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Enzyme Nomenclature
Information on EC 1.1.99.4 - dehydrogluconate dehydrogenase
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The enzyme appears in viruses and cellular organisms
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EC NUMBER 
COMMENTARY 
1.1.99.4
-
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RECOMMENDED NAME
GeneOntology No.
dehydrogluconate dehydrogenase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
2-dehydro-D-gluconate + acceptor = 2,5-didehydro-D-gluconate + reduced acceptor
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
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SYSTEMATIC NAME
IUBMB Comments
2-dehydro-D-gluconate:acceptor 2-oxidoreductase
A flavoprotein.
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CAS REGISTRY NUMBER
COMMENTARY
9028-82-4
-
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
cytochrome c subunit and large subunit and small subunit
A0A0B6VQG4 and A0A0B6VN56 and A0A0B6VKP6
UniProt
cytochrome c subunit and large subunit and small subunit
A0A0B6VQG4 and A0A0B6VN56 and A0A0B6VKP6
UniProt
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-dehydro-D-gluconate + methylene blue
2,5-didehydro-D-gluconate + ?
-
methylene blue is not as effective as 2,6-dichlorophenolindophenol
-
-
?
2-dehydro-D-gluconate + nitro blue tetrazolium
2,5-didehydro-D-gluconate + ?
-
-
-
-
?
2-dehydro-D-gluconate + phenazine methosulfate
2,5-didehydro-D-gluconate + ?
-
-
-
-
?
2-dehydro-D-gluconate + pyocyanine
2,5-didehydro-D-gluconate + ?
-
pyocyanine is not as effective as 2,6-dichlorophenolindophenol
-
-
?
2-dehydro-D-gluconate + 2,6-dichlorophenolindophenol
2,5-didehydro-D-gluconate + ?
-
-
-
-
?
2-dehydro-D-gluconate + 2,6-dichlorophenolindophenol
2,5-didehydro-D-gluconate + ?
-
-
-
-
?
2-dehydro-D-gluconate + 2,6-dichlorophenolindophenol
2,5-didehydro-D-gluconate + ?
-
-
-
-
?
2-dehydro-D-gluconate + 2,6-dichlorophenolindophenol
2,5-didehydro-D-gluconate + ?
-
-
-
-
?
2-dehydro-D-gluconate + acceptor
?
-
enzyme of the D-glucose oxidation pathway
-
-
?
2-dehydro-D-gluconate + acceptor
?
-
enzyme is the primary dehydrogenase of the 2-keto-D-gluconate oxidizing system
-
-
?
2-dehydro-D-gluconate + acceptor
?
-
enzyme of the D-glucose oxidation pathway
-
-
?
2-dehydro-D-gluconate + acceptor
?
-
enzyme of the D-glucose oxidation pathway
-
-
?
2-dehydro-D-gluconate + acceptor
?
-
enzyme of the D-glucose oxidation pathway
-
-
?
2-dehydro-D-gluconate + acceptor
?
-
enzyme of the D-glucose oxidation pathway
-
-
?
2-dehydro-D-gluconate + acceptor
?
-
enzyme of the D-glucose oxidation pathway
-
-
?
2-dehydro-D-gluconate + acceptor
?
-
enzyme of the D-glucose oxidation pathway
-
-
?
2-dehydro-D-gluconate + acceptor
?
-
enzyme of the D-glucose oxidation pathway
-
-
?
2-dehydro-D-gluconate + ferricyanide
2,5-didehydro-D-gluconate + ferrocyanide
-
-
-
-
?
2-dehydro-D-gluconate + ferricyanide
2,5-didehydro-D-gluconate + ferrocyanide
A0A0B6VQG4 and A0A0B6VN56 and A0A0B6VKP6
-
-
-
?
2-dehydro-D-gluconate + ferricyanide
2,5-didehydro-D-gluconate + ferrocyanide
A0A0B6VQG4 and A0A0B6VN56 and A0A0B6VKP6
-
-
-
?
2-dehydro-D-gluconate + ferricyanide
2,5-didehydro-D-gluconate + ferrocyanide
-
-
-
-
?
additional information
?
-
A0A0B6VQG4 and A0A0B6VN56 and A0A0B6VKP6
the enzyme is completely inert toward 5-oxoglutarate, D-gluconate, D-glucose, D-sorbitol, L-lactate, L-malate, and D-fructose
-
-
-
additional information
?
-
-
the enzyme is completely inert toward 5-oxoglutarate, D-gluconate, D-glucose, D-sorbitol, L-lactate, L-malate, and D-fructose
-
-
-
additional information
?
-
A0A0B6VQG4 and A0A0B6VN56 and A0A0B6VKP6
the enzyme is completely inert toward 5-oxoglutarate, D-gluconate, D-glucose, D-sorbitol, L-lactate, L-malate, and D-fructose
-
-
-
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-dehydro-D-gluconate + acceptor
?
-
enzyme of the D-glucose oxidation pathway
-
-
?
2-dehydro-D-gluconate + acceptor
?
-
enzyme is the primary dehydrogenase of the 2-keto-D-gluconate oxidizing system
-
-
?
2-dehydro-D-gluconate + acceptor
?
-
enzyme of the D-glucose oxidation pathway
-
-
?
2-dehydro-D-gluconate + acceptor
?
-
enzyme of the D-glucose oxidation pathway
-
-
?
2-dehydro-D-gluconate + acceptor
?
-
enzyme of the D-glucose oxidation pathway
-
-
?
2-dehydro-D-gluconate + acceptor
?
-
enzyme of the D-glucose oxidation pathway
-
-
?
2-dehydro-D-gluconate + acceptor
?
-
enzyme of the D-glucose oxidation pathway
-
-
?
2-dehydro-D-gluconate + acceptor
?
-
enzyme of the D-glucose oxidation pathway
-
-
?
2-dehydro-D-gluconate + acceptor
?
-
enzyme of the D-glucose oxidation pathway
-
-
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
cytochrome
-
contains 0.91 mol of tightly bound c-type cytochrome per mol of enzyme
-
flavin
-
contains 8alpha-(N3-histidyl) riboflavin in the dinucleotide form; flavoprotein
flavin
-
contains 0.44 mol of covalently bound flavin per mol of enzyme; flavoprotein
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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
25000
-
1 * 61000, flavoprotein + 1 * 47000, cytochrome component, + 1 * 25000, function unclear, SDS-PAGE
47000
-
1 * 61000, flavoprotein + 1 * 47000, cytochrome component, + 1 * 25000, function unclear, SDS-PAGE
61000
-
1 * 61000, flavoprotein + 1 * 47000, cytochrome component, + 1 * 25000, function unclear, SDS-PAGE
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SUBUNITS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
trimer
trimer
-
1 * 61000, flavoprotein + 1 * 47000, cytochrome component, + 1 * 25000, function unclear, SDS-PAGE
trimer
A0A0B6VQG4 and A0A0B6VN56 and A0A0B6VKP6
a small subunit, a large subunit, and a cytochrome c subunit
trimer
-
a small subunit, a large subunit, and a cytochrome c subunit
-
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pH STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in Gluconobacter japonicas strain NBRC3271
A0A0B6VQG4 and A0A0B6VN56 and A0A0B6VKP6
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APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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LINKS TO OTHER DATABASES (specific for EC-Number 1.1.99.4)
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