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Information on EC 1.1.2.10 - lanthanide-dependent methanol dehydrogenase

for references in articles please use BRENDA:EC1.1.2.10

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IUBMB Comments

Isolated from the bacterium Methylacidiphilum fumariolicum and many Methylobacterium species. Requires La3+, Ce3+, Pr3+ or Nd3+. The higher lanthanides show decreasing activity with Sm3+, Eu3+ and Gd3+. The lanthanide is coordinated by the enzyme and pyrroloquinoline quinone. Shows little activity with Ca2+, the required cofactor of EC 1.1.2.7, methanol dehydrogenase (cytochrome c).

The expected taxonomic range for this enzyme is: Bacteria
Reaction Schemes
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methanol
+
2
oxidized cytochrome cL
=
formaldehyde
+
2
reduced cytochrome cL
+
2
oxidized cytochrome cL
=
+
2
reduced cytochrome cL

Synonyms
xoxf1, xoxf5, xoxf-type methanol dehydrogenase, xoxf-type mdh, eu-mdh, lanthanide-dependent mdh, lanthanide-dependent methanol dehydrogenase, xoxf-mdh, ce-mdh, ln-dependent ethanol dehydrogenase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
methanol + 2 oxidized cytochrome cL = formaldehyde + 2 reduced cytochrome cL
show the reaction diagram
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