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Information on EC 1.1.99.36 - alcohol dehydrogenase (nicotinoprotein)

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IUBMB Comments
Contains Zn2+. Nicotinoprotein alcohol dehydrogenases are unique medium-chain dehydrogenases/reductases (MDR) alcohol dehydrogenases that have a tightly bound NAD+/NADH cofactor that does not dissociate during the catalytic process. Instead, the cofactor is regenerated by a second substrate or electron carrier. While the in vivo electron acceptor is not known, N,N-dimethyl-4-nitrosoaniline (NDMA), which is reduced to 4-(hydroxylamino)-N,N-dimethylaniline, can serve this function in vitro. The enzyme from the Gram-positive bacterium Amycolatopsis methanolica can accept many primary alcohols as substrates, including benzylalcohol .
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The enzyme appears in viruses and cellular organisms
Synonyms
ndma-adh, np-adh, ndma-dependent alcohol dehydrogenase, more
REACTION
REACTION DIAGRAM
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ORGANISM
UNIPROT
LITERATURE
ethanol + acceptor = acetaldehyde + reduced acceptor
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