Any feedback?
Information on EC 1.1.1.72 - glycerol dehydrogenase (NADP+)
for references in articles please use BRENDA:EC1.1.1.72Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
1.1.1.72 glycerol dehydrogenase (NADP+)Specify your search results
Word Map
- 1.1.1.72
- polyols
-
racemic
- oxydans
-
gluconobacter
- l-glyceraldehyde
- stearothermophilus
-
nadp-dependent
- nidulans
-
enantioselectivity
-
1.1.1.6
-
hypothesise
-
hypocrea
-
aldo-keto
- erythritol
- gli1
- jecorina
- 1,3-dihydroxyacetone
-
bioproduction
-
iron-containing
-
enantiopure
- medicine
The enzyme appears in viruses and cellular organisms
Synonyms
glydh, gox1615, akr11b4, nadp+-dependent glycerol dehydrogenase, 
more
topPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
gamma-hydroxybutyrate dehydrogenase
-
-
-
-
glycerol dehydrogenase
NADP+-dependent glycerol dehydrogenase
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
glycerol + NADP+ = D-glyceraldehyde + NADPH + H+
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
PATHWAY SOURCE
PATHWAYS
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYSTEMATIC NAME
IUBMB Comments
glycerol:NADP+ oxidoreductase
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
CAS REGISTRY NUMBER
COMMENTARY
37250-11-6
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(2,2-dimethyl-1,3-dioxolan-4-yl)methanol + NADP+
2,2-dimethyl-1,3-dioxolane-4-carbaldehyde + NADPH
-
oxidation reaction. Specific activity: 0.03 micromol/min/mg
-
-
?
(2E)-pent-2-enal + NADPH + H+
(2E)-pent-2-enol + NADP+
-
reduction reaction: specific activity: 4.9 micromol/min/mg. Oxidation reaction specific activity: 0.74 micromol/min/mg
-
-
?
(2R)-2,4-dihydroxybutanal + NADPH + H+
(2R)-2,4-dihydroxybutanol + NADP+
-
reduction reaction. Specific activity: 46.6 micromol/min/mg
-
-
?
(2R,3S)-butane-1,2,3,4-tetrol + NADP+
? + NADPH
-
oxidation reaction. Specific activity: 0.75 micromol/min/mg
-
-
?
(2R,3S,4R,5S)-hexane-1,2,3,4,5,6-hexol + NADP+
? + NADPH
-
oxidation reaction. Specific activity: 1.08 micromol/min/mg
-
-
?
(2R,3S,4S)-pentane-1,2,3,4,5-pentol + NADP+
? + NADPH
-
oxidation reaction. Specific activity: 0.25 micromol/min/mg
-
-
?
(2R,4S)-pentane-1,2,3,4,5-pentol + NADP+
? + NADPH
-
oxidation reaction. Specific activity: 2.46 micromol/min/mg
-
-
?
(2S)-2,4-dihydroxybutanal + NADPH + H+
(2S)-2,4-dihydroxybutanol + NADP+
-
reduction reaction. Specific activity: 2.0 micromol/min/mg
-
-
?
(2S,3S)-butane-1,2,3,4-tetrol + NADP+
? + NADPH
-
oxidation reaction. Specific activity: 0.9 micromol/min/mg
-
-
?
1,3-dihydroxypropan-2-one + NADPH + H+
propane-1,2,3-triol + NADP+
-
reduction reaction. Specific activity: 0.5 micromol/min/mg
-
-
?
1-phenylethane-1,2-diol + NADP+
? + NADPH
-
oxidation reaction. Specific activity: 0.77 micromol/min/mg
-
-
?
1-phenylethanone + NADPH + H+
1-phenylethanol + NADP+
-
reduction reaction. Specific activity: 0.04 micromol/min/mg
-
-
?
1-phenylpropanone + NADPH + H+
1-phenylpropanol + NADP+
-
reduction reaction. Specific activity: 0.03 micromol/min/mg
-
-
?
2,4-difluorobenzaldehyde + NADPH + H+
(2,4-difluorophenyl)methanol + NADP+
-
reduction reaction. Specific activity: 19.6 micromol/min/mg
-
-
?
2,4-dihydroxybutanal + NADPH + H+
2,4-dihydroxybutanol + NADP+
-
reduction reaction. Specific activity: 39.1 micromol/min/mg
-
-
?
2-methylbutanal + NADPH + H+
2-methylbutanol + NADP+
-
reduction reaction. Specific activity: 26.8 micromol/min/mg
-
-
?
2-methylpentanal + NADPH + H+
2-methylpentanol + NADP+
-
reduction reaction. Specific activity: 25.7 micromol/min/mg
-
-
?
2-methylpropanal + NADPH + H+
2-methylpropanol + NADP+
-
reduction reaction. Specific activity: 6.7 micromol/min/mg
-
-
?
4-methoxybenzaldehyde + NADPH + H+
(4-methoxyphenyl)methanol + NADP+
-
reduction reaction. Specific activity: 0.3 micromol/min/mg
-
-
?
6-methylheptane-2,5-dione + NADPH + H+
? + NADP+
-
reduction reaction. Specific activity: 0.03 micromol/min/mg
-
-
?
benzaldehyde + NADPH + H+
benzyl alcohol + NADP+
-
reduction reaction. Specific activity: 13.8 micromol/min/mg
-
-
?
butane-1,2,4-triol + NADP+
? + NADPH
-
oxidation reaction. Specific activity: 1.21 micromol/min/mg
-
-
?
butane-1,2-diol + NADP+
? + NADPH
-
oxidation reaction. Specific activity: 0.66 micromol/min/mg
-
-
?
butane-1,3-diol + NADP+
? + NADPH
-
oxidation reaction. Specific activity: 0.04 micromol/min/mg
-
-
?
butane-1,4-diol + NADP+
? + NADPH
-
oxidation reaction. Specific activity: 0.21 micromol/min/mg
-
-
?
DL-glyceraldehyde + NADPH + H+
glycerol + NADP+
significant enantioselectivity
-
-
r
dodecanal + NADPH + H+
dodecanol + NADP+
-
reduction reaction. Specific activity: 19.3 micromol/min/mg
-
-
?
ethane-1,1-diol + NADP+
? + NADPH
-
oxidation reaction. Specific activity: 0.5 micromol/min/mg
-
-
?
glycerol + NADP+
? + NADPH + H+
-
oxidation reaction. Specific activity: 0.17 micromol/min/mg
-
-
?
hexan-2-ol + NADP+
hexan-2-one + NADPH
-
oxidation reaction. Specific activity: 0.22 micromol/min/mg
-
-
?
hexane-1,2,3-triol + NADP+
? + NADPH
-
oxidation reaction. Specific activity: 0.76 micromol/min/mg
-
-
?
hexane-1,6-diol + NADP+
? + NADPH
-
oxidation reaction. Specific activity: 0.87 micromol/min/mg
-
-
?
methanediol + NADP+
? + NADPH
-
oxidation reaction. Specific activity: 0.05 micromol/min/mg
-
-
?
nonanal + NADPH + H+
nonanol + NADP+
-
reduction reaction. Specific activity: 15.9 micromol/min/mg
-
-
?
octan-3-one + NADPH + H+
octan-3-ol + NADP+
-
reduction reaction. Specific activity: 0.02 micromol/min/mg
-
-
?
octanal + NADPH + H+
octanol + NADP+
-
reduction reaction. Specific activity: 35.5 micromol/min/mg
-
-
?
pentane-1,2-diol + NADP+
? + NADPH
-
oxidation reaction. Specific activity: 0.39 micromol/min/mg
-
-
?
pentane-1,5-diol + NADP+
? + NADPH
-
oxidation reaction. Specific activity: 0.59 micromol/min/mg
-
-
?
propanal + NADPH + H+
propanol + NADP+
-
reduction reaction. Specific activity: 1.1 micromol/min/mg
-
-
?
acetaldehyde + NADPH + H+
ethanol + NADP+
-
reduction reaction. Specific activity: 0.1 micromol/min/mg
-
-
?
butanal + NADPH + H+
butanol + NADP+
-
reduction reaction. Specific activity: 23.3 micromol/min/mg
-
-
?
D-glyceraldehyde + NADPH + H+
glycerol + NADP+
-
enzyme favors reduction reaction
-
-
?
D-glyceraldehyde + NADPH + H+
glycerol + NADP+
-
-
-
-
r
dihydroxyacetone + NADPH
glycerol + NADP+
-
43% of D-glyceraldehyde activity
-
-
r
glycerol + NADP+
D-glyceraldehyde + NADPH + H+
-
significant enantioselectivity
-
r
glycerol + NADP+
D-glyceraldehyde + NADPH + H+
-
the reverse reaction is energetically more favorable
-
-
r
glycerol + NADP+
D-glyceraldehyde + NADPH + H+
-
-
-
-
r
glycerol + NADP+
D-glyceraldehyde + NADPH + H+
-
the reverse reaction is energetically more favorable
-
-
r
glycerol + NADP+
D-glyceraldehyde + NADPH + H+
-
the reverse reaction is energetically more favorable
-
-
r
glycerol + NADP+
D-glyceraldehyde + NADPH + H+
-
the reverse reaction is energetically more favorable
-
-
r
glycerol + NADP+
D-glyceraldehyde + NADPH + H+
-
the reverse reaction is energetically more favorable
-
-
r
glycerol + NADP+
D-glyceraldehyde + NADPH + H+
-
the reverse reaction is energetically more favorable
-
-
r
glycerol + NADP+
dihydroxyacetone + NADPH + H+
The enzyme plays a role in the glycerol biosynthesis during growth and in osmotolerance. The glycerol biosynthesis by enzyme is required for germination at high osmolarity.
-
-
r
hexanal + NADPH + H+
hexanol + NADP+
-
reduction reaction. Specific activity: 31.9 micromol/min/mg
-
-
r
hexane-1,2,6-triol + NADP+
? + NADPH
-
oxidation reaction. Specific activity: 0.3 micromol/min/mg
-
-
?
hexane-1,2,6-triol + NADP+
? + NADPH
-
oxidation reaction. Specific activity: 0.45 micromol/min/mg
-
-
?
L-glyceraldehyde + NADPH
glycerol + NADP+
-
36% of D-glyceraldehyde activity
-
-
?
additional information
?
-
-
the enzyme is part of the biosynthetic pathway for glycerol
-
-
?
additional information
?
-
-
glycerol dehydrogenase activity is detected in all Lactobacillus strains studied but only for the reduction of glyceraldehyde with NADPH. This enzyme shows a very low oxidative activity with glycerol and NADP+ and, most likely, under physiological conditions, the oxidative reaction does not occur
-
-
?
additional information
?
-
-
glycerol dehydrogenase activity is detected in all Lactobacillus strains studied but only for the reduction of glyceraldehyde with NADPH. This enzyme shows a very low oxidative activity with glycerol and NADP+ and, most likely, under physiological conditions, the oxidative reaction does not occur
-
-
?
additional information
?
-
-
glycerol dehydrogenase activity is detected in all Lactobacillus strains. This enzyme shows a very low oxidative activity with glycerol and NADP+ and, most likely, under physiological conditions, the oxidative reaction does not occur
-
-
?
additional information
?
-
-
glycerol dehydrogenase activity is detected in all Lactobacillus strains. This enzyme shows a very low oxidative activity with glycerol and NADP+ and, most likely, under physiological conditions, the oxidative reaction does not occur
-
-
?
additional information
?
-
-
glycerol dehydrogenase activity is detected in all Lactobacillus strains studied. This enzyme shows a very low oxidative activity with glycerol and NADP+ and, most likely, under physiological conditions, the oxidative reaction does not occur
-
-
?
additional information
?
-
-
glycerol dehydrogenase activity is detected in all Lactobacillus strains studied. This enzyme shows a very low oxidative activity with glycerol and NADP+ and, most likely, under physiological conditions, the oxidative reaction does not occur
-
-
?
additional information
?
-
-
no substrates: D-fructose, D-ribose, D-xylose
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
glycerol + NADP+
dihydroxyacetone + NADPH + H+
The enzyme plays a role in the glycerol biosynthesis during growth and in osmotolerance. The glycerol biosynthesis by enzyme is required for germination at high osmolarity.
-
-
r
D-glyceraldehyde + NADPH + H+
glycerol + NADP+
-
-
-
-
r
glycerol + NADP+
D-glyceraldehyde + NADPH + H+
-
-
-
-
r
additional information
?
-
-
the enzyme is part of the biosynthetic pathway for glycerol
-
-
?
additional information
?
-
-
glycerol dehydrogenase activity is detected in all Lactobacillus strains studied but only for the reduction of glyceraldehyde with NADPH. This enzyme shows a very low oxidative activity with glycerol and NADP+ and, most likely, under physiological conditions, the oxidative reaction does not occur
-
-
?
additional information
?
-
-
glycerol dehydrogenase activity is detected in all Lactobacillus strains studied but only for the reduction of glyceraldehyde with NADPH. This enzyme shows a very low oxidative activity with glycerol and NADP+ and, most likely, under physiological conditions, the oxidative reaction does not occur
-
-
?
additional information
?
-
-
glycerol dehydrogenase activity is detected in all Lactobacillus strains. This enzyme shows a very low oxidative activity with glycerol and NADP+ and, most likely, under physiological conditions, the oxidative reaction does not occur
-
-
?
additional information
?
-
-
glycerol dehydrogenase activity is detected in all Lactobacillus strains. This enzyme shows a very low oxidative activity with glycerol and NADP+ and, most likely, under physiological conditions, the oxidative reaction does not occur
-
-
?
additional information
?
-
-
glycerol dehydrogenase activity is detected in all Lactobacillus strains studied. This enzyme shows a very low oxidative activity with glycerol and NADP+ and, most likely, under physiological conditions, the oxidative reaction does not occur
-
-
?
additional information
?
-
-
glycerol dehydrogenase activity is detected in all Lactobacillus strains studied. This enzyme shows a very low oxidative activity with glycerol and NADP+ and, most likely, under physiological conditions, the oxidative reaction does not occur
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
NADPH
-
prefers NADPH over NADH. Using NADPH, a 200fold increase in activity compared to the activity achieved with the same concentration of NADH is observed
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
NaCl
The presence of 1 M NaCl results in a significant increase in activity in the wild-type strain.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
2.69
D-glyceraldehyde
-
reduction, pH 7.0, 30°C, Vmax: 77.9 micromol/min/mg
12.8
D-glyceraldehyde
-
reverse reaction, pH 6.5, 25°C, crude extract
20.2
D-glyceraldehyde
-
reverse reaction, pH 6.5, 25°C, crude extract
32.3
D-glyceraldehyde
-
reverse reaction, pH 6.5, 25°C, crude extract
additional information
additional information
KM-value 118.0 mM with substrate DL-glyceraldehyde, W23A mutant protein, pH 7.0, 30°C
-
additional information
additional information
-
KM-value 118.0 mM with substrate DL-glyceraldehyde, W23A mutant protein, pH 7.0, 30°C
-
additional information
additional information
KM-value 2.4 mM with substrate DL-glyceraldehyde, wild-type protein, pH 7.0, 30°C
-
additional information
additional information
-
KM-value 2.4 mM with substrate DL-glyceraldehyde, wild-type protein, pH 7.0, 30°C
-
additional information
additional information
KM-value 49.4 mM with substrate DL-glyceraldehyde, W23M mutant protein, pH 7.0, 30°C
-
additional information
additional information
-
KM-value 49.4 mM with substrate DL-glyceraldehyde, W23M mutant protein, pH 7.0, 30°C
-
additional information
additional information
-
enzyme kinetic parameters are determined by fitting the initial rates to irreversible single substrate Michaelis-Menten models
-
additional information
additional information
-
enzyme kinetic parameters are determined by fitting the initial rates to irreversible single substrate Michaelis-Menten models
-
additional information
additional information
-
enzyme kinetic parameters are determined by fitting the initial rates to irreversible single substrate Michaelis-Menten models
-