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Information on EC 1.1.1.82 - malate dehydrogenase (NADP+) and Organism(s) Zea mays and UniProt Accession P15719

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EC Tree
IUBMB Comments
Activated by light.
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This record set is specific for:
Zea mays
UNIPROT: P15719
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Word Map
The taxonomic range for the selected organisms is: Zea mays
The expected taxonomic range for this enzyme is: Eukaryota, Archaea, Bacteria
Reaction Schemes
Synonyms
nadp malate dehydrogenase, nadp-linked malate dehydrogenase, malate nadp dehydrogenase, malate dehydrogenase (nadp+), more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
NADP-dependent malate dehydrogenase
-
NADP-malate dehydrogenase
-
dehydrogenase, malate (nicotinamide adenine dinucleotide phosphate)
-
-
-
-
malate NADP dehydrogenase
-
-
-
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malic dehydrogenase (nicotinamide adenine dinucleotide phosphate)
-
-
-
-
NADP malate dehydrogenase
-
-
-
-
NADP-linked malate dehydrogenase
-
-
-
-
NADP-malate dehydrogenase
-
-
-
-
NADP-malic enzyme
-
-
-
-
NADP-MDH
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
redox reaction
-
-
-
-
oxidation
-
-
-
-
reduction
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
(S)-malate:NADP+ oxidoreductase
Activated by light.
CAS REGISTRY NUMBER
COMMENTARY hide
37250-19-4
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(S)-malate + NADP+
oxaloacetate + NADPH + H+
show the reaction diagram
-
-
-
r
oxaloacetate + NADPH + H+
(S)-malate + NADP+
show the reaction diagram
(S)-malate + NAD+
oxaloacetate + NADH + H+
show the reaction diagram
-
-
-
r
(S)-malate + NADP+
oxaloacetate + NADPH + H+
show the reaction diagram
oxaloacetate + NADH
(S)-malate + NAD+
show the reaction diagram
oxaloacetate + NADPH
(S)-malate + NADP+
show the reaction diagram
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
(S)-malate + NADP+
oxaloacetate + NADPH + H+
show the reaction diagram
-
-
-
r
oxaloacetate + NADPH + H+
(S)-malate + NADP+
show the reaction diagram
-
-
-
r
oxaloacetate + NADPH
(S)-malate + NADP+
show the reaction diagram
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NADPH
-
cofactor
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
diethyldicarbonate
-
inactivation follows pseudo-first-order reaction kinetics, partial protection by NADP+, complete protection in presence of NADP+, 0.25 M hydroxylamine causes total reversal of inhibition
oxaloacetate
-
2.5 mM
additional information
-
sensitivity of the light-activation of the enzyme to high light is at least partially due to a competition for electrons with CO2 fixation
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
dithiothreitol
-
activates
thioredoxin
additional information
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
24 - 32
(S)-malate
0.8
NAD+
-
cosubstrate malate
0.83
NADH
-
cosubstrate oxaloacetate
0.045 - 0.073
NADP+
0.024 - 0.05
NADPH
0.018 - 0.061
oxaloacetate
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
160
-
-
945
-
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7 - 8.5
-
activated enzyme
7.5 - 8.3
-
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
maize enzyme-overexpressing Arabidopsis thaliana plants are tolerant to salt stress (150 mM NaCl)
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
MDHP_MAIZE
432
0
46860
Swiss-Prot
Chloroplast (Reliability: 3)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
110000 - 120000
-
unactivated enzyme, gel filtration
143000 - 150000
-
activated enzyme, gel filtration
150000
-
gel filtration
39000
-
2 * 39000, SDS-PAGE
43000
50000 - 60000
-
unactivated enzyme, gel filtration
61000
-
equilibrium sedimentation
81000
-
gel filtration
88000
-
gradient pore-PAGE
91000
-
gel filtration
98000
-
gel filtration
additional information
-
-
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * 41000, SDS-PAGE
dimer
OXIDATION STABILITY
ORGANISM
UNIPROT
LITERATURE
the enzyme undergoes reversible oxidation/reduction during its photoregulation
-
287411
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-15°C, 37.5 mM Na-acetate, pH 5.5, 0.37 mM EDTA, 25% glycerol, no significant loss of activity after 3 months
-
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Arabidopsis thaliana
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Agostino, A.; Jeffrey, P.; Hatch, M.D.
Amino acid sequence and molecular weight of native NADP malate dehydrogenase from the C4 plant Zea mays
Plant Physiol.
98
1506-1510
1992
Zea mays
Manually annotated by BRENDA team
Miginiac-Maslow, M.; Decottignies, P.; Jacquot, J.P.; Gadal, P.
Regulation of corn leaf NADP-malate dehydrogenase light-activation by the photosynthetic electron flow. Effect of photoinhibition studied in a reconstituted system
Biochim. Biophys. Acta
1017
273-279
1990
Pisum sativum, Spinacia oleracea, Zea mays
-
Manually annotated by BRENDA team
Kagawa, T.; Bruno, P.L.
NADP-malate dehydrogenase from leaves of Zea mays: purification and physical, chemical, and kinetic properties
Arch. Biochem. Biophys.
260
674-695
1988
Zea mays
Manually annotated by BRENDA team
Jawali, N.; Bhagwat, A.S.
Presence of essential histidine residues in NADP-malic enzyme from maize
Phytochemistry
26
1859-1862
1987
Zea mays
-
Manually annotated by BRENDA team
Jacquot, J.P.; Decottignies, P.
Further evidence for a role of sulfhydryl in the thioredoxin dependent activation of corn NADP-malate dehydrogenase
FEBS Lett.
209
87-91
1986
Zea mays
-
Manually annotated by BRENDA team
Nakamoto, H.; Edwards, G.E.
Light activation of pyruvate, Pi dikinase and NADP-malate dehydrogenase in mesophyll protoplasts in maize
Plant Physiol.
82
312-315
1986
Zea mays
Manually annotated by BRENDA team
Edwards, G.E.; Nakamoto, H.; Burnell, J.N.; Hatch, M.D.
Pyruvate, Pi dikinase and NADP-malate dehydrogenase in C4 photosynthesis: properties and mechanism of light/dark regulation
Annu. Rev. Plant Physiol.
36
255-286
1985
Pisum sativum, Zea mays
-
Manually annotated by BRENDA team
Ferte, N.; Jaquot, J.P.; Meunier, J.C.
Structural, immunological and kinetic comparisons of NADP-dependent malate dehydrogenases from spinach (C3) and corn (C4) chloroplasts
Eur. J. Biochem.
154
587-595
1986
Spinacia oleracea, Zea mays
Manually annotated by BRENDA team
Perrot-Rechenmann, C.; Jacquot, J.P.; Gadal, P.; Weeden, N.F.; Cseke, C.; Buchanan, B.B.
Localization of NADP-malate dehydrogenase of corn leaves by immunological methods
Plant Sci. Lett.
30
219-226
1983
Zea mays
-
Manually annotated by BRENDA team
Jacquot, J.P.P.; Buchanan, B.B.; Martin, F.; Vidal, J.
Enzyme regulation in C4 photosynthesis. Purification and properties of thioredoxin-linked NADP-malate dehydrogenase from corn leaves
Plant Physiol.
68
300-304
1981
Zea mays
Manually annotated by BRENDA team
Hatch, M.D.; Slack, C.R.
NADPH-specific malate dehydrogenase and glycerate kinase in leaves and evidence for their location in chloroplasts
Biochem. Biophys. Res. Commun.
34
589-593
1969
Amaranthus palmeri, Beta vulgaris, Daucus carota, Pisum sativum, Saccharum sp., Spinacia oleracea, Zea mays
Manually annotated by BRENDA team
Rondeau, P.; Rouch, C.; Besnard, G.
NADP-malate dehydrogenase gene evolution in Andropogoneae (Poaceae): gene duplication followed by sub-functionalization
Ann. Bot.
96
1307-1314
2005
Chrysopogon zizanioides (Q8H0J7), Chrysopogon zizanioides (Q8L5S9), Dichanthium aristatum (Q8H0R5), Flaveria trinervia (Q42737), Heteropogon contortus (Q2MG92), Hyparrhenia rufa (Q2MG94), Ischaemum koleostachys (Q8H0Q3), Megathyrsus maximus (Q8H0N9), Melinis repens (Q2MG93), Oplismenus compositus (Q8H0P4), Oryza sativa, Paspalum paniculatum (Q8H0N5), Pogonatherum paniceum (Q8H0N4), Saccharum hybrid cultivar R570 (Q4W4C2), Saccharum officinarum (Q1RS10), Saccharum officinarum (Q8L6C8), Saccharum spontaneum (Q8H0M0), Setaria geminata (Q1RS11), Sorghum arundinaceum (Q8H0L7), Sorghum bicolor (P17606), Sorghum bicolor (P37229), Themeda quadrivalvis (Q8H0K0), Zea mays (P15719)
Manually annotated by BRENDA team
Kandoi, D.; Mohanty, S.; Tripathy, B.C.
Overexpression of plastidic maize NADP-malate dehydrogenase (ZmNADP-MDH) in Arabidopsis thaliana confers tolerance to salt stress
Protoplasma
255
547-563
2018
Zea mays (P15719)
Manually annotated by BRENDA team