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Information on EC 1.1.3.39 - nucleoside oxidase (H2O2-forming)

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IUBMB Comments
A heme-containing flavoprotein (FAD). Other purine and pyrimidine nucleosides (as well as 2'-deoxyribonucleosides and arabinosides) are substrates, but ribose and nucleotides are not substrates. The overall reaction takes place in two separate steps, with the 5'-dehydro nucleoside being released from the enzyme to serve as substrate for the second reaction. This enzyme differs from EC 1.1.3.28, nucleoside oxidase, as it produces hydrogen peroxide rather than water.
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The expected taxonomic range for this enzyme is: Elizabethkingia meningoseptica
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
adenosine + 2 O2 + H2O = 9-riburonosyladenine + 2 H2O2
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; A heme-containing flavoprotein, FAD. Other purine and pyrimidine nucleosides, as well as 2'-deoxynucleosides and arabinosides, are substrates, but ribose and nucleotides are not substrates. The overall reaction takes place in two separate steps: 1. adenosine and O2: 5'-dehydroadenosine and H2O2 2. 5'dehydroadenosine and O2: 9-riburonosyladenine + H2O2 with the 5'-dehydro nucleoside being released from the enzyme to serve as substrate for the second reaction. This enzyme differs from EC 1.1.3.28, nucleoside oxidase, as it produces hydrogen peroxide rather than water
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adenosine + O2 = 5'-dehydroadenosine + H2O2
show the reaction diagram
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