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Information on EC 1.1.1.85 - 3-isopropylmalate dehydrogenase

for references in articles please use BRENDA:EC1.1.1.85
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IUBMB Comments
The product decarboxylates spontaneously to yield 4-methyl-2-oxopentanoate.
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Word Map
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
ipmdh, beta-isopropylmalate dehydrogenase, isopropylmalate dehydrogenase, ipmdh2, ipmdh3, beta-ipm dehydrogenase, ipmdh1, saci_0600, 3-ipm dehydrogenase, soipmdh, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(2R,3S)-3-isopropylmalate + NAD+ = (2S)-2-isopropyl-3-oxosuccinate + NADH + H+
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