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Information on EC 1.1.1.71 - alcohol dehydrogenase [NAD(P)+]
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EC Tree
1.1.1.71 alcohol dehydrogenase [NAD(P)+]IUBMB Comments
Reduces aliphatic aldehydes of carbon chain length from 2 to 14, with greatest activity on C4, C6 and C8 aldehydes; also reduces retinal to retinol.
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Word Map
- 1.1.1.71
-
retinoids
- thermoanaerobacter
- all-trans-retinaldehyde
-
retinyl
-
ethanolicus
- all-trans-retinol
-
r-1-phenylethanol
-
cyp26a1
- akr1b10
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
dhrs3, retinaldehyde reductase, tesadh, retsdr1, nadph-dependent alcohol dehydrogenase, adh12, tsib_0319, phadh, nad(p)h-dependent adh, retinol-active alcohol dehydrogenase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
ADH
ADH2
Adh319
AdhA
alcohol dehydrogenase
aldehyde reductase (NADPH/NADH)
-
-
-
-
HvADH2
HVO_B0071
NAD(P)+-dependent alcohol dehydrogenase
NAD(P)H-dependent aldehyde reductase
NADPH-dependent ADHA
NADPH-dependent alcohol dehydrogenase
PH0743
PhADH
RADH
retinal reductase
-
-
-
-
TsAdh319
Tsib_0319
VNG_2617G
YqhD
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
a primary alcohol + NAD(P)+ = an aldehyde + NAD(P)H + H+
enzyme is stereospecific for the pro-R hydride of NADPH
-
a primary alcohol + NAD(P)+ = an aldehyde + NAD(P)H + H+
enzyme is stereospecific for the pro-R hydride of NADPH
-
a primary alcohol + NAD(P)+ = an aldehyde + NAD(P)H + H+
the defence-related alcohol dehydrogenase DRD-1 is an alcohol:NADP+ oxidoreductase with preference for various aromatic and aliphatic aldehydes
a primary alcohol + NAD(P)+ = an aldehyde + NAD(P)H + H+
the enzyme is an aldo-keto reductase
-
a primary alcohol + NAD(P)+ = an aldehyde + NAD(P)H + H+
the human pancreas protein 2 has a retinal reductase activity
a primary alcohol + NAD(P)+ = an aldehyde + NAD(P)H + H+
enzyme is stereospecific for the pro-R hydride of NADPH
-
-
a primary alcohol + NAD(P)+ = an aldehyde + NAD(P)H + H+
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
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SYSTEMATIC NAME
IUBMB Comments
alcohol:NAD(P)+ oxidoreductase
Reduces aliphatic aldehydes of carbon chain length from 2 to 14, with greatest activity on C4, C6 and C8 aldehydes; also reduces retinal to retinol.
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CAS REGISTRY NUMBER
COMMENTARY
37250-10-5
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(1R)-1-hydroxy-1-phenylpropan-2-one + NADPH + H+
(1R)-1-phenylpropane-1,2-diol + NADP+
-
-
-
-
?
(2R)-2-hydroxy-1-(4-methoxyphenyl)propan-1-one + NADPH + H+
(2R)-1-(4-methoxyphenyl)propane-1,2-diol + NADP+
-
-
-
-
?
(2S)-2-hydroxy-1-(4-methoxyphenyl)propan-1-one + NADPH + H+
(2S)-1-(4-methoxyphenyl)propane-1,2-diol + NADP+
-
-
-
-
?
(4R,6S)-6-(chloromethyl)oxane-2,4-diol + NAD+
(4R,6S)-6-(chloromethyl)-4-hydroxyoxan-2-one + NADH + H+
-
-
-
-
?
(4R,6S)-6-(chloromethyl)oxane-2,4-diol + NADP+
(4R,6S)-6-(chloromethyl)-4-hydroxyoxan-2-one + NADPH + H+
-
-
-
-
?
(RS)-1-phenylethanol + NAD+
1-phenylethanone + NADH + H+
-
100% activity
-
-
?
(RS)-1-phenylethanol + NADP+
1-phenylethanone + NADPH + H+
-
100% activity
-
-
?
(S)-2-butanol + NADP+
butanone + NADPH
196% relative activity as compared to 2-propanol
-
-
?
(S)-2-butanol + NADP+
butanone + NADPH + H+
196% of the activity with 2-propanol, 2fold preference for (S)-2-butanol over (RS)-2-butanol
-
-
?
1,3-butanediol + NADP+
? + NADPH + H+
91% relative activity as compared to 2-propanol
-
-
?
1-(2-bromophenyl)ethanol + NAD(P)+
1-(2-bromophenyl)ethanone + NAD(P)H + H+
-
11.3% activity compared to (RS)-1-phenylethanol
-
-
?
1-(2-chlorophenyl)ethanol + NAD(P)+
1-(2-chlorophenyl)ethanone + NAD(P)H + H+
-
16.4% activity compared to (RS)-1-phenylethanol
-
-
?
1-(3-bromophenyl)ethanol + NAD(P)+
1-(3-bromophenyl)ethanone + NAD(P)H + H+
-
315% activity compared to (RS)-1-phenylethanol
-
-
?
1-(3-chlorophenyl)ethanol + NAD(P)+
1-(3-chlorophenyl)ethanone + NAD(P)H + H+
-
205% activity compared to (RS)-1-phenylethanol
-
-
?
1-(4-bromophenyl)ethanol + NAD(P)+
1-(4-bromophenyl)ethanone + NAD(P)H + H+
-
167% activity compared to (RS)-1-phenylethanol
-
-
?
1-(4-chlorophenyl)ethanone + NAD(P)+
1-(4-chlorophenyl)ethanone + NAD(P)H + H+
-
151% activity compared to (RS)-1-phenylethanol
-
-
?
1-(4-fluorophenyl)ethanol + NAD(P)+
1-(4-fluorophenyl)ethanol + NAD(P)H + H+
-
119% activity compared to (RS)-1-phenylethanol
-
-
?
1-(4-methylphenyl)ethanone + NAD(P)+
1-(4-methylphenyl)ethanol + NAD(P)H + H+
-
189% activity compared to (RS)-1-phenylethanol
-
-
?
1-butanol + NAD(P)+
butanal + NAD(P)H + H+
-
2.3% activity compared to (RS)-1-phenylethanol
-
-
?
1-butanol + NADP+
butanal + NADPH
80% relative activity as compared to 2-propanol
-
-
?
1-heptanol + NAD(P)+
heptanal + NAD(P)H + H+
-
3.3% activity compared to (RS)-1-phenylethanol
-
-
?
1-hexanol + NAD(P)+
hexanal + NAD(P)H + H+
-
2.8% activity compared to (RS)-1-phenylethanol
-
-
?
1-octanol + NAD(P)+
octanal + NAD(P)H + H+
-
2.3% activity compared to (RS)-1-phenylethanol
-
-
?
1-pentanol + NAD(P)+
pentanal + NAD(P)H + H+
-
2.8% activity compared to (RS)-1-phenylethanol
-
-
?
1-phenyl-1,2-ethanediol + NAD(P)+
?
-
3.4% activity compared to (RS)-1-phenylethanol
-
-
?
1-phenyl-1-propanol + NAD(P)+
1-phenylpropionaldehyde + NAD(P)H + H+
-
13.1% activity compared to (RS)-1-phenylethanol
-
-
?
1-phenyl-2-propanol + NAD(P)+
1-phenylpropan-2-one + NAD(P)H + H+
-
39.1% activity compared to (RS)-1-phenylethanol
-
-
?
1-phenylethanol + NADP+
1-phenylethanone + NADPH + H+
35% of the activtiy with 1-propanol
-
-
?
1-phenylethanol + NADP+
acetophenone + NADPH + H+
35% compared to activity with 1-propanol
-
-
?
1-phenylmethanol + NADP+
benzaldehyde + NADPH + H+
180% relative activity as compared to 2-propanol
-
-
?
1-propanol + NAD(P)+
propionaldehyde + NAD(P)H + H+
-
1.2% activity compared to (RS)-1-phenylethanol
-
-
?
2,2,2-trifluoroacetophenone + NAD(P)H + H+
2,2,2-trifluoro-1-phenylethan-1-ol + NAD(P)+
-
180% activity compared to acetoin
-
-
?
2-bromoacetophenone + NAD(P)H + H+
1-(2-bromophenyl)ethanone + NAD(P)+
-
8.7% activity compared to acetoin
-
-
?
2-butanol + NAD(P)+
butan-2-one + NAD(P)H + H+
-
22.3% activity compared to (RS)-1-phenylethanol
-
-
?
2-butanol + NADP+
2-butanone + NADPH + H+
43% of the activity compared to ethanol
-
-
?
2-chloro-1-phenylethanol + NAD(P)+
2-chloro-1-phenylethan-1-one + NAD(P)H + H+
-
0.3% activity compared to (RS)-1-phenylethanol
-
-
?
2-heptanol + NAD(P)+
heptan-2-one + NAD(P)H + H+
-
61.6% activity compared to (RS)-1-phenylethanol
-
-
?
2-hexanol + NAD(P)+
hexan-2-one + NAD(P)H + H+
-
38.7% activity compared to (RS)-1-phenylethanol
-
-
?
2-hexanone + NAD(P)H + H+
hexan-2-ol + NAD(P)+
-
3.6% activity compared to acetoin
-
-
?
2-hydroxy-2-methyl-1-phenylpropan-1-one + NADPH + H+
2-methyl-1-phenylpropan-1,2-diol + NADP+
-
-
-
-
?
2-hydroxy-3-methoxybenzaldehyde + NADPH + H+
2-hydroxy-3-methoxybenzyl alcohol + NADP+
-
-
-
?
2-octanol + NAD(P)+
octan-2-one + NAD(P)H + H+
-
45.8% activity compared to (RS)-1-phenylethanol
-
-
?
2-pentanol + NAD(P)+
pentan-2-one + NAD(P)H + H+
-
30.2% activity compared to (RS)-1-phenylethanol
-
-
?
2-pentanol + NADP+
2-pentanone + NADPH + H+
67% relative activity as compared to 2-propanol
-
-
?
2-pentanol + NADP+
pentan-2-one + NADPH + H+
67% of the activity with 2-propanol
-
-
?
2-phenylethanol + NAD(P)+
phenylacetaldehyde + NAD(P)H + H+
-
0.3% activity compared to (RS)-1-phenylethanol
-
-
?
2-propanol + NAD(P)+
propan-2-one + NAD(P)H + H+
-
5.3% activity compared to (RS)-1-phenylethanol
-
-
?
3,4-dimethoxybenzaldehyde + NADPH + H+
3,4-dimethoxybenzyl alcohol + NADP+
-
-
-
?
3-methyl-2-pentanone + NADPH + H+
? + NADP+
13% relative activity as compared to pyruvaldehyde
-
-
?
3-methylbutanal + NADP+
? + NADPH + H+
about% of the activity with 1-butanol
-
-
?
acetoin + NAD(P)+
butan-2,3-dione + NAD(P)H + H+
-
100% activity
-
-
?
acetoin + NAD(P)H + H+
2,3-butanediol + NAD(P)+
-
4.5% activity compared to (RS)-1-phenylethanol
-
-
?
acetoin + NADPH + H+
?
-
1.9% activity compared to 3-hydroxypropionaldehyde
-
-
?
acetone + NAD(P)H + H+
propan-2-ol + NAD(P)+
-
4.1% activity compared to acetoin
-
-
?
acrolein + NADPH + H+
prop-2-en-1-ol + NADP+
-
41.8% activity compared to 3-hydroxypropionaldehyde
-
-
?
butan-1,4-diol + NADP+
butandialdehyde + NADPH
-
29% of activity with hexan-1-ol
-
r
butanal + NADPH + H+
1-butanol + NAD(P)+
44% activity compared to pentanal
-
-
?
cis-4-cyclopentene-1,3-diol + NADP+
(R)-4-hydroxy-2-cyclopentenone + NADPH + H+
-
-
-
-
?
cis-hex-3-en-1-ol + NADP+
cis-hex-3-en-1-al + NADPH
-
18.7% of activity with hexan-1ol
-
r
cyclohexanol + NAD(P)+
cyclohexanone + NAD(P)H + H+
-
52.3% activity compared to (RS)-1-phenylethanol
-
-
?
cyclohexanone + NAD(P)H + H+
cyclohexanol + NAD(P)+
-
19.1% activity compared to acetoin
-
-
?
D-arabinose + NAD(P)+
?
-
21.4% activity compared to (RS)-1-phenylethanol
-
-
?
D-arabinose + NADP+
? + NADPH + H+
200% relative activity as compared to 2-propanol
-
-
?
D-arabinose + NADP+
D-arabitol + NADPH + H+
200% of the activity with 2-propanol. D-arabinose is preferred over L-arabinose
-
-
?
D-mannose + NADP+
? + NADPH + H+
48% relative activity as compared to 2-propanol
-
-
?
D-ribose + NADP+
? + NADPH + H+
35% relative activity as compared to 2-propanol
-
-
?
decan-1-ol + NADP+
decanal + NADPH
-
decrease in enzyme activity with increase in chain length
-
r
dihydroxyacetone + NAD(P)H + H+
?
-
34.8% activity compared to acetoin
-
-
?
dodecan-1-ol + NADP+
dodecanal + NADPH
-
decrease in enzyme activity with increase in chain length
-
r
ethanol + NAD(P)+
acetaldehyde + NAD(P)H + H+
-
0.5% activity compared to (RS)-1-phenylethanol
-
-
?
ethyl pyruvate + NAD(P)H + H+
?
-
294% activity compared to acetoin
-
-
?
furfural + NADPH + H+
(furan-2-yl)methanol + NAD(P)+
5% activity compared to pentanal
-
-
?
glycerol + NADP+
glyceraldehyde + NADPH + H+
16% relative activity as compared to 2-propanol
-
-
?
glycoaldehyde + NADPH + H+
?
5% activity compared to pentanal
-
-
?
glyoxylic acid + NADPH + H+
? + NADP+
36% relative activity as compared to pyruvaldehyde
-
-
?
heptanal + NADPH + H+
1-heptanol + NAD(P)+
56% activity compared to pentanal
-
-
?
hexanal + NAD(P)H + H+
hexan-1-ol + NAD(P)+
-
12.9% activity compared to acetoin
-
-
?
hexanal + NADPH + H+
1-hexanol + NAD(P)+
62% activity compared to pentanal
-
-
?
hydrocinnamaldehyde + NADPH + H+
hydrocinnamyl alcohol + NADP+
-
-
-
?
isoamyl alcohol + NADP+
? + NADPH + H+
about 80% of the activity with 1-butanol
-
-
?
L-arabinose + NAD(P)+
?
-
5.2% activity compared to (RS)-1-phenylethanol
-
-
?
L-arabinose + NADP+
? + NADPH + H+
17% relative activity as compared to 2-propanol
-
-
?
mannitol + NADP+
D-mannose + NADPH
-
6.5% of activity with hexan-1-ol
-
r
meso-2,3-butanediol + NAD+
?
-
272% activity compared to (RS)-1-phenylethanol
-
-
?
meso-2,3-butanediol + NADP+
?
-
272% activity compared to (RS)-1-phenylethanol
-
-
?
methanol + NAD(P)+
formaldehyde + NAD(P)H + H+
-
0.2% activity compared to (RS)-1-phenylethanol
-
-
?
methyl benzoylformate + NAD(P)H + H+
?
-
67% activity compared to acetoin
-
-
?
methylglyoxal + NADPH + H+
?
29% activity compared to pentanal
-
-
?
octan-1-ol + NADP+
octanal + NADPH
-
decrease in enzyme activity with increase in chain length
-
r