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Information on EC 1.1.2.4 - D-lactate dehydrogenase (cytochrome) and Organism(s) Homo sapiens and UniProt Accession Q86WU2

for references in articles please use BRENDA:EC1.1.2.4
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EC Tree
IUBMB Comments
A flavoprotein (FAD).
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This record set is specific for:
Homo sapiens
UNIPROT: Q86WU2
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Word Map
The taxonomic range for the selected organisms is: Homo sapiens
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
d-ildh, d-lcr, d-lactate ferricytochrome c oxidoreductase, atd-ldh, d-lactate dehydrogenase (cytochrome), d-lactate cytochrome c oxidoreductase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
cytochrome-dependent D-(-)-lactate dehydrogenase
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D(-)-lactic cytochrome c reductase
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D-lactate ferricytochrome c oxidoreductase
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D-lactate-cytochrome c reductase
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D-LCR
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lactic acid dehydrogenase
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-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
redox reaction
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oxidation
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reduction
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PATHWAY SOURCE
PATHWAYS
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-, -
SYSTEMATIC NAME
IUBMB Comments
(R)-lactate:ferricytochrome-c 2-oxidoreductase
A flavoprotein (FAD).
CAS REGISTRY NUMBER
COMMENTARY hide
37250-79-6
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(R)-lactate + 2 ferricytochrome c
pyruvate + 2 ferrocytochrome c
show the reaction diagram
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?
additional information
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D-LDH activity assay and (R)-lactate-dependent cyt c and flavin reduction
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-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
(R)-lactate + 2 ferricytochrome c
pyruvate + 2 ferrocytochrome c
show the reaction diagram
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-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
FAD
the enzyme is a flavoprotein. The flavin/pyridine cofactor redox state is detected fluorimetrically in cell homogenates
ferricytochrome c
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.5
assay at
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
37
assay at
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
the enzyme is located on the inner face of the inner mitochondrial membrane
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
prostate cancer cells metabolize D-lactate inside mitochondria via a D-lactate dehydrogenase which is more active and highly expressed than in normal cells. D-Lactate can enter prostate mitochondria and cause the export of newly synthesized malate in a carrier-mediated manner, with the rate of malate efflux from mitochondria being twofold higher in cancer compared to healthy cells, overview
physiological function
the mitochondrial D-lactate dehydrogenase, a membrane flavoprotein, from both cancer (PC-3) and normal (PNT1A) prostate cells can metabolize D-lactate in an energy competent manner
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
LDHD_HUMAN
507
0
54871
Swiss-Prot
Mitochondrion (Reliability: 5)
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
de Bari, L.; Moro, L.; Passarella, S.
Prostate cancer cells metabolize D-lactate inside mitochondria via a D-lactate dehydrogenase which is more active and highly expressed than in normal cells
FEBS Lett.
587
467-473
2013
Homo sapiens (Q86WU2)
Manually annotated by BRENDA team