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Information on EC 1.1.99.1 - choline dehydrogenase

for references in articles please use BRENDA:EC1.1.99.1

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IUBMB Comments

A quinoprotein. In many bacteria, plants and animals, the osmoprotectant betaine is synthesized using different enzymes to catalyse the conversion of (1) choline into betaine aldehyde and (2) betaine aldehyde into betaine. In plants, the first reaction is catalysed by EC 1.14.15.7, choline monooxygenase, whereas in animals and many bacteria, it is catalysed by either membrane-bound choline dehydrogenase (EC 1.1.99.1) or soluble choline oxidase (EC 1.1.3.17) . The enzyme involved in the second step, EC 1.2.1.8, betaine-aldehyde dehydrogenase, appears to be the same in plants, animals and bacteria.

The enzyme appears in viruses and cellular organisms

Synonyms
choline dehydrogenase, chdh, chodh, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
choline + acceptor = betaine aldehyde + reduced acceptor
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
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