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Information on EC 1.1.3.28 - nucleoside oxidase

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EC Tree
     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.3 With oxygen as acceptor
                1.1.3.28 nucleoside oxidase
IUBMB Comments
Other purine and pyrimidine nucleosides (as well as 2'-deoxyribonucleosides) are substrates, but ribose and nucleotides are not substrates. The overall reaction takes place in two separate steps, with the 5'-dehydro nucleoside being released from the enzyme to serve as substrate for the second reaction. This enzyme differs from EC 1.1.3.39, nucleoside oxidase (H2O2-forming), as it produces water rather than hydrogen peroxide.
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The expected taxonomic range for this enzyme is: Stenotrophomonas maltophilia
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
inosine + O2 = 9-riburonosylhypoxanthine + H2O
show the reaction diagram
Other purine and pyrimidine nucleosides, as well as 2'-deoxynucleoside, are substrates, but ribose and nucleotides are not substrates. The overall reaction takes place in two separate steps: 1. 2 inosine + O2 = 2 5'-dehydroinosine + 2 H2O. 2. 2 5'-dehydroinosine + O2 = 2 9-riburonosylhypoxanthine + 2 H2O, with the 5'-dehydro nucleoside being released from the enzyme to serve as substrate for the second reaction. This enzyme differs from EC 1.1.3.39, nucleoside oxidase (H2O2-forming), as it produces water rather than hydrogen peroxide
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