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Information on EC 1.1.3.6 - cholesterol oxidase

for references in articles please use BRENDA:EC1.1.3.6

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IUBMB Comments

Contains flavin adenine dinucleotide (FAD). Cholesterol oxidases are secreted bacterial bifunctional enzymes that catalyse the first two steps in the degradation of cholesterol. The enzyme catalyses the oxidation of the 3β-hydroxyl group to a keto group, and the isomerization of the double bond in the oxidized steroid ring system from the Δ5 position to Δ6 position (cf. EC 5.3.3.1, steroid Δ-isomerase).

The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota

Synonyms
cholesterol oxidase, coase, chom2, chori, chorii, cholox, chom1, cho-u, cod-b, cholesterol oxidase ii, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
cholesterol + O2 = cholest-5-en-3-one + H2O2
show the reaction diagram