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Synonyms
4HmO,
fegC, HmO, hydroxymandelate oxidase, L-4-hydroxymandelate oxidase, p-hydroxymandelate oxidase, Sco3228,
more
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(S)-2-hydroxy-2-(4-hydroxyphenyl)acetate + O2
2-(4-hydroxyphenyl)-2-oxoacetate + H2O2
(S)-3,5-dihydroxymandelate + O2
2-(3,5-dihydroxyphenyl)-2-oxoacetate + H2O2
(S)-4-hydroxymandelate + O2
2-(4-hydroxyphenyl)-2-oxoacetate + H2O2
(S)-mandelate + O2
2-phenyl-2-oxoacetate + H2O2
no activity with (R)-mandelate
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-
?
4-hydroxyphenylpyruvate + O2
phenylpyruvate + H2O2
L-mandelate + O2
?
-
-
-
?
(S)-2-hydroxy-2-(4-hydroxyphenyl)acetate + O2

2-(4-hydroxyphenyl)-2-oxoacetate + H2O2
(S)-2-hydroxy-2-(4-hydroxyphenyl)acetate i.e. (S)-4-hydroxymandelate. The enzyme is involed in the biosynthesis of (S)-4-hydroxyphenylglycine and (S)-3,5-dihydroxyphenylglycine, two non-proteinogenic amino acids occurring in the vancomycin group of antibiotics
2-(4-hydroxyphenyl)-2-oxoacetate i.e. 4-hydroxyphenylglyoxylate
-
?
(S)-2-hydroxy-2-(4-hydroxyphenyl)acetate + O2
2-(4-hydroxyphenyl)-2-oxoacetate + H2O2
(S)-2-hydroxy-2-(4-hydroxyphenyl)acetate i.e. (S)-4-hydroxymandelate. The enzyme is involed in the biosynthesis of the non-proteinogenic amino acid (S)-4-hydroxyphenylglycine a constituent of peptide antibiotics
2-(4-hydroxyphenyl)-2-oxoacetate i.e. 4-hydroxyphenylglyoxylate
-
?
(S)-2-hydroxy-2-(4-hydroxyphenyl)acetate + O2
2-(4-hydroxyphenyl)-2-oxoacetate + H2O2
(S)-2-hydroxy-2-(4-hydroxyphenyl)acetate i.e. (S)-4-hydroxymandelate
2-(4-hydroxyphenyl)-2-oxoacetate i.e. 4-hydroxyphenylglyoxylate
-
?
(S)-3,5-dihydroxymandelate + O2

2-(3,5-dihydroxyphenyl)-2-oxoacetate + H2O2
-
-
-
?
(S)-3,5-dihydroxymandelate + O2
2-(3,5-dihydroxyphenyl)-2-oxoacetate + H2O2
the enzyme is involed in the biosynthesis of (S)-4-hydroxyphenylglycine and (S)-3,5-dihydroxyphenylglycine, two non-proteinogenic amino acids occurring in the vancomycin group of antibiotics
-
-
?
(S)-4-hydroxymandelate + O2

2-(4-hydroxyphenyl)-2-oxoacetate + H2O2
-
-
-
-
?
(S)-4-hydroxymandelate + O2
2-(4-hydroxyphenyl)-2-oxoacetate + H2O2
-
-
-
?
(S)-4-hydroxymandelate + O2
2-(4-hydroxyphenyl)-2-oxoacetate + H2O2
-
-
-
-
?
(S)-4-hydroxymandelate + O2
2-(4-hydroxyphenyl)-2-oxoacetate + H2O2
-
-
-
-
?
(S)-4-hydroxymandelate + O2
2-(4-hydroxyphenyl)-2-oxoacetate + H2O2
-
-
-
?
(S)-4-hydroxymandelate + O2
2-(4-hydroxyphenyl)-2-oxoacetate + H2O2
-
-
-
-
?
(S)-4-hydroxymandelate + O2
2-(4-hydroxyphenyl)-2-oxoacetate + H2O2
-
-
-
?
(S)-4-hydroxymandelate + O2
2-(4-hydroxyphenyl)-2-oxoacetate + H2O2
-
-
-
?
4-hydroxyphenylpyruvate + O2

phenylpyruvate + H2O2
-
-
-
?
4-hydroxyphenylpyruvate + O2
phenylpyruvate + H2O2
-
-
-
-
?
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(S)-2-hydroxy-2-(4-hydroxyphenyl)acetate + O2
2-(4-hydroxyphenyl)-2-oxoacetate + H2O2
(S)-3,5-dihydroxymandelate + O2
2-(3,5-dihydroxyphenyl)-2-oxoacetate + H2O2
the enzyme is involed in the biosynthesis of (S)-4-hydroxyphenylglycine and (S)-3,5-dihydroxyphenylglycine, two non-proteinogenic amino acids occurring in the vancomycin group of antibiotics
-
-
?
(S)-4-hydroxymandelate + O2
2-(4-hydroxyphenyl)-2-oxoacetate + H2O2
(S)-2-hydroxy-2-(4-hydroxyphenyl)acetate + O2

2-(4-hydroxyphenyl)-2-oxoacetate + H2O2
(S)-2-hydroxy-2-(4-hydroxyphenyl)acetate i.e. (S)-4-hydroxymandelate. The enzyme is involed in the biosynthesis of (S)-4-hydroxyphenylglycine and (S)-3,5-dihydroxyphenylglycine, two non-proteinogenic amino acids occurring in the vancomycin group of antibiotics
2-(4-hydroxyphenyl)-2-oxoacetate i.e. 4-hydroxyphenylglyoxylate
-
?
(S)-2-hydroxy-2-(4-hydroxyphenyl)acetate + O2
2-(4-hydroxyphenyl)-2-oxoacetate + H2O2
(S)-2-hydroxy-2-(4-hydroxyphenyl)acetate i.e. (S)-4-hydroxymandelate. The enzyme is involed in the biosynthesis of the non-proteinogenic amino acid (S)-4-hydroxyphenylglycine a constituent of peptide antibiotics
2-(4-hydroxyphenyl)-2-oxoacetate i.e. 4-hydroxyphenylglyoxylate
-
?
(S)-4-hydroxymandelate + O2

2-(4-hydroxyphenyl)-2-oxoacetate + H2O2
-
-
-
-
?
(S)-4-hydroxymandelate + O2
2-(4-hydroxyphenyl)-2-oxoacetate + H2O2
-
-
-
?
(S)-4-hydroxymandelate + O2
2-(4-hydroxyphenyl)-2-oxoacetate + H2O2
-
-
-
-
?
(S)-4-hydroxymandelate + O2
2-(4-hydroxyphenyl)-2-oxoacetate + H2O2
-
-
-
-
?
(S)-4-hydroxymandelate + O2
2-(4-hydroxyphenyl)-2-oxoacetate + H2O2
-
-
-
?
(S)-4-hydroxymandelate + O2
2-(4-hydroxyphenyl)-2-oxoacetate + H2O2
-
-
-
-
?
(S)-4-hydroxymandelate + O2
2-(4-hydroxyphenyl)-2-oxoacetate + H2O2
-
-
-
?
(S)-4-hydroxymandelate + O2
2-(4-hydroxyphenyl)-2-oxoacetate + H2O2
-
-
-
?
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Müller, U.; van Assema, F.; Gunsior, M.; Orf, S.; Kremer, S.; Schipper, D.; Wagemans, A.; Townsend, C.A.; Sonke, T.; Bovenberg, R.; Wubbolts, M.
Metabolic engineering of the E. coli L-phenylalanine pathway for the production of D-phenylglycine (D-Phg)
Metab. Eng.
8
196-208
2006
Streptomyces coelicolor, Amycolatopsis orientalis (O52791), Amycolatopsis orientalis
brenda
Hubbard, B.K.; Thomas, M.G.; Walsh, C.T.
Biosynthesis of L-p-hydroxyphenylglycine, a non-proteinogenic amino acid constituent of peptide antibiotics
Chem. Biol.
7
931-942
2000
Amycolatopsis orientalis (G4V4S8), Amycolatopsis orientalis
brenda
Li, T.L.; Choroba, O.W.; Charles, E.H.; Sandercock, A.M.; Williams, D.H.; Spencer, J.B.
Characterisation of a hydroxymandelate oxidase involved in the biosynthesis of two unusual amino acids occurring in the vancomycin group of antibiotics
Chem. Commun. (Camb. )
21
1752-1753
2001
Amycolatopsis orientalis (G4V4S8)
brenda
Liu, S.P.; Liu, R.X.; El-Rotail, A.A.; Ding, Z.Y.; Gu, Z.H.; Zhang, L.; Shi, G.Y.
Heterologous pathway for the production of L-phenylglycine from glucose by E. coli
J. Biotechnol.
186C
91-97
2014
Amycolatopsis orientalis, Streptomyces coelicolor, Streptomyces coelicolor CGMCC 4.1092, Amycolatopsis orientalis ATCC 19795
brenda
Diez, V.; Loznik, M.; Taylor, S.; Winn, M.; Rattray, N.J.; Podmore, H.; Micklefield, J.; Goodacre, R.; Medema, M.H.; Mueller, U.; Bovenberg, R.; Janssen, D.B.; Takano, E.
Functional exchangeability of oxidase and dehydrogenase reactions in the biosynthesis of hydroxyphenylglycine, a nonribosomal peptide building block
ACS Synth. Biol.
4
796-807
2015
Streptomyces coelicolor (Q9Z4X8), Streptomyces coelicolor
brenda
Gonsior, M.; Muehlenweg, A.; Tietzmann, M.; Rausch, S.; Poch, A.; Suessmuth, R.D.
Biosynthesis of the peptide antibiotic feglymycin by a linear nonribosomal peptide synthetase mechanism
ChemBioChem
16
2610-2614
2015
Streptomyces sp. (A0A0P0KG57), Streptomyces sp. DSM11171 (A0A0P0KG57)
brenda