A flavoprotein (FAD). L-Galactono-1,4-lactone, L-gulono-1,4-lactone and L-xylono-1,4-lactone can also act as substrates but D-glucono-1,5-lactone, L-arabinono-1,4-lactone, D-galactono-1,4-lactone and D-gulono-1,4-lactone cannot . With L-galactono-1,4-lactone as substrate, the product is L-ascorbate . The product dehydro-D-arabinono-1,4-lactone had previously been referred to erroneously as D-erythroascorbate (CAS no.: 5776-48-7; formula: C6H8O6), although it was referred to as a five-carbon compound .
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SYSTEMATIC NAME
IUBMB Comments
D-arabinono-1,4-lactone:oxygen oxidoreductase
A flavoprotein (FAD). L-Galactono-1,4-lactone, L-gulono-1,4-lactone and L-xylono-1,4-lactone can also act as substrates but D-glucono-1,5-lactone, L-arabinono-1,4-lactone, D-galactono-1,4-lactone and D-gulono-1,4-lactone cannot [1]. With L-galactono-1,4-lactone as substrate, the product is L-ascorbate [3]. The product dehydro-D-arabinono-1,4-lactone had previously been referred to erroneously as D-erythroascorbate (CAS no.: 5776-48-7; formula: C6H8O6), although it was referred to as a five-carbon compound [1].
the enzyme catalyzes the reaction of L-gulonolactone oxidase, EC 1.1.3.8, producing L-ascorbate, but has sequence similarities to D-arabinono-1,4-lactone oxidase, EC 1.1.3.37
the enzyme catalyzes the reaction of L-gulonolactone oxidase, EC 1.1.3.8, producing L-ascorbate, but has sequence similarities to D-arabinono-1,4-lactone oxidase, EC 1.1.3.37
the enzyme catalyzes the reaction of L-gulonolactone oxidase, EC 1.1.3.8, producing L-ascorbate, but has sequence similarities to D-arabinono-1,4-lactone oxidase, EC 1.1.3.37
the enzyme catalyzes the reaction of L-gulonolactone oxidase, EC 1.1.3.8, producing L-ascorbate, but has sequence similarities to D-arabinono-1,4-lactone oxidase, EC 1.1.3.37
the enzyme catalyzes the reaction of L-gulonolactone oxidase, EC 1.1.3.8, producing L-ascorbate, but has sequence similarities to D-arabinono-1,4-lactone oxidase, EC 1.1.3.37
the enzyme catalyzes the reaction of L-gulonolactone oxidase, EC 1.1.3.8, producing L-ascorbate, but has sequence similarities to D-arabinono-1,4-lactone oxidase, EC 1.1.3.37
enzyme deletion in Leishmania donovani results in increased pro-inflammatory responses from host immune cells. Enzyme null mutant parasites show growth defect and loss in virulence
the enzyme catalyzes the last step in the biosynthesis of L-ascorbic acid involving the conversion of an aldonolactone substrate to ascorbate (or analogues)
the enzyme catalyzes the last step in the biosynthesis of L-ascorbic acid involving the conversion of an aldonolactone substrate to ascorbate (or analogues)
overexpression of LdALO in Leishmannia donovani results in better ability of survival of the parasite within the host in comparison to the vector transfectants
overexpression of LdALO in Leishmannia donovani results in better ability of survival of the parasite within the host in comparison to the vector transfectants
overexpression of LdALO in Leishmannia donovani results in better ability of survival of the parasite within the host in comparison to the vector transfectants
gene AtGulLO2, transgenic expression of the isozyme in Nicotiana tabacum BY-2 cells, the overexpression does not affect the cells. Expression of His-tagged isozyme in Escherichia coli strain BL21(DE3)pLysS is not successful
gene AtGulLO3, transgenic expression of the isozyme in Nicotiana tabacum BY-2 cells, the overexpression does not affect the cells. Expression of His-tagged isozyme in Escherichia coli strain BL21(DE3)pLysS is not successful
gene AtGulLO5, transgenic expression of the isozyme in Nicotiana tabacum BY-2 cells, the overexpression does not affect the cells. Expression of His-tagged isozyme in Escherichia coli strain BL21(DE3)pLysS is not successful
yeasts do not possess an endogenous biochemical pathway for the synthesis of vitamin C. Overexpression of D-arabinose dehydrogenase and D-arabino-1,4-lactone oxidase enhance this ability significantly, production of vitamin C from metabiolically engineered Saccharomyces cerevisaie as well as from Zygosaccharomyces bailii
Lee, B.H.; Huh, W.K.; Kim, S.T.; Lee, J.S.; Kang, S.O.
Bacterial production of D-erythroascorbic acid and L-ascorbic acid through functional expression of Saccharomyces cerevisiae D-arabinono-1,4-lactone oxidase in Escherichia coli
Manhas, R.; Anand, S.; Tripathi, P.; Madhubala, R.
Deletion of vitamin C biosynthesis enzyme, arabino-1, 4-lactone oxidase in Leishmania donovani results in increased pro-inflammatory responses from host immune cells