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Information on EC 1.1.99.39 - D-2-hydroxyglutarate dehydrogenase

for references in articles please use BRENDA:EC1.1.99.39
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IUBMB Comments
Contains FAD. The enzyme has no activity with NAD+ or NADP+, and was assayed in vitro using artificial electron acceptors. It has lower activity with (R)-lactate, (R)-2-hydroxybutyrate and meso-tartrate, and no activity with the (S) isomers. The mammalian enzyme is stimulated by Zn2+, Co2+ and Mn2+.
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The enzyme appears in viruses and cellular organisms
Synonyms
d-2-hga, d2hgdh, atd-2hgdh, d2-hydroxyglutarate dehydrogenase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(R)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor
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