Information on EC 1.1.1.65 - pyridoxine 4-dehydrogenase
for references in articles please use BRENDA:EC1.1.1.65Word Map on EC 1.1.1.65

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The enzyme appears in viruses and cellular organisms
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pyridoxine 4-dehydrogenase
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pyridoxine + NADP+ = pyridoxal + NADPH + H+
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4-amino-2-methyl-5-diphosphomethylpyrimidine biosynthesis (yeast)
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pyridoxal 5'-phosphate salvage II (plants)
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Vitamin B6 metabolism
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pyridoxine:NADP+ 4-oxidoreductase
Also oxidizes pyridoxine phosphate.
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dehydrogenase, pyridoxol 4-
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pyridoxin dehydrogenase
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pyridoxine dehydrogenase
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pyridoxol dehydrogenase
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brenda
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Uniprot
brenda
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2-nitrobenzaldehyde + NADPH
2-nitrobenzyl alcohol + NADP+
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pyridoxine + NADP+
pyridoxal + NADPH
pyridoxine phosphate + NADP+
pyridoxal 5'-phosphate + NADPH
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pyridoxine + NADP+

pyridoxal + NADPH
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pyridoxine is identical with pyridoxol, equilibrium lies far to the side of pyridoxol
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pyridoxine + NADP+
pyridoxal + NADPH
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pyridoxine + NADP+
pyridoxal + NADPH
pyridoxine + NADP+

pyridoxal + NADPH
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pyridoxine is identical with pyridoxol, equilibrium lies far to the side of pyridoxol
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pyridoxine + NADP+
pyridoxal + NADPH
O14295
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r
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ZnCl2
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0.1 mM: activation, 10 mM: inhibition
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p-Chloromercuriphenyl sulfonic acid
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ZnCl2
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0.1 mM: activation, 10 mM: inhibition
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0.096
2-nitrobenzaldehyde
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0.9
pyridoxal

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6.5 - 7.5
for formation of pyridoxine
7.5 - 8.5
for formation of pyridoxal
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5 - 8
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at pH 5.0 and 8.0 about 50% of activity maximum
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purified enzyme very unstable but can be stabilized by low concentrations of various detergents such as Tween 40
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expression in Escherichia coli
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Holzer, H.; Schneider, S.
Purification and characterization of a TPN-dependent pyridoxol dehydrogenase from brewers yeast
Biochim. Biophys. Acta
48
71-76
1961
Saccharomyces cerevisiae
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Nakano, M.; Morita, T.; Yamamoto, T.; Sano, H.; Ashiuchi, M.; Masui, R.; Kuramitsu, S.; Toshiharu, Y.
Purification, molecular cloning, and catalytic activity of Schizosaccharomyces pombe pyridoxal reductase
J. Biol. Chem.
274
23185-23190
1999
Schizosaccharomyces pombe, Schizosaccharomyces pombe (O14295)
brenda
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