.
Carcinogenesis
Evaluation of Efficacy and Toxicity of Exfoliated Silicate Nanoclays as a Feed Additive for Fumonisin Detoxification.
Carcinogenesis
Expression of human peroxiredoxin isoforms in response to cervical carcinogenesis.
Carcinogenesis
Gene expression profiling of paired ovarian tumors obtained prior to and following adjuvant chemotherapy: molecular signatures of chemoresistant tumors.
Carcinogenesis
Human peroxiredoxin 1 modulates TGF-?1-induced epithelial-mesenchymal transition through its peroxidase activity.
Carcinogenesis
Induced nitric oxide synthetase and peroxiredoxin expression in intramucosal poorly differentiated gastric cancer of young patients.
Carcinogenesis
Overexpression of peroxiredoxin 2 inhibits TGF-?1-induced epithelial-mesenchymal transition and cell migration in colorectal cancer.
Carcinogenesis
p53 status is a major determinant of effects of decreasing peroxiredoxin I expression on tumor growth and response of lung cancer cells to treatment.
Carcinogenesis
Peroxiredoxin 1 Interacts with TBK1/IKK? and Negatively Regulates Pseudorabies Virus Propagation by Promoting Innate Immunity.
Carcinogenesis
Peroxiredoxin 1 promotes invasion and migration by regulating epithelial-to-mesenchymal transition during oral carcinogenesis.
Carcinogenesis
Peroxiredoxin 1 promotes tumorigenesis through regulating the activity of mTOR/p70S6K pathway in esophageal squamous cell carcinoma.
Carcinogenesis
Peroxiredoxin 2 expression is increased in neutrophils of patients with refractory cytopenia with multilineage dysplasia.
Carcinogenesis
Peroxiredoxin 3 is a novel marker for cell proliferation in cervical cancer.
Carcinogenesis
Peroxiredoxin I is important for cancer-cell survival in Ras-induced hepatic tumorigenesis.
Carcinogenesis
Peroxiredoxin II promotes hepatic tumorigenesis through cooperation with Ras/Forkhead box M1 signaling pathway.
Carcinogenesis
PRDX1 is a Tumor Suppressor for Nasopharyngeal Carcinoma by Inhibiting PI3K/AKT/TRAF1 Signaling.
Carcinogenesis
PRDX2 Promotes the Proliferation and Metastasis of Non-Small Cell Lung Cancer In Vitro and In Vivo.
Carcinogenesis
PRDX2 protects against oxidative stress induced by H. pylori and promotes resistance to cisplatin in gastric cancer.
Carcinogenesis
PRDX2 protects hepatocellular carcinoma SMMC-7721 cells from oxidative stress.
Carcinogenesis
Prdx2 Upregulation Promotes the Growth and Survival of Gastric Cancer Cells.
Carcinogenesis
Progression of secondary hyperparathyroidism involves deregulation of genes related to DNA and RNA stability.
Carcinogenesis
Prx I suppresses K-ras-driven lung tumorigenesis by opposing redox-sensitive ERK/cyclin D1 pathway.
Carcinogenesis
Silencing the Peroxiredoxin III gene inhibits cell proliferation in breast cancer.
Carcinogenesis
Survival of APC-mutant colorectal cancer cells requires interaction between tankyrase and a thiol peroxidase, peroxiredoxin II.
Carcinogenesis
[Proteomic analysis of proteins related to radiation-induced carcinogenesis]
Carcinoma
Angiogenesis in salivary carcinomas with and without myoepithelial differentiation.
Carcinoma
Assessment of Potential Prognostic Value of Peroxiredoxin 1 in Oral Squamous Cell Carcinoma.
Carcinoma
Downregulation of Peroxiredoxin I by a Novel Fully Human Phage Display Recombinant Antibody Induces Apoptosis and Enhances Radiation Sensitization in A549 Lung Carcinoma Cells.
Carcinoma
Dual inhibition of BRD4 and PI3K-AKT by SF2523 suppresses human renal cell carcinoma cell growth.
Carcinoma
Erratum: Assessment of Potential Prognostic Value of Peroxiredoxin 1 in Oral Squamous Cell Carcinoma [Corrigendum].
Carcinoma
Exploring the Natural Piericidins as Anti-Renal Cell Carcinoma Agents Targeting Peroxiredoxin 1.
Carcinoma
Expression of cyclooxygenase-2, peroxiredoxin I, peroxiredoxin 6 and nuclear factor-?B in oral squamous cell carcinoma.
Carcinoma
Expression of peroxiredoxin 1, 2, 3, and 6 genes in cancer cells during drug resistance formation.
Carcinoma
High Expression of Peroxiredoxin 1 Is Associated with Epithelial-Mesenchymal Transition Marker and Poor Prognosis in Gastric Cancer.
Carcinoma
Induction of peroxiredoxin 1 by hypoxia regulates heme oxygenase-1 via NF-?B in oral cancer.
Carcinoma
Inhibition of lung tumor growth and augmentation of radiosensitivity by decreasing peroxiredoxin I expression.
Carcinoma
Knockdown of PRDX2 sensitizes colon cancer cells to 5-FU by suppressing the PI3K/AKT signaling pathway.
Carcinoma
LncRNA LINC00460 promotes EMT in head and neck squamous cell carcinoma by facilitating peroxiredoxin-1 into the nucleus.
Carcinoma
Loss of Peroxiredoxin Expression Is Associated with an Aggressive Phenotype in Pancreatic Adenocarcinoma.
Carcinoma
Nicotine suppresses apoptosis by regulating ?7nAChR/Prx1 axis in oral precancerous lesions.
Carcinoma
Peroxiredoxin 1 is a tumor-associated antigen in esophageal squamous cell carcinoma.
Carcinoma
Peroxiredoxin 1 promotes tumorigenesis through regulating the activity of mTOR/p70S6K pathway in esophageal squamous cell carcinoma.
Carcinoma
Peroxiredoxin 2 is highly expressed in human oral squamous cell carcinoma cells and is upregulated by human papillomavirus oncoproteins and arecoline, promoting proliferation.
Carcinoma
Peroxiredoxin 4 as an independent prognostic marker for survival in patients with early-stage lung squamous cell carcinoma.
Carcinoma
Peroxiredoxin 5 is involved in cancer cell invasion and tumor growth of oral squamous cell carcinoma.
Carcinoma
Peroxiredoxin I expression in tongue squamous cell carcinomas as involved in tumor recurrence.
Carcinoma
Peroxiredoxin I, platelet-derived growth factor A, and platelet-derived growth factor receptor alpha are overexpressed in carcinoma ex pleomorphic adenoma: association with malignant transformation.
Carcinoma
Peroxiredoxin III protein expression is associated with platinum resistance in epithelial ovarian cancer.
Carcinoma
Peroxiredoxin IV protects cells from radiation-induced apoptosis in head-and-neck squamous cell carcinoma.
Carcinoma
Peroxiredoxin V is essential for protection against apoptosis in human lung carcinoma cells.
Carcinoma
PRDX2 plays an oncogenic role in esophageal squamous cell carcinoma via Wnt/?-catenin and AKT pathways.
Carcinoma
Proteomic profiling of fetal esophageal epithelium, esophageal cancer, and tumor-adjacent esophageal epithelium and immunohistochemical characterization of a representative differential protein, PRX6.
Carcinoma
Recombinant protein transduction domain-Cu/Zn superoxide dismutase alleviates bone cancer pain via peroxiredoxin 4 modulation and antioxidation.
Carcinoma
REV7 confers radioresistance of esophagus squamous cell carcinoma by recruiting PRDX2.
Carcinoma
Silencing Prx1 and/or Prx5 sensitizes human esophageal cancer cells to ionizing radiation and increases apoptosis via intracellular ROS accumulation.
Carcinoma
[Effects of yiqi chutan recipe on tumor growth, survival time and expressions of PRDX-1 and PRDX-6 in Lewis lung carcinoma model mice with pi-deficiency syndrome].
Carcinoma
[Proteomic identification and comparison of differentiation-related proteins in gastric carcinoma cell lines]
Carcinoma
[Quantitative and comparative proteomics analysis in clear cell renal cell carcinoma and adjacent noncancerous tissues by 2-D DIGE].
Carcinoma, Hepatocellular
Adenanthin targets peroxiredoxin I/II to kill hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
Detection and identification of peroxiredoxin 3 as a biomarker in hepatocellular carcinoma by a proteomic approach.
Carcinoma, Hepatocellular
Diagnostic and prognostic significance of peroxiredoxin 1 expression in human hepatocellular carcinoma.
Carcinoma, Hepatocellular
Increased oxidation and degradation of cytosolic proteins in alcohol-exposed mouse liver and hepatoma cells.
Carcinoma, Hepatocellular
Interplay Between Mitochondrial Peroxiredoxins and ROS in Cancer Development and Progression.
Carcinoma, Hepatocellular
Measurement of peroxiredoxin-4 serum levels in rat tissue and its use as a potential marker for hepatic disease.
Carcinoma, Hepatocellular
Overexpression of mitochondrial thioredoxin reductase and peroxiredoxin III in hepatocellular carcinomas.
Carcinoma, Hepatocellular
Peroxiredoxin 1 is essential for natamycin-triggered apoptosis and protective autophagy in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Peroxiredoxin 1, restraining cell migration and invasion, is involved in hepatocellular carcinoma recurrence.
Carcinoma, Hepatocellular
Peroxiredoxin 4 suppresses anoikis and augments growth and metastasis of hepatocellular carcinoma cells through the ?-catenin/ID2 pathway.
Carcinoma, Hepatocellular
Peroxiredoxin I contributes to TRAIL resistance through suppression of redox-sensitive caspase activation in human hepatoma cells.
Carcinoma, Hepatocellular
Peroxiredoxin I is important for cancer-cell survival in Ras-induced hepatic tumorigenesis.
Carcinoma, Hepatocellular
Peroxiredoxin II is essential for maintaining stemness by redox regulation in liver cancer cells.
Carcinoma, Hepatocellular
Peroxiredoxin II promotes hepatic tumorigenesis through cooperation with Ras/Forkhead box M1 signaling pathway.
Carcinoma, Hepatocellular
Persistent hepatitis C virus infection impairs ribavirin antiviral activity through clathrin-mediated trafficking of equilibrative nucleoside transporter 1.
Carcinoma, Hepatocellular
Plasma nuclear factor kappa B and serum peroxiredoxin 3 in early diagnosis of hepatocellular carcinoma.
Carcinoma, Hepatocellular
PRDX2 protects hepatocellular carcinoma SMMC-7721 cells from oxidative stress.
Carcinoma, Hepatocellular
The Association of Peroxiredoxin 4 with the Initiation and Progression of Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
[The expression of peroxiredoxin II in hepatocellular carcinoma and its significance]
Carcinoma, Lewis Lung
[Effects of yiqi chutan recipe on tumor growth, survival time and expressions of PRDX-1 and PRDX-6 in Lewis lung carcinoma model mice with pi-deficiency syndrome].
Carcinoma, Mucoepidermoid
Angiogenesis in salivary carcinomas with and without myoepithelial differentiation.
Carcinoma, Non-Small-Cell Lung
Elevated peroxiredoxin 1, but not NF-E2-related factor 2, is an independent prognostic factor for disease recurrence and reduced survival in stage I non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Peroxiredoxin 4 as an independent prognostic marker for survival in patients with early-stage lung squamous cell carcinoma.
Carcinoma, Non-Small-Cell Lung
PRDX2 Promotes the Proliferation and Metastasis of Non-Small Cell Lung Cancer In Vitro and In Vivo.
Carcinoma, Non-Small-Cell Lung
Proteomic and genomic biomarkers for Non-Small Cell Lung Cancer: Peroxiredoxin, Haptoglobin, and Alpha-1 antitrypsin.
Carcinoma, Non-Small-Cell Lung
Silencing of PRDX2 Inhibits the Proliferation and Invasion of Non-Small Cell Lung Cancer Cells.
Carcinoma, Ovarian Epithelial
Peroxiredoxin III protein expression is associated with platinum resistance in epithelial ovarian cancer.
Carcinoma, Renal Cell
Dual inhibition of BRD4 and PI3K-AKT by SF2523 suppresses human renal cell carcinoma cell growth.
Carcinoma, Renal Cell
Oxidative/nitrosative stress and peroxiredoxin 2 are associated with grade and prognosis of human renal carcinoma.
Carcinoma, Renal Cell
[Quantitative and comparative proteomics analysis in clear cell renal cell carcinoma and adjacent noncancerous tissues by 2-D DIGE].
Carcinoma, Squamous Cell
Comparative proteomic analysis of esophageal squamous cell carcinoma.
Carcinoma, Squamous Cell
Expression of thioredoxin 1 and peroxiredoxins in squamous cervical carcinoma and its predictive role in NACT.
Carcinoma, Squamous Cell
LncRNA LINC00460 promotes EMT in head and neck squamous cell carcinoma by facilitating peroxiredoxin-1 into the nucleus.
Carcinoma, Squamous Cell
Peroxiredoxin 4 as an independent prognostic marker for survival in patients with early-stage lung squamous cell carcinoma.
Carcinoma, Squamous Cell
Peroxiredoxin I expression in tongue squamous cell carcinomas as involved in tumor recurrence.
Carcinoma, Squamous Cell
Peroxiredoxin IV protects cells from radiation-induced apoptosis in head-and-neck squamous cell carcinoma.
Carcinoma, Squamous Cell
Proteomic analysis and characterisation of human cervico-vaginal fluid proteins.
Carcinoma, Squamous Cell
REV7 confers radioresistance of esophagus squamous cell carcinoma by recruiting PRDX2.
Carcinoma, Squamous Cell
Silencing of Peroxiredoxin 1 Inhibits the Proliferation of Esophageal Cancer Cells and Promotes Apoptosis by Inhibiting the Activity of the PI3K/AKT Pathway.
Cardiomegaly
Alterations in NO/ROS ratio and expression of Trx1 and Prdx2 in isoproterenol-induced cardiac hypertrophy.
Cardiomegaly
Peroxiredoxin-1 ameliorates pressure overload-induced cardiac hypertrophy and fibrosis.
Cardiomyopathies
Proteomics analysis identified peroxiredoxin 2 involved in early-phase left ventricular impairment in hamsters with cardiomyopathy.
Cardiomyopathy, Dilated
(Letter to the Editor) Response to: protective role of peroxiredoxin-4 in heart failure.
Cardiotoxicity
Galectin-3 inhibition attenuates doxorubicin-induced cardiac dysfunction by upregulating the expression of peroxiredoxin-4.
Cardiotoxicity
Hydrogen sulfide attenuates doxorubicin-induced cardiotoxicity by inhibiting the expression of peroxiredoxin III in H9c2 cells.
Cardiotoxicity
Peroxiredoxin-1 Overexpression Attenuates Doxorubicin-Induced Cardiotoxicity by Inhibiting Oxidative Stress and Cardiomyocyte Apoptosis.
Cardiovascular Diseases
Peroxiredoxin 4, a novel circulating biomarker for oxidative stress and the risk of incident cardiovascular disease and all-cause mortality.
Cardiovascular Diseases
Regulation of PDGF signalling and vascular remodelling by peroxiredoxin II.
Cardiovascular Diseases
The left ventricle proteome differentiates middle-aged and old left ventricles in mice.
Cerebral Hemorrhage
Peroxiredoxin 1-mediated activation of TLR4/NF-?B pathway contributes to neuroinflammatory injury in intracerebral hemorrhage.
Cerebral Infarction
Diagnostic performance of peroxiredoxin 1 to determine time-of-onset of acute cerebral infarction.
Cerebral Infarction
Identifying patients with cerebral infarction within the time window compatible with reperfusion therapy, diagnostic performance of glutathione S-transferase-? (GST-?) and peroxiredoxin 1 (PRDX1): exploratory prospective multicentre study FLAG-1 protocol.
Cholangiocarcinoma
Prognostic significance of peroxiredoxin 1 and ezrin-radixin-moesin-binding phosphoprotein 50 in cholangiocarcinoma.
Cholesteatoma
Upregulation of phosphorylated HSP27, PRDX2, GRP75, GRP78 and GRP94 in acquired middle ear cholesteatoma growth.
Cholesteatoma, Middle Ear
Upregulation of phosphorylated HSP27, PRDX2, GRP75, GRP78 and GRP94 in acquired middle ear cholesteatoma growth.
Colitis
Ablation of Peroxiredoxin II Attenuates Experimental Colitis by Increasing FoxO1-Induced Foxp3+ Regulatory T Cells.
Colitis
Attenuation of experimental colitis in glutathione peroxidase 1 and catalase double knockout mice through enhancing regulatory T cell function.
Colitis
Sigma-1 Receptor Engages an Anti-Inflammatory and Antioxidant Feedback Loop Mediated by Peroxiredoxin in Experimental Colitis.
Colitis, Ulcerative
Elevated antibody responses in patients with Crohn's disease against a 14-kDa secreted protein purified from Mycobacterium avium subsp. paratuberculosis.
Colitis, Ulcerative
Peroxiredoxin 1 expression in active ulcerative colitis mucosa identified by proteome analysis and involvement of thioredoxin based on immunohistochemistry.
Colitis, Ulcerative
Silencing of peroxiredoxin 1 expression ameliorates ulcerative colitis in a rat model.
Colonic Neoplasms
Knockdown of PRDX2 sensitizes colon cancer cells to 5-FU by suppressing the PI3K/AKT signaling pathway.
Colonic Neoplasms
Peroxiredoxin 2 is essential for maintaining cancer stem cell-like phenotype through activation of Hedgehog signaling pathway in colon cancer.
Colonic Neoplasms
Peroxiredoxin 5 promotes the epithelial-mesenchymal transition in colon cancer.
Colonic Neoplasms
Peroxiredoxin V Reduces ?-Lapachone-induced Apoptosis of Colon Cancer Cells.
Colonic Neoplasms
Shikonin-induced Apoptosis of Colon Cancer Cells Is Reduced by Peroxiredoxin V Expression.
Colonic Neoplasms
siPRDX2-elevated DNM3 inhibits the proliferation and metastasis of colon cancer cells via AKT signaling pathway.
Colorectal Neoplasms
High expression of peroxiredoxin 4 affects the survival time of colorectal cancer patients, but is not an independent unfavorable prognostic factor.
Colorectal Neoplasms
Interaction of tankyrase and peroxiredoxin II is indispensable for the survival of colorectal cancer cells.
Colorectal Neoplasms
Overexpression of peroxiredoxin 2 inhibits TGF-?1-induced epithelial-mesenchymal transition and cell migration in colorectal cancer.
Colorectal Neoplasms
Peroxiredoxin 1 promoted tumor metastasis and angiogenesis in colorectal cancer.
Colorectal Neoplasms
Peroxiredoxin 2 is associated with colorectal cancer progression and poor survival of patients.
Colorectal Neoplasms
Peroxiredoxin 2 is essential for maintaining cancer stem cell-like phenotype through activation of Hedgehog signaling pathway in colon cancer.
Colorectal Neoplasms
Peroxiredoxin 2 is involved in vasculogenic mimicry formation by targeting VEGFR2 activation in colorectal cancer.
Colorectal Neoplasms
Peroxiredoxin 2 is upregulated in colorectal cancer and contributes to colorectal cancer cells' survival by protecting cells from oxidative stress.
Colorectal Neoplasms
Peroxiredoxin 2 knockdown by RNA interference inhibits the growth of colorectal cancer cells by downregulating Wnt/?-catenin signaling.
Colorectal Neoplasms
PRDX2 promotes the proliferation of colorectal cancer cells by increasing the ubiquitinated degradation of p53.
Colorectal Neoplasms
PRDX2 removal inhibits the cell cycle and autophagy in colorectal cancer cells.
Colorectal Neoplasms
Prognostic role of serum AZGP1, PEDF and PRDX2 in colorectal cancer patients.
Colorectal Neoplasms
Survival of APC-mutant colorectal cancer cells requires interaction between tankyrase and a thiol peroxidase, peroxiredoxin II.
Corneal Dystrophies, Hereditary
Confirmation of PRDX3 c.568G>C as the Genetic Basis of Punctiform and Polychromatic Pre-Descemet Corneal Dystrophy.
Corneal Dystrophies, Hereditary
Torin 1 alleviates impairment of TFEB-mediated lysosomal biogenesis and autophagy in TGFBI (p.G623_H626del)-linked Thiel-Behnke corneal dystrophy.
Coronary Artery Disease
[Concentration of proinflammatory cytokines, peroxiredoxin-1 and glutathione peroxidase activity in the blood plasma of patients with coronary artery disease undergoing coronary artery bypass grafting].
Coronary Occlusion
Hyperbaric oxygenation improves redox control and reduces mortality in the acute phase of myocardial infarction in a rat model.
COVID-19
Blockade of SARS-CoV-2 infection in vitro by highly potent PI3K-?/mTOR/BRD4 inhibitor.
Crohn Disease
Elevated antibody responses in patients with Crohn's disease against a 14-kDa secreted protein purified from Mycobacterium avium subsp. paratuberculosis.
Crohn Disease
Molecular cloning reveals nearly half of patients with Crohn's disease have an antibody to peroxiredoxin 6-like protein.
Cryptorchidism
Impaired expression of peroxiredoxin 4 in damaged testes by artificial cryptorchidism.
Cysticercosis
Taenia solium: antioxidant metabolism enzymes as targets for cestocidal drugs and vaccines.
Cysts
Cloning, expression and functional characterisation of a peroxiredoxin from the potato cyst nematode Globodera rostochiensis.
Cysts
Quantitative Proteomic Analysis and Evaluation of the Potential Prognostic Biomarkers in Cholangiocarcinoma.
Dengue
Differential expression of aldolase, alpha tubulin and thioredoxin peroxidase in peripheral blood mononuclear cells from dengue fever and dengue hemorrhagic fever patients.
Diabetes Mellitus
Hyperhomocysteinemic diabetic cardiomyopathy: oxidative stress, remodeling, and endothelial-myocyte uncoupling.
Diabetes Mellitus
Peroxiredoxin isoforms are associated with cardiovascular risk factors in type 2 diabetes mellitus.
Diabetes Mellitus
Proteomic analysis of mouse islets after multiple low-dose streptozotocin injection.
Diabetes Mellitus
Serum peroxiredoxin 4: a marker of oxidative stress associated with mortality in type 2 diabetes (ZODIAC-28).
Diabetes Mellitus, Type 1
Peroxiredoxin III protects pancreatic {beta} cells from apoptosis.
Diabetes Mellitus, Type 1
Proteomic analysis of mouse islets after multiple low-dose streptozotocin injection.
Diabetes Mellitus, Type 2
Circulating peroxiredoxin 4 and type 2 diabetes risk: the Prevention of Renal and Vascular Endstage Disease (PREVEND) study.
Diabetes Mellitus, Type 2
Expression of hepatic antioxidant enzymes in non-obese type-2 diabetic Goto-Kakizaki rats.
Diabetes Mellitus, Type 2
PEROXIREDOXIN 4 PROTECTS AGAINST NONALCOHOLIC STEATOHEPATITIS AND TYPE 2 DIABETES IN A NONGENETIC MOUSE MODEL.
Diabetes Mellitus, Type 2
Peroxiredoxin isoforms are associated with cardiovascular risk factors in type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
Serum peroxiredoxin 4: a marker of oxidative stress associated with mortality in type 2 diabetes (ZODIAC-28).
Diabetes Mellitus, Type 2
Training increases peroxiredoxin 2 contents in the erythrocytes of overweight/obese men suffering from type 2 diabetes.
Diabetic Cardiomyopathies
Mitochondrial Peroxiredoxin-3 protects against hyperglycemia induced myocardial damage in Diabetic cardiomyopathy.
Diabetic Nephropathies
Decoy receptor 2 mediation of the senescent phenotype of tubular cells by interacting with peroxiredoxin 1 presents a novel mechanism of renal fibrosis in diabetic nephropathy.
dimethylargininase deficiency
Dimethylarginine Dimethylaminohydrolase 1 Deficiency Induces the Epithelial to Mesenchymal Transition in Renal Proximal Tubular Epithelial Cells and Exacerbates Kidney Damage in Aged and Diabetic Mice.
Down Syndrome
Peroxiredoxin 2 (PRDX2), an antioxidant enzyme, is under-expressed in Down syndrome fetal brains.
Down Syndrome
Protein levels of human peroxiredoxin subtypes in brains of patients with Alzheimer's disease and Down syndrome.
Drug Hypersensitivity
Variability of the Genes Involved in the Cellular Redox Status and Their Implication in Drug Hypersensitivity Reactions.
Dry Eye Syndromes
Antigen-Antibody Affinity for Dry Eye Biomarkers by Label Free Biosensing. Comparison with the ELISA Technique.
Dysentery, Amebic
Comparative proteomic analysis of two Entamoeba histolytica strains with different virulence phenotypes identifies peroxiredoxin as an important component of amoebic virulence.
Echinococcosis
Functional expression and characterization of Echinococcus granulosus thioredoxin peroxidase suggests a role in protection against oxidative damage.
Echinococcosis
Preliminary Evaluation of Recombinant EPC1 and TPx for Serological Diagnosis of Animal Cystic Echinococcosis.
Echinococcosis
Thioredoxin peroxidase from Echinococcus granulosus: a candidate to extend the antigenic panel for the immunodiagnosis of human cystic echinococcosis.
Elephantiasis, Filarial
Brugia malayi thioredoxin peroxidase as a potential vaccine candidate antigen for lymphatic filariasis.
Elephantiasis, Filarial
Evaluation of immunoprophylactic efficacy of Brugia malayi transglutaminase (BmTGA) in single and multiple antigen vaccination with BmALT-2 and BmTPX for human lymphatic filariasis.
Elephantiasis, Filarial
Proliferative responses of Brugia malayi TPX-1 and its epitopic peptide(29-43) in an endemic population of human lymphatic filariasis.
Endometrial Hyperplasia
Expression and prognostic significance of human peroxiredoxin isoforms in endometrial cancer.
Endometrial Neoplasms
Expression and prognostic significance of human peroxiredoxin isoforms in endometrial cancer.
Endometrial Neoplasms
Overexpression of peroxiredoxin-3 and -5 is a potential biomarker for prognosis in endometrial cancer.
Endometrial Neoplasms
Peroxiredoxin 3 maintains the survival of endometrial cancer stem cells by regulating oxidative stress.
Endometriosis
An investigation of the effects of endometriosis on the proteome of human eutopic endometrium: a heterogeneous tissue with a complex disease.
Endometriosis
Decreased Expression of Peroxiredoxin in Patients with Ovarian Endometriosis Cysts.
Endometriosis
Down-regulation of 8-Hydroxydeoxyguanosine and Peroxiredoxin II in the Pathogenesis of Endometriosis-associated Ovarian Cancer.
Esophageal Neoplasms
Polymorphisms of peroxiredoxin 1, 2 and 6 are not associated with esophageal cancer.
Esophageal Neoplasms
Pro-Apoptotic Effects of JDA-202, a Novel Natural Diterpenoid, on Esophageal Cancer Through Targeting Peroxiredoxin I.
Esophageal Neoplasms
Proteomic profiling of fetal esophageal epithelium, esophageal cancer, and tumor-adjacent esophageal epithelium and immunohistochemical characterization of a representative differential protein, PRX6.
Esophageal Neoplasms
Silencing of Peroxiredoxin 1 Inhibits the Proliferation of Esophageal Cancer Cells and Promotes Apoptosis by Inhibiting the Activity of the PI3K/AKT Pathway.
Esophageal Neoplasms
Silencing Prx1 and/or Prx5 sensitizes human esophageal cancer cells to ionizing radiation and increases apoptosis via intracellular ROS accumulation.
Esophageal Squamous Cell Carcinoma
Peroxiredoxin 1 is a tumor-associated antigen in esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
Peroxiredoxin 1 promotes tumorigenesis through regulating the activity of mTOR/p70S6K pathway in esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
PRDX2 plays an oncogenic role in esophageal squamous cell carcinoma via Wnt/?-catenin and AKT pathways.
Fanconi Anemia
Defective mitochondrial peroxiredoxin-3 results in sensitivity to oxidative stress in Fanconi anemia.
Fatty Liver
Peroxiredoxin 5 ameliorates obesity-induced non-alcoholic fatty liver disease through the regulation of oxidative stress and AMP-activated protein kinase signaling.
Fatty Liver, Alcoholic
The critical role of redox regulation of PTEN and peroxiredoxin III in alcoholic fatty liver.
Fetal Alcohol Spectrum Disorders
Catalase and peroxiredoxin 5 protect Xenopus embryos against alcohol-induced ocular anomalies.
Fibrosarcoma
Peroxiredoxin 1 (PRDX1) Suppresses Progressions and Metastasis of Osteosarcoma and Fibrosarcoma of Bone.
Fuchs' Endothelial Dystrophy
Decreased expression of peroxiredoxins in Fuchs' endothelial dystrophy.
Gallstones
Identification of cholesterol gallstone with two-dimensional gel electrophoresis and mass spectrometry.
Gastritis
Induced nitric oxide synthetase and peroxiredoxin expression in intramucosal poorly differentiated gastric cancer of young patients.
Gastritis
Production of polyclonal antibody against alkyl hydroperoxide reductase of Helicobacter pylori and its antigenicity.
Gastrointestinal Neoplasms
Genetic Inactivation of Peroxiredoxin-I Impairs the Growth of Human Pancreatic Cancer Cells.
Gastrointestinal Stromal Tumors
PCAT6 mediates cellular biological functions in gastrointestinal stromal tumor via upregulation of PRDX5 and activation of Wnt pathway.
Glioblastoma
High cell density increases glioblastoma cell viability under glucose deprivation via degradation of the cystine/glutamate transporter xCT (SLC7A11).
Glioblastoma
Inhibition of reductase systems by 2-AAPA modulates peroxiredoxin oxidation and mitochondrial function in A172 glioblastoma cells.
Glioblastoma
Mammalian target of rapamycin inhibitors, temsirolimus and torin 1, attenuate stemness-associated properties and expression of mesenchymal markers promoted by phorbol-myristate-acetate and oncostatin-M in glioblastoma cells.
Glioblastoma
Suppression of peroxiredoxin 4 in glioblastoma cells increases apoptosis and reduces tumor growth.
Glioma
Decreasing peroxiredoxin II expression decreases glutathione, alters cell cycle distribution, and sensitizes glioma cells to ionizing radiation and H(2)O(2).
Glioma
Downregulation of PRDX1 by promoter hypermethylation is frequent in 1p/19q-deleted oligodendroglial tumours and increases radio- and chemosensitivity of Hs683 glioma cells in vitro.
Glioma
lnc-NLC1-C inhibits migration, invasion and autophagy of glioma cells by targeting miR-383 and regulating PRDX-3 expression.
Glioma
MicroRNA-383 promotes reactive oxygen species-induced autophagy via downregulating peroxiredoxin 3 in human glioma U87 cells.
Glioma
Piperlongumine treatment inactivates peroxiredoxin 4, exacerbates endoplasmic reticulum stress, and preferentially kills high-grade glioma cells.
Glioma
Redox proteomics reveal stress responsive proteins linking peroxiredoxin-1 status in glioma to chemosensitivity and oxidative stress.
Glioma
Tissue Proteome Analysis of Different Grades of Human Gliomas Provides Major Cues for Glioma Pathogenesis.
Head and Neck Neoplasms
The role of peroxiredoxin II in chemoresistance of breast cancer cells.
Hearing Loss, Sensorineural
PRDX1 activates autophagy via the PTEN-AKT signaling pathway to protect against cisplatin-induced spiral ganglion neuron damage.
Heart Arrest
CT-proAVP (copeptin), MR-proANP and Peroxiredoxin 4 after cardiac arrest: release profiles and correlation to outcome.
Heart Failure
(Letter to the Editor) Response to: protective role of peroxiredoxin-4 in heart failure.
Heart Failure
Proteomic analysis of left ventricular remodeling in an experimental model of heart failure.
Hemangiosarcoma
Expression of peroxiredoxin II in vascular tumors of the skin: a novel vascular marker of endothelial cells.
Hepatitis
Laser capture microdissection in comparative proteomic analysis of hepatocellular carcinoma.
Hepatitis B
Peroxiredoxin 2: a potential biomarker for early diagnosis of hepatitis B virus related liver fibrosis identified by proteomic analysis of the plasma.
Hepatoblastoma
Peroxiredoxin 4 promotes embryonal hepatoblastoma cell migration but induces fetal cell differentiation.
Hepatolenticular Degeneration
Measurement of peroxiredoxin-4 serum levels in rat tissue and its use as a potential marker for hepatic disease.
Herpes Zoster
Identification of differentially expressed reproductive and metabolic proteins in the female abalone (Haliotis laevigata) gonad following artificial induction of spawning.
Herpes Zoster
Imbalanced testicular metabolism induced by thyroid disorders: New evidences from quantitative proteome.
HIV Infections
HIV-1 antiviral activity of recombinant natural killer cell enhancing factors, NKEF-A and NKEF-B, members of the peroxiredoxin family.
Hodgkin Disease
Differential protein expression of peroxiredoxin-1 in classical Hodgkin Lymphoma: a possible correlation to clinical behaviour.
Hodgkin Disease
Interplay Between Mitochondrial Peroxiredoxins and ROS in Cancer Development and Progression.
Hodgkin Disease
The PRDX2 gene is transcriptionally silenced and de novo methylated in Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma.
Hydronephrosis
Peroxiredoxin I protein, a potential biomarker of hydronephrosis in fetal mice exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Hyperalgesia
Recombinant protein transduction domain-Cu/Zn superoxide dismutase alleviates bone cancer pain via peroxiredoxin 4 modulation and antioxidation.
Hyperglycemia
Changes in mouse liver and chicken embryo yolk sac membrane soluble proteins due to an organophosphorous insecticide (OPI) diazinon linked to several noncholinergic OPI effects in mice and chicken embryos.
Hyperglycemia
Mitochondrial Peroxiredoxin-3 protects against hyperglycemia induced myocardial damage in Diabetic cardiomyopathy.
Hyperhomocysteinemia
Hyperhomocysteinemia and Bleomycin Hydrolase Modulate the Expression of Mouse Brain Proteins Involved in Neurodegeneration.
Hypersensitivity
Humoral and in vivo cellular immunity against the raw insect-derived recombinant Leishmania infantum antigens KMPII, TRYP, LACK, and papLe22 in dogs from an endemic area.
Hypertension
Analysis of peroxiredoxin decreasing oxidative stress in hypertensive aortic smooth muscle.
Hypertension
S 35171 exerts protective effects in spontaneously hypertensive stroke-prone rats by preserving mitochondrial function.
Hyperthyroidism
Redox Regulation of Myocardial ERK 1/2 Phosphorylation in Experimental Hyperthyroidism: Role of Thioredoxin - Peroxiredoxin System.
Idiopathic Pulmonary Fibrosis
Bronchoalveolar lavage fluid protein composition in patients with sarcoidosis and idiopathic pulmonary fibrosis: a two-dimensional electrophoretic study.
Idiopathic Pulmonary Fibrosis
Peroxiredoxin II expression and its association with oxidative stress and cell proliferation in human idiopathic pulmonary fibrosis.
Idiopathic Pulmonary Fibrosis
The overexpression of peroxiredoxin-4 affects the progression of idiopathic pulmonary fibrosis.
Infarction, Middle Cerebral Artery
Human umbilical cord blood cells protect oligodendrocytes from brain ischemia through Akt signal transduction.
Infections
A study of the interaction between H. pylori mice passage strains and gastric epithelial cells.
Infections
Analysis of thioredoxin peroxidase as a promising antigen for diagnosis of Fasciola gigantica infection A preliminary study.
Infections
Biomphalaria glabrata peroxiredoxin: Effect of Schistosoma mansoni infection on differential gene regulation.
Infections
Blood-based gene expression profile of oxidative stress and antioxidant genes for identifying surrogate markers of liver tissue injury in chronic hepatitis C patients.
Infections
Brucella infection regulates peroxiredoxin-5 protein expression to facilitate intracellular survival by reducing the production of nitric oxide and reactive oxygen species.
Infections
Cofilin-1, peroxiredoxin-1, and galectin-3: Major proteins released by macrophages infected with Corynebacterium pseudotuberculosis.
Infections
Comparative proteomic analysis of two Entamoeba histolytica strains with different virulence phenotypes identifies peroxiredoxin as an important component of amoebic virulence.
Infections
Comparison of gene expression of pyruvate kinase and tryparedoxin peroxidase in metacyclic promastigote forms of Leishmania (L.) tropica and L. major by real-time PCR
Infections
Differential expression of aldolase, alpha tubulin and thioredoxin peroxidase in peripheral blood mononuclear cells from dengue fever and dengue hemorrhagic fever patients.
Infections
Differential proteomic analysis of children infected with respiratory syncytial virus.
Infections
Effects of overexpression of the alkyl hydroperoxide reductase AhpC on the virulence and isoniazid resistance of Mycobacterium tuberculosis.
Infections
Essential role of the peroxiredoxin 4 in Procambarus clarkii antioxidant defense and immune responses.
Infections
Evaluation of the immune response against Trypanosoma cruzi cytosolic tryparedoxin peroxidase in human natural infection.
Infections
Excretory/secretory products from in vitro-cultured Echinococcus granulosus protoscoleces.
Infections
Expression profiles of peroxiredoxins in liver stage of the rodent malaria parasite Plasmodium berghei.
Infections
Functional expression and characterization of Echinococcus granulosus thioredoxin peroxidase suggests a role in protection against oxidative damage.
Infections
Helminth 2-Cys peroxiredoxin drives Th2 responses through a mechanism involving alternatively activated macrophages.
Infections
Identification and characterization of atypical 2-cysteine peroxiredoxins from mud crab Scylla paramamosain: The first evidence of two peroxiredoxin 5 genes in non-primate species and their involvement in immune defense against pathogen infection.
Infections
Identification of a thioredoxin peroxidase gene involved in resistance to nucleopolyhedrovirus infection in Helicoverpa armigera with RNA interference.
Infections
Immunization with alkyl hydroperoxide reductase subunit C reduces Fusobacterium nucleatum load in the intestinal tract.
Infections
Induction of autophagy by PI3K/MTOR and PI3K/MTOR/BRD4 inhibitors suppresses HIV-1 replication.
Infections
Influenza virus differentially activates mTORC1 and mTORC2 signaling to maximize late stage replication.
Infections
Intraphagosomal peroxynitrite as a macrophage-derived cytotoxin against internalized Trypanosoma cruzi: consequences for oxidative killing and role of microbial peroxiredoxins in infectivity.
Infections
JNK/FOXO mediated PeroxiredoxinV expression regulates redox homeostasis during Drosophila melanogaster gut infection.
Infections
Leishmania mitochondrial peroxiredoxin plays a crucial peroxidase-unrelated role during infection: insight into its novel chaperone activity.
Infections
Litopenaeus vannamei peroxiredoxin 2-like is involved in WSSV infection by interaction with wsv089 and VP26.
Infections
Molecular cloning, expression analysis and characterization of peroxiredoxin during WSSV infection in shrimp Fenneropenaeus indicus.
Infections
Molecular cloning, expression and enzymatic activity of a thioredoxin peroxidase from Dirofilaria immitis.
Infections
Molecular Mechanisms of AhpC in Resistance to Oxidative Stress in Burkholderia thailandensis.
Infections
Molecular structure and functional characterization of the peroxiredoxin 5 in Procambarus clarkii following LPS and Poly I:C challenge.
Infections
Oligomerization dynamics and functionality of Trypanosoma cruzi cytosolic tryparedoxin peroxidase as peroxidase and molecular chaperone.
Infections
Peroxiredoxin 1 protects the pea aphid Acyrthosiphon pisum from oxidative stress induced by Micrococcus luteus infection.
Infections
Peroxiredoxin 3 promotes IL-12 production from macrophages and partially protects mice against infection with Toxoplasma gondii.
Infections
Peroxiredoxin Asp f3 Is Essential for Aspergillus fumigatus To Overcome Iron Limitation during Infection.
Infections
Peroxiredoxin I protects gastric mucosa from oxidative injury induced by H. pylori infection.
Infections
Peroxiredoxin-1 of macrophage is critical for mycobacterial infection and is controlled by early secretory antigenic target protein through the activation of p38 MAPK.
Infections
Peroxiredoxins from Trypanosoma cruzi: virulence factors and drug targets for treatment of Chagas disease?
Infections
Poplar peroxiredoxin Q. A thioredoxin-linked chloroplast antioxidant functional in pathogen defense.
Infections
Potential of recombinant 2-Cys peroxiredoxin protein as a vaccine for Fasciola gigantica infection.
Infections
PRDX2 protects against oxidative stress induced by H. pylori and promotes resistance to cisplatin in gastric cancer.
Infections
Protective Role of Peroxiredoxin I in Heat-Killed Staphylococcus Aureus-infected Mice.
Infections
Proteomic analysis reveals differentially abundant proteins probably involved in the virulence of amastigote and promastigote forms of Leishmania infantum.
Infections
Proteomic Changes during MCMV Infection Revealed by iTRAQ Quantitative Proteomic Analysis in Maize.
Infections
Proteomic profiles of mouse neuro N2a cells infected with variant virulence of rabies viruses.
Infections
Recognition Pattern of the Fasciola hepatica Excretome/Secretome during the Course of an Experimental Infection in Sheep by 2D Immunoproteomics.
Infections
Roles of alkyl hydroperoxide reductase subunit C (AhpC) in viable but nonculturable Vibrio parahaemolyticus.
Infections
S-nitrosylation of peroxiredoxin 1 contributes to viability of lung epithelial cells during Bacillus anthracis infection.
Infections
Schistosome infection stimulates host CD4(+) T helper cell and B-cell responses against a novel egg antigen, thioredoxin peroxidase.
Infections
Thioredoxin peroxidase secreted by Echinococcus granulosus (sensu stricto) promotes the alternative activation of macrophages via PI3K/AKT/mTOR pathway.
Infections
Trans-sialidase overcomes many antigens to be used as a vaccine candidate against Trypanosoma cruzi.
Infections
Up-regulation of cytosolic tryparedoxin in Amp B resistant isolates of Leishmania donovani and its interaction with cytosolic tryparedoxin peroxidase.
Infections
Use of in vivo induced technology to identify antigens expressed by Photobacterium damselae subsp. piscicida during infection of Senegalese sole (Solea senegalensis).
Infections
VACCINE-INDUCED PROTECTION AGAINST MURINE SCHISTOSOMIASIS MANSONI WITH LARVAL EXCRETORY-SECRETORY ANTIGENS AND PAPAIN OR TYPE-2 CYTOKINES.
Infertility
Melatonin in testes of infertile men: evidence for anti-proliferative and anti-oxidant effects on local macrophage and mast cell populations.
Influenza, Human
Peroxiredoxin 1 protein interacts with influenza virus ribonucleoproteins and is required for efficient virus replication.
Influenza, Human
Redox proteomics of the inflammatory secretome identifies a common set of redoxins and other glutathionylated proteins released in inflammation, influenza virus infection and oxidative stress.
Influenza, Human
The tetrameric structure of Haemophilus influenza hybrid Prx5 reveals interactions between electron donor and acceptor proteins.
Insulin Resistance
Down regulation of Peroxiredoxin-3 in 3T3-L1 adipocytes leads to oxidation of Rictor in the mammalian-target of rapamycin complex 2 (mTORC2).
Insulin Resistance
Increased peroxiredoxin 4 levels in patients with prediabetes compared to normal glucose tolerance subjects.
Insulin Resistance
Peroxiredoxin 2 deficiency does not affect insulin resistance and oxidative stress in high-fat diet-fed obese mice.
Insulin Resistance
Peroxiredoxin 2 mediates insulin sensitivity of skeletal muscles through regulation of protein tyrosine phosphatase oxidation.
Insulin Resistance
Plekhs1 and Prdx3 are candidate genes responsible for mild hyperglycemia associated with obesity in a new animal model of F344-fa-nidd6 rat.
Insulin Resistance
Redox-Oligomeric State of Peroxiredoxin-2 and Glyceraldehyde-3-Phosphate Dehydrogenase in Obstructive Sleep Apnea Red Blood Cells under Positive Airway Pressure Therapy.
Intestinal Neoplasms
Adenovirus-mediated transfer of siRNA against peroxiredoxin I enhances the radiosensitivity of human intestinal cancer.
Intestinal Volvulus
Molecular cloning of an enzymatically active thioredoxin peroxidase from Onchocerca volvulus.
Intestinal Volvulus
Thioredoxin peroxidase from Onchocerca volvulus: a major hydrogen peroxide detoxifying enzyme in filarial parasites.
Iron Overload
Peroxiredoxin 5 prevents iron overload-induced neuronal death by inhibiting mitochondrial fragmentation and endoplasmic reticulum stress in mouse hippocampal HT-22 cells.
Irritable Bowel Syndrome
Association of Peroxiredoxin 1 and brain-derived neurotrophic factor serum levels with depression and anxiety symptoms in patients with irritable bowel syndrome.
Irritable Bowel Syndrome
Peroxiredoxin 1 as an inflammatory marker in diarrhea-predominant and postinfectious irritable bowel syndrome.
Ischemic Attack, Transient
Changes in the expression of mitochondrial peroxiredoxin and thioredoxin in neurons and glia and their protective effects in experimental cerebral ischemic damage.
Ischemic Attack, Transient
Comparison of the Immunoreactivity of Trx2/Prx3 Redox System in the Hippocampal CA1 Region Between the Young and Adult Gerbil Induced by Transient Cerebral Ischemia.
Ischemic Stroke
Neuroprotective effect of a novel gastrodin derivative against ischemic brain injury: involvement of peroxiredoxin and TLR4 signaling inhibition.
Ischemic Stroke
Peroxiredoxin 2 activates microglia by interacting with Toll-like receptor 4 after subarachnoid hemorrhage.
Ischemic Stroke
Peroxiredoxin 5 (PRX5) is correlated inversely to systemic markers of inflammation in acute stroke.
Leishmaniasis
Cloning, expression and dynamic simulation of TRYP6 from Leishmania major (MRHO/IR/75/ER).
Leishmaniasis
Dataset generated for Dissection of mechanisms of Trypanothione Reductase and Tryparedoxin Peroxidase through dynamic network analysis and simulations in leishmaniasis.
Leishmaniasis
Identification of antibodies to Leishmania silent information regulatory 2 (SIR2) protein homologue during canine natural infections: pathological implications.
Leishmaniasis
Leishmania amazonensis amastigotes highly express a tryparedoxin peroxidase isoform that increases parasite resistance to macrophage antimicrobial defenses and Fosters parasite virulence.
Leishmaniasis
Molecular diagnosis of Old World leishmaniasis: real-time PCR based on tryparedoxin peroxidase gene for the detection and identification of Leishmania spp.
Leishmaniasis
Targeting polyamine metabolism for finding new drugs against leishmaniasis: a review.
Leishmaniasis
Tryparedoxin peroxidase of Leishmania braziliensis: homology modeling and inhibitory effects of flavonoids for anti-leishmanial activity.
Leishmaniasis, Cutaneous
Molecular diagnosis of Old World leishmaniasis: real-time PCR based on tryparedoxin peroxidase gene for the detection and identification of Leishmania spp.
Leishmaniasis, Visceral
Antibodies against a Leishmania infantum peroxiredoxin as a possible marker for diagnosis of visceral leishmaniasis and for monitoring the efficacy of treatment.
Leishmaniasis, Visceral
Crucial role of cytosolic tryparedoxin peroxidase in Leishmania donovani survival, drug response and virulence.
Leishmaniasis, Visceral
Immunological consequences of stress-related proteins - cytosolic tryparedoxin peroxidase and chaperonin TCP20 - identified in splenic amastigotes of Leishmania donovani as Th1 stimulatory, in experimental visceral leishmaniasis.
Leukemia
Downregulation of the c-MYC target gene, peroxiredoxin III, contributes to arsenic trioxide-induced apoptosis in acute promyelocytic leukemia.
Leukemia
Identification of H7 as a novel peroxiredoxin I inhibitor to induce differentiation of leukemia cells.
Leukemia
Peroxiredoxin 3 Has Important Roles on Arsenic Trioxide Induced Apoptosis in Human Acute Promyelocytic Leukemia Cell Line via Hyperoxidation of Mitochondrial Specific Reactive Oxygen Species.
Leukemia
Redox Control of Leukemia: From Molecular Mechanisms to Therapeutic Opportunities.
Leukemia
Targeting antioxidant enzyme expression as a therapeutic strategy for ischemic stroke.
Leukemia
Targeting peroxiredoxin I potentiates 1,25-dihydroxyvitamin D3-induced cell differentiation in leukemia cells.
Leukemia
The antioxidant protein peroxiredoxin 4 is epigenetically down regulated in acute promyelocytic leukemia.
Leukemia
Thioredoxin peroxidase is a novel inhibitor of apoptosis with a mechanism distinct from that of Bcl-2.
Leukemia
[Adenanthin Induces Differentiation of Acute Promyelocytic Leukemia Cells by Targeting Peroxiredoxin III].
Leukemia, B-Cell
Cytotoxicity and expression of genes involved in the cellular stress response and apoptosis in mammalian fibroblast exposed to cotton cellulose nanofibers.
Leukemia, Erythroblastic, Acute
Expression of peroxiredoxin 1, 2, 3, and 6 genes in cancer cells during drug resistance formation.
Leukemia, Erythroblastic, Acute
The role of peroxiredoxin III on late stage of proerythrocyte differentiation.
Leukemia, Myeloid
Downregulation of topoisomerase IIbeta in myeloid leukemia cell lines leads to activation of apoptosis following all-trans retinoic acid-induced differentiation/growth arrest.
Leukemia, Myeloid
Genetic and Epigenetic Perturbations by DNMT3A-R882 Mutants Impaired Apoptosis through Augmentation of PRDX2 in Myeloid Leukemia Cells.
Leukemia, Myeloid
Peroxiredoxin genes are not induced in myeloid leukemia cells exposed to ionizing radiation.
Leukemia, Myeloid, Acute
MicroRNA-26a-5p and microRNA-23b-3p up-regulate peroxiredoxin III in acute myeloid leukemia.
Leukemia, Myeloid, Acute
PRDX4, a member of the peroxiredoxin family, is fused to AML1 (RUNX1) in an acute myeloid leukemia patient with a t(X;21)(p22;q22).
Leukemia, Myeloid, Acute
Sulforaphane Modulates AQP8-Linked Redox Signalling in Leukemia Cells.
Leukemia, Promyelocytic, Acute
Downregulation of the c-MYC target gene, peroxiredoxin III, contributes to arsenic trioxide-induced apoptosis in acute promyelocytic leukemia.
Leukemia, Promyelocytic, Acute
Peroxiredoxin 3 Has Important Roles on Arsenic Trioxide Induced Apoptosis in Human Acute Promyelocytic Leukemia Cell Line via Hyperoxidation of Mitochondrial Specific Reactive Oxygen Species.
Leukemia, Promyelocytic, Acute
The antioxidant protein peroxiredoxin 4 is epigenetically down regulated in acute promyelocytic leukemia.
Leukemia, Promyelocytic, Acute
[Adenanthin Induces Differentiation of Acute Promyelocytic Leukemia Cells by Targeting Peroxiredoxin III].
Leukoplakia, Oral
Nicotine promotes the development of oral leukoplakia via regulating peroxiredoxin 1 and its binding proteins.
Leukoplakia, Oral
Peroxiredoxin 1 suppresses apoptosis via regulation of the apoptosis signal-regulating kinase 1 signaling pathway in human oral leukoplakia.
Leukoplakia, Oral
Proteome profiling to identify peroxiredoxin 1 interacting protein partners in nicotine-associated oral leukoplakia.
Lipoma
Adult rhabdomyoma with oncocytic changes affecting the floor of the mouth: optical, immunohistochemical, and ultrastructural study.
Liver Abscess
Peroxynitrite and peroxiredoxin in the pathogenesis of experimental amebic liver abscess.
Liver Abscess, Amebic
Obtaining of three recombinant antigens of Entamoeba histolytica and evaluation of their immunogenic ability without adjuvant in a hamster model of immunoprotection.
Liver Abscess, Amebic
Peroxynitrite and peroxiredoxin in the pathogenesis of experimental amebic liver abscess.
Liver Cirrhosis
Peroxiredoxin 2: a potential biomarker for early diagnosis of hepatitis B virus related liver fibrosis identified by proteomic analysis of the plasma.
Liver Diseases
Identification and Analysis of the Tegument Protein and Excretory-Secretory Products of the Carcinogenic Liver Fluke Clonorchis sinensis.
Liver Diseases
Overexpression of Peroxiredoxin 4 Affects Intestinal Function in a Dietary Mouse Model of Nonalcoholic Fatty Liver Disease.
Liver Diseases
Peroxiredoxin 3 Inhibits Acetaminophen-Induced Liver Pyroptosis Through the Regulation of Mitochondrial ROS.
Liver Diseases
Peroxiredoxin 4 (PRDX4): Its critical in vivo roles in animal models of metabolic syndrome ranging from atherosclerosis to nonalcoholic fatty liver disease.
Liver Diseases
Peroxiredoxin 5 ameliorates obesity-induced non-alcoholic fatty liver disease through the regulation of oxidative stress and AMP-activated protein kinase signaling.
Liver Failure
Double Knockout of Peroxiredoxin 4 (Prdx4) and Superoxide Dismutase 1 (Sod1) in Mice Results in Severe Liver Failure.
Liver Neoplasms
Aberrant expression of peroxiredoxin 1 and its clinical implications in liver cancer.
Liver Neoplasms
Gamma-tocotrienol treatment increased peroxiredoxin-4 expression in HepG2 liver cancer cell line.
Liver Neoplasms
Peroxiredoxin 3 is resistant to oxidation-induced apoptosis of Hep-3b cells.
Liver Neoplasms
Peroxiredoxin I contributes to TRAIL resistance through suppression of redox-sensitive caspase activation in human hepatoma cells.
Liver Neoplasms
Peroxiredoxin II is essential for maintaining stemness by redox regulation in liver cancer cells.
Liver Neoplasms
Proteome analysis of aflatoxin B1-induced hepatocarcinogenesis in tree shrew (Tupaia belangeri chinensis) and functional identification of candidate protein peroxiredoxin II.
Liver Neoplasms
[The biological function of peroxiredoxin II on Hep3B cells and its underlying mechanism]
Lung Diseases
Induction of peroxiredoxin gene expression by oxygen in lungs of newborn primates.
Lung Diseases, Interstitial
Peroxiredoxin II expression and its association with oxidative stress and cell proliferation in human idiopathic pulmonary fibrosis.
Lung Neoplasms
An important role for peroxiredoxin II in survival of A549 lung cancer cells resistant to gefitinib.
Lung Neoplasms
Downregulation of Peroxiredoxin I by a Novel Fully Human Phage Display Recombinant Antibody Induces Apoptosis and Enhances Radiation Sensitization in A549 Lung Carcinoma Cells.
Lung Neoplasms
Elevated peroxiredoxin 1, but not NF-E2-related factor 2, is an independent prognostic factor for disease recurrence and reduced survival in stage I non-small cell lung cancer.
Lung Neoplasms
Expression of peroxiredoxin and thioredoxin in human lung cancer and paired normal lung.
Lung Neoplasms
Glycoproteomic Analysis of Human Lung Adenocarcinomas Using Glycoarrays and Tandem Mass Spectrometry: Differential Expression and Glycosylation Patterns of Vimentin and Fetuin A Isoforms.
Lung Neoplasms
Inhibition of lung tumor growth and augmentation of radiosensitivity by decreasing peroxiredoxin I expression.
Lung Neoplasms
Interplay Between Mitochondrial Peroxiredoxins and ROS in Cancer Development and Progression.
Lung Neoplasms
Nuclear factor E2-related factor 2 dependent overexpression of sulfiredoxin and peroxiredoxin III in human lung cancer.
Lung Neoplasms
Overexpression of PRDX4 Modulates Tumor Microenvironment and Promotes Urethane-Induced Lung Tumorigenesis.
Lung Neoplasms
p53 status is a major determinant of effects of decreasing peroxiredoxin I expression on tumor growth and response of lung cancer cells to treatment.
Lung Neoplasms
Peroxiredoxin 4 as an independent prognostic marker for survival in patients with early-stage lung squamous cell carcinoma.
Lung Neoplasms
Peroxiredoxins and tropomyosins as plasma biomarkers for lung cancer and asbestos exposure.
Lung Neoplasms
PRDX2 Promotes the Proliferation and Metastasis of Non-Small Cell Lung Cancer In Vitro and In Vivo.
Lung Neoplasms
Preferential elevation of Prx I and Trx expression in lung cancer cells following hypoxia and in human lung cancer tissues.
Lung Neoplasms
Preferential overexpression of glutaredoxin3 in human colon and lung carcinoma.
Lung Neoplasms
Proteomic and genomic biomarkers for Non-Small Cell Lung Cancer: Peroxiredoxin, Haptoglobin, and Alpha-1 antitrypsin.
Lung Neoplasms
Prx1 suppresses radiation-induced c-Jun NH2-terminal kinase signaling in lung cancer cells through interaction with the glutathione S-transferase Pi/c-Jun NH2-terminal kinase complex.
Lung Neoplasms
Reactive oxygen species-regulating proteins peroxiredoxin 2 and thioredoxin, and glyceraldehyde-3-phosphate dehydrogenase are differentially abundant in induced sputum from smokers with lung cancer or asbestos exposure.
Lung Neoplasms
Regulatory function of peroxiredoxin I on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung cancer development.
Lung Neoplasms
ROS?mediated hypomethylation of PRDX5 promotes STAT3 binding and activates the Nrf2 signaling pathway in NSCLC.
Lung Neoplasms
S-nitrosylation of the Peroxiredoxin-2 promotes S-nitrosoglutathione-mediated lung cancer cells apoptosis via AMPK-SIRT1 pathway.
Lung Neoplasms
Secretomic analysis of large cell lung cancer cell lines using two-dimensional gel electrophoresis coupled to mass spectrometry.
Lung Neoplasms
Silencing of PRDX2 Inhibits the Proliferation and Invasion of Non-Small Cell Lung Cancer Cells.
Lung Neoplasms
Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis.
Lung Neoplasms
Up-regulation of peroxiredoxin 1 in lung cancer and its implication as a prognostic and therapeutic target.
Lupus Erythematosus, Systemic
Autoantibodies to peroxiredoxin I and IV in patients with systemic autoimmune diseases.
Lymphatic Metastasis
Downregulation of peroxiredoxin II suppresses the proliferation and metastasis of gastric cancer cells.
Lymphatic Metastasis
Peroxiredoxin 2 is associated with colorectal cancer progression and poor survival of patients.
Lymphatic Metastasis
Peroxiredoxin 2 specifically regulates the oxidative and metabolic stress response of human metastatic breast cancer cells in lungs.
Lymphatic Metastasis
Peroxiredoxin I expression in oral cancer: a potential new tumor marker.
Lymphocytic Choriomeningitis
Quantitative Proteomics Reveal Peroxiredoxin Perturbation Upon Persistent Lymphocytic Choriomeningitis Virus Infection in Human Cells.
Lymphoma
Epigenetic silencing of the tumor suppressor genes SPI1, PRDX2, KLF4, DLEC1, and DAPK1 in childhood and adolescent lymphomas.
Lymphoma
Novel endogenous negative modulators of platelet function as potential anti-thrombotic targets.
Lymphoma, B-Cell
Loss of mitofusin 2 links beta-amyloid-mediated mitochondrial fragmentation and Cdk5-induced oxidative stress in neuron cells.
Lymphoma, B-Cell
Peroxiredoxin V Silencing Elevates Susceptibility to Doxorubicin-induced Cell Apoptosis via ROS-dependent Mitochondrial Dysfunction in AGS Gastric Cancer Cells.
Lymphoma, B-Cell
Protective Effect of Fenofibrate on Oxidative Stress-Induced Apoptosis in Retinal-Choroidal Vascular Endothelial Cells: Implication for Diabetic Retinopathy Treatment.
Lymphoma, Follicular
Total peroxiredoxin expression is associated with survival in patients with follicular lymphoma.
Malaria
2-Cys Peroxiredoxin TPx-1 is involved in gametocyte development in Plasmodium berghei.
Malaria
A Genome-wide Chromatin-associated Nuclear Peroxiredoxin from the Malaria Parasite Plasmodium falciparum.
Malaria
A mosquito 2-Cys peroxiredoxin protects against nitrosative and oxidative stresses associated with malaria parasite infection.
Malaria
Development of monoclonal antibodies against Plasmodium falciparum thioredoxin peroxidase 1 and its possible application for malaria diagnosis.
Malaria
Expression profiles of peroxiredoxin proteins of the rodent malaria parasite Plasmodium yoelii.
Malaria
Molecular characterization of a 2-Cys peroxiredoxin from the human malaria parasite Plasmodium falciparum.
Malaria
Molecular cloning and characterization of a peroxiredoxin from the human malaria parasite Plasmodium falciparum.
Malaria
Molecular cloning, characterization and expression profile of a glutathione peroxidase-like thioredoxin peroxidase (TPxGl) of the rodent malaria parasite Plasmodium berghei.
Malaria
Prokaryotic ancestry and gene fusion of a dual localized peroxiredoxin in malaria parasites.
Malaria
Roles of 1-Cys peroxiredoxin in haem detoxification in the human malaria parasite Plasmodium falciparum.
Malaria
Thioredoxin, thioredoxin reductase, and thioredoxin peroxidase of malaria parasite Plasmodium falciparum.
Measles
Peroxiredoxin 1 is required for efficient transcription and replication of measles virus.
Medulloblastoma
Integrated proteomic platforms for the comparative characterization of medulloblastoma and pilocytic astrocytoma pediatric brain tumors: a preliminary study.
Medulloblastoma
MiR-383 is Downregulated in Medulloblastoma and Targets Peroxiredoxin 3 (PRDX3).
Medulloblastoma
Validation of Cadherin HAV6 Peptide in the Transient Modulation of the Blood-Brain Barrier for the Treatment of Brain Tumors.
Melanoma
Analysis of candidate genes through a proteomics-based approach in primary cell lines from malignant melanomas and their metastases.
Melanoma
Immunogenicity without immunoselection: a mutant but functional antioxidant enzyme retained in a human metastatic melanoma and targeted by CD8(+) T cells with a memory phenotype.
Melanoma
Peptides with dual binding specificity for HLA-A2 and HLA-E are encoded by alternatively spliced isoforms of the antioxidant enzyme peroxiredoxin 5.
Melanoma
Silencing of Peroxiredoxin 2 and aberrant methylation of 33 CpG islands in putative promoter regions in human malignant melanomas.
Melioidosis
T Cell Immunity to the Alkyl Hydroperoxide Reductase of Burkholderia pseudomallei: A Correlate of Disease Outcome in Acute Melioidosis.
Mesothelioma, Malignant
Disabling Mitochondrial Peroxide Metabolism via Combinatorial Targeting of Peroxiredoxin 3 as an Effective Therapeutic Approach for Malignant Mesothelioma.
Mesothelioma, Malignant
Mitochondrial-targeted nitroxides disrupt mitochondrial architecture and inhibit expression of peroxiredoxin 3 and FOXM1 in malignant mesothelioma cells.
Mesothelioma, Malignant
Peroxiredoxin 3 is a redox-dependent target of thiostrepton in malignant mesothelioma cells.
Mesothelioma, Malignant
Peroxiredoxin 3 levels regulate a mitochondrial redox setpoint in malignant mesothelioma cells.
Metabolic Syndrome
Improvement of Plasma Biomarkers after Switching Stroke Patients from Other Angiotensin II Type I Receptor Blockers to Olmesartan.
Metabolic Syndrome
Increased peroxiredoxin 4 levels in patients with prediabetes compared to normal glucose tolerance subjects.
Metabolic Syndrome
Peroxiredoxin 4 (PRDX4): Its critical in vivo roles in animal models of metabolic syndrome ranging from atherosclerosis to nonalcoholic fatty liver disease.
Migraine Disorders
[Herbs for calming liver and suppressing liver-yang in treatment of migraine with hyperactive liver-yang syndrome and its effects on lymphocyte protein expression: a randomized controlled trial]
Mouth Neoplasms
High-throughput screening of saliva for early detection of oral cancer: a pilot study.
Mouth Neoplasms
Induction of peroxiredoxin 1 by hypoxia regulates heme oxygenase-1 via NF-?B in oral cancer.
Mouth Neoplasms
Nicotine promotes cervical metastasis of oral cancer by regulating peroxiredoxin 1 and epithelial-mesenchymal transition in mice.
Multiple Myeloma
Peroxiredoxin I is differentially expressed in multiple myelomas and in plasmablastic lymphomas.
Multiple Myeloma
The role of peroxiredoxin V in (-)-epigallocatechin 3-gallate-induced multiple myeloma cell death.
Multiple Sclerosis
Expression of the Antioxidative Enzyme Peroxiredoxin 2 in Multiple Sclerosis Lesions in Relation to Inflammation.
Multiple Sclerosis
Peroxiredoxin V in multiple sclerosis lesions: predominant expression by astrocytes.
Mycoses
A peroxiredoxin Q homolog from gentians is involved in both resistance against fungal disease and oxidative stress.
Mycoses
ROS-induced Oxidative Injury involved in Pathogenesis of Fungal Keratitis via p38 MAPK Activation.
Myocardial Infarction
Overexpression of mitochondrial peroxiredoxin-3 prevents left ventricular remodeling and failure after myocardial infarction in mice.
Myocardial Infarction
Peroxiredoxin2 (Prdx2) Reduces Oxidative Stress and Apoptosis of Myocardial Cells Induced by Acute Myocardial Infarction by Inhibiting the TLR4/Nuclear Factor kappa B (NF-?B) Signaling Pathway.
Myocardial Infarction
PRDX2 in Myocyte Hypertrophy and Survival is Mediated by TLR4 in Acute Infarcted Myocardium.
Nasopharyngeal Carcinoma
Serum proteomic-based analysis identifying autoantibodies against PRDX2 and PRDX3 as potential diagnostic biomarkers in nasopharyngeal carcinoma.
Neoplasm Metastasis
Bcl-x(L)-mediated changes in metabolic pathways of breast cancer cells: from survival in the blood stream to organ-specific metastasis.
Neoplasm Metastasis
Comparative protein profiling identifies elongation factor-1beta and tryparedoxin peroxidase as factors associated with metastasis in Leishmania guyanensis.
Neoplasm Metastasis
Comprehensive profiling of metastasis-related proteins in paired hepatocellular carcinoma cells with different metastasis potentials.
Neoplasm Metastasis
Disruption of the c-Myc/miR-200b-3p/PRDX2 regulatory loop enhances tumor metastasis and chemotherapeutic resistance in colorectal cancer.
Neoplasm Metastasis
Downregulation of peroxiredoxin II suppresses the proliferation and metastasis of gastric cancer cells.
Neoplasm Metastasis
Identification of potential biomarkers for giant cell tumor of bone using comparative proteomics analysis.
Neoplasm Metastasis
Identification of the functional role of peroxiredoxin 6 in the progression of breast cancer.
Neoplasm Metastasis
Inhibition of lung tumor growth and augmentation of radiosensitivity by decreasing peroxiredoxin I expression.
Neoplasm Metastasis
Nicotine promotes cervical metastasis of oral cancer by regulating peroxiredoxin 1 and epithelial-mesenchymal transition in mice.
Neoplasm Metastasis
Overexpression of peroxiredoxin 2 inhibits TGF-?1-induced epithelial-mesenchymal transition and cell migration in colorectal cancer.
Neoplasm Metastasis
Oxidative/nitrosative stress and peroxiredoxin 2 are associated with grade and prognosis of human renal carcinoma.
Neoplasm Metastasis
Peroxiredoxin 1 (PRDX1) Suppresses Progressions and Metastasis of Osteosarcoma and Fibrosarcoma of Bone.
Neoplasm Metastasis
Peroxiredoxin 1 promoted tumor metastasis and angiogenesis in colorectal cancer.
Neoplasm Metastasis
Peroxiredoxin 2 is associated with colorectal cancer progression and poor survival of patients.
Neoplasm Metastasis
Peroxiredoxin 2 is upregulated in colorectal cancer and contributes to colorectal cancer cells' survival by protecting cells from oxidative stress.
Neoplasm Metastasis
Peroxiredoxin 2 specifically regulates the oxidative and metabolic stress response of human metastatic breast cancer cells in lungs.
Neoplasm Metastasis
Peroxiredoxin 4 suppresses anoikis and augments growth and metastasis of hepatocellular carcinoma cells through the ?-catenin/ID2 pathway.
Neoplasm Metastasis
Peroxiredoxin I expression in oral cancer: a potential new tumor marker.
Neoplasm Metastasis
Peroxiredoxin-1 promotes cell proliferation and metastasis through enhancing Akt/mTOR in human osteosarcoma cells.
Neoplasm Metastasis
PRDX2 Promotes the Proliferation and Metastasis of Non-Small Cell Lung Cancer In Vitro and In Vivo.
Neoplasm Metastasis
Prognostic role of serum AZGP1, PEDF and PRDX2 in colorectal cancer patients.
Neoplasm Metastasis
Protein Signatures in Human MDA-MB-231 Breast Cancer Cells Indicating a More Invasive Phenotype Following Knockdown of Human Endometase/Matrilysin-2 by siRNA.
Neoplasm Metastasis
ROS?mediated hypomethylation of PRDX5 promotes STAT3 binding and activates the Nrf2 signaling pathway in NSCLC.
Neoplasm Metastasis
SF2523: Dual PI3K/BRD4 Inhibitor Blocks Tumor Immunosuppression and Promotes Adaptive Immune Responses in Cancer.
Neoplasm Metastasis
Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis.
Neoplasm Metastasis
Up-regulation of peroxiredoxin-1 promotes cell proliferation and metastasis and inhibits apoptosis in cervical cancer.
Neoplasm Metastasis
[Effects of yiqi chutan recipe on tumor growth, survival time and expressions of PRDX-1 and PRDX-6 in Lewis lung carcinoma model mice with pi-deficiency syndrome].
Neoplasms
2D-DIGE Proteomic Analysis of Changes in Estrogen/Progesterone-Induced Rat Breast Hyperplasia upon Treatment with the Mongolian Remedy RuXian-I.
Neoplasms
8-hydroxydeguanosine and nitrotyrosine are prognostic factors in urinary bladder carcinoma.
Neoplasms
A PRDX1-p38? heterodimer amplifies MET-driven invasion of IDH-wildtype and IDH-mutant gliomas.
Neoplasms
A redox-sensitive peroxiredoxin that is important for longevity has tissue- and stress-specific roles in stress resistance.
Neoplasms
Absence of Cytosolic 2-Cys Prx Subtypes I and II Exacerbates TNF-?-Induced Apoptosis via Different Routes.
Neoplasms
Adult rhabdomyoma with oncocytic changes affecting the floor of the mouth: optical, immunohistochemical, and ultrastructural study.
Neoplasms
Aggravation of Bleomycin-Induced Pulmonary Inflammation and Fibrosis in Mice Lacking Peroxiredoxin I.
Neoplasms
An important role for peroxiredoxin II in survival of A549 lung cancer cells resistant to gefitinib.
Neoplasms
Blue light activates phase 2 response proteins and slows growth of a431 epidermoid carcinoma xenografts.
Neoplasms
Candidate diagnostic markers and tumor suppressor genes for adrenocortical carcinoma by expression profile of genes on chromosome 11q13.
Neoplasms
Catalytic Thr or Ser Residue Modulates Structural Switches in 2-Cys Peroxiredoxin by Distinct Mechanisms.
Neoplasms
Celastrol induces ROS-mediated apoptosis via directly targeting peroxiredoxin-2 in gastric cancer cells.
Neoplasms
Comparative proteomic analysis of drug sodium iron chlorophyllin addition to Hep 3B cell line.
Neoplasms
Conjugated linoleic acid synthesis-related protein proteasome subunit ? 5 (PSMA5) is increased by vaccenic acid treatment in goat mammary tissue.
Neoplasms
Cytosolic peroxiredoxin attenuates the activation of Jnk and p38 but potentiates that of Erk in Hela cells stimulated with tumor necrosis factor-alpha.
Neoplasms
Danhong Injection Protects Hemorrhagic Brain by Increasing Peroxiredoxin 1 in Aged Rats.
Neoplasms
Detection of cathepsin B up-regulation in neoplastic thyroid tissues by proteomic analysis.
Neoplasms
Differences in Redox Regulatory Systems in Human Lung and Liver Tumors Suggest Different Avenues for Therapy.
Neoplasms
Differential protein expression in honeybee (Apis mellifera L.) larvae: underlying caste differentiation.
Neoplasms
Differential protein expression using proteomics from a crustacean brine shrimp (Artemia sinica) under CO2-driven seawater acidification.
Neoplasms
Downregulation of Peroxiredoxin I by a Novel Fully Human Phage Display Recombinant Antibody Induces Apoptosis and Enhances Radiation Sensitization in A549 Lung Carcinoma Cells.
Neoplasms
Downregulation of peroxiredoxin II suppresses the proliferation and metastasis of gastric cancer cells.
Neoplasms
Downregulation of peroxiredoxin-1 by ?-elemene enhances the radiosensitivity of lung adenocarcinoma xenografts.
Neoplasms
Dual inhibition of BRD4 and PI3K by SF2523 suppresses human prostate cancer cell growth in vitro and in vivo.
Neoplasms
Dual inhibition of EGFR at protein and activity level via combinatorial blocking of PI4KII? as anti-tumor strategy.
Neoplasms
Effective Killing of Cancer Cells Through ROS-Mediated Mechanisms by AMRI-59 Targeting Peroxiredoxin I.
Neoplasms
Effects of 5'-azacytidine and alendronate on a hepatocellular carcinoma cell line: a proteomics perspective.
Neoplasms
Elevated prx1 provides resistance to docetaxel, but is not associated with predictive significance in lung cancer.
Neoplasms
Enhanced Expression of Peroxiredoxin I and VI Correlates with Development, Recurrence and Progression of Human Bladder Cancer.
Neoplasms
Enhanced targeting of mitochondrial peroxide defense by the combined use of thiosemicarbazones and inhibitors of thioredoxin reductase.
Neoplasms
Epigenetic silencing of the tumor suppressor genes SPI1, PRDX2, KLF4, DLEC1, and DAPK1 in childhood and adolescent lymphomas.
Neoplasms
Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression.
Neoplasms
Exploring the Natural Piericidins as Anti-Renal Cell Carcinoma Agents Targeting Peroxiredoxin 1.
Neoplasms
Expression and clinical value of peroxiredoxin-1 in patients with pancreatic cancer.
Neoplasms
Expression of human peroxiredoxin isoforms in response to cervical carcinogenesis.
Neoplasms
Expression of multiple epigenetically regulated cancer/germline genes in nonsmall cell lung cancer.
Neoplasms
Expression of peroxiredoxin 1, 2, 3, and 6 genes in cancer cells during drug resistance formation.
Neoplasms
Expression of peroxiredoxin and thioredoxin in human lung cancer and paired normal lung.
Neoplasms
Expression of peroxiredoxin II in vascular tumors of the skin: a novel vascular marker of endothelial cells.
Neoplasms
Expression of peroxiredoxins I and IV in multiple myeloma: association with immunoglobulin accumulation.
Neoplasms
Expression of reactive species related genes is associated with patient survival in luminal B breast cancer.
Neoplasms
Expression of thioredoxin 1 and peroxiredoxins in squamous cervical carcinoma and its predictive role in NACT.
Neoplasms
Expression pattern of the PRDX2, RAB1A, RAB1B, RAB5A and RAB25 genes in normal and cancer cervical tissues.
Neoplasms
Fine-needle aspiration of thyroid nodules: proteomic analysis to identify cancer biomarkers.
Neoplasms
FOXM1-Induced PRX3 Regulates Stemness and Survival of Colon Cancer Cells via Maintenance of Mitochondrial Function.
Neoplasms
Frenolicin B Targets Peroxiredoxin 1 and Glutaredoxin 3 to Trigger ROS/4E-BP1-Mediated Antitumor Effects.
Neoplasms
Functional dissection of Nrf2-dependent phase II genes in vascular inflammation and endotoxic injury using Keap1 siRNA.
Neoplasms
Gene expression profiling of paired ovarian tumors obtained prior to and following adjuvant chemotherapy: molecular signatures of chemoresistant tumors.
Neoplasms
Genetic Inactivation of Peroxiredoxin-I Impairs the Growth of Human Pancreatic Cancer Cells.
Neoplasms
Genome-wide analysis of histone H3 acetylation patterns in AML identifies PRDX2 as an epigenetically silenced tumor suppressor gene.
Neoplasms
Glucose transporter protein 1 expression in mucoepidermoid carcinoma of salivary gland: correlation with grade of malignancy.
Neoplasms
Highly sensitive saturation labeling reveals changes in abundance of cell cycle-associated proteins and redox enzyme variants during oocyte maturation in vitro.
Neoplasms
Human peroxiredoxin 1 modulates TGF-?1-induced epithelial-mesenchymal transition through its peroxidase activity.
Neoplasms
Human prx1 gene is a target of Nrf2 and is up-regulated by hypoxia/reoxygenation: implication to tumor biology.
Neoplasms
Hydrogen peroxide produced by Aplysia ink toxin kills tumor cells independent of apoptosis via peroxiredoxin I sensitive pathways.
Neoplasms
Identification and Analysis of the Tegument Protein and Excretory-Secretory Products of the Carcinogenic Liver Fluke Clonorchis sinensis.
Neoplasms
Identification and functional analysis of senescence-associated secretory phenotype of premature senescent hepatocytes induced by hexavalent chromium.
Neoplasms
Identification and verification of PRDX1 as an inflammation marker for colorectal cancer progression.
Neoplasms
Identification of isocitrate dehydrogenase 1 as a potential diagnostic and prognostic biomarker for non-small cell lung cancer by proteomic analysis.
Neoplasms
Identification of peroxiredoxin 6 as a potential lung-adenocarcinoma biomarker for predicting chemotherapy response by proteomic analysis.
Neoplasms
Identification of potential biomarkers for giant cell tumor of bone using comparative proteomics analysis.
Neoplasms
Improvement of Plasma Biomarkers after Switching Stroke Patients from Other Angiotensin II Type I Receptor Blockers to Olmesartan.
Neoplasms
Inactivation of a peroxiredoxin by hydrogen peroxide is critical for thioredoxin-mediated repair of oxidized proteins and cell survival.
Neoplasms
Increased expression of mitochondrial peroxiredoxin-3 (thioredoxin peroxidase-2) protects cancer cells against hypoxia and drug-induced hydrogen peroxide-dependent apoptosis.
Neoplasms
Induced nitric oxide synthetase and peroxiredoxin expression in intramucosal poorly differentiated gastric cancer of young patients.
Neoplasms
Induction of peroxiredoxin 1 by hypoxia regulates heme oxygenase-1 via NF-?B in oral cancer.
Neoplasms
Inhibition of lung tumor growth and augmentation of radiosensitivity by decreasing peroxiredoxin I expression.
Neoplasms
Inhibitory effect of novel internalized fully human phage antibody fragments on proliferation of lung adenocarcinoma cell line overexpressing peroxiredoxin I.
Neoplasms
Interaction of tankyrase and peroxiredoxin II is indispensable for the survival of colorectal cancer cells.
Neoplasms
Interplay Between Mitochondrial Peroxiredoxins and ROS in Cancer Development and Progression.
Neoplasms
Involvement of peroxiredoxin IV in the 16alpha-hydroxyestrone-induced proliferation of human MCF-7 breast cancer cells.
Neoplasms
Knockdown of PRDX2 sensitizes colon cancer cells to 5-FU by suppressing the PI3K/AKT signaling pathway.
Neoplasms
Long Non-coding RNA CASC15 Promotes Intrahepatic Cholangiocarcinoma Possibly through Inducing PRDX2/PI3K/AKT Axis.
Neoplasms
Loss of Peroxiredoxin Expression Is Associated with an Aggressive Phenotype in Pancreatic Adenocarcinoma.
Neoplasms
Mammalian peroxiredoxin isoforms can reduce hydrogen peroxide generated in response to growth factors and tumor necrosis factor-alpha.
Neoplasms
Mammalian target of rapamycin inhibitors, temsirolimus and torin 1, attenuate stemness-associated properties and expression of mesenchymal markers promoted by phorbol-myristate-acetate and oncostatin-M in glioblastoma cells.
Neoplasms
Marginal zinc intake reduces the protective effect of lactation on mammary gland carcinogenesis in a DMBA-induced tumor model in mice.
Neoplasms
MicroRNA-122 negatively associates with peroxiredoxin-II expression in human gefitinib-resistant lung cancer stem cells.
Neoplasms
Natural products triptolide, celastrol, and withaferin A inhibit the chaperone activity of peroxiredoxin I.
Neoplasms
Nicotine promotes the development of oral leukoplakia via regulating peroxiredoxin 1 and its binding proteins.
Neoplasms
Nicotine suppresses apoptosis by regulating ?7nAChR/Prx1 axis in oral precancerous lesions.
Neoplasms
Nrf2-peroxiredoxin I axis in polymorphous adenocarcinoma is associated with low matrix metalloproteinase 2 level.
Neoplasms
Overexpression of mitochondrial thioredoxin reductase and peroxiredoxin III in hepatocellular carcinomas.
Neoplasms
Overexpression of peroxiredoxin 2 inhibits TGF-?1-induced epithelial-mesenchymal transition and cell migration in colorectal cancer.
Neoplasms
Overexpression of Peroxiredoxin 6 Protects Neoplastic Cells against Apoptosis in Canine Haemangiosarcoma.
Neoplasms
Overexpression of peroxiredoxin-3 and -5 is a potential biomarker for prognosis in endometrial cancer.
Neoplasms
Overexpression of Prdx6 and resistance to peroxide-induced death in Hepa1-6 cells: Prdx suppression increases apoptosis.
Neoplasms
Oxidation of 2-Cys-peroxiredoxins by arachidonic acid peroxide metabolites of lipoxygenases and cyclooxygenase-2.
Neoplasms
Oxidative stress-induced antioxidant enzyme expression is an early phenomenon in ovarian carcinogenesis.
Neoplasms
Oxidative/nitrosative stress and peroxiredoxin 2 are associated with grade and prognosis of human renal carcinoma.
Neoplasms
p53 status is a major determinant of effects of decreasing peroxiredoxin I expression on tumor growth and response of lung cancer cells to treatment.
Neoplasms
PCAT6 mediates cellular biological functions in gastrointestinal stromal tumor via upregulation of PRDX5 and activation of Wnt pathway.
Neoplasms
Peroxiredoxin 1 (PRDX1) Suppresses Progressions and Metastasis of Osteosarcoma and Fibrosarcoma of Bone.
Neoplasms
Peroxiredoxin 1 controls prostate cancer growth through Toll-like receptor 4-dependent regulation of tumor vasculature.
Neoplasms
Peroxiredoxin 1 knockdown sensitizes cancer cells to reactive oxygen species-generating drugs - an alternative approach for chemotherapy.
Neoplasms
Peroxiredoxin 1 promotes tumorigenesis through regulating the activity of mTOR/p70S6K pathway in esophageal squamous cell carcinoma.
Neoplasms
Peroxiredoxin 1 stimulates secretion of proinflammatory cytokines by binding to TLR4.
Neoplasms
Peroxiredoxin 1 suppresses apoptosis via regulation of the apoptosis signal-regulating kinase 1 signaling pathway in human oral leukoplakia.
Neoplasms
Peroxiredoxin 2 expression is increased in neutrophils of patients with refractory cytopenia with multilineage dysplasia.
Neoplasms
Peroxiredoxin 2 is associated with colorectal cancer progression and poor survival of patients.
Neoplasms
Peroxiredoxin 2 is essential for maintaining cancer stem cell-like phenotype through activation of Hedgehog signaling pathway in colon cancer.
Neoplasms
Peroxiredoxin 2 is highly expressed in human oral squamous cell carcinoma cells and is upregulated by human papillomavirus oncoproteins and arecoline, promoting proliferation.
Neoplasms
Peroxiredoxin 2 is involved in vasculogenic mimicry formation by targeting VEGFR2 activation in colorectal cancer.
Neoplasms
Peroxiredoxin 2 is upregulated in colorectal cancer and contributes to colorectal cancer cells' survival by protecting cells from oxidative stress.
Neoplasms
Peroxiredoxin 2 specifically regulates the oxidative and metabolic stress response of human metastatic breast cancer cells in lungs.
Neoplasms
Peroxiredoxin 4 as an independent prognostic marker for survival in patients with early-stage lung squamous cell carcinoma.
Neoplasms
Peroxiredoxin 4 promotes embryonal hepatoblastoma cell migration but induces fetal cell differentiation.
Neoplasms
Peroxiredoxin 5 is involved in cancer cell invasion and tumor growth of oral squamous cell carcinoma.
Neoplasms
Peroxiredoxin I deficiency increases keratinocyte apoptosis in a skin tumor model via the ROS-p38 MAPK pathway.
Neoplasms
Peroxiredoxin I expression in tongue squamous cell carcinomas as involved in tumor recurrence.
Neoplasms
Peroxiredoxin I is important for cancer-cell survival in Ras-induced hepatic tumorigenesis.
Neoplasms
Peroxiredoxin II is an essential antioxidant enzyme that prevents the oxidative inactivation of VEGF receptor-2 in vascular endothelial cells.
Neoplasms
Peroxiredoxin II is essential for maintaining stemness by redox regulation in liver cancer cells.
Neoplasms
Peroxiredoxin II promotes hepatic tumorigenesis through cooperation with Ras/Forkhead box M1 signaling pathway.
Neoplasms
Peroxiredoxin II Regulates Cancer Stem Cells and Stemness-Associated Properties of Cancers.
Neoplasms
Peroxiredoxin II Restrains DNA Damage-induced Death in Cancer Cells by Positively Regulating JNK-dependent DNA Repair.
Neoplasms
Peroxiredoxin III Protects Tumor Suppressor PTEN from Oxidation by 15-Hydroperoxy-eicosatetraenoic Acid.
Neoplasms
Peroxiredoxin V Inhibits Emodin-induced Gastric Cancer Cell Apoptosis via the ROS/Bcl2 Pathway.
Neoplasms
Peroxiredoxin V Silencing Elevates Susceptibility to Doxorubicin-induced Cell Apoptosis via ROS-dependent Mitochondrial Dysfunction in AGS Gastric Cancer Cells.
Neoplasms
Peroxiredoxin-1 Tyr194 phosphorylation regulates LOX-dependent extracellular matrix remodelling in breast cancer.
Neoplasms
Peroxiredoxin-3 is overexpressed in prostate cancer and promotes cancer cell survival by protecting cells from oxidative stress.
Neoplasms
Peroxiredoxin2 downregulation enhances hepatocellular carcinoma proliferation and migration, and is associated with unfavorable prognosis in patients.
Neoplasms
Peroxiredoxins 3 and 4 are overexpressed in prostate cancer tissue and affect the proliferation of prostate cancer cells in vitro.
Neoplasms
PRDX2 in Myocyte Hypertrophy and Survival is Mediated by TLR4 in Acute Infarcted Myocardium.
Neoplasms
PRDX2 Promotes the Proliferation and Metastasis of Non-Small Cell Lung Cancer In Vitro and In Vivo.
Neoplasms
PRDX2 Protects Against Atherosclerosis by Regulating the Phenotype and Function of the Vascular Smooth Muscle Cell.
Neoplasms
PRDX5 as a novel binding partner in Nrf2-mediated NSCLC progression under oxidative stress.
Neoplasms
Preferential elevation of Prx I and Trx expression in lung cancer cells following hypoxia and in human lung cancer tissues.
Neoplasms
Production and radioimmunoimaging of novel fully human phage display recombinant antibodies and growth inhibition of lung adenocarcinoma cell line overexpressing Prx I.
Neoplasms
Prognostic significance of peroxiredoxin 1 and ezrin-radixin-moesin-binding phosphoprotein 50 in cholangiocarcinoma.
Neoplasms
Prognostic Value of Peroxiredoxin-1 Expression in Patients with Solid Tumors: a Meta-Analysis of Cohort Study.
Neoplasms
Protective role of cytosolic 2-cys peroxiredoxin in the TNF-alpha-induced apoptotic death of human cancer cells.
Neoplasms
Protein expression profiles in pancreatic adenocarcinoma compared with normal pancreatic tissue and tissue affected by pancreatitis as detected by two-dimensional gel electrophoresis and mass spectrometry.
Neoplasms
Proteome analysis of aflatoxin B1-induced hepatocarcinogenesis in tree shrew (Tupaia belangeri chinensis) and functional identification of candidate protein peroxiredoxin II.
Neoplasms
Proteomic analysis of psoriatic skin tissue for identification of differentially expressed proteins: Up-regulation of GSTP1, SFN and PRDX2 in psoriatic skin.
Neoplasms
Proteomic-based biosignatures in breast cancer classification and prediction of therapeutic response.
Neoplasms
Proteomics analysis of cellular response to oxidative stress. Evidence for in vivo overoxidation of peroxiredoxins at their active site.
Neoplasms
Proteomics-based approach identifying autoantibody against peroxiredoxin VI as a novel serum marker in esophageal squamous cell carcinoma.
Neoplasms
Prx I suppresses K-ras-driven lung tumorigenesis by opposing redox-sensitive ERK/cyclin D1 pathway.
Neoplasms
PRX1 knockdown potentiates vitamin K3 toxicity in cancer cells: a potential new therapeutic perspective for an old drug.
Neoplasms
Re: Peroxiredoxin 4: A Novel Secreted Mediator of Cancer Induced Osteoclastogenesis.
Neoplasms
Reactive oxygen species-regulating proteins peroxiredoxin 2 and thioredoxin, and glyceraldehyde-3-phosphate dehydrogenase are differentially abundant in induced sputum from smokers with lung cancer or asbestos exposure.
Neoplasms
Recombinant protein transduction domain-Cu/Zn superoxide dismutase alleviates bone cancer pain via peroxiredoxin 4 modulation and antioxidation.
Neoplasms
Redox proteomics reveal stress responsive proteins linking peroxiredoxin-1 status in glioma to chemosensitivity and oxidative stress.
Neoplasms
ROS?mediated hypomethylation of PRDX5 promotes STAT3 binding and activates the Nrf2 signaling pathway in NSCLC.
Neoplasms
SF2523: Dual PI3K/BRD4 Inhibitor Blocks Tumor Immunosuppression and Promotes Adaptive Immune Responses in Cancer.
Neoplasms
Silencing of PRDX2 Inhibits the Proliferation and Invasion of Non-Small Cell Lung Cancer Cells.
Neoplasms
Silencing the Peroxiredoxin III gene inhibits cell proliferation in breast cancer.
Neoplasms
Small interfering RNA targeting of peroxiredoxin? gene enhances formaldehyde-induced toxicity in bone marrow cells isolated from BALB/c mice.
Neoplasms
Specific expression profile and prognostic significance of peroxiredoxins in grade II-IV astrocytic brain tumors.
Neoplasms
Spirulina phycocyanin induces differential protein expression and apoptosis in SKOV-3 cells.
Neoplasms
Suppression of peroxiredoxin 4 in glioblastoma cells increases apoptosis and reduces tumor growth.
Neoplasms
Survival of APC-mutant colorectal cancer cells requires interaction between tankyrase and a thiol peroxidase, peroxiredoxin II.
Neoplasms
Synergistic effect of peroxiredoxin II antisense on cisplatin-induced cell death.
Neoplasms
Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis.
Neoplasms
Targeting peroxiredoxin 1 impairs growth of breast cancer cells and potently sensitises these cells to prooxidant agents.
Neoplasms
The Combination Of Weak Expression Of PRDX4 And Very High MIB-1 Labelling Index Independently Predicts Shorter Disease-free Survival In Stage I Lung Adenocarcinoma.
Neoplasms
The effect of peroxiredoxin 4 on fly physiology is a complex interplay of antioxidant and signaling functions.
Neoplasms
The functional role of peroxiredoxin 3 in reactive oxygen species, apoptosis, and chemoresistance of cancer cells.
Neoplasms
The Role of Redox-Regulating Enzymes in Inoperable Breast Cancers Treated with Neoadjuvant Chemotherapy.
Neoplasms
The Synergistic Effect of an ATP-Competitive Inhibitor of mTOR and Metformin on Pancreatic Tumor Growth.
Neoplasms
The tumor suppressor mst1 promotes changes in the cellular redox state by phosphorylation and inactivation of peroxiredoxin-1 protein.
Neoplasms
Threonine modulates immune response, antioxidant status and gene expressions of antioxidant enzymes and antioxidant-immune-cytokine-related signaling molecules in juvenile blunt snout bream (Megalobrama amblycephala).
Neoplasms
Tubular Peroxiredoxin 3 as a Predictor of Renal Recovery from Acute Tubular Necrosis in Patients with Chronic Kidney Disease.
Neoplasms
Tumor protein D52 (isoform 3) interacts with and promotes peroxidase activity of Peroxiredoxin 1 in prostate cancer cells implicated in cell growth and migration.
Neoplasms
Upregulation of Peroxiredoxin-2 in Well-Differentiated Pancreatic Neuroendocrine Tumors and Its Utility as a Biomarker for Predicting the Response to Everolimus.
Neoplasms
Ursodeoxycholic acid suppresses epithelial-mesenchymal transition and cancer stem cell formation by reducing the levels of peroxiredoxin II and reactive oxygen species in pancreatic cancer cells.
Neoplasms
Validation of Cadherin HAV6 Peptide in the Transient Modulation of the Blood-Brain Barrier for the Treatment of Brain Tumors.
Neoplasms
[Effects of yiqi chutan recipe on tumor growth, survival time and expressions of PRDX-1 and PRDX-6 in Lewis lung carcinoma model mice with pi-deficiency syndrome].
Neoplasms
[Proteomic analysis on portal vein tumor thrombus-associated proteins for hepatocellular carcinoma]
Neoplasms
[The biological function of peroxiredoxin II on Hep3B cells and its underlying mechanism]
Nervous System Diseases
Effects of Peroxiredoxin 2 in Neurological Disorders: A Review of its Molecular Mechanisms.
Nervous System Diseases
The antioxidant enzyme peroxiredoxin and its protective role in neurological disorders.
Neuroblastoma
Cypermethrin Activates Autophagosome Formation Albeit Inhibits Autophagy Owing to Poor Lysosome Quality: Relevance to Parkinson's Disease.
Neuroblastoma
Peroxiredoxin 2 (PRDX2), an antioxidant enzyme, is under-expressed in Down syndrome fetal brains.
Neuroblastoma
Peroxiredoxin I regulates the component expression of ?-secretase complex causing the Alzheimer's disease.
Neuroblastoma
Silencing of peroxiredoxin 3 and peroxiredoxin 5 reveals the role of mitochondrial peroxiredoxins in the protection of human neuroblastoma SH-SY5Y cells toward MPP(+).
Neuroblastoma
The novel cholinesterase-monoamine oxidase inhibitor and antioxidant, ladostigil, confers neuroprotection in neuroblastoma cells and aged rats.
Neurodegenerative Diseases
Aberrant expression of peroxiredoxin subtypes in neurodegenerative disorders.
Neurodegenerative Diseases
Hyperhomocysteinemia and Bleomycin Hydrolase Modulate the Expression of Mouse Brain Proteins Involved in Neurodegeneration.
Neurodegenerative Diseases
Numerous proteins in Mammalian cells are prone to iron-dependent oxidation and proteasomal degradation.
Neurodegenerative Diseases
Peroxiredoxin 2 is involved in the neuroprotective effects of PACAP in cultured cerebellar granule neurons.
Neurodegenerative Diseases
Peroxiredoxin distribution in the mouse brain with emphasis on neuronal populations affected in neurodegenerative disorders.
Neurodegenerative Diseases
Posttranslational modification of cysteine in redox signaling and oxidative stress: focus on s-glutathionylation.
Neurodegenerative Diseases
Role of Peroxiredoxin 2 in the Protection Against Ferrous Sulfate-Induced Oxidative and Inflammatory Injury in PC12 Cells.
Neuroinflammatory Diseases
Modulation of vascular integrity and neuroinflammation by peroxiredoxin 4 following cerebral ischemia-reperfusion injury.
Neuroinflammatory Diseases
Peroxiredoxin I is a ROS/p38 MAPK-dependent inducible antioxidant that regulates NF-?B-mediated iNOS induction and microglial activation.
Non-alcoholic Fatty Liver Disease
Overexpression of Peroxiredoxin 4 Affects Intestinal Function in a Dietary Mouse Model of Nonalcoholic Fatty Liver Disease.
Non-alcoholic Fatty Liver Disease
Peroxiredoxin 4 (PRDX4): Its critical in vivo roles in animal models of metabolic syndrome ranging from atherosclerosis to nonalcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
PEROXIREDOXIN 4 PROTECTS AGAINST NONALCOHOLIC STEATOHEPATITIS AND TYPE 2 DIABETES IN A NONGENETIC MOUSE MODEL.
Non-alcoholic Fatty Liver Disease
Peroxiredoxin 5 ameliorates obesity-induced non-alcoholic fatty liver disease through the regulation of oxidative stress and AMP-activated protein kinase signaling.
Obesity
Author Correction: Lgals9 deficiency ameliorates obesity by modulating redox state of PRDX2.
Obesity
Differential representation of liver proteins in obese human subjects suggests novel biomarkers and promising targets for drug development in obesity.
Obesity
Effects of Obesity on Perivascular Adipose Tissue Vasorelaxant Function: Nitric Oxide, Inflammation and Elevated Systemic Blood Pressure.
Obesity
Expression of hepatic antioxidant enzymes in non-obese type-2 diabetic Goto-Kakizaki rats.
Obesity
Plekhs1 and Prdx3 are candidate genes responsible for mild hyperglycemia associated with obesity in a new animal model of F344-fa-nidd6 rat.
Opisthorchiasis
Secretion of Thioredoxin Peroxidase Protein of Cat Liver Fluke Opisthorchis felineus during Modeling of Experimental Opisthorchiasis.
Osteoarthritis
Intra-articular injection of Torin 1 reduces degeneration of articular cartilage in a rabbit osteoarthritis model.
Osteoarthritis
Oxidative Stress Promotes Peroxiredoxin Hyperoxidation and Attenuates Pro-survival Signaling in Aging Chondrocytes.
Osteoarthritis
The protective role of autophagy in experimental osteoarthritis, and the therapeutic effects of Torin 1 on osteoarthritis by activating autophagy.
Osteosarcoma
?-Elemene Enhances the Sensitivity of Osteosarcoma Cells to Doxorubicin via Downregulation of Peroxiredoxin-1.
Osteosarcoma
Peroxiredoxin 1 (PRDX1) Suppresses Progressions and Metastasis of Osteosarcoma and Fibrosarcoma of Bone.
Osteosarcoma
Peroxiredoxin 2 as a chemotherapy responsiveness biomarker candidate in osteosarcoma revealed by proteomics.
Osteosarcoma
Peroxiredoxin Expression of Human Osteosarcoma Cells Is Influenced by Cold Atmospheric Plasma Treatment.
Osteosarcoma
Peroxiredoxin-1 promotes cell proliferation and metastasis through enhancing Akt/mTOR in human osteosarcoma cells.
Osteosarcoma
Proteomics study of open biopsy samples identifies peroxiredoxin 2 as a predictive biomarker of response to induction chemotherapy in osteosarcoma.
Out-of-Hospital Cardiac Arrest
The Combination of Biomarkers for Prognostication of Long-Term Outcome in Patients Treated with Mild Hypothermia After Out-of-Hospital Cardiac Arrest-A Pilot Study.
Ovarian Neoplasms
CircRAB11FIP1 promoted autophagy flux of ovarian cancer through DSC1 and miR-129.
Ovarian Neoplasms
Down-regulation of 8-Hydroxydeoxyguanosine and Peroxiredoxin II in the Pathogenesis of Endometriosis-associated Ovarian Cancer.
Ovarian Neoplasms
Peroxiredoxin III protein expression is associated with platinum resistance in epithelial ovarian cancer.
Ovarian Neoplasms
Proteomic analysis of ovarian cancer proximal fluids: validation of elevated peroxiredoxin 1 in patient peripheral circulation.
Pancreatic Neoplasms
Comparative proteomic analysis of differentially expressed proteins in human pancreatic cancer tissue.
Pancreatic Neoplasms
Expression and clinical value of peroxiredoxin-1 in patients with pancreatic cancer.
Pancreatic Neoplasms
Peroxiredoxin 1 Promotes Pancreatic Cancer Cell Invasion by Modulating p38 MAPK Activity.
Pancreatic Neoplasms
Peroxiredoxin 1 silencing inhibited the growth and promoted apoptosis of pancreatic cancer cells via targeting FOXO3 gene.
Pancreatic Neoplasms
Proteomics finding heat shock protein 27 as a biomarker for resistance of pancreatic cancer cells to gemcitabine.
Pancreatic Neoplasms
Thioredoxin system-mediated regulation of mutant Kras associated pancreatic neoplasia and cancer.
Pancreatic Neoplasms
Ursodeoxycholic acid suppresses epithelial-mesenchymal transition and cancer stem cell formation by reducing the levels of peroxiredoxin II and reactive oxygen species in pancreatic cancer cells.
Pancreatitis
Protein expression profiles in pancreatic adenocarcinoma compared with normal pancreatic tissue and tissue affected by pancreatitis as detected by two-dimensional gel electrophoresis and mass spectrometry.
Papillomavirus Infections
Peroxiredoxin 2 is highly expressed in human oral squamous cell carcinoma cells and is upregulated by human papillomavirus oncoproteins and arecoline, promoting proliferation.
Parasitemia
Trans-sialidase overcomes many antigens to be used as a vaccine candidate against Trypanosoma cruzi.
Parasitic Diseases
A mosquito 2-Cys peroxiredoxin protects against nitrosative and oxidative stresses associated with malaria parasite infection.
Paratuberculosis
Elevated antibody responses in patients with Crohn's disease against a 14-kDa secreted protein purified from Mycobacterium avium subsp. paratuberculosis.
Parkinson Disease
Oxidative Modification of Peroxiredoxin Is Associated with Drug-induced Apoptotic Signaling in Experimental Models of Parkinson Disease.
Parkinson Disease
Peroxiredoxin 5 links mitochondrial redox signalling with calcium dynamics: impact on Parkinson's disease.
Parkinson Disease
Proteomic Profiling of the Insoluble Pellets of the Transected Rat Spinal Cord.
Parkinson Disease
S-nitrosylation of peroxiredoxin 2 promotes oxidative stress-induced neuronal cell death in Parkinson's disease.
Parkinsonian Disorders
Involvement of Peroxiredoxin-3, Thioredoxin-2, and Protein Deglycase-1 in Cypermethrin-Induced Parkinsonism.
Peptic Ulcer
Production of polyclonal antibody against alkyl hydroperoxide reductase of Helicobacter pylori and its antigenicity.
Periodontitis
Dual function of peroxiredoxin I in lipopolysaccharide-induced osteoblast apoptosis via reactive oxygen species and the apoptosis signal-regulating kinase 1 signaling pathway.
Persistent Infection
Leishmania amazonensis amastigotes highly express a tryparedoxin peroxidase isoform that increases parasite resistance to macrophage antimicrobial defenses and Fosters parasite virulence.
Plasmablastic Lymphoma
Peroxiredoxin I is differentially expressed in multiple myelomas and in plasmablastic lymphomas.
Pneumonia
Aggravation of Bleomycin-Induced Pulmonary Inflammation and Fibrosis in Mice Lacking Peroxiredoxin I.
Pneumonia
Evolution and function of the Mycoplasma hyopneumoniae peroxiredoxin, a 2-Cys-like enzyme with a single Cys residue.
Pneumonia
Increased annexin A1 and A2 levels in bronchoalveolar lavage fluid are associated with resistance to respiratory disease in beef calves.
Pneumonia
Peroxiredoxin I null mice exhibits reduced acute lung inflammation following ozone exposure.
Pneumonia
The effect of exposure time and concentration of airborne PM2.5 on lung injury in mice: A transcriptome analysis.
Polycystic Ovary Syndrome
Downregulated Expression of Peroxiredoxin 4 in Granulosa Cells from Polycystic Ovary Syndrome.
Polycystic Ovary Syndrome
Plasma level of peroxiredoxin 3 in patients with polycystic ovarian syndrome.
Pre-Eclampsia
Association of glutamate cystein ligase (GCL) activity Peroxiredoxin 4 (prxR4) and apelin levels in women with preeclampsia.
Pre-Eclampsia
Role of peroxiredoxin III in the pathogenesis of pre-eclampsia as evidenced in mice.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Rapamycin-resistant and torin-sensitive mTOR signaling promotes the survival and proliferation of leukemic cells.
Prediabetic State
Increased peroxiredoxin 4 levels in patients with prediabetes compared to normal glucose tolerance subjects.
Premature Birth
Induction of peroxiredoxin gene expression by oxygen in lungs of newborn primates.
Prostatic Hyperplasia
Mitochondrion-associated protein peroxiredoxin 3 promotes benign prostatic hyperplasia through autophagy suppression and pyroptosis activation.
Prostatic Intraepithelial Neoplasia
Peroxiredoxin-3 is overexpressed in prostate cancer and promotes cancer cell survival by protecting cells from oxidative stress.
Prostatic Neoplasms
Dual inhibition of BRD4 and PI3K by SF2523 suppresses human prostate cancer cell growth in vitro and in vivo.
Prostatic Neoplasms
Peroxiredoxin 1 controls prostate cancer growth through Toll-like receptor 4-dependent regulation of tumor vasculature.
Prostatic Neoplasms
Peroxiredoxin 2 in the nucleus and cytoplasm distinctly regulates androgen receptor activity in prostate cancer cells.
Prostatic Neoplasms
Peroxiredoxin-3 is overexpressed in prostate cancer and promotes cancer cell survival by protecting cells from oxidative stress.
Prostatic Neoplasms
The nrf1 and nrf2 balance in oxidative stress regulation and androgen signaling in prostate cancer cells.
Prostatic Neoplasms
Tumor protein D52 (isoform 3) interacts with and promotes peroxidase activity of Peroxiredoxin 1 in prostate cancer cells implicated in cell growth and migration.
Pseudorabies
Peroxiredoxin 1 Interacts with TBK1/IKK? and Negatively Regulates Pseudorabies Virus Propagation by Promoting Innate Immunity.
Psoriasis
Ezrin, maspin, peroxiredoxin 2, and heat shock protein 27: potential targets of a streptococcal-induced autoimmune response in psoriasis.
Pterygium
Expression of Peroxiredoxin 2 and Vascular Endothelial Growth Factor Receptor 2 in Pterygium.
Pterygium
Peroxiredoxin I and II in human eyes: cellular distribution and association with pterygium and DNA damage.
Pterygium
Proteomic analysis in pterygium; upregulated protein expression of ALDH3A1, PDIA3, and PRDX2.
Pulmonary Disease, Chronic Obstructive
Peroxiredoxins and Immune Infiltrations in Colon Adenocarcinoma: Their Negative Correlations and Clinical Significances, an In Silico Analysis.
Pulmonary Disease, Chronic Obstructive
Susceptibility to COPD: differential proteomic profiling after acute smoking.
Pulmonary Fibrosis
Aggravation of Bleomycin-Induced Pulmonary Inflammation and Fibrosis in Mice Lacking Peroxiredoxin I.
Rabies
Proteomic profiles of mouse neuro N2a cells infected with variant virulence of rabies viruses.
Renal Insufficiency, Chronic
Tubular Peroxiredoxin 3 as a Predictor of Renal Recovery from Acute Tubular Necrosis in Patients with Chronic Kidney Disease.
Reperfusion Injury
Increased expression of peroxiredoxin 1 and identification of a novel lipid-metabolizing enzyme in the early phase of liver ischemia reperfusion injury.
Reperfusion Injury
Modulation of vascular integrity and neuroinflammation by peroxiredoxin 4 following cerebral ischemia-reperfusion injury.
Retinal Detachment
Proteomic Analysis of the Vitreous following Experimental Retinal Detachment in Rabbits.
Rhabdomyoma
Adult rhabdomyoma with oncocytic changes affecting the floor of the mouth: optical, immunohistochemical, and ultrastructural study.
Rheumatic Diseases
[Investigation of the spreading of rheumatic disease; incidence of rheumatic disease in the members of a Bus and Streetcar Society of Torin; clinical & radiological findings.]
Sarcoidosis
A quantitative proteomic analysis of soluble bronchoalveolar fluid proteins from patients with sarcoidosis and chronic beryllium disease.
Sarcoidosis
Bronchoalveolar lavage fluid protein composition in patients with sarcoidosis and idiopathic pulmonary fibrosis: a two-dimensional electrophoretic study.
Sarcoma, Ewing
Augmented Antitumor Activity for Novel Dual PI3K/BDR4 Inhibitors, SF2523 and SF1126 in Ewing Sarcoma.
Sarcoma, Kaposi
Expression of peroxiredoxin II in vascular tumors of the skin: a novel vascular marker of endothelial cells.
Scabies
Characterisation and analysis of thioredoxin peroxidase as a potential antigen for the serodiagnosis of sarcoptic mange in rabbits by dot-ELISA.
Schistosomiasis
Biochemical characterization of 2-Cys peroxiredoxins from Schistosoma mansoni.
Schistosomiasis mansoni
Biomphalaria glabrata peroxiredoxin: Effect of Schistosoma mansoni infection on differential gene regulation.
Scleroderma, Systemic
Autoantibody against peroxiredoxin I, an antioxidant enzyme, in patients with systemic sclerosis: possible association with oxidative stress.
Sepsis
Circulating levels of Peroxiredoxin 4 as a Novel Biomarker of Oxidative Stress in Patients with Sepsis.
Sepsis
Increased circulating peroxiredoxin-4 in sepsis model rats involves secretion from hepatocytes and is mitigated by GYY4137.
Sepsis
Targeting Peroxiredoxin 1 by a Curcumin Analogue, AI-44, Inhibits NLRP3 Inflammasome Activation and Attenuates Lipopolysaccharide-Induced Sepsis in Mice.
Severe Dengue
Differential expression of aldolase, alpha tubulin and thioredoxin peroxidase in peripheral blood mononuclear cells from dengue fever and dengue hemorrhagic fever patients.
Shock, Cardiogenic
Peroxiredoxin 1 induces inflammatory cytokine response and predicts outcome of cardiogenic shock patients necessitating extracorporeal membrane oxygenation: an observational cohort study and translational approach.
Shock, Septic
Peroxiredoxin-1 aggravates lipopolysaccharide-induced septic shock via promoting inflammation.
Silicosis
[Differential expression of PRDX4 in alveolar macrophages of patients with silicosis].
Skin Neoplasms
Peroxiredoxin I deficiency increases keratinocyte apoptosis in a skin tumor model via the ROS-p38 MAPK pathway.
Spinal Cord Injuries
Expression of Peroxiredoxin 1 After Traumatic Spinal Cord Injury in Rats.
Squamous Cell Carcinoma of Head and Neck
Assessment of Potential Prognostic Value of Peroxiredoxin 1 in Oral Squamous Cell Carcinoma.
Squamous Cell Carcinoma of Head and Neck
Differential expression of peroxiredoxin 3 in laryngeal squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Erratum: Assessment of Potential Prognostic Value of Peroxiredoxin 1 in Oral Squamous Cell Carcinoma [Corrigendum].
Squamous Cell Carcinoma of Head and Neck
Expression of cyclooxygenase-2, peroxiredoxin I, peroxiredoxin 6 and nuclear factor-?B in oral squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Induction of peroxiredoxin 1 by hypoxia regulates heme oxygenase-1 via NF-?B in oral cancer.
Squamous Cell Carcinoma of Head and Neck
LncRNA LINC00460 promotes EMT in head and neck squamous cell carcinoma by facilitating peroxiredoxin-1 into the nucleus.
Squamous Cell Carcinoma of Head and Neck
Nicotine suppresses apoptosis by regulating ?7nAChR/Prx1 axis in oral precancerous lesions.
Squamous Cell Carcinoma of Head and Neck
Peroxiredoxin 2 is highly expressed in human oral squamous cell carcinoma cells and is upregulated by human papillomavirus oncoproteins and arecoline, promoting proliferation.
Squamous Cell Carcinoma of Head and Neck
Peroxiredoxin 5 is involved in cancer cell invasion and tumor growth of oral squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Peroxiredoxin I expression in oral cancer: a potential new tumor marker.
Starvation
A proteome analysis of the tetracyanonickelate (II) responses in Klebsiella oxytoca.
Starvation
Biallelic VPS35L pathogenic variants cause 3C/Ritscher-Schinzel-like syndrome through dysfunction of retriever complex.
Starvation
Characterization of the Vibrio vulnificus 1-Cys peroxiredoxin Prx3 and regulation of its expression by the Fe-S cluster regulator IscR in response to oxidative stress and iron starvation.
Starvation
Sulfur transfer and activation by ubiquitin-like modifier system Uba4Urm1 link protein urmylation and tRNA thiolation in yeast.
Starvation
The cytidine repressor regulates the survival of Pantoea agglomerans YS19 under oxidative stress and sulfur starvation conditions.
Starvation
The response of Cupriavidus metallidurans CH34 to spaceflight in the international space station.
Stomach Neoplasms
Celastrol induces ROS-mediated apoptosis via directly targeting peroxiredoxin-2 in gastric cancer cells.
Stomach Neoplasms
CircDIDO1 inhibits gastric cancer progression by encoding a novel DIDO1-529aa protein and regulating PRDX2 protein stability.
Stomach Neoplasms
Downregulation of peroxiredoxin II suppresses the proliferation and metastasis of gastric cancer cells.
Stomach Neoplasms
High Expression of Peroxiredoxin 1 Is Associated with Epithelial-Mesenchymal Transition Marker and Poor Prognosis in Gastric Cancer.
Stomach Neoplasms
Induced nitric oxide synthetase and peroxiredoxin expression in intramucosal poorly differentiated gastric cancer of young patients.
Stomach Neoplasms
Inhibition of peroxiredoxin 2 suppresses Wnt/?-catenin signaling in gastric cancer.
Stomach Neoplasms
Peroxiredoxin 5 overexpression enhances tumorigenicity and correlates with poor prognosis in gastric cancer.
Stomach Neoplasms
Peroxiredoxin V Inhibits Emodin-induced Gastric Cancer Cell Apoptosis via the ROS/Bcl2 Pathway.
Stomach Neoplasms
Peroxiredoxin V Silencing Elevates Susceptibility to Doxorubicin-induced Cell Apoptosis via ROS-dependent Mitochondrial Dysfunction in AGS Gastric Cancer Cells.
Stomach Neoplasms
PRDX2 protects against oxidative stress induced by H. pylori and promotes resistance to cisplatin in gastric cancer.
Stomach Neoplasms
Prdx2 Upregulation Promotes the Growth and Survival of Gastric Cancer Cells.
Stomach Neoplasms
Quantitative proteomic analysis of gastric cancer tissue reveals novel proteins in platelet-derived growth factor b signaling pathway.
Stomach Neoplasms
RKIP and peroxiredoxin 2 expression predicts the proliferative potential of gastric cancer stem cells.
Stomach Neoplasms
Serum Helicobacter pylori KatA and AhpC antibodies as novel biomarkers for gastric cancer.
Stomach Neoplasms
Silencing of peroxiredoxin II by promoter methylation is necessary for the survival and migration of gastric cancer cells.
Stomach Neoplasms
Synergistic effect of peroxiredoxin II antisense on cisplatin-induced cell death.
Stomach Neoplasms
Systematic Characterization of Prognostic Values of Peroxiredoxin Family in Gastric Cancer.
Stomach Neoplasms
[New early gastric cancer marker PRDX4 promote the tumorigenesis and progression of gastric cancer via eliminating ROS].
Stroke
Diagnostic performance of peroxiredoxin 1 to determine time-of-onset of acute cerebral infarction.
Stroke
Different effects of arginine vasopressin on high-mobility group box 1 expression in astrocytes isolated from stroke-prone spontaneously hypertensive rats and congenic SHRpch1_18 rats.
Stroke
Effects of Peroxiredoxin 2 in Neurological Disorders: A Review of its Molecular Mechanisms.
Stroke
Effects of the Prdx2 depletion on blood pressure and life span in spontaneously hypertensive rats.
Stroke
Peroxiredoxin 5 (PRX5) is correlated inversely to systemic markers of inflammation in acute stroke.
Subarachnoid Hemorrhage
Peroxiredoxin 1/2 protects brain against H2O2-induced apoptosis after subarachnoid hemorrhage.
Subarachnoid Hemorrhage
Peroxiredoxin 2 activates microglia by interacting with Toll-like receptor 4 after subarachnoid hemorrhage.
Systemic Vasculitis
Peroxiredoxin 2 is a novel autoantigen for anti-endothelial cell antibodies in systemic vasculitis.
Tauopathies
Identification of non-Alzheimer's disease tauopathies-related proteins by proteomic analysis.
Teratoma
Dominant Role of Peroxiredoxin/JNK Axis in Stemness Regulation During Neurogenesis from Embryonic Stem Cells.
Thalassemia
Peroxiredoxin II is essential for preventing hemolytic anemia from oxidative stress through maintaining hemoglobin stability.
Thalassemia
The Interplay Between Peroxiredoxin-2 and Nuclear Factor-Erythroid 2 Is Important in Limiting Oxidative Mediated Dysfunction in ?-Thalassemic Erythropoiesis.
thioredoxin-dependent peroxiredoxin deficiency
Ablation of Peroxiredoxin II Attenuates Experimental Colitis by Increasing FoxO1-Induced Foxp3+ Regulatory T Cells.
thioredoxin-dependent peroxiredoxin deficiency
Deficiency of peroxiredoxin 2 exacerbates angiotensin II-induced abdominal aortic aneurysm.
thioredoxin-dependent peroxiredoxin deficiency
Peroxiredoxin 2 deficiency accelerates age-related ovarian failure through the reactive oxygen species-mediated JNK pathway in mice.
thioredoxin-dependent peroxiredoxin deficiency
Peroxiredoxin 2 deficiency does not affect insulin resistance and oxidative stress in high-fat diet-fed obese mice.
thioredoxin-dependent peroxiredoxin deficiency
Peroxiredoxin 2 Deficiency Exacerbates Atherosclerosis in Apolipoprotein E-Deficient Mice.
thioredoxin-dependent peroxiredoxin deficiency
Peroxiredoxin 2 deficiency reduces white adipogenesis due to the excessive ROS generation.
thioredoxin-dependent peroxiredoxin deficiency
Peroxiredoxin 3 deficiency accelerates chronic kidney injury in mice through interactions between macrophages and tubular epithelial cells.
thioredoxin-dependent peroxiredoxin deficiency
Peroxiredoxin 5 deficiency exacerbates iron overload-induced neuronal death via ER-mediated mitochondrial fission in mouse hippocampus.
thioredoxin-dependent peroxiredoxin deficiency
Peroxiredoxin I deficiency attenuates phagocytic capacity of macrophage in clearance of the red blood cells damaged by oxidative stress.
thioredoxin-dependent peroxiredoxin deficiency
Peroxiredoxin I deficiency increases keratinocyte apoptosis in a skin tumor model via the ROS-p38 MAPK pathway.
thioredoxin-dependent peroxiredoxin deficiency
Peroxiredoxin I deficiency increases LPS?induced lethal shock in mice.
thioredoxin-dependent peroxiredoxin deficiency
Peroxiredoxin I is a ROS/p38 MAPK-dependent inducible antioxidant that regulates NF-?B-mediated iNOS induction and microglial activation.
thioredoxin-dependent peroxiredoxin deficiency
Peroxiredoxin II is an antioxidant enzyme that negatively regulates collagen-stimulated platelet function.
thioredoxin-dependent peroxiredoxin deficiency
Peroxiredoxin II is an essential antioxidant enzyme that prevents the oxidative inactivation of VEGF receptor-2 in vascular endothelial cells.
thioredoxin-dependent peroxiredoxin deficiency
Peroxiredoxin-null yeast cells are hypersensitive to oxidative stress and are genomically unstable.
thioredoxin-dependent peroxiredoxin deficiency
Protective Role of Peroxiredoxin I in Heat-Killed Staphylococcus Aureus-infected Mice.
thioredoxin-dependent peroxiredoxin deficiency
Regulation of PDGF signalling and vascular remodelling by peroxiredoxin II.
Thrombosis
Peroxiredoxin II is an antioxidant enzyme that negatively regulates collagen-stimulated platelet function.
Thrombosis
[Proteomic analysis on portal vein tumor thrombus-associated proteins for hepatocellular carcinoma]
Thymoma
PRDX1 activates autophagy via the PTEN-AKT signaling pathway to protect against cisplatin-induced spiral ganglion neuron damage.
Thyroid Neoplasms
Suppression of MG132-mediated cell death by peroxiredoxin 1 through influence on ASK1 activation in human thyroid cancer cells.
Tongue Neoplasms
Peroxiredoxin I expression in tongue squamous cell carcinomas as involved in tumor recurrence.
Toxoplasmosis
Evaluation of toxoplasmosis in pregnant women using dot-immunogold-silver staining with recombinant Toxoplasma gondii peroxiredoxin protein.
Toxoplasmosis
Immunization with Toxoplasma gondii peroxiredoxin 1 induces protective immunity against toxoplasmosis in mice.
Triple Negative Breast Neoplasms
Triple Combination of Ascorbate, Menadione and the Inhibition of Peroxiredoxin-1 Produces Synergistic Cytotoxic Effects in Triple-Negative Breast Cancer Cells.
Tuberculosis
Alkyl hydroperoxide reductases C and D are major antigens constitutively expressed by Mycobacterium avium subsp. paratuberculosis.
Tuberculosis
An extracellular disulfide bond forming protein (DsbF) from Mycobacterium tuberculosis: structural, biochemical, and gene expression analysis.
Tuberculosis
Compensatory functions of two alkyl hydroperoxide reductases in the oxidative defense system of Legionella pneumophila.
Tuberculosis
Crystal Structure of AhpE from Mycobacterium tuberculosis, a 1-Cys peroxiredoxin.
Tuberculosis
Disruption of redox catalytic functions of peroxiredoxin-thioredoxin complex in Mycobacterium tuberculosis H37Rv using small interface binding molecules.
Tuberculosis
Effects of overexpression of the alkyl hydroperoxide reductase AhpC on the virulence and isoniazid resistance of Mycobacterium tuberculosis.
Tuberculosis
Functional and structural characterization of a thiol peroxidase from Mycobacterium tuberculosis.
Tuberculosis
Green fluorescent protein as a marker for gene expression and cell biology of mycobacterial interactions with macrophages.
Tuberculosis
Inhibition of Mycobacterium tuberculosis AhpD, an element of the peroxiredoxin defense against oxidative stress.
Tuberculosis
Kinetics of formation and reactivity of the persulfide in the one-cysteine peroxiredoxin from Mycobacterium tuberculosis.
Tuberculosis
Multiple thioredoxin-mediated routes to detoxify hydroperoxides in Mycobacterium tuberculosis.
Tuberculosis
Multiscale Modeling of Thiol Overoxidation in Peroxiredoxins by Hydrogen Peroxide.
Tuberculosis
Mycobacterium tuberculosis is a natural mutant with an inactivated oxidative-stress regulatory gene: implications for sensitivity to isoniazid.
Tuberculosis
Oxidative stress response and characterization of the oxyR-ahpC and furA-katG loci in Mycobacterium marinum.
Tuberculosis
Oxidative stress response and its role in sensitivity to isoniazid in mycobacteria: characterization and inducibility of ahpC by peroxides in Mycobacterium smegmatis and lack of expression in M. aurum and M. tuberculosis.
Tuberculosis
Oxidizing substrate specificity of Mycobacterium tuberculosis alkyl hydroperoxide reductase E: kinetics and mechanisms of oxidation and overoxidation.
Tuberculosis
Peroxiredoxin 1 Contributes to Host Defenses against Mycobacterium tuberculosis.
Tuberculosis
Prospective Discrimination of Controllers From Progressors Early After Low-Dose Mycobacterium tuberculosis Infection of Cynomolgus Macaques using Blood RNA Signatures.
Tuberculosis
PrxQ B from Mycobacterium tuberculosis is a monomeric, thioredoxin-dependent and highly efficient fatty acid hydroperoxide reductase.
Tuberculosis
Role of Oxidative Stress in the Pathology and Management of Human Tuberculosis.
Tuberculosis
Silencing of oxidative stress response in Mycobacterium tuberculosis: expression patterns of ahpC in virulent and avirulent strains and effect of ahpC inactivation.
Tuberculosis
Site-directed mutagenesis reveals a novel catalytic mechanism of Mycobacterium tuberculosis alkylhydroperoxidase C.
Tuberculosis
The mycobacterial thioredoxin peroxidase can act as a one-cysteine peroxiredoxin.
Tuberculosis
Thiol and sulfenic acid oxidation of AhpE, the one-cysteine peroxiredoxin from mycobacterium tuberculosis: kinetics, acidity constants, and conformational dynamics.
Tuberculosis
[Multidrug-resistant tuberculosis. 2. Mechanisms of drug-resistance in Mycobacterium tuberculosis--genetic mechanisms of drug-resistance]
Tularemia
Role of peroxiredoxin of the AhpC/TSA family in antioxidant defense mechanisms of Francisella tularensis.
Urinary Bladder Neoplasms
Enhanced Expression of Peroxiredoxin I and VI Correlates with Development, Recurrence and Progression of Human Bladder Cancer.
Urinary Bladder Neoplasms
Screening of Differentially Expressed Genes Related to Bladder Cancer and Functional Analysis with DNA Microarray.
Uterine Cervical Neoplasms
Anti-apoptotic role of peroxiredoxin III in cervical cancer cells.
Uterine Cervical Neoplasms
Differential proteins among normal cervix cells and cervical cancer cells with HPV-16 infection, through mass spectrometry-based Proteomics (2D-DIGE) in women from Southern México.
Uterine Cervical Neoplasms
Expression of human peroxiredoxin isoforms in response to cervical carcinogenesis.
Uterine Cervical Neoplasms
Expression of thioredoxin 1 and peroxiredoxins in squamous cervical carcinoma and its predictive role in NACT.
Uterine Cervical Neoplasms
Peroxiredoxin 3 is a novel marker for cell proliferation in cervical cancer.
Uterine Cervical Neoplasms
Proteomic Identification of Neoadjuvant Chemotherapy-Related Proteins in Bulky Stage IB-IIA Squamous Cervical Cancer.
Uterine Cervical Neoplasms
Up-regulation of peroxiredoxin-1 promotes cell proliferation and metastasis and inhibits apoptosis in cervical cancer.
Vaccinia
A prime/boost DNA/Modified vaccinia virus Ankara vaccine expressing recombinant Leishmania DNA encoding TRYP is safe and immunogenic in outbred dogs, the reservoir of zoonotic visceral leishmaniasis.
Vaccinia
Heterologous priming-boosting with DNA and modified vaccinia virus Ankara expressing tryparedoxin peroxidase promotes long-term memory against Leishmania major in susceptible BALB/c Mice.
Vaccinia
IL-10 from regulatory T cells determines vaccine efficacy in murine Leishmania major infection.
Vaccinia
Selection of appropriate serological tests to measure the incidence of natural Leishmania infantum infection during DNA/MVA prime/boost canine vaccine trials.
Varicocele
Proteomic analysis of seminal plasma from bilateral varicocele patients indicates an oxidative state and increased inflammatory response.
Vascular Diseases
Deficiency of peroxiredoxin 2 exacerbates angiotensin II-induced abdominal aortic aneurysm.
Vascular System Injuries
Vascular Injury Involves the Overoxidation of Peroxiredoxin Type II and Is Recovered by the Peroxiredoxin Activity Mimetic That Induces Reendothelialization.
Vasculitis
Autoantibodies to peroxiredoxin I and IV in patients with systemic autoimmune diseases.
Vasculitis
Vasculitis induced by immunization with Bacillus Calmette-Guérin followed by atypical mycobacterium antigen: a new mouse model for Kawasaki disease.
Virus Diseases
Characterization of a silkworm thioredoxin peroxidase that is induced by external temperature stimulus and viral infection.
Virus Diseases
Molecular characterization, immune response against white spot syndrome virus infection of peroxiredoxin 4 in Fenneropenaeus chinensis and its antioxidant activity.
Virus Diseases
Quantitative Proteomics Reveal Peroxiredoxin Perturbation Upon Persistent Lymphocytic Choriomeningitis Virus Infection in Human Cells.
Virus Diseases
The Human Cytomegalovirus Protein pUL38 Suppresses Endoplasmic Reticulum Stress-Mediated Cell Death Independently of Its Ability To Induce mTORC1 Activation.
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
5.4 - 9
no activity at or below pH 5.4, optimal activity at pH 9.0
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
sensitive to trypsin and chymotrypsin treatment. Very little or no activity detected after 40 min incubation with either protease
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Wen, L.; Huang, H.M.; Juang, R.H.; Lin, C.T.
Biochemical characterization of 1-Cys peroxiredoxin from Antrodia camphorata
Appl. Microbiol. Biotechnol.
73
1314-1322
2007
Taiwanofungus camphoratus (A1KZ88), Taiwanofungus camphoratus
brenda
EXTERNAL LINKS (specific for EC-Number 1.11.1.24)
Transporter Classification Database (TCDB): 8.A.147.1.1
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
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