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Abortion, Spontaneous
Long non-coding RNA H19 regulates Bcl-2, Bax and phospholipid hydroperoxide glutathione peroxidase expression in spontaneous abortion.
Adenocarcinoma
Erastin, a ferroptosis-inducing agent, sensitized cancer cells to X-ray irradiation via glutathione starvation in vitro and in vivo.
Adenocarcinoma
Mitochondrial DNA stress triggers autophagy-dependent ferroptotic death.
Adenocarcinoma
The dark side of ferroptosis in pancreatic cancer.
Adenocarcinoma
Tissue microarray assessment of selenoprotein P expression in gastric adenocarcinoma.
Adenoma
Inverse mRNA expression of the selenocysteine-containing proteins GI-GPx and SeP in colorectal adenomas compared with adjacent normal mucosa.
Alzheimer Disease
Association of selenoprotein p with Alzheimer's pathology in human cortex.
Alzheimer Disease
Delineating the role of glutathione peroxidase 4 in protecting cells against lipid hydroperoxide damage and in Alzheimer's disease.
Alzheimer Disease
Increased selenoprotein P in choroid plexus and cerebrospinal fluid in Alzheimer's disease brain.
Alzheimer Disease
Role of selenoprotein P in Alzheimer's disease.
Alzheimer Disease
Selenium, selenoprotein P, and Alzheimer's disease: is there a link?
Alzheimer Disease
Selenoprotein P and its potential role in Alzheimer's disease.
Aortic Aneurysm, Abdominal
Associations and interactions between variants in selenoprotein genes, selenoprotein levels and the development of abdominal aortic aneurysm, peripheral arterial disease, and heart failure.
Aortic Aneurysm, Abdominal
SEPP1 gene variants and abdominal aortic aneurysm: gene association in relation to metabolic risk factors and peripheral arterial disease coexistence.
Asthma
Maternal selenium status in pregnancy, offspring glutathione peroxidase 4 genotype, and childhood asthma.
Atherosclerosis
Overexpression of PHGPx inhibits hydroperoxide-induced oxidation, NFkappaB activation and apoptosis and affects oxLDL-mediated proliferation of rabbit aortic smooth muscle cells.
Atherosclerosis
Selenium in the prevention of atherosclerosis and its underlying mechanisms.
Atherosclerosis
Serum selenoprotein p levels in patients with type 2 diabetes and prediabetes: implications for insulin resistance, inflammation, and atherosclerosis.
Atherosclerosis
Suppression of atherogenesis by overexpression of glutathione peroxidase-4 in apolipoprotein E-deficient mice.
Bacterial Infections
Four selenoprotein P genes exist in salmonids: Analysis of their origin and expression following Se supplementation and bacterial infection.
Bacterial Infections
GPx4 in Bacterial Infection and Polymicrobial Sepsis: Involvement of Ferroptosis and Pyroptosis.
Barrett Esophagus
Genetic Variation in GPX1 Is Associated with GPX1 Activity in a Comprehensive Analysis of Genetic Variations in Selenoenzyme Genes and Their Activity and Oxidative Stress in Humans.
Bile Duct Neoplasms
Prediagnostic selenium status and hepatobiliary cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort.
Biliary Tract Neoplasms
Prediagnostic selenium status and hepatobiliary cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort.
Brain Injuries
Dauricine alleviated secondary brain injury after intracerebral hemorrhage by upregulating GPX4 expression and inhibiting ferroptosis of nerve cells.
Brain Injuries
Extract of Naotaifang, a compound Chinese herbal medicine, protects neuron ferroptosis induced by acute cerebral ischemia in rats.
Brain Injuries
Glutathione peroxidase 4 participates in secondary brain injury through mediating ferroptosis in a rat model of intracerebral hemorrhage.
Brain Injuries
Role for glutathione peroxidase-4 in brain development and neuronal apoptosis: specific induction of enzyme expression in reactive astrocytes following brain injury.
Brain Ischemia
Cross Talk Between Ferroptosis and Cerebral Ischemia.
Breast Neoplasms
Association between Polymorphisms in Glutathione Peroxidase and Selenoprotein P Genes, Glutathione Peroxidase Activity, HRT Use and Breast Cancer Risk.
Breast Neoplasms
Identification of a novel putative non-selenocysteine containing phospholipid hydroperoxide glutathione peroxidase (NPGPx) essential for alleviating oxidative stress generated from polyunsaturated fatty acids in breast cancer cells.
Breast Neoplasms
Impaired expression of glutathione peroxidase-4 gene in peripheral blood mononuclear cells: A biomarker of increased breast cancer risk.
Breast Neoplasms
Phospholipid hydroperoxide glutathione peroxidase induces a delay in G1 of the cell cycle.
Breast Neoplasms
Phospholipid hydroperoxide glutathione peroxidase protects against singlet oxygen-induced cell damage of photodynamic therapy.
Breast Neoplasms
Selenium and cancer: a story that should not be forgotten-insights from genomics.
Burkitt Lymphoma
Cloning of phospholipid hydroperoxide glutathione peroxidase (PHGPx) as an anti-apoptotic and growth promoting gene of Burkitt lymphoma cells.
Carcinogenesis
Loss of the oxidative stress sensor NPGPx compromises GRP78 chaperone activity and induces systemic disease.
Carcinogenesis
Redox Pioneer: Professor Regina Brigelius-Flohé.
Carcinogenesis
Selenoprotein P influences colitis-induced tumorigenesis by mediating stemness and oxidative damage.
Carcinoma
Antitumor Effect of 5-Aminolevulinic Acid Through Ferroptosis in Esophageal Squamous Cell Carcinoma.
Carcinoma
Inverse regulation of lipid-peroxidizing and hydroperoxyl lipid-reducing enzymes by interleukins 4 and 13.
Carcinoma
PHGPx overexpression induces an increase in COX-2 activity in colon carcinoma cells.
Carcinoma
Selenoprotein P in colitis-associated carcinoma.
Carcinoma
[Effect of GPX4 on proliferation and metastasis of renal clear cell carcinoma and its relationship with expression of IGF-1R and COX-2].
Carcinoma
[Overexpression of SEPP1 inhibits the proliferation and induces cell cycle G2/M arrest of 786-O and 769-P human renal carcinoma cells].
Carcinoma, Ductal
Phospholipid hydroperoxide glutathione peroxidase (PHGPx) expression is downregulated in poorly differentiated breast invasive ductal carcinoma.
Carcinoma, Hepatocellular
Activation of ferritinophagy is required for the RNA-binding protein ELAVL1/HuR to regulate ferroptosis in hepatic stellate cells.
Carcinoma, Hepatocellular
Direct separation of hydroperoxy- and hydroxy-phosphatidylcholine derivatives: application to the assay of phospholipid hydroperoxide glutathione peroxidase.
Carcinoma, Hepatocellular
Hepatitis B virus X protein induces TNF-alpha expression via down-regulation of selenoprotein P in human hepatoma cell line, HepG2.
Carcinoma, Hepatocellular
Impact of glutathione peroxidase 4 on cell proliferation, angiogenesis and cytokine production in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Molecular cloning and functional expression of a cDNA for rat phospholipid hydroperoxide glutathione peroxidase: 3'-untranslated region of the gene is necessary for functional expression.
Carcinoma, Hepatocellular
mRNA stability and selenocysteine insertion sequence efficiency rank gastrointestinal glutathione peroxidase high in the hierarchy of selenoproteins.
Carcinoma, Hepatocellular
Nano red elemental selenium has no size effect in the induction of seleno-enzymes in both cultured cells and mice.
Carcinoma, Hepatocellular
Nitric oxide protects against ferroptosis by aborting the lipid peroxidation chain reaction.
Carcinoma, Hepatocellular
Polysome distribution of phospholipid hydroperoxide glutathione peroxidase mRNA: evidence for a block in elongation at the UGA/selenocysteine codon.
Carcinoma, Hepatocellular
Possible involvement of reactive oxygen species in D-galactosamine-induced sensitization against tumor necrosis factor-alpha-induced hepatocyte apoptosis.
Carcinoma, Hepatocellular
Prediagnostic selenium status and hepatobiliary cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort.
Carcinoma, Hepatocellular
RNA-binding protein ZFP36/TTP protects against ferroptosis by regulating autophagy signaling pathway in hepatic stellate cells.
Carcinoma, Hepatocellular
Role of microRNA-7 and selenoprotein P in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Selective control of cytosolic glutathione peroxidase and phospholipid hydroperoxide glutathione peroxidase mRNA stability by selenium supply.
Carcinoma, Hepatocellular
Selenoprotein P mRNA expression in human hepatic tissues.
Carcinoma, Hepatocellular
Stimulation of selenoprotein P promoter activity in hepatoma cells by FoxO1a transcription factor.
Carcinoma, Renal Cell
[Overexpression of SEPP1 inhibits the proliferation and induces cell cycle G2/M arrest of 786-O and 769-P human renal carcinoma cells].
Carcinoma, Squamous Cell
Depletion of phospholipid hydroperoxide glutathione peroxidase up-regulates arachidonate metabolism by 12S-lipoxygenase and cyclooxygenase 1 in human epidermoid carcinoma A431 cells.
Carcinoma, Squamous Cell
Inhibition of arachidonate metabolism in human epidermoid carcinoma a431 cells overexpressing phospholipid hydroperoxide glutathione peroxidase.
Carcinoma, Squamous Cell
Involvement of reactive oxygen species in arsenite-induced downregulation of phospholipid hydroperoxide glutathione peroxidase in human epidermoid carcinoma A431 cells.
Carcinoma, Squamous Cell
Regulation of cyclooxygenase and 12-lipoxygenase catalysis by phospholipid hydroperoxide glutathione peroxidase in A431 cells.
Carcinoma, Squamous Cell
The CCAAT-box binding factor NF-Y is required for the expression of phospholipid hydroperoxide glutathione peroxidase in human epidermoid carcinoma A431 cells.
Cardiomegaly
Cytosolic, but not mitochondrial, oxidative stress is a likely contributor to cardiac hypertrophy resulting from cardiac specific GLUT4 deletion in mice.
Cardiotoxicity
Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity.
Cardiotoxicity
Protective effect of dietary selenium supplementation on delayed cardiotoxicity of adriamycin in rat: is PHGPX but not GPX involved?
Cardiovascular Diseases
Association of expression of selenoprotein P in mRNA and protein levels with metabolic syndrome in subjects with cardiovascular disease: Results of the Selenegene study.
Cardiovascular Diseases
Obesity in a model of gpx4 haploinsufficiency uncovers a causal role for lipid-derived aldehydes in human metabolic disease and cardiomyopathy.
Cardiovascular Diseases
Proposal of a study protocol of a preliminary double-blind randomized controlled trial. Verifying effects of selenium supplementation on selenoprotein p and s genes expression in protein and mRNA levels in subjects with coronary artery disease: selenegene.
Cardiovascular Diseases
Trace element profile and incidence of type 2 diabetes, cardiovascular disease and colorectal cancer: results from the EPIC-Potsdam cohort study.
Cataract
Effect of plant-based feed ingredients on osmoregulation in the Atlantic salmon lens.
Cataract
Serum selenium levels are associated with age-related cataract.
Cerebral Hemorrhage
Dauricine alleviated secondary brain injury after intracerebral hemorrhage by upregulating GPX4 expression and inhibiting ferroptosis of nerve cells.
Cerebral Hemorrhage
Glutathione peroxidase 4 participates in secondary brain injury through mediating ferroptosis in a rat model of intracerebral hemorrhage.
Cholangiocarcinoma
Vitellocyte-specific expression of phospholipid hydroperoxide glutathione peroxidases in Clonorchis sinensis.
Choline Deficiency
A Comparative Study on Antioxidant System in Fish Hepatopancreas and Intestine Affected by Choline Deficiency: Different Change Patterns of Varied Antioxidant Enzyme Genes and Nrf2 Signaling Factors.
Choroidal Neovascularization
Protective role of glutathione peroxidase 4 in laser-induced choroidal neovascularization in mice.
Colitis-Associated Neoplasms
Colonic Epithelial-Derived Selenoprotein P Is the Source for Antioxidant-Mediated Protection in Colitis-Associated Cancer.
Colitis-Associated Neoplasms
Selenoprotein P in colitis-associated carcinoma.
Colonic Neoplasms
Expression profiling and genetic alterations of the selenoproteins GI-GPx and SePP in colorectal carcinogenesis.
Colonic Neoplasms
HMGB1 mediates lipopolysaccharide-induced inflammation via interacting with GPX4 in colon cancer cells.
Colorectal Neoplasms
Aberrant expression of selenoproteins in the progression of colorectal cancer.
Colorectal Neoplasms
Evidence that a polymorphism within the 3'UTR of glutathione peroxidase 4 is functional and is associated with susceptibility to colorectal cancer.
Colorectal Neoplasms
Glutathione peroxidase 4 has a major role in protecting mitochondria from oxidative damage and maintaining oxidative phosphorylation complexes in gut epithelial cells.
Colorectal Neoplasms
Inhibition of SRSF9 enhances the sensitivity of colorectal cancer to erastin-induced ferroptosis by reducing glutathione peroxidase 4 expression.
Colorectal Neoplasms
Proinflammatory cytokines down-regulate intestinal selenoprotein P biosynthesis via NOS2 induction.
Colorectal Neoplasms
Selenium and cancer: a story that should not be forgotten-insights from genomics.
Colorectal Neoplasms
Trace element profile and incidence of type 2 diabetes, cardiovascular disease and colorectal cancer: results from the EPIC-Potsdam cohort study.
Coronary Artery Disease
Proposal of a study protocol of a preliminary double-blind randomized controlled trial. Verifying effects of selenium supplementation on selenoprotein p and s genes expression in protein and mRNA levels in subjects with coronary artery disease: selenegene.
COVID-19
Prediction of survival odds in COVID-19 by zinc, age and selenoprotein P as composite biomarker.
COVID-19
Selenium Deficiency Is Associated with Mortality Risk from COVID-19.
Cryptorchidism
Phospholipid hydroperoxide glutathione peroxidase is involved in the maintenance of male fertility under cryptorchidism in mice.
Death, Sudden, Cardiac
Selenoprotein P and Yunnan endemic sudden cardiac death--an ecological study.
Diabetes Complications
Glutathione peroxidase 4 functional variant rs713041 modulates the risk for cardiovascular autonomic neuropathy in individuals with type 1 diabetes.
Diabetes Complications
Testis glutathione peroxidase and phospholipid hydroperoxide glutathione peroxidase activities in aminoguanidine-treated diabetic rats.
Diabetes Mellitus
Selenium Levels in Community Dwellers with Type 2 Diabetes Mellitus.
Diabetes Mellitus
Selenium supplementation trials for cancer prevention and the subsequent risk of type 2 diabetes mellitus:.
Diabetes Mellitus
Selenoprotein P is not elevated in gestational diabetes mellitus.
Diabetes Mellitus
[Selenoprotein P in type 2 diabetes mellitus and its association with insulin resistance].
Diabetes Mellitus, Type 1
Glutathione peroxidase 4 functional variant rs713041 modulates the risk for cardiovascular autonomic neuropathy in individuals with type 1 diabetes.
Diabetes Mellitus, Type 1
Sex-specific associations of variants in regulatory regions of NADPH oxidase-2 (CYBB) and glutathione peroxidase 4 (GPX4) genes with kidney disease in type 1 diabetes.
Diabetes Mellitus, Type 2
Alcohol Intake Is Associated With Elevated Serum Levels of Selenium and Selenoprotein P in Humans.
Diabetes Mellitus, Type 2
Eicosapentaenoic acid down-regulates expression of the selenoprotein P gene by inhibiting SREBP-1c protein independently of the AMP-activated protein kinase pathway in H4IIEC3 hepatocytes.
Diabetes Mellitus, Type 2
Hepatokine Selenoprotein P-Mediated Reductive Stress Causes Resistance to Intracellular Signal Transduction.
Diabetes Mellitus, Type 2
Identification of hepatokines involved in pathology of type 2 diabetes and obesity.
Diabetes Mellitus, Type 2
Inverse correlation between serum levels of selenoprotein P and adiponectin in patients with type 2 diabetes.
Diabetes Mellitus, Type 2
Metformin suppresses expression of the selenoprotein P gene via an AMP-activated kinase (AMPK)/FoxO3a pathway in H4IIEC3 hepatocytes.
Diabetes Mellitus, Type 2
Pathophysiological significance of hepatokine overproduction in type 2 diabetes.
Diabetes Mellitus, Type 2
Selenium Levels in Community Dwellers with Type 2 Diabetes Mellitus.
Diabetes Mellitus, Type 2
Selenium supplementation trials for cancer prevention and the subsequent risk of type 2 diabetes mellitus:.
Diabetes Mellitus, Type 2
Selenoprotein P as an in vivo redox regulator: disorders related to its deficiency and excess.
Diabetes Mellitus, Type 2
Selenoprotein P is not elevated in gestational diabetes mellitus.
Diabetes Mellitus, Type 2
Serum selenoprotein p levels in patients with type 2 diabetes and prediabetes: implications for insulin resistance, inflammation, and atherosclerosis.
Diabetes Mellitus, Type 2
Trace element profile and incidence of type 2 diabetes, cardiovascular disease and colorectal cancer: results from the EPIC-Potsdam cohort study.
Diabetes Mellitus, Type 2
[Selenoprotein P in type 2 diabetes mellitus and its association with insulin resistance].
Diabetes, Gestational
Selenoprotein P is not elevated in gestational diabetes mellitus.
Diabetes, Gestational
The relationship between gestational diabetes mellitus and selenoprotein-P plasma 1 (SEPP1) gene polymorphisms.
Diabetic Nephropathies
HMGB1 regulates ferroptosis through Nrf2 pathway in mesangial cells in response to high glucose.
Dry Eye Syndromes
Autologous Serum and Serum Components.
Dry Eye Syndromes
Selenium-binding lactoferrin is taken into corneal epithelial cells by a receptor and prevents corneal damage in dry eye model animals.
Encephalomyelitis
Reduced expression of the ferroptosis inhibitor glutathione peroxidase-4 in multiple sclerosis and experimental autoimmune encephalomyelitis.
Encephalomyelitis, Autoimmune, Experimental
Reduced expression of the ferroptosis inhibitor glutathione peroxidase-4 in multiple sclerosis and experimental autoimmune encephalomyelitis.
Endometriosis
Association between the Genetic Variants of Glutathione Peroxidase 4 and Severity of Endometriosis.
Endometriosis
Higher SOD1 Gene Expression in Cumulus Cells From Infertile Women With Moderate and Severe Endometriosis.
Esophageal Neoplasms
Genetic Variation in GPX1 Is Associated with GPX1 Activity in a Comprehensive Analysis of Genetic Variations in Selenoenzyme Genes and Their Activity and Oxidative Stress in Humans.
Esophageal Squamous Cell Carcinoma
Antitumor Effect of 5-Aminolevulinic Acid Through Ferroptosis in Esophageal Squamous Cell Carcinoma.
Essential Hypertension
The C718T polymorphism in the 3'-untranslated region of glutathione peroxidase-4 gene is a predictor of cerebral stroke in patients with essential hypertension.
Fatty Liver
Alcohol Intake Is Associated With Elevated Serum Levels of Selenium and Selenoprotein P in Humans.
Fatty Liver
Hepatokine Selenoprotein P-Mediated Reductive Stress Causes Resistance to Intracellular Signal Transduction.
Fatty Liver
Interplay between Oxidative Stress and Metabolic Derangements in Non-Alcoholic Fatty Liver Disease: The Role of Selenoprotein P.
Fibrosarcoma
Exquisite sensitivity of adrenocortical carcinomas to induction of ferroptosis.
Fowlpox
SECIS elements in the coding regions of selenoprotein transcripts are functional in higher eukaryotes.
Glioma
Dihydroartemisinin-induced unfolded protein response feedback attenuates ferroptosis via PERK/ATF4/HSPA5 pathway in glioma cells.
Glioma
RSL3 induced autophagic death in glioma cells via causing glycolysis dysfunction.
Glucose Intolerance
Effects of exercise on biological trace element concentrations and selenoprotein P expression in rats with fructose-induced glucose intolerance.
Glucose Intolerance
Identification of hepatokines involved in pathology of type 2 diabetes and obesity.
Graves Disease
Serum selenium and selenoprotein-P levels in autoimmune thyroid diseases patients in a select center: a transversal study.
Hepatitis B
Hepatitis B virus X protein induces TNF-alpha expression via down-regulation of selenoprotein P in human hepatoma cell line, HepG2.
Hepatitis C
Alcohol Intake Is Associated With Elevated Serum Levels of Selenium and Selenoprotein P in Humans.
Hepatitis C
Induction of Selenoprotein P mRNA during Hepatitis C Virus Infection Inhibits RIG-I-Mediated Antiviral Immunity.
Hepatitis C, Chronic
Alterations in serum levels of fetuin A and selenoprotein P in chronic hepatitis C patients with concomitant type 2 diabetes: A case-control study.
Hypercholesterolemia
Diet-induced obesity in the selenocysteine lyase knockout mouse.
Hyperglycemia
Attenuation of hepatic expression and secretion of selenoprotein P by metformin.
Hyperglycemia
Circulating concentrations of insulin resistance-associated hepatokines, selenoprotein P and leukocyte cell-derived chemotaxin 2, during an oral glucose tolerance test in humans.
Hyperglycemia
Pathophysiological significance of hepatokine overproduction in type 2 diabetes.
Hyperglycemia
Serum selenoprotein P, but not selenium, predicts future hyperglycemia in a general Japanese population.
Hyperinsulinism
Diet-induced obesity in the selenocysteine lyase knockout mouse.
Hypersensitivity
Molecular basis for antioxidant enzymes in mediating copper detoxification in the nematode Caenorhabditis elegans.
Hypersensitivity
Reverse genetic analysis of the glutathione metabolic pathway suggests a novel role of PHGPX and URE2 genes in aluminum resistance in Saccharomyces cerevisiae.
Hypersensitivity
Selenoperoxidase-mediated cytoprotection against the damaging effects of tert-butyl hydroperoxide on leukemia cells.
Hypertension
Selenoprotein P Promotes the Development of Pulmonary Arterial Hypertension: A Possible Novel Therapeutic Target.
Hypothyroidism
Selenium and its relationship with selenoprotein P and glutathione peroxidase in children and adolescents with Hashimoto's thyroiditis and hypothyroidism.
Idiopathic Pulmonary Fibrosis
Involvement of selenoprotein P in the regulation of redox balance and myofibroblast viability in idiopathic pulmonary fibrosis.
Infarction, Middle Cerebral Artery
Inhibition of Acyl-CoA Synthetase Long-Chain Family Member 4 Facilitates Neurological Recovery After Stroke by Regulation Ferroptosis.
Infections
Alternatively activated myeloid cells limit pathogenicity associated with African trypanosomiasis through the IL-10 inducible gene selenoprotein P.
Infections
Ebselen alleviates testicular pathology in mice with Zika virus infection and prevents its sexual transmission.
Infections
Four selenoprotein P genes exist in salmonids: Analysis of their origin and expression following Se supplementation and bacterial infection.
Infections
Induction of Selenoprotein P mRNA during Hepatitis C Virus Infection Inhibits RIG-I-Mediated Antiviral Immunity.
Infections
Suppression of the malignant phenotype in pancreatic cancer by overexpression of phospholipid hydroperoxide glutathione peroxidase.
Infections
The oxido-reductase enzyme glutathione peroxidase 4 (GPX4) governs Salmonella Typhimurium-induced neutrophil transepithelial migration.
Infertility
Essential role of the apolipoprotein E receptor-2 in sperm development.
Infertility
Genetic variations of gpx-4 and male infertility in humans.
Infertility
Hepatic selenoprotein P (SePP) expression restores selenium transport and prevents infertility and motor-incoordination in Sepp-knockout mice.
Infertility
Molecular genetics of human male infertility: from genes to new therapeutic perspectives.
Infertility
[Biological significance of lipid hydroperoxide and its reducing enzyme, phospholipid hydroperoxide glutathione peroxidase, in mammalian cells]
Infertility, Male
Genetic variations of gpx-4 and male infertility in humans.
Infertility, Male
Male fertility is linked to the selenoprotein phospholipid hydroperoxide glutathione peroxidase.
Infertility, Male
Male subfertility induced by heterozygous expression of catalytically inactive glutathione peroxidase 4 is rescued in vivo by systemic inactivation of the Alox15 gene.
Infertility, Male
Mitochondrial glutathione peroxidase 4 disruption causes male infertility.
Infertility, Male
New Strategy of Functional Analysis of PHGPx Knockout Mice Model Using Transgenic Rescue Method and Cre-LoxP System.
Infertility, Male
Oral carnitine supplementation increases sperm motility in asthenozoospermic men with normal sperm phospholipid hydroperoxide glutathione peroxidase levels.
Infertility, Male
Testosterone mediates expression of the selenoprotein PHGPx by induction of spermatogenesis and not by direct transcriptional gene activation.
Infertility, Male
[Association between single nucleotide polymorphisms of 5'-untranslated region of GPx4 gene and male infertility].
Insulin Resistance
A liver-derived secretory protein, selenoprotein P, causes insulin resistance.
Insulin Resistance
Alterations in serum levels of fetuin A and selenoprotein P in chronic hepatitis C patients with concomitant type 2 diabetes: A case-control study.
Insulin Resistance
AMPK activator-mediated inhibition of endoplasmic reticulum stress ameliorates carrageenan-induced insulin resistance through the suppression of selenoprotein P in HepG2 hepatocytes.
Insulin Resistance
Bright and dark sides of exercise effects on biological responses such as energy metabolism and renal function in rats with renal failure and fructose-induced glucose intolerance.
Insulin Resistance
Circulating concentrations of insulin resistance-associated hepatokines, selenoprotein P and leukocyte cell-derived chemotaxin 2, during an oral glucose tolerance test in humans.
Insulin Resistance
Dietary Selenium Requirement for the Prevention of Glucose Intolerance and Insulin Resistance in Middle-Aged Mice.
Insulin Resistance
Effects of Intermittent Hypoxia on Pulmonary Vascular and Systemic Diseases.
Insulin Resistance
Eicosapentaenoic acid down-regulates expression of the selenoprotein P gene by inhibiting SREBP-1c protein independently of the AMP-activated protein kinase pathway in H4IIEC3 hepatocytes.
Insulin Resistance
Evaluation of endothelial dysfunction in patients with nonalcoholic fatty liver disease: Association of selenoprotein P with carotid intima-media thickness and endothelium-dependent vasodilation.
Insulin Resistance
Exendin-4 Inhibits the Expression of SEPP1 and Fetuin-A via Improvement of Palmitic Acid-Induced Endoplasmic Reticulum Stress by AMPK.
Insulin Resistance
Genetic variants in selenoprotein P plasma 1 gene (SEPP1) are associated with fasting insulin and first phase insulin response in Hispanics.
Insulin Resistance
Hepatokine Selenoprotein P-Mediated Reductive Stress Causes Resistance to Intracellular Signal Transduction.
Insulin Resistance
Hybrid Training System Improves Insulin Resistance in Patients with Nonalcoholic Fatty Liver Disease: A Randomized Controlled Pilot Study.
Insulin Resistance
Increased selenoprotein p levels in subjects with visceral obesity and nonalcoholic Fatty liver disease.
Insulin Resistance
Induction of Selenoprotein P mRNA during Hepatitis C Virus Infection Inhibits RIG-I-Mediated Antiviral Immunity.
Insulin Resistance
Inverse correlation between serum levels of selenoprotein P and adiponectin in patients with type 2 diabetes.
Insulin Resistance
Metformin suppresses expression of the selenoprotein P gene via an AMP-activated kinase (AMPK)/FoxO3a pathway in H4IIEC3 hepatocytes.
Insulin Resistance
Pathophysiological significance of hepatokine overproduction in type 2 diabetes.
Insulin Resistance
Protectin DX ameliorates palmitate-induced hepatic insulin resistance through AMPK/SIRT1-mediated modulation of fetuin-A and SeP expression.
Insulin Resistance
Role of Supplementary Selenium on the Induction of Insulin Resistance and Oxidative Stress in NSY Mice Fed a High Fat Diet.
Insulin Resistance
S-Adenosylmethionine Dependent Protein Methylation is Required for Expression of Selenoprotein P and Gluconeogenic Enzymes in Human Hepatocytes.
Insulin Resistance
Salsalate and Adiponectin Improve Palmitate-Induced Insulin Resistance via Inhibition of Selenoprotein P through the AMPK-FOXO1? Pathway.
Insulin Resistance
Selenoprotein P as a diabetes-associated hepatokine that impairs angiogenesis by inducing VEGF resistance in vascular endothelial cells.
Insulin Resistance
Selenoprotein P is elevated in individuals with obesity, but is not independently associated with insulin resistance.
Insulin Resistance
Selenoprotein P is not elevated in gestational diabetes mellitus.
Insulin Resistance
Serum selenoprotein p levels in patients with type 2 diabetes and prediabetes: implications for insulin resistance, inflammation, and atherosclerosis.
Insulin Resistance
Serum selenoprotein P, but not selenium, predicts future hyperglycemia in a general Japanese population.
Insulin Resistance
The relationship between gestational diabetes mellitus and selenoprotein-P plasma 1 (SEPP1) gene polymorphisms.
Insulin Resistance
[Selenoprotein P in type 2 diabetes mellitus and its association with insulin resistance].
Insulinoma
Biosynthesis of hepoxilins: evidence for the presence of a hepoxilin synthase activity in rat insulinoma cells.
Intestinal Diseases
Roles for selenium and selenoprotein P in the development, progression, and prevention of intestinal disease.
Iron Overload
Cross Talk Between Ferroptosis and Cerebral Ischemia.
Iron Overload
Liproxstatin-1 Attenuates Morphine Tolerance through Inhibiting Spinal Ferroptosis-like Cell Death.
Iron Overload
miR-137 boosts the neuroprotective effect of endothelial progenitor cell-derived exosomes in oxyhemoglobin-treated SH-SY5Y cells partially via COX2/PGE2 pathway.
Iron Overload
Revisiting Tumors and the Cardiovascular System: Mechanistic Intersections and Divergences in Ferroptosis.
Ischemic Attack, Transient
Inhibition of Acyl-CoA Synthetase Long-Chain Family Member 4 Facilitates Neurological Recovery After Stroke by Regulation Ferroptosis.
Kashin-Beck Disease
Selenoprotein P gene r25191g/a polymorphism and quantification of selenoprotein P mRNA level in patients with Kashin-Beck disease.
Kashin-Beck Disease
SNP and mRNA expression for glutathione peroxidase 4 in Kashin-Beck disease.
Kidney Diseases
Sex-specific associations of variants in regulatory regions of NADPH oxidase-2 (CYBB) and glutathione peroxidase 4 (GPX4) genes with kidney disease in type 1 diabetes.
Kidney Neoplasms
Selenoprotein P status correlates to cancer-specific mortality in renal cancer patients.
Leukemia
Alteration of gene expressions by the overexpression of mitochondrial phospholipid hydroperoxide glutathione peroxidase (mtPHGPx).
Leukemia
Amplification and hyperexpression of the catalase gene in selenoperoxidase-deficient leukemia cells.
Leukemia
Cytoprotection against merocyanine 540-sensitized photoinactivation of the Na+,K(+)-adenosine triphosphatase in leukemia cells: glutathione and selenoperoxidase involvement.
Leukemia
Induction of phospholipid hydroperoxide glutathione peroxidase in human polymorphonuclear neutrophils and HL60 cells stimulated with TNF-alpha.
Leukemia
Overexpression of phospholipid hydroperoxide glutathione peroxidase suppressed cell death due to oxidative damage in rat basophile leukemia cells (RBL-2H3).
Leukemia
Selenoperoxidase-mediated cytoprotection against merocyanine 540-sensitized photoperoxidation and photokilling of leukemia cells.
Leukemia L1210
Hyperexpression of catalase in selenium-deprived murine L1210 cells.
Leukemia L1210
Selenoperoxidase-dependent glutathione cycle activity in peroxide-challenged leukemia cells.
Leukemia, Erythroblastic, Acute
Expression Silencing of Glutathione Peroxidase 4 in Mouse Erythroleukemia Cells Delays In Vitro Erythropoiesis.
Liver Cirrhosis
Obacunone Attenuates Liver Fibrosis with Enhancing Anti-Oxidant Effects of GPx-4 and Inhibition of EMT.
Liver Cirrhosis
Selenoprotein P mRNA expression in human hepatic tissues.
Liver Diseases
Alcohol Intake Is Associated With Elevated Serum Levels of Selenium and Selenoprotein P in Humans.
Liver Diseases
Evaluation of endothelial dysfunction in patients with nonalcoholic fatty liver disease: Association of selenoprotein P with carotid intima-media thickness and endothelium-dependent vasodilation.
Liver Diseases
Exendin-4 Inhibits the Expression of SEPP1 and Fetuin-A via Improvement of Palmitic Acid-Induced Endoplasmic Reticulum Stress by AMPK.
Liver Diseases
Increased selenoprotein p levels in subjects with visceral obesity and nonalcoholic Fatty liver disease.
Liver Diseases
Interplay between Oxidative Stress and Metabolic Derangements in Non-Alcoholic Fatty Liver Disease: The Role of Selenoprotein P.
Liver Diseases
Role of microRNA-7 and selenoprotein P in hepatocellular carcinoma.
Liver Diseases
Selenium and selenoprotein P in nonalcoholic fatty liver disease.
Liver Diseases
Selenoprotein P in Patients with Nonalcoholic Fatty Liver Disease.
Liver Neoplasms
TRIB2 modulates proteasome function to reduce ubiquitin stability and protect liver cancer cells against oxidative stress.
Lung Neoplasms
A prospective study of plasma Selenoprotein P and lung cancer risk among low-income adults.
Lung Neoplasms
Inhibition of GPX4 or mTOR overcomes resistance to Lapatinib via promoting ferroptosis in NSCLC cells.
Lung Neoplasms
Plasma selenoprotein P concentration and lung cancer risk: Results from a case-control study nested within the Shanghai Men's Health Study.
Lung Neoplasms
Selenium and cancer: a story that should not be forgotten-insights from genomics.
Lymphoma
Targeted reduction of cholesterol uptake in cholesterol-addicted lymphoma cells blocks turnover of oxidized lipids to cause ferroptosis.
Lymphoma, B-Cell
Glutathione peroxidase 4 overexpression inhibits ROS-induced cell death in diffuse large B-cell lymphoma.
Lymphoma, B-Cell
SECISBP2 is a novel prognostic predictor that regulates selenoproteins in diffuse large B-cell lymphoma.
Lymphoma, Large B-Cell, Diffuse
Glutathione peroxidase 4 overexpression inhibits ROS-induced cell death in diffuse large B-cell lymphoma.
Lymphoma, Large B-Cell, Diffuse
SECISBP2 is a novel prognostic predictor that regulates selenoproteins in diffuse large B-cell lymphoma.
Melanoma
Integrated proteomics pipeline yields novel biomarkers for predicting preeclampsia.
Metabolic Diseases
Acute Hyperenergetic, High-Fat Feeding Increases Circulating FGF21, LECT2, and Fetuin-A in Healthy Men.
Metabolic Diseases
Green tea extracts reduce leukocyte cell-Derived chemotaxin 2 and selenoprotein P levels in the livers of C57BL/6J mice fed a high-fat diet.
Metabolic Diseases
Higher Serum Selenoprotein P Level as a Novel Inductor of Metabolic Complications in Psoriasis.
Metabolic Diseases
Psoriasis: Pathogenesis, Comorbidities, and Therapy Updated.
Metabolic Syndrome
Association of expression of selenoprotein P in mRNA and protein levels with metabolic syndrome in subjects with cardiovascular disease: Results of the Selenegene study.
Metabolic Syndrome
Levels of circulating selenoprotein P, fibroblast growth factor (FGF) 21 and FGF23 in relation to the metabolic syndrome in young children.
Mouth Neoplasms
Down-regulation of Glutathione Peroxidase 4 in Oral Cancer Inhibits Tumor Growth Through SREBP1 Signaling.
Movement Disorders
Selenium and brain function: a poorly recognized liaison.
Multiple Sclerosis
Reduced expression of the ferroptosis inhibitor glutathione peroxidase-4 in multiple sclerosis and experimental autoimmune encephalomyelitis.
Muscular Atrophy
Denervation induces cytosolic phospholipase A2-mediated fatty acid hydroperoxide generation by muscle mitochondria.
Muscular Diseases
Why 21? The significance of selenoproteins for human health revealed by inborn errors of metabolism.
Myocardial Infarction
Selenoprotein P in Myocardial Infarction with Cardiogenic Shock.
Myocardial Ischemia
Protective Effects and Mechanisms of Recombinant Human Glutathione Peroxidase 4 on Isoproterenol-Induced Myocardial Ischemia Injury.
Neonatal Sepsis
Oxidant and antioxidant status in neonatal proven and clinical sepsis according to selenium status.
Neoplasm Metastasis
Tissue microarray assessment of selenoprotein P expression in gastric adenocarcinoma.
Neoplasm Metastasis
[Effect of GPX4 on proliferation and metastasis of renal clear cell carcinoma and its relationship with expression of IGF-1R and COX-2].
Neoplasms
A mTORC1-mediated cyst(e)ine sensing mechanism governing GPX4 synthesis and ferroptosis.
Neoplasms
A thin layer chromatographic method for determining the enzymatic activity of peroxidases catalyzing the two-electron reduction of lipid hydroperoxides.
Neoplasms
Absence of glutathione peroxidase 4 affects tumor angiogenesis through increased 12/15-lipoxygenase activity.
Neoplasms
Accurate Quantification of Selenoprotein P (SEPP1) in Plasma Using Isotopically Enriched Seleno-peptides and Species-Specific Isotope Dilution with HPLC Coupled to ICP-MS/MS.
Neoplasms
BID links ferroptosis to mitochondrial cell death pathways.
Neoplasms
Blocking tumor cell eicosanoid synthesis by GPx4 impedes tumor growth and malignancy.
Neoplasms
Blue light-triggered Fe2+-release from monodispersed ferrihydrite nanoparticles for cancer iron therapy.
Neoplasms
Chaperone-mediated autophagy is involved in the execution of ferroptosis.
Neoplasms
Co-Administration of iRGD with Sorafenib-Loaded Iron-Based Metal-Organic Framework as a Targeted Ferroptosis Agent for Liver Cancer Therapy.
Neoplasms
Coenzyme Q differentially modulates phospholipid hydroperoxide glutathione peroxidase gene expression and free radicals production in malignant and non-malignant prostate cells.
Neoplasms
Colonic Epithelial-Derived Selenoprotein P Is the Source for Antioxidant-Mediated Protection in Colitis-Associated Cancer.
Neoplasms
Comparative Study on the Effects of Paullinia cupana, PC-18 and Magnesium Chloride on Solid Ehrlich Tumor.
Neoplasms
Directly targeting glutathione peroxidase 4 may be more effective than disrupting glutathione on ferroptosis-based cancer therapy.
Neoplasms
Down-regulation of Glutathione Peroxidase 4 in Oral Cancer Inhibits Tumor Growth Through SREBP1 Signaling.
Neoplasms
Effect of selenium on expression of selenoproteins in mouse fibrosarcoma cells.
Neoplasms
Effects of selenium status, dietary glucosinolate intake and serum glutathione S-transferase ? activity on the risk of benign prostatic hyperplasia.
Neoplasms
Enhancement of tumor invasion depends on transdifferentiation of skin fibroblasts mediated by reactive oxygen species.
Neoplasms
Establishing optimal selenium status: results of a randomized, double-blind, placebo-controlled trial.
Neoplasms
Expression of the potential therapeutic target CXXC5 in primary acute myeloid leukemia cells - high expression is associated with adverse prognosis as well as altered intracellular signaling and transcriptional regulation.
Neoplasms
Ferroptosis-driven nanotherapeutics for cancer treatment.
Neoplasms
Glutathione peroxidase 4 maintains a stemness phenotype, oxidative homeostasis and regulates biological processes in Panc?1 cancer stem?like cells.
Neoplasms
Glutathione peroxidases and redox-regulated transcription factors.
Neoplasms
Hepatic Arterial Infusion of Low-Density Lipoprotein Docosahexaenoic Acid Nanoparticles Selectively Disrupts Redox Balance in Hepatoma Cells and Reduces Growth of Orthotopic Liver Tumors in Rats.
Neoplasms
Hepatitis B virus X protein induces TNF-alpha expression via down-regulation of selenoprotein P in human hepatoma cell line, HepG2.
Neoplasms
High Dietary Selenium Intake Alters Lipid Metabolism and Protein Synthesis in Liver and Muscle of Pigs.
Neoplasms
Inactivation of the glutathione peroxidase GPx4 by the ferroptosis-inducing molecule RSL3 requires the adaptor protein 14-3-3?.
Neoplasms
Inhibition of tumor propellant glutathione peroxidase 4 induces ferroptosis in cancer cells and enhances anticancer effect of cisplatin.
Neoplasms
Inhibitory effect of phospholipid hydroperoxide glutathione peroxidase on the activity of lipoxygenases and cyclooxygenases.
Neoplasms
Interaction between single nucleotide polymorphisms in selenoprotein P and mitochondrial superoxide dismutase determines prostate cancer risk.
Neoplasms
JTC801 Induces pH-dependent Death Specifically in Cancer Cells and Slows Growth of Tumors in Mice.
Neoplasms
Metadherin enhances vulnerability of cancer cells to ferroptosis.
Neoplasms
Neutrophil-induced ferroptosis promotes tumor necrosis in glioblastoma progression.
Neoplasms
Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer.
Neoplasms
Overexpression of phospholipid-hydroperoxide glutathione peroxidase in human dermal fibroblasts abrogates UVA irradiation-induced expression of interstitial collagenase/matrix metalloproteinase-1 by suppression of phosphatidylcholine hydroperoxide-mediated NFkappaB activation and interleukin-6 release.
Neoplasms
pH-Sensitive Molecular-Switch-Containing Polymer Nanoparticle for Breast Cancer Therapy with Ferritinophagy-Cascade Ferroptosis and Tumor Immune Activation.
Neoplasms
Pharmacologic Screening Identifies Metabolic Vulnerabilities of CD8+ T Cells.
Neoplasms
Phospholipid hydroperoxide glutathione peroxidase (PHGPx) expression is downregulated in poorly differentiated breast invasive ductal carcinoma.
Neoplasms
Phospholipid hydroperoxide glutathione peroxidase is the 18-kDa selenoprotein expressed in human tumor cell lines.
Neoplasms
Phospholipid hydroperoxide glutathione peroxidase plays a role in protecting cancer cells from docosahexaenoic acid-induced cytotoxicity.
Neoplasms
Phospholipid hydroperoxide glutathione peroxidase protects against singlet oxygen-induced cell damage of photodynamic therapy.
Neoplasms
Phosphorescent rhenium(I) complexes conjugated with artesunate: Mitochondrial targeting and apoptosis-ferroptosis dual induction.
Neoplasms
Prediagnostic selenium status and hepatobiliary cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort.
Neoplasms
Regulated necrosis-related molecule mRNA expression in humans and mice and in murine acute tissue injury and systemic autoimmunity leading to progressive organ damage, and progressive fibrosis.
Neoplasms
Relative abundance of selenoprotein p isoforms in human plasma depends on genotype, se intake, and cancer status.
Neoplasms
RNA-binding protein ZFP36/TTP protects against ferroptosis by regulating autophagy signaling pathway in hepatic stellate cells.
Neoplasms
Role of ferritinophagy in cystine deprivation-induced cell death in glioblastoma cells.
Neoplasms
Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles.
Neoplasms
Selenium status is associated with colorectal cancer risk in the European prospective investigation of cancer and nutrition cohort.
Neoplasms
Selenium supplementation trials for cancer prevention and the subsequent risk of type 2 diabetes mellitus:.
Neoplasms
Selenium, but not lycopene or vitamin E, decreases growth of transplantable dunning R3327-H rat prostate tumors.
Neoplasms
Selenoperoxidase-dependent glutathione cycle activity in peroxide-challenged leukemia cells.
Neoplasms
Selenoprotein P in plasma in relation to cancer morbidity in middle-aged Swedish men.
Neoplasms
Selenoproteins and human health: Insights from epidemiological data.
Neoplasms
Studies of gene variants related to inflammation, oxidative stress, dyslipidemia, and obesity: implications for a nutrigenetic approach.
Neoplasms
Suppression of the malignant phenotype in pancreatic cancer by overexpression of phospholipid hydroperoxide glutathione peroxidase.
Neoplasms
The dark side of ferroptosis in pancreatic cancer.
Neoplasms
The Role of Ferroptosis in Cancer Development and Treatment Response.
Neoplasms
Tissue microarray assessment of selenoprotein P expression in gastric adenocarcinoma.
Neoplasms
Vaccination with early ferroptotic cancer cells induces efficient antitumor immunity.
Non-alcoholic Fatty Liver Disease
Alcohol Intake Is Associated With Elevated Serum Levels of Selenium and Selenoprotein P in Humans.
Non-alcoholic Fatty Liver Disease
Evaluation of endothelial dysfunction in patients with nonalcoholic fatty liver disease: Association of selenoprotein P with carotid intima-media thickness and endothelium-dependent vasodilation.
Non-alcoholic Fatty Liver Disease
Exendin-4 Inhibits the Expression of SEPP1 and Fetuin-A via Improvement of Palmitic Acid-Induced Endoplasmic Reticulum Stress by AMPK.
Non-alcoholic Fatty Liver Disease
Increased selenoprotein p levels in subjects with visceral obesity and nonalcoholic Fatty liver disease.
Non-alcoholic Fatty Liver Disease
Interplay between Oxidative Stress and Metabolic Derangements in Non-Alcoholic Fatty Liver Disease: The Role of Selenoprotein P.
Non-alcoholic Fatty Liver Disease
Non-alcoholic fatty liver disease in the first trimester and subsequent development of gestational diabetes mellitus.
Non-alcoholic Fatty Liver Disease
Selenium and selenoprotein P in nonalcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
Selenoprotein P in Patients with Nonalcoholic Fatty Liver Disease.
Non-alcoholic Fatty Liver Disease
SeP is elevated in NAFLD and participates in NAFLD pathogenesis through AMPK/ACC pathway.
Non-alcoholic Fatty Liver Disease
The risk of pregnancy-associated hypertension in women with nonalcoholic fatty liver disease.
Obesity
Deficiency of NPGPx, an oxidative stress sensor, leads to obesity in mice and human.
Obesity
Hepatokine Selenoprotein P-Mediated Reductive Stress Causes Resistance to Intracellular Signal Transduction.
Obesity
Higher Serum Selenoprotein P Level as a Novel Inductor of Metabolic Complications in Psoriasis.
Obesity
Identification of hepatokines involved in pathology of type 2 diabetes and obesity.
Obesity
Obesity in a model of gpx4 haploinsufficiency uncovers a causal role for lipid-derived aldehydes in human metabolic disease and cardiomyopathy.
Obesity
Selenoprotein P is elevated in individuals with obesity, but is not independently associated with insulin resistance.
Obesity, Abdominal
Increased selenoprotein p levels in subjects with visceral obesity and nonalcoholic Fatty liver disease.
Ovarian Neoplasms
Phospholipid hydroperoxide glutathione peroxidase plays a role in protecting cancer cells from docosahexaenoic acid-induced cytotoxicity.
Ovarian Neoplasms
Significance of glutathione peroxidase 4 and intracellular iron level in ovarian cancer cells-"utilization" of ferroptosis mechanism.
Pancreatic Neoplasms
Interplay between MTOR and GPX4 signaling modulates autophagy-dependent ferroptotic cancer cell death.
Pancreatic Neoplasms
Mitochondrial DNA stress triggers autophagy-dependent ferroptotic death.
Pancreatic Neoplasms
Selenoprotein P, as a predictor for evaluating gemcitabine resistance in human pancreatic cancer cells.
Pancreatic Neoplasms
Suppression of the malignant phenotype in pancreatic cancer by overexpression of phospholipid hydroperoxide glutathione peroxidase.
Paralysis
Ablation of ferroptosis inhibitor glutathione peroxidase 4 in neurons results in rapid motor neuron degeneration and paralysis.
Paralysis
NPGPx-Mediated Adaptation to Oxidative Stress Protects Motor Neurons from Degeneration in Aging by Directly Modulating O-GlcNAcase.
Parkinson Disease
Changes in Selenoprotein P in Substantia Nigra and Putamen in Parkinson's Disease.
Parkinson Disease
Prioritized brain selenium retention and selenoprotein expression: Nutritional insights into Parkinson's disease.
phospholipid-hydroperoxide glutathione peroxidase deficiency
Alterations in neuronal control of body weight and anxiety behavior by glutathione peroxidase 4 deficiency.
phospholipid-hydroperoxide glutathione peroxidase deficiency
Altered hippocampus synaptic function in Selenoprotein P deficient mice.
phospholipid-hydroperoxide glutathione peroxidase deficiency
Physiological role of phospholipid hydroperoxide glutathione peroxidase in mammals.
phospholipid-hydroperoxide glutathione peroxidase deficiency
Selenium and Selenoprotein P Deficiency Correlates with Complications and Adverse Outcome After Major Trauma.
phospholipid-hydroperoxide glutathione peroxidase deficiency
Selenoprotein P Deficiency and Risk of Mortality and Rehospitalization in Acute Heart Failure.
Polycystic Ovary Syndrome
Elevated circulating Selenoprotein P levels in patients with polycystic ovary syndrome.
Pre-Eclampsia
Evaluation of Glutathione Peroxidase 4 role in Preeclampsia.
Pre-Eclampsia
Identification of SEPP1 polymorphisms is not a genetic risk factor for preeclampsia in Chinese Han women: A clinical trial and experimental study.
Pre-Eclampsia
Specific systemic antioxidant response to preeclampsia in late pregnancy: the study of intracellular glutathione peroxidases in maternal and fetal blood.
Prediabetic State
Serum selenoprotein p levels in patients with type 2 diabetes and prediabetes: implications for insulin resistance, inflammation, and atherosclerosis.
Prostatic Neoplasms
6-(3,4-Dihydro-1H-isoquinoline-2-yl)-N-(6-methoxypyridine-2-yl) nicotinamide-26 (DIMN-26) decreases cell proliferation by induction of apoptosis and downregulation of androgen receptor signaling in human prostate cancer cells.
Prostatic Neoplasms
Interaction between single nucleotide polymorphisms in selenoprotein P and mitochondrial superoxide dismutase determines prostate cancer risk.
Prostatic Neoplasms
Reduced serum selenoprotein P concentrations in German prostate cancer patients.
Prostatic Neoplasms
Selenium and cancer: a story that should not be forgotten-insights from genomics.
Prostatic Neoplasms
Selenium status and risk of prostate cancer in a Danish population.
Prostatic Neoplasms
Selenoprotein gene variants, toenail selenium levels, and risk for advanced prostate cancer.
Prostatic Neoplasms
Selenoprotein P genetic variants and mrna expression, circulating selenium, and prostate cancer risk and survival.
Prostatic Neoplasms
Toenail selenium, plasma selenoprotein P and risk of advanced prostate cancer: A nested case-control study.
Proteinuria
Effect of selenium-deficient diet on tubular epithelium in normal rats.
Psoriasis
Higher Serum Selenoprotein P Level as a Novel Inductor of Metabolic Complications in Psoriasis.
Psoriasis
Psoriasis: Pathogenesis, Comorbidities, and Therapy Updated.
Pulmonary Arterial Hypertension
Selenoprotein P Promotes the Development of Pulmonary Arterial Hypertension: A Possible Novel Therapeutic Target.
Pulmonary Fibrosis
Lipid Peroxidation and GPX4 Inhibition Are Common Causes for Myofibroblast Differentiation and Ferroptosis.
Renal Insufficiency
Bright and dark sides of exercise effects on biological responses such as energy metabolism and renal function in rats with renal failure and fructose-induced glucose intolerance.
Renal Insufficiency, Chronic
Chronic Kidney Disease Distinctly Affects Relationship Between Selenoprotein P Status and Serum Thyroid Hormone Parameters.
Respiratory Insufficiency
Why 21? The significance of selenoproteins for human health revealed by inborn errors of metabolism.
Seizures
Competition between the Brain and Testes under Selenium-Compromised Conditions: Insight into Sex Differences in Selenium Metabolism and Risk of Neurodevelopmental Disease.
Seizures
Mice lacking selenoprotein p and selenocysteine lyase exhibit severe neurological dysfunction, neurodegeneration, and audiogenic seizures.
Seizures
Selenium and brain function: a poorly recognized liaison.
Seizures
Targeting ferroptosis: A novel therapeutic strategy for the treatment of mitochondrial disease-related epilepsy.
Sepsis
GPx4 in Bacterial Infection and Polymicrobial Sepsis: Involvement of Ferroptosis and Pyroptosis.
Sepsis
New assay for the measurement of selenoprotein P as a sepsis biomarker from serum.
Sepsis
Selenoprotein P neutralizes lipopolysaccharide and participates in hepatic cell endoplasmic reticulum stress response.
Shock, Cardiogenic
Selenoprotein P in Myocardial Infarction with Cardiogenic Shock.
Shock, Septic
Effects of high doses of selenium, as sodium selenite, in septic shock patients a placebo-controlled, randomized, double-blind, multi-center phase II study--selenium and sepsis.
Shock, Septic
Seleno-enzymes and seleno-compounds: the two faces of selenium.
Shock, Septic
Selenoprotein P, Rather than Glutathione Peroxidase, as a Potential Marker of Septic Shock and Related Syndromes.
Silicosis
Serum selenium and selenoprotein P in patients with silicosis.
Skin Diseases
Higher Serum Selenoprotein P Level as a Novel Inductor of Metabolic Complications in Psoriasis.
Starvation
Mechanisms of Ferroptosis and Relations With Regulated Cell Death: A Review.
Starvation
Molecular characterization of a phospholipid-hydroperoxide glutathione peroxidase from the bumblebee Bombus ignitus.
Starvation
Molecular characterization of phospholipid hydroperoxide glutathione peroxidases from Hydra vulgaris.
Starvation
Nitric oxide protects against ferroptosis by aborting the lipid peroxidation chain reaction.
Starvation
Superoxide produced by mitochondrial complex III plays a pivotal role in the execution of ferroptosis induced by cysteine starvation.
Starvation
The Potency of Diarylamine Radical-Trapping Antioxidants as Inhibitors of Ferroptosis Underscores the Role of Autoxidation in the Mechanism of Cell Death.
Stroke
Depressed serum selenoprotein P: possible new predicator of increased risk for cerebrovascular events.
Stroke
The C718T polymorphism in the 3'-untranslated region of glutathione peroxidase-4 gene is a predictor of cerebral stroke in patients with essential hypertension.
Stroke
The metal and metalloprotein profile of human plasma as biomarkers for stroke diagnosis.
Subarachnoid Hemorrhage
Neuroprotective role of glutathione peroxidase 4 in experimental subarachnoid hemorrhage models.
Thrombosis
Combined deficiency in glutathione peroxidase 4 and vitamin E causes multiorgan thrombus formation and early death in mice.
Thymoma
Dietary Selenium Requirement for the Prevention of Glucose Intolerance and Insulin Resistance in Middle-Aged Mice.
Thyroid Diseases
A case-control study of selenoprotein genes polymorphisms and autoimmune thyroid diseases in a Chinese population.
Thyroid Diseases
Bone Turnover and Bone Mineral Density Are Independently Related to Selenium Status in Healthy Euthyroid Postmenopausal Women.
Thyroiditis
Selenium and its relationship with selenoprotein P and glutathione peroxidase in children and adolescents with Hashimoto's thyroiditis and hypothyroidism.
Thyroiditis
Selenoproteins of the thyroid gland: expression, localization and possible function of glutathione peroxidase 3.
Thyroiditis
Serum selenium and selenoprotein-P levels in autoimmune thyroid diseases patients in a select center: a transversal study.
Trypanosomiasis, African
Alternatively activated myeloid cells limit pathogenicity associated with African trypanosomiasis through the IL-10 inducible gene selenoprotein P.
Virus Diseases
Induction of Selenoprotein P mRNA during Hepatitis C Virus Infection Inhibits RIG-I-Mediated Antiviral Immunity.
Virus Diseases
The Differential Expression of Mitochondrial Function-Associated Proteins and Antioxidant Enzymes during Bovine Herpesvirus 1 Infection: A Potential Mechanism for Virus Infection-Induced Oxidative Mitochondrial Dysfunction.
Vitamin E Deficiency
Minimum Selenium Requirements Increase When Repleting Second-Generation Selenium-Deficient Rats but Are Not Further Altered by Vitamin E Deficiency.
Vitamin E Deficiency
Vitamin E deficiency has different effects on brain and liver phospholipid hydroperoxide glutathione peroxidase activities in the rat.
Wilms Tumor
Molecular cloning and functional expression of a cDNA for rat phospholipid hydroperoxide glutathione peroxidase: 3'-untranslated region of the gene is necessary for functional expression.
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Saito, Y.; Hayashi, T.; Tanaka, A.; Watanabe, Y.; Suzuki, M.; Saito, E.; Takahashi, K.
Selenoprotein P in human plasma as an extracellular phospholipid hydroperoxide glutathione peroxidase. Isolation and enzymatic characterization of human selenoprotein P
J. Biol. Chem.
274
2866-2871
1999
Homo sapiens
brenda
Chambers, S.J.; Lambert, N.; Williamson, G.
Purification of a cytosolic enzyme from human liver with phospholipid hydroperoxide glutathione peroxidase activity
Int. J. Biochem.
26
1279-1286
1994
Homo sapiens
brenda
Schnurr, K.; Borchert, A.; Gerth, C.; Anton, M.; Kuhn, H.
Bacterial and nonbacterial expression of wild-type and mutant human phospholipid hydroperoxide glutathione peroxidase and purification of the mutant enzyme in the milligram scale
Protein Expr. Purif.
19
403-410
2000
Homo sapiens
brenda
Foresta, C.; Flohe, L.; Garolla, A.; Roveri, A.; Ursini, F.; Maiorino, M.
Male fertility is linked to the selenoprotein phospholipid hydroperoxide glutathione peroxidase
Biol. Reprod.
67
967-971
2002
Homo sapiens
brenda
Tramer, F.; Caponecchia, L.; Sgro, P.; Martinelli, M.; Sandri, G.; Panfili, E.; Lenzi, A.; Gandini, L.
Native specific activity of glutathione peroxidase (GPx-1), phospholipid hydroperoxide glutathione peroxidase (PHGPx) and glutathione reductase (GR)does not differ between normo- and hypomotile human sperm samples
Int. J. Androl.
27
88-93
2004
Homo sapiens
brenda
Utomo, A.; Jiang, X.; Furuta, S.; Yun, J.; Levin, D.S.; Wang, Y.C.; Desai, K.V.; Green, J.E.; Chen, P.L.; Lee, W.H.
Identification of a novel putative non-selenocysteine containing phospholipid hydroperoxide glutathione peroxidase (NPGPx) essential for alleviating oxidative stress generated from polyunsaturated fatty acids in breast cancer cells
J. Biol. Chem.
279
43522-43529
2004
Homo sapiens
brenda
Diaconu, M.; Tangat, Y.; Boehm, D.; Kuehn, H.; Michelmann, H.W.; Schreiber, G.; Haidl, G.; Glander, H.J.; Engel, W.; Nayernia, K.
Failure of phospholipid hydroperoxide glutathione peroxidase expression in oligoasthenozoospermia and mutations in the PHGPx gene
Andrologia
38
152-157
2006
Homo sapiens
brenda
Hattori, H.; Imai, H.; Furuhama, K.; Sato, O.; Nakagawa, Y.
Induction of phospholipid hydroperoxide glutathione peroxidase in human polymorphonuclear neutrophils and HL60 cells stimulated with TNF-alpha
Biochem. Biophys. Res. Commun.
337
464-473
2005
Homo sapiens
brenda
Januel, C.; El Hentati, F.; Carreras, M.; Arthur, J.R.; Calzada, C.; Lagarde, M.; Vericel, E.
Phospholipid-hydroperoxide glutathione peroxidase (GPx-4) localization in resting platelets, and compartmental change during platelet activation
Biochim. Biophys. Acta
1761
1228-1234
2006
Homo sapiens
brenda
Steinbrenner, H.; Bilgic, E.; Alili, L.; Sies, H.; Brenneisen, P.
Selenoprotein P protects endothelial cells from oxidative damage by stimulation of glutathione peroxidase expression and activity
Free Radic. Res.
40
936-943
2006
Homo sapiens
brenda
Liu, J.; Du, J.; Zhang, Y.; Sun, W.; Smith, B.J.; Oberley, L.W.; Cullen, J.J.
Suppression of the malignant phenotype in pancreatic cancer by overexpression of phospholipid hydroperoxide glutathione peroxidase
Hum. Gene Ther.
17
105-116
2006
Homo sapiens
brenda
Kriska, T.; Girotti, A.W.
A thin layer chromatographic method for determining the enzymatic activity of peroxidases catalyzing the two-electron reduction of lipid hydroperoxides
J. Chromatogr. B
827
58-64
2005
Homo sapiens
brenda
Scheerer, P.; Borchert, A.; Krauss, N.; Wessner, H.; Gerth, C.; Hoehne, W.; Kuhn, H.
Structural basis for catalytic activity and enzyme polymerization of phospholipid hydroperoxide glutathione peroxidase-4 (GPx4)
Biochemistry
46
9041-9049
2007
Homo sapiens (P36969), Homo sapiens
brenda
Conrad, M.; Schneider, M.; Seiler, A.; Bornkamm, G.W.
Physiological role of phospholipid hydroperoxide glutathione peroxidase in mammals
Biol. Chem.
388
1019-1025
2007
Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa
brenda
Cejas, P.; Garcia-Cabezas, M.A.; Casado, E.; Belda-Iniesta, C.; De Castro, J.; Fresno, J.A.; Sereno, M.; Barriuso, J.; Espinosa, E.; Zamora, P.; Feliu, J.; Redondo, A.; Hardisson, D.A.; Renart, J.; Gonzalez-Baron, M.
Phospholipid hydroperoxide glutathione peroxidase (PHGPx) expression is downregulated in poorly differentiated breast invasive ductal carcinoma
Free Radic. Res.
41
681-687
2007
Homo sapiens
brenda
Ding, W.Q.; Lind, S.E.
Phospholipid hydroperoxide glutathione peroxidase plays a role in protecting cancer cells from docosahexaenoic acid-induced cytotoxicity
Mol. Cancer Ther.
6
1467-1474
2007
Homo sapiens
brenda
Guo, Z.; Ran, Q.; Roberts, L.J.; Zhou, L.; Richardson, A.; Sharan, C.; Wu, D.; Yang, H.
Suppression of atherogenesis by overexpression of glutathione peroxidase-4 in apolipoprotein E-deficient mice
Free Radic. Biol. Med.
44
343-352
2008
Homo sapiens
brenda
Han, X.; Fan, Z.; Yu, Y.; Liu, S.; Hao, Y.; Huo, R.; Wei, J.
Expression and characterization of recombinant human phospholipid hydroperoxide glutathione peroxidase
IUBMB Life
65
951-956
2013
Homo sapiens (D6W5Y2), Homo sapiens
brenda
Yu, Y.; Song, J.; Guo, X.; Wang, S.; Yang, X.; Chen, L.; Wei, J.
Characterization and structural analysis of human selenium-dependent glutathione peroxidase 4 mutant expressed in Escherichia coli
Free Radic. Biol. Med.
71
332-338
2014
Homo sapiens (P36969), Homo sapiens
brenda
Moosmayer, D.; Hilpmann, A.; Hoffmann, J.; Schnirch, L.; Zimmermann, K.; Badock, V.; Furst, L.; Eaton, J.; Viswanathan, V.; Schreiber, S.; Gradl, S.; Hillig, R.
Crystal structures of the selenoprotein glutathione peroxidase 4 in its apo form and in complex with the covalently bound inhibitor ML162
Acta Crystallogr. D Struct. Biol.
77
237-248
2021
Homo sapiens (P36969), Homo sapiens
brenda
Corteselli, E.M.; Gibbs-Flournoy, E.; Simmons, S.O.; Bromberg, P.; Gold, A.; Samet, J.M.
Long chain lipid hydroperoxides increase the glutathione redox potential through glutathione peroxidase 4
Biochim. Biophys. Acta
1863
950-959
2019
Homo sapiens (P36969)
brenda
Borchert, A.; Kalms, J.; Roth, S.; Rademacher, M.; Schmidt, A.; Holzhutter, H.; Kuhn, H.; Scheerer, P.
Crystal structure and functional characterization of selenocysteine-containing glutathione peroxidase 4 suggests an alternative mechanism of peroxide reduction
Biochim. Biophys. Acta Mol. Cell Biol. Lipids
1863
1095-1107
2018
Homo sapiens (P36969), Homo sapiens
brenda
1.11.1.12 phospholipid-hydroperoxide glutathione peroxidase
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The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). 
