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EC Tree
IUBMB Comments This enzyme is involved in the biosynthesis of vindoline and vindorosine in the plant Catharanthus roseus (Madagascar periwinkle). In vivo, it functions in the direction of reduction. It has no activity with 3-epoxylated compounds, which can form spontaneously from its unstable substrates.
The expected taxonomic range for this enzyme is: Catharanthus roseus
Synonyms
ADHL1 , BARS1, T3R, tabersonine 3-reductas, tabersonine 3-reductase,
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tabersonine 3-reductase
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(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + acceptor = (3R)-3-hydroxy-16-methoxy-1,2-didehydro-2,3-dihydrotabersonine + reduced acceptor
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(3R)-3-hydroxy-2,3-dihydrotabersonine + acceptor = (3R)-3-hydroxy-1,2-didehydro-2,3-dihydrotabersonine + reduced acceptor
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(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine:acceptor oxidoreductase
This enzyme is involved in the biosynthesis of vindoline and vindorosine in the plant Catharanthus roseus (Madagascar periwinkle). In vivo, it functions in the direction of reduction. It has no activity with 3-epoxylated compounds, which can form spontaneously from its unstable substrates.
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16-hydroxytabersonine + NADPH + H+
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16-methoxytabersonine + NADPH + H+
3-hydroxy-16-methoxy-2,3-dihydrotabersonine
2,3-dihydrotabersonine + NADPH + H+
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tabersonine + NADPH + H+
2,3-dihydro-3-hydroxytabersonine + NADP+
16-methoxytabersonine + NADPH + H+
3-hydroxy-16-methoxy-2,3-dihydrotabersonine
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16-methoxytabersonine + NADPH + H+
3-hydroxy-16-methoxy-2,3-dihydrotabersonine
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tabersonine + NADPH + H+
2,3-dihydro-3-hydroxytabersonine + NADP+
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tabersonine + NADPH + H+
2,3-dihydro-3-hydroxytabersonine + NADP+
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16-methoxytabersonine + NADPH + H+
3-hydroxy-16-methoxy-2,3-dihydrotabersonine
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tabersonine + NADPH + H+
2,3-dihydro-3-hydroxytabersonine + NADP+
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UniProt
brenda
cultivar Little Delicata
UniProt
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brenda
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T3R_CATRO
356
0
38566
Swiss-Prot
Chloroplast (Reliability: 5 )
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H189Y
the mutation diminishes the activity of the enzyme by 95%
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Ni-NTA column chromatography
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expressed in Escherichia coli BL21-(DE3) cells
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Edge, A.; Qu, Y.; Easson, M.L.A.E.; Thamm, A.M.K.; Kim, K.H.; De Luca, V.
A tabersonine 3-reductase Catharanthus roseus mutant accumulates vindoline pathway intermediates
Planta
247
155-169
2018
Catharanthus roseus (A0A161CAI1), Catharanthus roseus
brenda
Qu, Y.; Easson, M.L.; Froese, J.; Simionescu, R.; Hudlicky, T.; De Luca, V.
Completion of the seven-step pathway from tabersonine to the anticancer drug precursor vindoline and its assembly in yeast
Proc. Natl. Acad. Sci. USA
112
6224-6229
2015
Catharanthus roseus (A0A161CAI1), Catharanthus roseus
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