Information on EC 1.1.99.B9 - (S)-2hydroxycarboxylate dehydrogenase

for references in articles please use BRENDA:EC1.1.99.B9
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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
1.1.99.B9
preliminary BRENDA-supplied EC number
RECOMMENDED NAME
GeneOntology No.
(S)-2hydroxycarboxylate dehydrogenase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a (S)-2-hydroxycarboxylate + acceptor = a 2-oxocarboxylate + reduced acceptor
show the reaction diagram
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SYSTEMATIC NAME
IUBMB Comments
(S)-2-hydroxycarboxylate:acceptor oxidoreductase
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(2S)-(2-chlorophenyl)(hydroxy)acetic acid + acceptor
(2-chlorophenyl)(oxo)acetic acid + reduced acceptor
show the reaction diagram
(2S)-(2-fluorophenyl)(hydroxy)acetic acid + acceptor
(2-fluorophenyl)(oxo)acetic acid + reduced acceptor
show the reaction diagram
(2S)-(3-chlorophenyl)(hydroxy)acetic acid + acceptor
(3-chlorophenyl)(oxo)acetic acid + reduced acceptor
show the reaction diagram
(2S)-(4-bromophenyl)(hydroxy)acetic acid + acceptor
(4-bromophenyl)(oxo)acetic acid + reduced acceptor
show the reaction diagram
(2S)-(4-chlorophenyl)(hydroxy)acetic acid + acceptor
(4-chlorophenyl)(oxo)acetic acid + reduced acceptor
show the reaction diagram
(2S)-(4-fluorophenyl)(hydroxy)acetic acid + acceptor
(4-fluorophenyl)(oxo)acetic acid + reduced acceptor
show the reaction diagram
(2S)-hydroxy(1,5-difluorophenyl)acetic acid + acceptor
(1,5-difluoroyphenyl)(oxo)acetic acid + reduced acceptor
show the reaction diagram
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-
-
-
?
(2S)-hydroxy(2,4-difluorophenyl)acetic acid + acceptor
(2,4-difluoroyphenyl)(oxo)acetic acid + reduced acceptor
show the reaction diagram
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-
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?
(2S)-hydroxy(4-hydroxyphenyl)acetic acid + acceptor
(4-hydroxyphenyl)(oxo)acetic acid + reduced acceptor
show the reaction diagram
(2S)-hydroxy(4-methylphenyl)acetic acid + acceptor
(4-methylphenyl)(oxo)acetic acid + reduced acceptor
show the reaction diagram
(2S)-hydroxy(phenyl)acetic acid + acceptor
oxo(phenyl)acetic acid + reduced acceptor
show the reaction diagram
(2S)-hydroxy-3-phenylpropanoic acid + acceptor
2-oxo-3-phenylpropanoic acid + reduced acceptor
show the reaction diagram
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-
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?
additional information
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
-
does not require NAD(P)+ as cofactors to catalyze the oxidation reaction
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
81.2
(2S)-(2-chlorophenyl)(hydroxy)acetic acid
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pH 8.0, 30C
11.5
(2S)-(2-fluorophenyl)(hydroxy)acetic acid
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pH 8.0, 30C
4.9
(2S)-(3-chlorophenyl)(hydroxy)acetic acid
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pH 8.0, 30C
3.6
(2S)-(4-bromophenyl)(hydroxy)acetic acid
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pH 8.0, 30C
3.7
(2S)-(4-chlorophenyl)(hydroxy)acetic acid
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pH 8.0, 30C
66.5
(2S)-(4-fluorophenyl)(hydroxy)acetic acid
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pH 8.0, 30C
8.6
(2S)-hydroxy(1,5-difluorophenyl)acetic acid
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pH 8.0, 30C
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15.2
(2S)-hydroxy(2,4-difluorophenyl)acetic acid
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pH 8.0, 30C
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73.5
(2S)-hydroxy(4-hydroxyphenyl)acetic acid
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pH 8.0, 30C
65.6
(2S)-hydroxy(4-methylphenyl)acetic acid
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pH 8.0, 30C
64.9
(2S)-hydroxy(phenyl)acetic acid
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pH 8.0, 30C
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68.5
(2S)-hydroxy-3-phenylpropanoic acid
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pH 8.0, 30C
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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
presence of 2-chloromandelic acid induces enzyme synthesis efficiently
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
synthesis