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Information on EC 1.1.99.41 - 3-hydroxy-1,2-didehydro-2,3-dihydrotabersonine reductase

for references in articles please use BRENDA:EC1.1.99.41

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IUBMB Comments

This enzyme is involved in the biosynthesis of vindoline and vindorosine in the plant Catharanthus roseus (Madagascar periwinkle). In vivo, it functions in the direction of reduction. It has no activity with 3-epoxylated compounds, which can form spontaneously from its unstable substrates.

The expected taxonomic range for this enzyme is: Catharanthus roseus

Synonyms
tabersonine 3-reductase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + acceptor = (3R)-3-hydroxy-16-methoxy-1,2-didehydro-2,3-dihydrotabersonine + reduced acceptor
show the reaction diagram
(1)
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(3R)-3-hydroxy-2,3-dihydrotabersonine + acceptor = (3R)-3-hydroxy-1,2-didehydro-2,3-dihydrotabersonine + reduced acceptor
show the reaction diagram
(1)
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PATHWAY SOURCE
PATHWAYS
MetaCyc
vindoline, vindorosine and vinblastine biosynthesis
Highest Expressing Human Cell Lines
Cell Line Links Gene Links