We're sorry, but BRENDA doesn't work properly without JavaScript. Please make sure you have JavaScript enabled in your browser settings.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments Reduces aliphatic aldehydes of carbon chain length from 2 to 14, with greatest activity on C4, C6 and C8 aldehydes; also reduces retinal to retinol.
The taxonomic range for the selected organisms is: Homo sapiens The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
dhrs3, retinaldehyde reductase, tesadh, retsdr1, nadph-dependent alcohol dehydrogenase, adh12, tsib_0319, phadh, nad(p)h-dependent adh, retinol-active alcohol dehydrogenase,
more
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
aldehyde reductase (NADPH/NADH)
-
-
-
-
retinal reductase
-
-
-
-
retinal short-chain dehydrogenase/reductase member 3
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
a primary alcohol + NAD(P)+ = an aldehyde + NAD(P)H + H+
the human pancreas protein 2 has a retinal reductase activity
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
alcohol:NAD(P)+ oxidoreductase
Reduces aliphatic aldehydes of carbon chain length from 2 to 14, with greatest activity on C4, C6 and C8 aldehydes; also reduces retinal to retinol.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
all-trans-retinol + NADP+
all-trans-retinal + NADPH + H+
-
-
-
r
retinaldehyde + NADH
retinol + NAD+
-
-
-
?
4-androstene-3,17-dione + NADPH + H+
?
-
-
-
-
?
4-methylnitrosamino-1-(3-pyridyl)-1-butanone + NADPH + H+
?
-
-
-
-
?
4-nitroacetophenone + NADPH + H+
?
-
-
-
-
?
acetohexamide + NADPH + H+
?
-
-
-
-
?
all-trans-retinal + NADPH + H+
all-trans-retinol + NADP+
-
-
-
-
?
DL-glyceraldehyde + NADPH + H+
?
-
-
-
-
?
estrone + NADPH + H+
?
-
-
-
-
?
additional information
?
-
-
4-nitroacetophenone, benzyl, cortisone and progesterone are no substrates
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
all-trans-retinal + NADPH + H+
all-trans-retinol + NADP+
-
-
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
NADPH
-
the enzyme prefers NADPH as a cofactor
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Carcinogenesis
Hypermethylation of DHRS3 as a Novel Tumor Suppressor Involved in Tumor Growth and Prognosis in Gastric Cancer.
Lymphatic Metastasis
Gene expression profiling of papillary thyroid carcinoma identifies transcripts correlated with BRAF mutational status and lymph node metastasis.
Melanoma
Silencing of Peroxiredoxin 2 and aberrant methylation of 33 CpG islands in putative promoter regions in human malignant melanomas.
Neoplasm Metastasis
Gene expression profiling of papillary thyroid carcinoma identifies transcripts correlated with BRAF mutational status and lymph node metastasis.
Neoplasm Metastasis
Induction of cell cycle arrest and inflammatory genes by combined treatment with epigenetic, differentiating, and chemotherapeutic agents in triple-negative breast cancer.
Neoplasms
Biological role of aldo-keto reductases in retinoic Acid biosynthesis and signaling.
Neoplasms
Evaluation of genes identified by microarray analysis in favorable neuroblastoma.
Neoplasms
Hypermethylation of DHRS3 as a Novel Tumor Suppressor Involved in Tumor Growth and Prognosis in Gastric Cancer.
Neoplasms
Identification of allelic expression imbalance genes in human hepatocellular carcinoma through massively parallel DNA and RNA sequencing.
Neoplasms
Induction of cell cycle arrest and inflammatory genes by combined treatment with epigenetic, differentiating, and chemotherapeutic agents in triple-negative breast cancer.
Neoplasms
p53-inducible DHRS3 Is an Endoplasmic Reticulum Protein Associated with Lipid Droplet Accumulation.
Neoplasms
retSDR1, a short-chain retinol dehydrogenase/reductase, is retinoic acid-inducible and frequently deleted in human neuroblastoma cell lines.
Neoplasms
Substrate Specificity, Inhibitor Selectivity and Structure-Function Relationships of Aldo-Keto Reductase 1B15: A Novel Human Retinaldehyde Reductase.
Neoplasms
The retinal dehydrogenase/reductase retSDR1/DHRS3 gene is activated by p53 and p63 but not by mutants derived from tumors or EEC/ADULT malformation syndromes.
Neuroblastoma
retSDR1, a short-chain retinol dehydrogenase/reductase, is retinoic acid-inducible and frequently deleted in human neuroblastoma cell lines.
Non-alcoholic Fatty Liver Disease
Genetic analysis of expression profile involved in retinoid metabolism in non-alcoholic fatty liver disease.
Obesity
p53-inducible DHRS3 Is an Endoplasmic Reticulum Protein Associated with Lipid Droplet Accumulation.
Stomach Neoplasms
Hypermethylation of DHRS3 as a Novel Tumor Suppressor Involved in Tumor Growth and Prognosis in Gastric Cancer.
Triple Negative Breast Neoplasms
Inhibition of retinoic acid receptor ? phosphorylation represses the progression of triple-negative breast cancer via transactivating miR-3074-5p to target DHRS3.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.08
all-trans-retinal
pH 7.4, 37°C
0.4
all-trans-retinol
pH 7.4, 37°C
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
SwissProt
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
brenda
-
brenda
-
brenda
-
brenda
-
brenda
-
brenda
-
brenda
-
brenda
-
brenda
-
brenda
-
brenda
-
brenda
-
brenda
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
highest expression
brenda
additional information
-
no or very low expression in lungs, spleen, pancreas, large intestine and eye
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
brenda
-
-
brenda
-
integral-membrane protein
brenda
-
-
-
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
RDH14_HUMAN
336
1
36865
Swiss-Prot
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
36000
-
x * 36000, SDS-PAGE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
HisTrap column chromatography, and Superdex 200 gel filtration
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
expression in insect SF9 cells
expressed in Sf9 insect cells
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Belyaeva, O.V.; Kedishvili, N.Y.
Human pancreas protein 2 (PAN2) has a retinal reductase activity and is ubiquitously expressed in human tissues
FEBS Lett.
531
489-493
2002
Homo sapiens (Q9HBH5)
brenda
Lundova, T.; Zemanova, L.; Malcekova, B.; Skarka, A.; Stambergova, H.; Havrankova, J.; Safr, M.; Wsol, V.
Molecular and biochemical characterisation of human short-chain dehydrogenase/reductase member 3 (DHRS3)
Chem. Biol. Interact.
234
178-187
2015
Homo sapiens
brenda