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Information on EC 1.1.3.20 - long-chain-alcohol oxidase
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1.1.3.20 long-chain-alcohol oxidaseIUBMB Comments
Oxidizes long-chain fatty alcohols; best substrate is dodecyl alcohol.
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Word Map
- 1.1.3.20
- oxidases
- candida
- n-alkanes
- glycolipids
- bombicola
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dicarboxylic
- cloacae
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starmerella
- n-hexadecane
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flavin-containing
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sophorolipids
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yarrowia
- lipolytica
- 1-dodecanol
- tropicalis
- alkane
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obviate
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
fatty alcohol oxidase, long chain alcohol oxidase, long-chain fatty alcohol oxidase, long chain fatty alcohol oxidase, fao1p, ljfao1 protein, long-chain fatty acid oxidase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
alcohol: O2 oxidoreductase
FAO
FAO1
Fao1p
fatty alcohol oxidase
fatty alcohol:oxygen oxidoreductase
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LCAO
long chain alcohol oxidase
long chain fatty acid oxidase
long chain fatty alcohol oxidase
long-chain fatty acid oxidase
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long-chain fatty alcohol oxidase
oxidase, long-chain fatty alcohol
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YALI0_B14014g
fatty alcohol oxidase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
a long-chain alcohol + O2 = a long-chain aldehyde + H2O2
ping-pong mechanism
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a long-chain alcohol + O2 = a long-chain aldehyde + H2O2
2 long-chain alcohol + O2 = 2 long-chain aldehyde + 2 H2O2
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a long-chain alcohol + O2 = a long-chain aldehyde + H2O2
2 long-chain alcohol + O2 = 2 long-chain aldehyde + 2 H2O2
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a long-chain alcohol + O2 = a long-chain aldehyde + H2O2
2 long-chain alcohol + O2 = 2 long-chain aldehyde + 2 H2O2
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a long-chain alcohol + O2 = a long-chain aldehyde + H2O2
2 long-chain alcohol + O2 = 2 long-chain aldehyde + 2 H2O2
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a long-chain alcohol + O2 = a long-chain aldehyde + H2O2
2 long-chain alcohol + O2 = 2 long-chain aldehyde + 2 H2O2
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a long-chain alcohol + O2 = a long-chain aldehyde + H2O2
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
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redox reaction
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reduction
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
long-chain-alcohol:oxygen oxidoreductase
Oxidizes long-chain fatty alcohols; best substrate is dodecyl alcohol.
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CAS REGISTRY NUMBER
COMMENTARY
129430-50-8
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
1-decanol + O2
decanal + H2O2
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?
1-docosanol + O2
docosanal + H2O2
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i.e. behenyl alcohol, poor substrate
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?
1-octanol + O2
octanal + H2O2
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?
2 long-chain alcohol + O2
2 long-chain aldehyde + 2 H2O
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involved in fatty acid metabolism
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?
geraniol + O2
3,7-dimethylocta-trans-2,6-dien-1-al + H2O2
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i.e. 3,7-dimethylocta-trans-2,6-dien-1-ol, better substrate than cis-isomer, the 2-ene-group enhances activity
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?
hex-trans-2-ene-1-ol + O2
hex-trans-2-ene-1-al + H2O2
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preferred substrate, the 2-ene-group enhances activity
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?
1-dodecanol + O2
dodecanal + H2O2
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?
1-eicosanol + O2
eicosanal + H2O2
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i.e. arachidyl alcohol, poor substrate
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?
1-tetradecanol + O2
tetradecanal + H2O2
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75% the rate of dodecanol oxidation
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?
1-tetradecanol + O2
tetradecanal + H2O2
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oxidation at 74% the rate of dodecanol oxidation
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?
1-tetradecanol + O2
tetradecanal + H2O2
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i.e. myristyl alcohol, best substrate
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?
1-tetradecanol + O2
tetradecanal + H2O2
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?
12-bromododecanol + O2
12-bromodecanal + H2O2
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oxidation at 92% the rate of dodecanol oxidation
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?
12-bromododecanol + O2
12-bromodecanal + H2O2
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oxidation at the same rate as dodecanol
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?
cis-11-eicosenol + O2
cis-11-eicosenal + H2O2
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oxidation at 1.9% the rate of dodecanol oxidation
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?
cis-11-eicosenol + O2
cis-11-eicosenal + H2O2
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higher oxidation rate than saturated analog
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?
cis-11-eicosenol + O2
cis-11-eicosenal + H2O2
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oxidation at 19% the rate of dodecanol oxidation
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?
decanol + O2
decanal + H2O2
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oxidation at 70% the rate of dodecanol oxidation
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?
decanol + O2
decanal + H2O2
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oxidation at 51% the rate of dodecanol oxidation
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?
docosenol + O2
docosenal + H2O2
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oxidation at 13% the rate of dodecanol oxidation
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?
docosenol + O2
docosenal + H2O2
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higher oxidation rate than saturated analog
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?
dodecanol + O2
dodecanal + H2O2
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i.e. lauryl alcohol, preferred substrate
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?
dodecanol + O2
dodecanal + H2O2
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i.e. lauryl alcohol, preferred substrate
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?
dodecanol + O2
dodecanal + H2O2
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i.e. lauryl alcohol, preferred substrate
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?
dodecanol + O2
dodecanal + H2O2
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i.e. lauryl alcohol, preferred substrate
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?
hexadecanol + O2
hexadecanal + H2O2
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19% the rate of dodecanol oxidation
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?
hexadecanol + O2
hexadecanal + H2O2
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68% the rate of dodecanol oxidation
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?
hexadecanol + O2
hexadecanal + H2O2
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i.e. palmityl or cetyl alcohol, oxidation at 26% the rate of dodecanol oxidation
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?
long-chain alcohol + O2
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reaction in wax ester catabolism in the storage wax bodies of jojoba plant during germination
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?
long-chain alcohol + O2
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constitutive enzyme, perhaps two enzymes
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?
long-chain alcohol + O2
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substrates are primary alcohols with a chain-length of C6-C10
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?
long-chain alcohol + O2
long-chain aldehyde + H2O2
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the enzyme oxidizes alcohol substrates with carbon chain length of usually above C6
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?
long-chain alcohol + O2
long-chain aldehyde + H2O2
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the enzyme oxidizes alcohol substrates with carbon chain length of usually above C6
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?
long-chain alcohol + O2
long-chain aldehyde + H2O2
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the enzyme oxidizes alcohol substrates with carbon chain length of usually above C6
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?
long-chain alcohol + O2
long-chain aldehyde + H2O2
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the enzyme oxidizes alcohol substrates with carbon chain length of usually above C6
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?
long-chain alcohol + O2
long-chain aldehyde + H2O2
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the enzyme oxidizes alcohol substrates with carbon chain length of usually above C6
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?
long-chain alcohol + O2
long-chain aldehyde + H2O2
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the enzyme oxidizes alcohol substrates with carbon chain length of usually above C6
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?
long-chain alcohol + O2
long-chain aldehyde + H2O2
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the enzyme oxidizes alcohol substrates with carbon chain length of usually above C6
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?
long-chain alcohol + O2
long-chain aldehyde + H2O2
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the enzyme oxidizes alcohol substrates with carbon chain length of usually above C6
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?
long-chain alcohol + O2
long-chain aldehyde + H2O2
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the enzyme oxidizes alcohol substrates with carbon chain length of usually above C6
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?
long-chain alcohol + O2
long-chain aldehyde + H2O2
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the enzyme oxidizes alcohol substrates with carbon chain length of usually above C6
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?
long-chain alcohol + O2
long-chain aldehyde + H2O2
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the enzyme oxidizes alcohol substrates with carbon chain length of usually above C6
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?
long-chain alcohol + O2
long-chain aldehyde + H2O2
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the enzyme oxidizes alcohol substrates with carbon chain length of usually above C6
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?
long-chain alcohol + O2
long-chain aldehyde + H2O2
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the enzyme oxidizes alcohol substrates with carbon chain length of usually above C6
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?
long-chain alcohol + O2
long-chain aldehyde + H2O2
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the enzyme oxidizes alcohol substrates with carbon chain length of usually above C6
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?
long-chain alcohol + O2
long-chain aldehyde + H2O2
Torulopsis candida
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the enzyme oxidizes alcohol substrates with carbon chain length of usually above C6
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?
long-chain alcohol + O2
long-chain aldehyde + H2O2
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the enzyme oxidizes alcohol substrates with carbon chain length of usually above C6
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?
long-chain alcohol + O2
long-chain aldehyde + H2O2
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the enzyme oxidizes alcohol substrates with carbon chain length of usually above C6
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?
long-chain alcohol + O2
long-chain aldehyde + H2O2
[Candida] cloacae FERM O-736
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the enzyme oxidizes alcohol substrates with carbon chain length of usually above C6
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?
n-octanol + O2
n-octanal + H2O2
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oxidation at 34% the rate of dodecanol oxidation
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?
octadecanol + O2
octadecanal + H2O2
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oxidation at 12% the rate of dodecanol oxidation
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?
octadecanol + O2
octadecanal + H2O2
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i.e. stearyl alcohol, oxidation at 16% the rate of dodecanol oxidation
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?
additional information
?
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the fungal enzyme forms H1, H2, H3, and H4 have similar biochemical properties, but show different substrate specificities from short chain alcohol oxidase for H1, aryl alcohol oxidase for H4, and secondary alcohol oxidase for H2, H3 is a long chain alcohol oxidase, overview
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?
additional information
?
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the fungal enzyme forms H1, H2, H3, and H4 have similar biochemical properties, but show different substrate specificities from short chain alcohol oxidase for H1, aryl alcohol oxidase for H4, and secondary alcohol oxidase for H2, H3 is a long chain alcohol oxidase, overview
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?
additional information
?
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no substrate: dodecan-4-ol, dodecan-5-ol
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?
additional information
?
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no substrates: dodecanal, omega-hydroxydodecanoate
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?
additional information
?
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no substrate: geraniol, hexadecan-2-ol, dodecan-5-ol, 2-adamantol, 5-phenylpentan-1-ol, 4-cyclohexylbutan-1-ol, 1-adamantane ethanol
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?
additional information
?
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the enzyme is a c-type haemoprotein and plays an important role in long chain fatty acid metabolism, different pathways of octadecane, hexadecane, oleic acid and palmitic acid utilization exist in the organism, overview
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?
additional information
?
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no substrates: ethanol, palmitic acid
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?
additional information
?
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no substrate: omega-hydroxy fatty acids
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?
additional information
?
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perhaps two long-chain alcohol oxidases in Candida bombicola: the two best substrates are decanol and tetradecanol
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?