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Information on EC 1.1.1.90 - aryl-alcohol dehydrogenase
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EC Tree
1.1.1.90 aryl-alcohol dehydrogenaseIUBMB Comments
A group of enzymes with broad specificity towards primary alcohols with an aromatic or cyclohex-1-ene ring, but with low or no activity towards short-chain aliphatic alcohols.
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Word Map
- 1.1.1.90
- benzaldehyde
-
chrysosporium
-
phanerochaete
- calcoaceticus
- xylene
-
white-rot
-
2,3-oxygenase
-
aryl-aldehyde
-
ligninolytic
-
upper-pathway
- veratraldehyde
-
veratryl
-
n.c.i.b
- phenylglyoxylate
- biotechnology
- synthesis
- degradation
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
benzyl alcohol dehydrogenase, aryl-alcohol dehydrogenase, ac-badh, tol-badh, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
AC-BADH
-
-
-
-
ADH
alcohol dehydrogenase
BADH
benzyl alcohol dehydrogenase
coniferyl alcohol dehydrogenase
dehydrogenase, aryl alcohol
-
-
-
-
p-hydroxybenzyl alcohol dehydrogenase
-
-
-
-
TOL-BADH
-
-
-
-
additional information
BADH
-
-
-
-
benzyl alcohol dehydrogenase
-
-
-
-
coniferyl alcohol dehydrogenase
-
-
-
-
additional information
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the enzyme is a member of the family of NAD(P)-dependent long-chain zinc-dependent alcohol dehydrogenases
additional information
Lactiplantibacillus plantarum WCFS1 NCIMB 8826
-
the enzyme is a member of the family of NAD(P)-dependent long-chain zinc-dependent alcohol dehydrogenases
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
an aromatic alcohol + NAD+ = an aromatic aldehyde + NADH + H+
ordered bi-bi kinetic mechanism
an aromatic alcohol + NAD+ = an aromatic aldehyde + NADH + H+
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
BRENDA
KEGG
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SYSTEMATIC NAME
IUBMB Comments
aryl-alcohol:NAD+ oxidoreductase
A group of enzymes with broad specificity towards primary alcohols with an aromatic or cyclohex-1-ene ring, but with low or no activity towards short-chain aliphatic alcohols.
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CAS REGISTRY NUMBER
COMMENTARY
37250-26-3
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2,4-dihydroxy-3-(hydroxymethyl)-6-methylbenzoic acid + NAD+
3-formyl-2,4-dihydroxy-6-methylbenzoic acid + NADH
2-hydroxymethyl-6-methylnaphthalene + NAD+
2-formyl-6-methylnaphthalene + NADH
low activity
-
-
?
2-hydroxymethylnaphthalene + NAD+
2-formylnaphthalene + NADH
low activity
-
-
?
2-methoxybenzyl alcohol + NAD+
2-methoxybenzaldehyde + NADH
-
-
-
-
r
2-methoxybenzyl alcohol + NAD+
2-methoxybenzaldehyde + NADH + H+
-
-
-
?
3,4-dimethoxybenzyl alcohol + NAD+
3,4-dimethoxybenzaldehyde + NADH
-
-
-
-
r
3,4-dimethylbenzyl alcohol + NAD+
3,4-dimethylbenzaldehyde + NADH + H+
-
-
-
-
r
3,5-dichlorobenzyl alcohol + NAD+
3,5-dichlorobenzaldehyde + NADH
-
-
-
-
r
3-methoxybenzyl alcohol + NAD+
3-methoxybenzaldehyde + NADH + H+
-
-
-
?
4-hydroxy-3-methoxybenzyl alcohol + NAD+
4-hydroxy-3-methoxybenzaldehyde + NADH
-
-
-
-
r
4-isopropylbenzyl alcohol + NAD+
4-isopropylbenzaldehyde + NADH
-
-
-
-
r
4-methoxybenzyl alcohol + NAD+
4-methoxybenzaldehyde + NADH
-
-
-
-
r
4-methoxybenzyl alcohol + NAD+
4-methoxybenzaldehyde + NADH + H+
-
-
-
?
anisaldehyde + NADH + H+
anisic alcohol + NAD+
-
relative activity: 72.2%
-
-
r
benzaldehyde + NADH + H+
benzyl alcohol + NAD+
-
relative activity: 100%
-
-
r
benzaldehyde + NADPH + H+
benzyl alcohol + NADP+
highest reductive activity with benzaldehyde
-
-
r
benzyl alcohol + NADP+
benzaldehyde + NADPH
-
less active in the presence of NADP+ than in the presence of NAD+
-
-
?
cinnamaldehyde + NADH + H+
cinnamic alcohol + NAD+
-
relative activity: 58.7%
-
-
r
cinnamyl alcohol + NAD+
cinnamyl aldehyde + NADH + H+
-
67% of the activity with benzyl alcohol
-
-
?
cis-11-hexadecenal + NADH + H+
cis-11-hexadecenol + NAD+
-
relative activity: 4.9%
-
-
r
citral + NADH + H+
citryl alcohol + NAD+
-
relative activity: 7.8%
-
-
r
citronellal + NADH + H+
citronellol + NAD+
-
relative activity: 21.8%
-
-
r
crotonyl alcohol + NADP+
crotonaldehyde + NADPH + H+
highest oxidative activity with crotyl alcohol
-
-
r
geraniol + NAD+
(2Z)-3,7-dimethylocta-2,6-dienal + NADH + H+
-
105% of the activity with benzyl alcohol
-
-
?
nerol + NAD+
(2E)-3,7-dimethylocta-2,6-dienal + NADH + H+
-
116% of the activity with benzyl alcohol
-
-
?
phenethyl alcohol + NAD+
phenylacetaldehyde + NADH + H+
-
73% of the activity with benzyl alcohol
-
-
?
salicyl aldehyde + NADH + H+
salicyl alcohol + NAD+
-
relative activity: 9%
-
-
r
vanillin + NADH + H+
vanillin alcohol + NAD+
-
relative activity: 4%
-
-
r
vanillyl alcohol + NAD+
vanillyl aldehyde + NADH + H+
-
-
-
?
xylene-2,2'-diol + NAD+
? + NADH
low activity
-
-
?
(R)-perillyl alcohol + NAD+
(R)-perillaldehyde + NADH
-
61% activity relative to benzyl alcohol
-
?
(R)-perillyl alcohol + NAD+
(R)-perillaldehyde + NADH
-
49% activity relative to benzyl alcohol
-
?
(S)-perillyl alcohol + NAD+
(S)-perillaldehyde + NADH
-
85% activity relative to benzyl alcohol
-
?
(S)-perillyl alcohol + NAD+
(S)-perillaldehyde + NADH
-
68% activity relative to benzyl alcohol
-
?
2,4-dihydroxy-3-(hydroxymethyl)-6-methylbenzoic acid + NAD+
3-formyl-2,4-dihydroxy-6-methylbenzoic acid + NADH
-
-
-
-
?
2,4-dihydroxy-3-(hydroxymethyl)-6-methylbenzoic acid + NAD+
3-formyl-2,4-dihydroxy-6-methylbenzoic acid + NADH
-
the enzyme plays a role in the atranorin pathway
-
-
?
2-hydroxybenzyl alcohol + NAD+
2-hydroxybenzaldehyde + NADH
-
-
-
-
r
2-hydroxybenzyl alcohol + NAD+
2-hydroxybenzaldehyde + NADH
-
-
-
?
2-hydroxymethylthiophene + NAD+
2-formylthiophene + NADH
-
-
-
-
r
2-methylbenzyl alcohol + NAD+
2-methylbenzaldehyde + NADH + H+
-
-
-
-
?
2-methylbenzyl alcohol + NAD+
2-methylbenzaldehyde + NADH + H+
Pseudomonas putida mt-2 / ATCC 33015 / DSM 3931 / NCIB 12182 / NCIMB 12182
-
-
-
-
r
2-methylbenzyl alcohol + NAD+
2-methylbenzaldehyde + NADH + H+
-
-
-
-
?
2-methylbenzyl alcohol + NAD+
2-methylbenzaldehyde + NADH + H+
-
-
-
?
2-methylbenzyl alcohol + NAD+
2-methylbenzaldehyde + NADH + H+
-
-
-
?
3-chlorobenzyl alcohol + NAD+
3-chlorobenzaldehyde + NADH
-
-
-
-
r
3-chlorobenzyl alcohol + NAD+
3-chlorobenzaldehyde + NADH
low activity
-
-
?
3-hydroxybenzyl alcohol + NAD+
3-hydroxybenzaldehyde + NADH
-
-
-
?
3-methoxybenzyl alcohol + NAD+
3-methoxybenzaldehyde + NADH
-
-
-
-
?
3-methoxybenzyl alcohol + NAD+
3-methoxybenzaldehyde + NADH
-
-
-
-
r
3-methoxybenzyl alcohol + NAD+
3-methoxybenzaldehyde + NADH
-
-
-
r
3-methyl-2-buten-1-ol + NAD+
3-methyl-2-buten-1-al + NADH
-
210% activity relative to benzyl alcohol
-
-
?
3-methyl-2-buten-1-ol + NAD+
3-methyl-2-buten-1-al + NADH
-
180% activity relative to benzyl alcohol
-
r
3-methylbenzyl alcohol + NAD+
3-methylbenzaldehyde + NADH + H+
-
-
-
-
?
3-methylbenzyl alcohol + NAD+
3-methylbenzaldehyde + NADH + H+
-
-
-
?
3-methylbenzyl alcohol + NAD+
3-methylbenzaldehyde + NADH + H+
-
-
-
-
?
3-methylbenzyl alcohol + NAD+
3-methylbenzaldehyde + NADH + H+
-
-
-
?
3-methylbenzyl alcohol + NAD+
3-methylbenzaldehyde + NADH + H+
-
-
-
?
4-aminobenzyl alcohol + NAD+
4-aminobenzaldehyde + NADH
-
270% activity relative to benzyl alcohol
-
-
r
4-aminobenzyl alcohol + NAD+
4-aminobenzaldehyde + NADH
-
280% activity relative to benzyl alcohol
-
-
r
4-hydroxybenzyl alcohol + NAD+
4-hydroxybenzaldehyde + NADH
-
-
-
-
r
4-hydroxybenzyl alcohol + NAD+
4-hydroxybenzaldehyde + NADH
-
-
-
?
4-hydroxybenzyl alcohol + NAD+
4-hydroxybenzaldehyde + NADH
-
125% of benzyl alcohol activity
-
-
r
4-methylbenzyl alcohol + NAD+
4-methylbenzaldehyde + NADH + H+
-
-
-
-
?
4-methylbenzyl alcohol + NAD+
4-methylbenzaldehyde + NADH + H+
-
-
-
-
?
4-methylbenzyl alcohol + NAD+
4-methylbenzaldehyde + NADH + H+
-
-
-
?
4-methylbenzyl alcohol + NAD+
4-methylbenzaldehyde + NADH + H+
-
-
-
?
benzyl alcohol + NAD(P)+
benzaldehyde + NAD(P)H + H+
-
-
-
-
?
benzyl alcohol + NAD(P)+
benzaldehyde + NAD(P)H + H+
Lactiplantibacillus plantarum WCFS1 NCIMB 8826
-
-
-
-
?
benzyl alcohol + NAD+
benzaldehyde + NADH
-
less active in the presence of NADP+ than in the presence of NAD+
-
-
?
benzyl alcohol + NAD+
benzaldehyde + NADH
Pseudomonas putida mt-2 / ATCC 33015 / DSM 3931 / NCIB 12182 / NCIMB 12182
-
-
-
r
benzyl alcohol + NAD+
benzaldehyde + NADH
-
-
-
?
benzyl alcohol + NAD+
benzaldehyde + NADH
a step in methylbenzene conversion
-
-
?
benzyl alcohol + NAD+
benzaldehyde + NADH
-
-
-
?
benzyl alcohol + NAD+
benzaldehyde + NADH
a step in methylbenzene conversion
-
-
?
cinnamyl alcohol + NAD(P)+
cinnamyl aldehyde + NAD(P)H + H+
-
-
-
-
?
cinnamyl alcohol + NAD(P)+
cinnamyl aldehyde + NAD(P)H + H+
-
67% activity compared to activity with benzyl alcohol
-
-
?
cinnamyl alcohol + NAD(P)+
cinnamyl aldehyde + NAD(P)H + H+
Lactiplantibacillus plantarum WCFS1 NCIMB 8826
-
-
-
-
?
cinnamyl alcohol + NAD(P)+
cinnamyl aldehyde + NAD(P)H + H+
Lactiplantibacillus plantarum WCFS1 NCIMB 8826
-
67% activity compared to activity with benzyl alcohol
-
-
?
coniferyl alcohol + NAD(P)+
coniferyl aldehyde + NAD(P)H + H+
-
-
-
-
?
coniferyl alcohol + NAD(P)+
coniferyl aldehyde + NAD(P)H + H+
-
59% activity compared to activity with benzyl alcohol
-
-
?
coniferyl alcohol + NAD(P)+
coniferyl aldehyde + NAD(P)H + H+
Lactiplantibacillus plantarum WCFS1 NCIMB 8826
-
-
-
-
?
coniferyl alcohol + NAD+
coniferyl aldehyde + NADH + H+
-
relative activity: 96%
-
-
r
coniferyl alcohol + NAD+
coniferyl aldehyde + NADH + H+
-
-
-
-
r
coniferyl alcohol + NAD+
coniferyl aldehyde + NADH + H+
-
biotransformation of eugenol to ferulic acid
-
-
?
coniferyl alcohol + NAD+
coniferyl aldehyde + NADH + H+
-
59% of the activity with benzyl alcohol
-
-
?
coniferyl alcohol + NAD+
coniferyl aldehyde + NADH + H+
-
biotransformation of eugenol to ferulic acid
-
-
?
coniferyl alcohol + NAD+
coniferyl aldehyde + NADH + H+
CADH requires NAD as a cofactor
-
-
?
furfuryl alcohol + NAD+
furfural + NADH
Pseudomonas putida mt-2 / ATCC 33015 / DSM 3931 / NCIB 12182 / NCIMB 12182
-
-
-
-
r
geraniol + NAD(P)+
geranial + NAD(P)H + H+
-
105% activity compared to activity with benzyl alcohol
-
-
?
geraniol + NAD+
geranial + NADH + H+
-
63% activity relative to benzyl alcohol
-
?
geraniol + NAD+
geranial + NADH + H+
-
68% activity relative to benzyl alcohol
-
?
nerol + NAD(P)+
(2E)-3,7-dimethylocta-2,6-dienal + NAD(P)H + H+
-
-
-
-
?
nerol + NAD(P)+
(2E)-3,7-dimethylocta-2,6-dienal + NAD(P)H + H+
-
116% activity compared to activity with benzyl alcohol
-
-
?
nerol + NAD+
neral + NADH + H+
-
25% activity relative to benzyl alcohol
-
?
nerol + NAD+
neral + NADH + H+
-
77% activity relative to benzyl alcohol
-
?
phenethyl alcohol + NAD(P)+
phenylacetaldehyde + NAD(P)H + H+
-
-
-
-
?
phenethyl alcohol + NAD(P)+
phenylacetaldehyde + NAD(P)H + H+
-
73% activity compared to activity with benzyl alcohol
-
-
?
additional information
?
-
-
alcohols that are not oxidized
-
-
?
additional information
?
-
-
no activity with tyrosol, tryptophol, pyrogallol, catechol, phloroglucinol, ethanol, p-coumaric acid, and caffeic acid
-
-
?
additional information
?
-
Lactiplantibacillus plantarum WCFS1 NCIMB 8826
-
no activity with tyrosol, tryptophol, pyrogallol, catechol, phloroglucinol, ethanol, p-coumaric acid, and caffeic acid
-
-
?
additional information
?
-
-
the enzyme is involved in the toluene metabolic pathway, overview
-
-
?
additional information
?
-
Paecilomyces variotii CBS115145
-
the enzyme is involved in the toluene metabolic pathway, overview
-
-
?
additional information
?
-
-
the enzyme plays a role in vanillin and aromatic compound metabolism, application of vanillin to the mycelium leads to up-regulation of enzymes involved in vanillin metabolism and also in glycolysis, the tricarboxylic acid cycle, the pentose-phosphate cycle, and heme biosynthesis, overview
-
-
?
additional information
?
-
-
a group of enzymes with broad specificity towards alcohols with an aromatic or cyclohex-1-ene ring, but with low or no activity towards short chain aliphatic alcohols
-
-
?
additional information
?
-
Pseudomonas putida mt-2 / ATCC 33015 / DSM 3931 / NCIB 12182 / NCIMB 12182
-
not: 4-nitrophenyl acetate
-
-
?
additional information
?
-
Pseudomonas putida mt-2 / ATCC 33015 / DSM 3931 / NCIB 12182 / NCIMB 12182
-
a group of enzymes with broad specificity towards alcohols with an aromatic or cyclohex-1-ene ring, but with low or no activity towards short chain aliphatic alcohols
-
-
?
additional information
?
-
-
enzyme from Rhodopseudomonas acidophila has broad specificity for aromatic alcohols and is also capable of oxidizing aliphatic alcohols with NAD+
-
-
?
additional information
?
-
-
enzyme also capable of oxidizing aliphatic primary alcohols with NAD+
-
-
?
additional information
?
-
the enzyme may play important role in the fungal conversion of 4-methyldibenzothiophene-5-oxide or its metabolic products
-
-
?
additional information
?
-
-
the enzyme may play important role in the fungal conversion of 4-methyldibenzothiophene-5-oxide or its metabolic products
-
-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2,4-dihydroxy-3-(hydroxymethyl)-6-methylbenzoic acid + NAD+
3-formyl-2,4-dihydroxy-6-methylbenzoic acid + NADH
-
the enzyme plays a role in the atranorin pathway
-
-
?
2-hydroxybenzyl alcohol + NAD+
2-hydroxybenzaldehyde + NADH
-
-
-
?
2-hydroxymethyl-6-methylnaphthalene + NAD+
2-formyl-6-methylnaphthalene + NADH
low activity
-
-
?
2-hydroxymethylnaphthalene + NAD+
2-formylnaphthalene + NADH
low activity
-
-
?
2-methoxybenzyl alcohol + NAD+
2-methoxybenzaldehyde + NADH + H+
-
-
-
?
3-chlorobenzyl alcohol + NAD+
3-chlorobenzaldehyde + NADH
low activity
-
-
?
3-hydroxybenzyl alcohol + NAD+
3-hydroxybenzaldehyde + NADH
-
-
-
?
3-methoxybenzyl alcohol + NAD+
3-methoxybenzaldehyde + NADH + H+
-
-
-
?
4-hydroxybenzyl alcohol + NAD+
4-hydroxybenzaldehyde + NADH
-
-
-
?
4-methoxybenzyl alcohol + NAD+
4-methoxybenzaldehyde + NADH + H+
-
-
-
?
coniferyl alcohol + NAD+
coniferyl aldehyde + NADH + H+
CADH requires NAD as a cofactor
-
-
?
nerol + NAD(P)+
(2E)-3,7-dimethylocta-2,6-dienal + NAD(P)H + H+
-
-