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Information on EC 1.1.1.85 - 3-isopropylmalate dehydrogenase

for references in articles please use BRENDA:EC1.1.1.85

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IUBMB Comments

The product decarboxylates spontaneously to yield 4-methyl-2-oxopentanoate.

The enzyme appears in viruses and cellular organisms

Synonyms
3-isopropylmalate dehydrogenase, ipmdh, beta-isopropylmalate dehydrogenase, isopropylmalate dehydrogenase, ipmdh2, ipmdh3, beta-ipm dehydrogenase, sbipmdh, ipmdh1, saci_0600, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(2R,3S)-3-isopropylmalate + NAD+ = (2S)-2-isopropyl-3-oxosuccinate + NADH + H+
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
MetaCyc
butanol and isobutanol biosynthesis (engineered)