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Information on EC 1.1.99.37 - methanol dehydrogenase (nicotinoprotein)

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IUBMB Comments
Contains Zn2+ and Mg2+. Nicotinoprotein methanol dehydrogenases have a tightly bound NADP+/NADPH cofactor that does not dissociate during the catalytic process. Instead, the cofactor is regenerated by a second substrate or electron carrier. While the in vivo electron acceptor is not known, N,N-dimethyl-4-nitrosoaniline (NDMA), which is reduced to 4-(hydroxylamino)-N,N-dimethylaniline, can serve this function in vitro. The enzyme has been detected in several Gram-positive methylotrophic bacteria, including Amycolatopsis methanolica, Rhodococcus rhodochrous and Rhodococcus erythropolis [1-3]. These enzymes are decameric, and possess a 5-fold symmetry . Some of the enzymes can also dismutate formaldehyde to methanol and formate .
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The enzyme appears in viruses and cellular organisms
Synonyms
MDH, MDO, methanol:N,N-dimethyl-4-nitrosoaniline oxidoreductase, NAD-dependent methanol dehydrogenase, NDMA-dependent methanol dehydrogenase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
methanol + acceptor = formaldehyde + reduced acceptor
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PATHWAY SOURCE
PATHWAYS
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