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Information on EC 1.1.1.69 - gluconate 5-dehydrogenase
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EC Tree
1.1.1.69 gluconate 5-dehydrogenaseSpecify your search results
Word Map
- 1.1.1.69
-
gluconobacter
- oxydans
- suboxydans
-
2-keto-d-gluconic
- dehydrogenases
- food industry
-
undesired
- l-sorbose
- tetramer
-
oxidoreduction
- synthesis
- analysis
The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
Synonyms
ga5dh, gluconate 5-dehydrogenase, 5-keto-d-gluconate 5-reductase, gluconate:nadp 5-oxidoreductase, nadph-dependent 5-keto-d-gluconate reductase, gluconate-5-dehydrogenase, 5kga reductase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
5-keto-D-gluconate 5-reductase
5-keto-D-gluconate reductase
5-ketogluconate 5-reductase
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-
-
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5-ketogluconate reductase
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-
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5KGR
dehydrogenase, gluconate 5-
-
-
-
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GA5DH
gluconate-5-dehydrogenase
gluconate:NADP 5-oxidoreductase
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GluF
GNO
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-
-
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NADPH-dependent 5-keto-D-gluconate reductase
reductase, 5-ketogluconate 5-
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-
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5-keto-D-gluconate 5-reductase
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-
-
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5-keto-D-gluconate reductase
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-
-
-
5KGR
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
D-gluconate + NAD(P)+ = 5-dehydro-D-gluconate + NAD(P)H + H+
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
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-
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redox reaction
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-
-
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reduction
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-
-
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SYSTEMATIC NAME
IUBMB Comments
D-gluconate:NAD(P)+ 5-oxidoreductase
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CAS REGISTRY NUMBER
COMMENTARY
9028-70-0
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
5-dehydro-D-fructose + NADPH
D-fructose + NADP+
-
23% of the activity with 5-dehydro-D-gluconate
-
-
?
D-glucono-delta-lactone + NADP+
?
-
14% of the activity with D-gluconate
-
-
?
glycerol + NAD+
? + NADH
138% of activity with D-sorbitol
-
-
?
meso-erytritol + NAD+
? + NADH
143% of activity with D-sorbitol
-
-
?
ribitol + NAD+
? + NADH
66% of activity with D-sorbitol
-
-
?
additional information
?
-
-
production of 5-keto D-gluconate from D-gluconate
-
-
?
2,3-butanediol + NAD+
? + NADH
169% of activity with D-sorbitol
-
-
?
2,3-butanediol + NAD+
? + NADH
169% of activity with D-sorbitol
-
-
?
5-dehydro-D-gluconate + NADH
D-gluconate + NAD+
-
reaction proceeds twice as fast with NADH as with NADPH
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-
?
5-dehydro-D-gluconate + NADH
D-gluconate + NAD+
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no reaction with NADH
-
-
?
5-dehydro-D-gluconate + NADH
D-gluconate + NAD+
-
reaction proceeds twice as fast with NADH as with NADPH
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-
?
5-dehydro-D-gluconate + NADH + H+
D-gluconate + NAD+
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-
-
-
?
5-dehydro-D-gluconate + NADH + H+
D-gluconate + NAD+
-
-
-
-
?
5-dehydro-D-gluconate + NADH + H+
D-gluconate + NAD+
-
-
-
-
?
5-dehydro-D-gluconate + NADH + H+
D-gluconate + NAD+
-
-
-
-
?
5-dehydro-D-gluconate + NADH + H+
D-gluconate + NAD+
-
-
-
-
?
5-dehydro-D-gluconate + NADH + H+
D-gluconate + NAD+
-
-
-
-
?
5-dehydro-D-gluconate + NADH + H+
D-gluconate + NAD+
-
-
-
-
?
5-dehydro-D-gluconate + NADH + H+
D-gluconate + NAD+
-
-
-
-
?
5-dehydro-D-gluconate + NADH + H+
D-gluconate + NAD+
-
-
-
-
?
5-dehydro-D-gluconate + NADPH
D-gluconate + NADP+
-
the rate of D-gluconate oxidation is about 60% of the rate of 5-keto-D-gluconate reduction
-
r
5-dehydro-D-gluconate + NADPH
D-gluconate + NADP+
-
the suggested physiological role of the enzyme is to reduce 5-dehydro-D-gluconate to D-gluconate to supply a carbon source and regenerate NADP+
-
?
5-dehydro-D-gluconate + NADPH
D-gluconate + NADP+
-
the suggested physiological role of the enzyme is to reduce 5-dehydro-D-gluconate to D-gluconate to supply a carbon source and regenerate NADP+
-
?
5-dehydro-D-gluconate + NADPH
D-gluconate + NADP+
-
maximum enzyme formation at the end of the exponential growth, in the decreasing growth phase, about 65% of the maximum enzyme activity remains
-
?
5-dehydro-D-gluconate + NADPH
D-gluconate + NADP+
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enzyme is involved in gluconate metabolism
-
?
5-dehydro-D-gluconate + NADPH
D-gluconate + NADP+
-
enzyme is involved in gluconate metabolism
-
?
5-dehydro-D-gluconate + NADPH + H+
D-gluconate + NADP+
-
-
-
r
5-dehydro-D-gluconate + NADPH + H+
D-gluconate + NADP+
-
-
-
-
?
5-dehydro-D-gluconate + NADPH + H+
D-gluconate + NADP+
-
-
-
-
?
5-dehydro-D-gluconate + NADPH + H+
D-gluconate + NADP+
-
-
-
-
?
5-dehydro-D-gluconate + NADPH + H+
D-gluconate + NADP+
-
-
-
-
?
5-dehydro-D-gluconate + NADPH + H+
D-gluconate + NADP+
-
-
-
-
?
5-dehydro-D-gluconate + NADPH + H+
D-gluconate + NADP+
-
-
-
-
?
5-dehydro-D-gluconate + NADPH + H+
D-gluconate + NADP+
-
-
-
-
?
5-dehydro-D-gluconate + NADPH + H+
D-gluconate + NADP+
-
-
-
-
?
5-dehydro-D-gluconate + NADPH + H+
D-gluconate + NADP+
-
-
-
-
?
D-arabitol + NAD+
? + NADH
130% of activity with D-sorbitol
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?
D-arabitol + NAD+
? + NADH
130% of activity with D-sorbitol
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-
?
D-fructose + NADPH
5-dehydro-D-fructose + NADP+
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42% of the activity with 5-dehydro-D-gluconate
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?
D-fructose + NADPH
5-dehydro-D-fructose + NADP+
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10% of the activity with 5-dehydrydro-D-gluconate
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-
?
D-gluconate + NADP+
5-dehydro-D-gluconate + NADPH
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-
-
?
D-gluconate + NADP+
5-dehydro-D-gluconate + NADPH
-
-
-
-
?
D-gluconate + NADP+
5-dehydro-D-gluconate + NADPH
-
the rate of D-gluconate oxidation is about 60% of the rate of 5-keto-D-gluconate reduction
-
r
D-gluconate + NADP+
5-dehydro-D-gluconate + NADPH
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-
-
-
?
D-gluconate + NADP+
5-dehydro-D-gluconate + NADPH + H+
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-
-
r
D-gluconic acid + NAD+
? + NADH
8% of activity with D-sorbitol
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?
D-gluconic acid + NAD+
? + NADH
8% of activity with D-sorbitol
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?
D-glucose + ?
5-keto-D-gluconic acid + ?
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-
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-
?
D-mannitol + NAD+
? + NADH
74% of activity with D-sorbitol
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?
D-mannitol + NAD+
? + NADH
74% of activity with D-sorbitol
-
-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
?
-
-
production of 5-keto D-gluconate from D-gluconate
-
-
?
5-dehydro-D-gluconate + NADH + H+
D-gluconate + NAD+
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-
-
-
?
5-dehydro-D-gluconate + NADH + H+
D-gluconate + NAD+
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-
-
-
?
5-dehydro-D-gluconate + NADH + H+
D-gluconate + NAD+
-
-
-
-
?
5-dehydro-D-gluconate + NADH + H+
D-gluconate + NAD+
-
-
-
-
?
5-dehydro-D-gluconate + NADH + H+
D-gluconate + NAD+
-
-
-
-
?
5-dehydro-D-gluconate + NADH + H+
D-gluconate + NAD+
-
-
-
-
?
5-dehydro-D-gluconate + NADH + H+
D-gluconate + NAD+
-
-
-
-
?
5-dehydro-D-gluconate + NADH + H+
D-gluconate + NAD+
-
-
-
-
?
5-dehydro-D-gluconate + NADH + H+
D-gluconate + NAD+
-
-
-
-
?
5-dehydro-D-gluconate + NADPH
D-gluconate + NADP+
-
the suggested physiological role of the enzyme is to reduce 5-dehydro-D-gluconate to D-gluconate to supply a carbon source and regenerate NADP+
-
?
5-dehydro-D-gluconate + NADPH
D-gluconate + NADP+
-
the suggested physiological role of the enzyme is to reduce 5-dehydro-D-gluconate to D-gluconate to supply a carbon source and regenerate NADP+
-
?
5-dehydro-D-gluconate + NADPH
D-gluconate + NADP+
-
maximum enzyme formation at the end of the exponential growth, in the decreasing growth phase, about 65% of the maximum enzyme activity remains
-
?
5-dehydro-D-gluconate + NADPH
D-gluconate + NADP+
-
enzyme is involved in gluconate metabolism
-
?
5-dehydro-D-gluconate + NADPH
D-gluconate + NADP+
-
enzyme is involved in gluconate metabolism
-
?
5-dehydro-D-gluconate + NADPH + H+
D-gluconate + NADP+
-
-
-
-
?
5-dehydro-D-gluconate + NADPH + H+
D-gluconate + NADP+
-
-
-
-
?
5-dehydro-D-gluconate + NADPH + H+
D-gluconate + NADP+
-
-
-
-
?
5-dehydro-D-gluconate + NADPH + H+
D-gluconate + NADP+
-
-
-
-
?
5-dehydro-D-gluconate + NADPH + H+
D-gluconate + NADP+
-
-
-
-
?
5-dehydro-D-gluconate + NADPH + H+
D-gluconate + NADP+
-
-
-
-
?
5-dehydro-D-gluconate + NADPH + H+
D-gluconate + NADP+
-
-
-
-
?
5-dehydro-D-gluconate + NADPH + H+
D-gluconate + NADP+
-
-
-
-
?
5-dehydro-D-gluconate + NADPH + H+
D-gluconate + NADP+
-
-
-
-
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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ACTIVATING COMPOUND
ORGANISM
UNIPROT