Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

Reference on EC 1.1.1.62 - 17beta-estradiol 17-dehydrogenase

Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
LaRhee, L.H.; Warren, J.C.
Purification and characterization of epimeric estradiol dehydrogenases (17alpha and 17beta) from equine placenta
Biochemistry
23
486-491
1984
Equus caballus
Manually annotated by BRENDA team
Strickler, R.C.; Tobias, B.; Covey, D.F.
Human placental 17beta-estradiol dehydrogenase and 20alpha-hydroxysteroid dehydrogenase. Two activities at a single enzyme active site
J. Biol. Chem.
256
316-321
1981
Homo sapiens
Manually annotated by BRENDA team
Blomquist, C.H.; Lindemann, N.J.; Hakanson, E.Y.
17beta-Hydroxysteroid and 20alpha-hydroxysteroid dehydrogenase activities of human placental microsomes: kinetic evidence for two enzymes differing in substrate specificity
Arch. Biochem. Biophys.
239
206-215
1985
Homo sapiens
Manually annotated by BRENDA team
Murdock, G.L.; Warren, J.C.; Sweet, F.
Human placental estradiol 17beta-dehydrogenase: evidence for inverted substrate orientation (wrong-way binding) at the active site
Biochemistry
27
4452-4458
1988
Homo sapiens
Manually annotated by BRENDA team
Mendoza-Hernandez, G.; Lopez-Solache, I.; Diaz-Zagoya, J.C.
Periodate-oxidized NADP+ is a powerful inhibitor of human placental estradiol-17beta dehydrogenase
Biochem. Biophys. Res. Commun.
146
645-651
1987
Homo sapiens
Manually annotated by BRENDA team
Mendoza-Hernandez, G.; Rendon, J.L.; Diaz-Zagoya, J.C.
A single step procedure for purification of estradiol 17beta-dehydrogenase from human placenta
Biochem. Biophys. Res. Commun.
126
477-481
1985
Homo sapiens
Manually annotated by BRENDA team
Mendoza-Hernandez, G.; Calcagno, M.; Sanchez-Nuncio, H.R.; Diaz-Zagoya, J.C.
Dehydroepiandrosterone is a substrate for estradiol 17beta-dehydrogenase from human placenta
Biochem. Biophys. Res. Commun.
119
83-87
1984
Homo sapiens
Manually annotated by BRENDA team
Renwick, A.G.C.; Soon, C.Y.; Chambers, S.M.; Brown, C.R.
Estradiol-17beta dehydrogenase from chicken liver
J. Biol. Chem.
256
1881-1887
1981
Gallus gallus
Manually annotated by BRENDA team
Pollow, K.; Luebbert, H.; Pollow, B.
On the mitochondrial 17beta-hydroxysteroid dehydrogenase from human endometrium and endometrial carcinoma: characterization and intramitochondrial distribution
J. Steroid Biochem.
7
45-50
1976
Homo sapiens
Manually annotated by BRENDA team
Nicolas, J.C.
Purification of an enzyme containing a NADP-protected cysteine on organomercuri-agarose 17beta-estradiol dehydrogenase
Methods Enzymol.
34
552-554
1974
Homo sapiens
Manually annotated by BRENDA team
Nicolas, J.C.
The soluble 17beta-estradiol dehydrogenase of human placenta
Methods Enzymol.
34
555-557
1974
Homo sapiens
Manually annotated by BRENDA team
Nicolas, J.C.; Harris, J.I.
Human placental 17-oestradiol dehydrogenase. Sequence of a tryptic peptide containing an essential cysteine
FEBS Lett.
29
173-176
1973
Homo sapiens
Manually annotated by BRENDA team
Nicolas, J.C.; Pons, M.; Descomps, B.; de Paulet, A.C
Affinity chromatography: large-scale purification of the soluble oestradiol-17-dehydrogenase of human placenta
FEBS Lett.
23
175-179
1972
Homo sapiens
Manually annotated by BRENDA team
Burns, D.J.W.; Engel, L.L.; Bethune, J.L.
Amino acid composition and subunit structure. Human placental 17-estradiol dehydrogenase
Biochemistry
11
2699-2703
1972
Homo sapiens
Manually annotated by BRENDA team
Kautsky, M.P.; Hagerman, D.D.
17beta-Estradiol dehydrogenase of ovine ovaries
J. Biol. Chem.
245
1978-1984
1970
Ovis aries
Manually annotated by BRENDA team
Langer, L.J.; Alexander, J.A.; Engel, L.L.
Human placental estradiol-17beta dehydrogenase
J. Biol. Chem.
234
2609-2614
1959
Homo sapiens
Manually annotated by BRENDA team
Luebbert, H.
Effects of ethanol and other organic solvents on the kinetic behaviour of purified human placental oestradiol-17beta-dehydrogenase
Acta Endocrinol.
99
448-453
1982
Homo sapiens
Manually annotated by BRENDA team
Engel, L.L.; Inano, H.
Some kinetic properties of human placental 17beta-estradiol dehydrogenase: patterns of inhibition by adenine nucleotides
Adv. Enzyme Regul.
17
363-371
1979
Homo sapiens
Manually annotated by BRENDA team
Pollow, K.; Luebbert, H.; Jeske, R.; Pollow, B.
Studies on 17beta-hydroxysteroid dehydrogenase in human endometrium and endometrial carcinoma
Acta Endocrinol.
79
146-156
1975
Homo sapiens
Manually annotated by BRENDA team
Murdock, G.L.; Chin, C.C.; Warren, J.C.
Human placental estradiol 17beta-dehydrogenase: sequence of a histidine-bearing peptide in the catalytic region
Biochemistry
25
641-646
1986
Homo sapiens
Manually annotated by BRENDA team
Chin, C.C.; Dence, J.B.; Warren, J.C.
Crystallization of human placental estradiol 17beta-dehydrogenase. A new method for crystallizing labile enzymes
J. Biol. Chem.
251
3700-3705
1976
Homo sapiens
Manually annotated by BRENDA team
Hara, A.; Nakayama, T.; Nakagawa, M.; Inoue, Y.; Tanabe, H.; Sawada, H.
Kinetic and stereochemical studies on reaction mechanism of mouse liver 17beta-hydroxysteroid dehydrogenases
J. Biochem.
102
1585-1592
1987
Mus musculus
Manually annotated by BRENDA team
Zhu, D.W.; Campbell, R.; Labrie, F.; Lin, S.X.
Crystallization and preliminary crystal structure of the complex of 17beta-hydroxysteroid dehydrogenase with a dual-site inhibitor
J. Steroid Biochem. Mol. Biol.
70
229-235
1999
Homo sapiens
Manually annotated by BRENDA team
Puranen, T.; Poutanen, M.; Ghosh, D.; Vihko, P.; Vihko, R.
Characterization of structural and functional properties of human 17beta-hydroxysteroid dehydrogenase type 1 using recombinant enzymes and site-directed mutagenesis
Mol. Endocrinol.
11
77-86
1997
Homo sapiens
Manually annotated by BRENDA team
Blomquist, C.H.; Leung, B.S.; Zhang, R.; Zhu, Y.; Chang, P.M.
Properties and regulation of 17beta-hydroxysteroid oxidoreductase of OVCAR-3, CAOV-3, and A431 cells: effects of epidermal growth factor, estradiol, and progesterone
J. Cell. Biochem.
59
409-417
1995
Homo sapiens
Manually annotated by BRENDA team
Ng, J.H.; Nesaretnam, K.; Reimann, K.; Lai, L.C.
Effect of retinoic acid and palm oil carotenoids on oestrone sulphatase and oestradiol-17beta hydroxysteroid dehydrogenase activities in MCF-7 and MDA-MB-231 breast cancer cell lines
Int. J. Cancer
88
135-138
2000
Homo sapiens
Manually annotated by BRENDA team
Kaufmann, M.; Carstensen, J.; Husen, B.; Adamski, J.
The tissue distribution of porcine 17beta-estradiol dehydrogenase and its induction by progesterone
J. Steroid Biochem. Mol. Biol.
55
535-539
1995
Sus scrofa
Manually annotated by BRENDA team
Malet, C.; Vacca, A.; Kuttenn, F.; Mauvais-Jarvis, P.
17beta-Estradiol dehydrogenase (E2DH) activity in T47D cells
J. Steroid Biochem. Mol. Biol.
39
769-775
1991
Homo sapiens
Manually annotated by BRENDA team
Newton, C.J.; Butta, A.; Nicholls, J.; Dowsett, M.
Oestradiol synthesis from oestrone in malignant breast epithelial cells: studies on a high affinity, 80 kDa form of oestradiol dehydrogenase
J. Steroid Biochem. Mol. Biol.
42
891-900
1992
Homo sapiens
Manually annotated by BRENDA team
Carstensen, J.F.; Tesdorpf, J.G.; Kaufmann, M.; Markus, M.M.; Husen, B.; Leenders, F.; Jakob, F.; de Launoit, Y.; Adamski, J.
Characterization of 17beta-hydroxysteroid dehydrogenase IV
J. Endocrinol.
150
S3-12
1996
Sus scrofa
Manually annotated by BRENDA team
Sawicki, M.W.; Erman, M.; Puranen, T.; Vihko, P.; Ghosh, D.
Structure of the ternary complex of human 17beta-hydroxysteroid dehydrogenase type 1 with 3-hydroxyestra-1,3,5,7-tetraen-17-one (equilin) and NADP+
Proc. Natl. Acad. Sci. USA
96
840-845
1999
Homo sapiens (P14061), Homo sapiens
Manually annotated by BRENDA team
Ghosh, D.; Pletnev, V.Z.; Zhu, D.W.; Wawrzak, Z.; Duax, W.L.; Pangborn, W.; Labrie, F.; Lin, S.X.
Structure of human estrogenic 17beta-hydroxysteroid dehydrogenase at 2.20 A resolution
Structure
3
503-513
1995
Homo sapiens
Manually annotated by BRENDA team
Reed, M.J.; Rea, D.; Duncan, L.J.; Parker, M.G.
Regulation of estradiol 17beta-hydroxysteroid dehydrogenase expression and activity by retinoic acid in T47D breast cancer cells
Endocrinology
135
4-9
1994
Homo sapiens
Manually annotated by BRENDA team
Pollow, K.; Elger, W.; Hesslinger, H.; Pollow, B.
Purification and properties of the soluble 17beta-hydroxysteroid dehydrogenase of rabbit uterus
Z. Naturforsch. C
34
726-737
1979
Oryctolagus cuniculus
Manually annotated by BRENDA team
Adamski, J.; Husen, B.; Marks, F.; Jungblut, P.W.
Purification and properties of oestradiol 17beta-dehydrogenase extracted from cytoplasmic vesicles of porcine endometrial cells
Biochem. J.
288
375-381
1992
Sus scrofa
Manually annotated by BRENDA team
Puranen, T.J.; Poutanen, M.H.; Peltoketo, H.E.; Vihko, P.T.; Vihko, R.K.
Site-directed mutagenesis of the putative active site of human 17beta-hydroxysteroid dehydrogenase type 1
Biochem. J.
304
289-293
1994
Homo sapiens
Manually annotated by BRENDA team
Deyashiki, Y.; Ohshima, K.; Nakanishi, M.; Sato, K.; Matsuura, K.; Hara, A.
Molecular cloning and characterization of mouse estradiol 17beta-dehydrogenase (A-specific), a member of the aldoketoreductase family
J. Biol. Chem.
270
10461-10467
1995
Mus musculus
Manually annotated by BRENDA team
Husen, B.; Adamski, J.; Bruns, A.; Deluca, D.; Fuhrmann, K.; Moller, G.; Schwabe, I.; Einspanier, A.
Characterization of 17beta-hydroxysteroid dehydrogenase type 7 in reproductive tissues of the marmoset monkey
Biol. Reprod.
68
2092-2099
2003
Callithrix jacchus (Q9GME2), Callithrix jacchus (Q9N0M8)
Manually annotated by BRENDA team
Brown, W.M.; Metzger, L.E.; Barlow, J.P.; Hunsaker, L.A.; Deck, L.M.; Royer, R.E.; Vander Jagt, D.L.
17-beta-Hydroxysteroid dehydrogenase type 1: computational design of active site inhibitors targeted to the Rossmann fold
Chem. Biol. Interact.
143-144
481-491
2003
Homo sapiens
Manually annotated by BRENDA team
Qiu, W.; Campbell, R.L.; Gangloff, A.; Dupuis, P.; Boivin, R.P.; Tremblay, M.R.; Poirier, D.; Lin, S.X.
A concerted, rational design of type 1 17beta-hydroxysteroid dehydrogenase inhibitors: estradiol-adenosine hybrids with high affinity
FASEB J.
16
1829-1831
2002
Homo sapiens (P14061), Homo sapiens
Manually annotated by BRENDA team
Zhu, S.J.; Li, Y.; Li, H.; Wang, Y.L.; Xiao, Z.J.; Vihko, P.; Piao, Y.S.
Retinoic acids promote the action of aromatase and 17beta-hydroxysteroid dehydrogenase type 1 on the biosynthesis of 17beta-estradiol in placental cells
J. Endocrinol.
172
31-43
2002
Homo sapiens
Manually annotated by BRENDA team
Pelletier, G.; Luu-The, V.; Li, S.; Ren, L.; Labrie, F.
Localization of 17beta-hydroxysteroid dehydrogenase type 1 mRNA in mouse tissues
J. Mol. Endocrinol.
33
459-465
2004
Mus musculus
Manually annotated by BRENDA team
Takano, H.; Niimura, S.
Changes in the activities of hydroxysteroid dehydrogenases in porcine oocytes during meiotic maturation in vitro
J. Reprod. Dev.
48
303-308
2002
Sus scrofa
-
Manually annotated by BRENDA team
Fiorelli, G.; Picariello, L.; Martineti, V.; Tognarini, I.; Tonelli, F.; Brandi, M.L.
Estrogen metabolism in human colorectal cancer cells
J. Steroid Biochem. Mol. Biol.
81
281-289
2002
Homo sapiens
Manually annotated by BRENDA team
Blomquist, C.H.; Bonenfant, M.; McGinley, D.M.; Posalaky, Z.; Lakatua, D.J.; Tuli-Puri, S.; Bealka, D.G.; Tremblay, Y.
Androgenic and estrogenic 17beta-hydroxysteroid dehydrogenase/17-ketosteroid reductase in human ovarian epithelial tumors: evidence for the type 1, 2 and 5 isoforms
J. Steroid Biochem. Mol. Biol.
81
343-351
2002
Homo sapiens
Manually annotated by BRENDA team
Steckelbroeck, S.; Watzka, M.; Reissinger, A.; Wegener-Toper, P.; Bidlingmaier, F.; Bliesener, N.; Hans, V.H.; Clusmann, H.; Ludwig, M.; Siekmann, L.; Klingmuller, D.
Characterisation of estrogenic 17beta-hydroxysteroid dehydrogenase (17beta-HSD) activity in the human brain
J. Steroid Biochem. Mol. Biol.
86
79-92
2003
Homo sapiens
Manually annotated by BRENDA team
Sahmi, M.; Nicola, E.S.; Silva, J.M.; Price, C.A.
Expression of 17beta- and 3beta-hydroxysteroid dehydrogenases and steroidogenic acute regulatory protein in non-luteinizing bovine granulosa cells in vitro
Mol. Cell. Endocrinol.
223
43-54
2004
Bos taurus
Manually annotated by BRENDA team
Khan, N.; Sharma, K.K.; Andersson, S.; Auchus, R.J.
Human 17beta-hydroxysteroid dehydrogenases types 1, 2, and 3 catalyze bi-directional equilibrium reactions, rather than unidirectional metabolism, in HEK-293 cells
Arch. Biochem. Biophys.
429
50-59
2004
Homo sapiens
Manually annotated by BRENDA team
Poirier, D.
Inhibitors of 17beta-hydroxysteroid dehydrogenases
Curr. Med. Chem.
10
453-477
2003
Homo sapiens
Manually annotated by BRENDA team
Li, Y.; Qin, L.; Xiao, Z.J.; Wang, Y.L.; Herva, R.; Leng, J.H.; Lang, J.H.; Isomaa, V.; Piao, Y.S.
Expression of P450 aromatase and 17beta-hydroxysteroid dehydrogenase type 1 at fetal-maternal interface during tubal pregnancy
J. Steroid Biochem. Mol. Biol.
87
241-246
2003
Homo sapiens
Manually annotated by BRENDA team
Cassetta, A.; Buedefeld, T.; Rizner, T.L.; Kristan, K.; Stojan, J.; Lamba, D.
Crystallization, X-ray diffraction analysis and phasing of 17beta-hydroxysteroid dehydrogenase from the fungus Cochliobolus lunatus
Acta Crystallogr. Sect. F
61
1032-1034
2005
Curvularia lunata
Manually annotated by BRENDA team
Nakanishi, T.; Hiromori, Y.; Yokoyama, H.; Koyanagi, M.; Itoh, N.; Nishikawa, J.; Tanaka, K.
Organotin compounds enhance 17beta-hydroxysteroid dehydrogenase type I activity in human choriocarcinoma JAr cells: potential promotion of 17beta-estradiol biosynthesis in human placenta
Biochem. Pharmacol.
71
1349-1357
2006
Homo sapiens
Manually annotated by BRENDA team
Vicker, N.; Lawrence, H.R.; Allan, G.M.; Bubert, C.; Smith, A.; Tutill, H.J.; Purohit, A.; Day, J.M.; Mahon, M.F.; Reed, M.J.; Potter, B.V.
Focused libraries of 16-substituted estrone derivatives and modified e-ring steroids: inhibitors of 17beta-hydroxysteroid dehydrogenase type 1
ChemMedChem
1
464-481
2006
Homo sapiens
Manually annotated by BRENDA team
Blomquist, C.H.; Lima, P.H.; Tarrant, A.M.; Atkinson, M.J.; Atkinson, S.
17beta-Hydroxysteroid dehydrogenase (17beta-HSD) in scleractinian corals and zooxanthellae
Comp. Biochem. Physiol. B Biochem. Mol. Biol.
143
397-403
2006
Montipora capitata, Tubastraea coccinea
Manually annotated by BRENDA team
Husen, B.; Huhtinen, K.; Saloniemi, T.; Messinger, J.; Thole, H.H.; Poutanen, M.
Human hydroxysteroid (17-beta) dehydrogenase 1 expression enhances estrogen sensitivity of MCF-7 breast cancer cell xenografts
Endocrinology
147
5333-5339
2006
Homo sapiens
Manually annotated by BRENDA team
Tremblay, M.R.; Boivin, R.P.; Luu-The, V.; Poirier, D.
Inhibitors of type 1 17beta-hydroxysteroid dehydrogenase with reduced estrogenic activity: modifications of the positions 3 and 6 of estradiol
J. Enzyme Inhib. Med. Chem.
20
153-163
2005
Homo sapiens
Manually annotated by BRENDA team
Fischer, D.S.; Allan, G.M.; Bubert, C.; Vicker, N.; Smith, A.; Tutill, H.J.; Purohit, A.; Wood, L.; Packham, G.; Mahon, M.F.; Reed, M.J.; Potter, B.V.
E-ring modified steroids as novel potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1
J. Med. Chem.
48
5749-5770
2005
Homo sapiens
Manually annotated by BRENDA team
Poirier, D.; Boivin, R.P.; Tremblay, M.R.; Berube, M.; Qiu, W.; Lin, S.X.
Estradiol-adenosine hybrid compounds designed to inhibit type 1 17beta-hydroxysteroid dehydrogenase
J. Med. Chem.
48
8134-8147
2005
Homo sapiens
Manually annotated by BRENDA team
Song, D.; Liu, G.; Luu-The, V.; Zhao, D.; Wang, L.; Zhang, H.; Xueling, G.; Li, S.; Desy, L.; Labrie, F.; Pelletier, G.
Expression of aromatase and 17beta-hydroxysteroid dehydrogenase types 1, 7 and 12 in breast cancer. An immunocytochemical study
J. Steroid Biochem. Mol. Biol.
101
136-144
2006
Homo sapiens
Manually annotated by BRENDA team
Pelletier, G.; Luu-The, V.; Li, S.; Labrie, F.
Localization of type 7 17beta-hydroxysteroid dehydrogenase in mouse tissues. In situ hybridization studies
J. Steroid Biochem. Mol. Biol.
93
49-57
2005
Mus musculus (O88736), Mus musculus
Manually annotated by BRENDA team
Liu, H.; Robert, A.; Luu-The, V.
Cloning and characterization of human form 2 type 7 17beta-hydroxysteroid dehydrogenase, a primarily 3beta-keto reductase and estrogen activating and androgen inactivating enzyme
J. Steroid Biochem. Mol. Biol.
94
173-179
2005
Homo sapiens (Q5MGS6)
Manually annotated by BRENDA team
Brooks, J.D.; Thompson, L.U.
Mammalian lignans and genistein decrease the activities of aromatase and 17beta-hydroxysteroid dehydrogenase in MCF-7 cells
J. Steroid Biochem. Mol. Biol.
94
461-467
2005
Homo sapiens
Manually annotated by BRENDA team
Otsuka, M.; Kato, N.; Ichimura, T.; Abe, S.; Tanaka, Y.; Taniguchi, H.; Hoshida, Y.; Moriyama, M.; Wang, Y.; Shao, R.X.; Narayan, D.; Muroyama, R.; Kanai, F.; Kawabe, T.; Isobe, T.; Omata, M.
Vitamin K2 binds 17beta-hydroxysteroid dehydrogenase 4 and modulates estrogen metabolism
Life Sci.
76
2473-2482
2005
Homo sapiens
Manually annotated by BRENDA team
Messinger, J.; Hirvelae, L.; Husen, B.; Kangas, L.; Koskimies, P.; Pentikaeinen, O.; Saarenketo, P.; Thole, H.
New inhibitors of 17beta-hydroxysteroid dehydrogenase type 1
Mol. Cell. Endocrinol.
248
192-198
2006
Homo sapiens (P14061), Homo sapiens
Manually annotated by BRENDA team
Purohit, A.; Tutill, H.J.; Day, J.M.; Chander, S.K.; Lawrence, H.R.; Allan, G.M.; Fischer, D.S.; Vicker, N.; Newman, S.P.; Potter, B.V.; Reed, M.J.
The regulation and inhibition of 17beta-hydroxysteroid dehydrogenase in breast cancer
Mol. Cell. Endocrinol.
248
199-203
2006
Homo sapiens
Manually annotated by BRENDA team
Allan, G.M.; Bubert, C.; Vicker, N.; Smith, A.; Tutill, H.J.; Purohit, A.; Reed, M.J.; Potter, B.V.
Novel, potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1
Mol. Cell. Endocrinol.
248
204-207
2006
Homo sapiens (P14061)
Manually annotated by BRENDA team
Alho-Richmond, S.; Lilienkampf, A.; Waehaelae, K.
Active site analysis of 17beta-hydroxysteroid dehydrogenase type 1 enzyme complexes with SPROUT
Mol. Cell. Endocrinol.
248
208-213
2006
Homo sapiens (P14061)
Manually annotated by BRENDA team
Poirier, D.; Chang, H.J.; Azzi, A.; Boivin, R.P.; Lin, S.X.
Estrone and estradiol C-16 derivatives as inhibitors of type 1 17beta-hydroxysteroid dehydrogenase
Mol. Cell. Endocrinol.
248
236-238
2006
Homo sapiens (P14061)
Manually annotated by BRENDA team
Day, J.M.; Tutill, H.J.; Newman, S.P.; Purohit, A.; Lawrence, H.R.; Vicker, N.; Potter, B.V.; Reed, M.J.
17beta-Hydroxysteroid dehydrogenase type 1 and type 2: association between mRNA expression and activity in cell lines
Mol. Cell. Endocrinol.
248
246-249
2006
Homo sapiens
Manually annotated by BRENDA team
Lin, S.X.; Shi, R.; Qiu, W.; Azzi, A.; Zhu, D.W.; Dabbagh, H.A.; Zhou, M.
Structural basis of the multispecificity demonstrated by 17beta-hydroxysteroid dehydrogenase types 1 and 5
Mol. Cell. Endocrinol.
248
38-46
2006
Homo sapiens
Manually annotated by BRENDA team
Luu-The, V.; Tremblay, P.; Labrie, F.
Characterization of type 12 17beta-hydroxysteroid dehydrogenase, an isoform of type 3 17beta-hydroxysteroid dehydrogenase responsible for estradiol formation in women
Mol. Endocrinol.
20
437-443
2006
Homo sapiens (Q53GQ0), Homo sapiens
Manually annotated by BRENDA team
Nagayoshi, Y.; Ohba, T.; Yamamoto, H.; Miyahara, Y.; Tashiro, H.; Katabuchi, H.; Okamura, H.
Characterization of 17beta-hydroxysteroid dehydrogenase type 4 in human ovarian surface epithelial cells
Mol. Hum. Reprod.
11
615-621
2005
Homo sapiens
Manually annotated by BRENDA team
Kristan, K.; Krajnc, K.; Konc, J.; Gobec, S.; Stojan, J.; Lanisnik Rizner, T.
Phytoestrogens as inhibitors of fungal 17beta-hydroxysteroid dehydrogenase
Steroids
70
626-635
2005
Curvularia lunata
Manually annotated by BRENDA team
Kristan, K.; Deluca, D.; Adamski, J.; Stojan, J.; Rizner, T.L.
Dimerization and enzymatic activity of fungal 17beta-hydroxysteroid dehydrogenase from the short-chain dehydrogenase/reductase superfamily
BMC Biochem.
6
28
2005
Curvularia lunata
Manually annotated by BRENDA team
Pelletier, G.; Van, L.; Li, S.; Labrie, F.
Localization of type 8 17beta-hydroxysteroid dehydrogenase mRNA in mouse tissues as studied by in situ hybridization
J. Histochem. Cytochem.
53
1257-1271
2005
Mus musculus
Manually annotated by BRENDA team
Kristan, K.; Stojan, J.; Moeller, G.; Adamski, J.; Rizner, T.L.
Coenzyme specificity in fungal 17beta-hydroxysteroid dehydrogenase
Mol. Cell. Endocrinol.
241
80-87
2005
Curvularia lunata
Manually annotated by BRENDA team
Brozic, P.; Golob, B.; Gomboc, N.; Rizner, T.L.; Gobec, S.
Cinnamic acids as new inhibitors of 17beta-hydroxysteroid dehydrogenase type 5 (AKR1C3)
Mol. Cell. Endocrinol.
248
233-235
2006
Homo sapiens
Manually annotated by BRENDA team
Moeller, G.; Adamski, J.
Multifunctionality of human 17beta-hydroxysteroid dehydrogenases
Mol. Cell. Endocrinol.
248
47-55
2006
Homo sapiens
Manually annotated by BRENDA team
Lukacik, P.; Kavanagh, K.L.; Oppermann, U.
Structure and function of human 17beta-hydroxysteroid dehydrogenases
Mol. Cell. Endocrinol.
248
61-71
2006
Homo sapiens
Manually annotated by BRENDA team
Aizawa, K.; Iemitsu, M.; Maeda, S.; Jesmin, S.; Otsuki, T.; Mowa, C.N.; Miyauchi, T.; Mesaki, N.
Expression of steroidogenic enzymes and synthesis of sex steroid hormones from DHEA in skeletal muscle of rats
Am. J. Physiol.
292
E577-E584
2007
Rattus norvegicus
Manually annotated by BRENDA team
Laplante, Y.; Cadot, C.; Fournier, M.A.; Poirier, D.
Estradiol and estrone C-16 derivatives as inhibitors of type 1 17beta-hydroxysteroid dehydrogenase: blocking of ER+ breast cancer cell proliferation induced by estrone
Bioorg. Med. Chem.
16
1849-1860
2008
Homo sapiens (P14061), Homo sapiens
Manually annotated by BRENDA team
Allan, G.M.; Vicker, N.; Lawrence, H.R.; Tutill, H.J.; Day, J.M.; Huchet, M.; Ferrandis, E.; Reed, M.J.; Purohit, A.; Potter, B.V.
Novel inhibitors of 17beta-hydroxysteroid dehydrogenase type 1: templates for design
Bioorg. Med. Chem.
16
4438-4456
2008
Homo sapiens, Homo sapiens (P14061)
Manually annotated by BRENDA team
Bey, E.; Marchais-Oberwinkler, S.; Kruchten, P.; Frotscher, M.; Werth, R.; Oster, A.; Alguel, O.; Neugebauer, A.; Hartmann, R.W.
Design, synthesis and biological evaluation of bis(hydroxyphenyl) azoles as potent and selective non-steroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) for the treatment of estrogen-dependent diseases
Bioorg. Med. Chem.
16
6423-6435
2008
Homo sapiens, Homo sapiens (P14061)
Manually annotated by BRENDA team
Liu, H.; Zheng, S.; Bellemare, V.; Pelletier, G.; Labrie, F.; Luu-The, V.
Expression and localization of estrogenic type 12 17beta-hydroxysteroid dehydrogenase in the cynomolgus monkey
BMC Biochem.
8
2
2007
Macaca fascicularis (Q4JK77), Macaca fascicularis
Manually annotated by BRENDA team
Brozic, P.; Lanisnik Risner, T.; Gobec, S.
Inhibitors of 17beta-hydroxysteroid dehydrogenase type 1
Curr. Med. Chem.
15
137-150
2008
Homo sapiens (P14061)
Manually annotated by BRENDA team
Bydal, P.; Luu-The, V.; Labrie, F.; Poirier, D.
Steroidal lactones as inhibitors of 17beta-hydroxysteroid dehydrogenase type 5: Chemical synthesis, enzyme inhibitory activity, and assessment of estrogenic and androgenic activities
Eur. J. Med. Chem.
44
632-644
2008
Homo sapiens
Manually annotated by BRENDA team
Day, J.M.; Foster, P.A.; Tutill, H.J.; Parsons, M.F.; Newman, S.P.; Chander, S.K.; Allan, G.M.; Lawrence, H.R.; Vicker, N.; Potter, B.V.; Reed, M.J.; Purohit, A.
17beta-Hydroxysteroid dehydrogenase type 1, and not type 12, is a target for endocrine therapy of hormone-dependent breast cancer
Int. J. Cancer
122
1931-1940
2008
Homo sapiens (P14061), Homo sapiens
Manually annotated by BRENDA team
Chen, G.; Bourneuf, E.; Marklund, S.; Zamaratskaia, G.; Madej, A.; Lundstroem, K.
Gene expression of 3beta-hydroxysteroid dehydrogenase and 17beta-hydroxysteroid dehydrogenase in relation to androstenone, testosterone, and estrone sulphate in gonadally intact male and castrated pigs
J. Anim. Sci.
85
2457-2463
2007
Sus scrofa
Manually annotated by BRENDA team
Kristan, K.; Stojan, J.; Adamski, J.; Lanisnik Rizner, T.
Rational design of novel mutants of fungal 17beta-hydroxysteroid dehydrogenase
J. Biotechnol.
129
123-130
2007
Curvularia lunata (O93874)
Manually annotated by BRENDA team
Blanchard, P.G.; Luu-The, V.
Differential androgen and estrogen substrates specificity in the mouse and primates type 12 17beta-hydroxysteroid dehydrogenase
J. Endocrinol.
194
449-455
2007
Mus musculus (Q0VGQ1), Mus musculus
Manually annotated by BRENDA team
Frotscher, M.; Ziegler, E.; Marchais-Oberwinkler, S.; Kruchten, P.; Neugebauer, A.; Fetzer, L.; Scherer, C.; Mueller-Vieira, U.; Messinger, J.; Thole, H.; Hartmann, R.W.
Design, synthesis, and biological evaluation of (hydroxyphenyl)naphthalene and -quinoline derivatives: potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) for the treatment of estrogen-dependent disease
J. Med. Chem.
51
2158-2169
2008
Homo sapiens (P14061)
Manually annotated by BRENDA team
Brown, K.A.; Sayasith, K.; Bouchard, N.; Lussier, J.G.; Sirois, J.
Molecular cloning of equine 17beta-hydroxysteroid dehydrogenase type 1 and its downregulation during follicular luteinization in vivo
J. Mol. Endocrinol.
38
67-78
2007
Equus caballus (A3QRK1), Equus caballus
Manually annotated by BRENDA team
Luu-The, V.; Ferraris, C.; Duche, D.; Belanger, P.; Leclaire, J.; Labrie, F.
Steroid metabolism and profile of steroidogenic gene expression in Episkin: high similarity with human epidermis
J. Steroid Biochem. Mol. Biol.
107
30-36
2007
Homo sapiens
Manually annotated by BRENDA team
Ohno, S.; Nishikawa, K.; Honda, Y.; Nakajin, S.
Expression in E. coli and tissue distribution of the human homologue of the mouse Ke 6 gene, 17beta-hydroxysteroid dehydrogenase type 8
Mol. Cell. Biochem.
309
209-215
2008
Homo sapiens
Manually annotated by BRENDA team
Saloniemi, T.; Lamminen, T.; Huhtinen, K.; Welsh, M.; Saunders, P.; Kujari, H.; Poutanen, M.
Activation of androgens by hydroxysteroid (17beta) dehydrogenase 1 in vivo as a cause of prenatal masculinization and ovarian benign serous cystadenomas
Mol. Endocrinol.
21
2627-2636
2007
Homo sapiens (P14016)
Manually annotated by BRENDA team
Parthasarathy, C.; Balasubramanian, K.
Assessment of in vitro effects of metyrapone on Leydig cell steroidogenesis
Steroids
73
328-338
2008
Rattus norvegicus
Manually annotated by BRENDA team
Fournier, D.; Poirier, D.; Mazumdar, M.; Lin, S.X.
Design and synthesis of bisubstrate inhibitors of type 1 17beta-hydroxysteroid dehydrogenase: overview and perspectives
Eur. J. Med. Chem.
43
2298-2306
2008
Homo sapiens (P14061)
Manually annotated by BRENDA team
Bak, B.; Carpio, L.; Kipp, J.L.; Lamba, P.; Wang, Y.; Ge, R.S.; Hardy, M.P.; Mayo, K.E.; Bernard, D.J.
Activins regulate 17beta-hydroxysteroid dehydrogenase type I transcription in murine gonadotrope cells
J. Endocrinol.
201
89-104
2009
Mus musculus
Manually annotated by BRENDA team
Marchais-Oberwinkler, S.; Kruchten, P.; Frotscher, M.; Ziegler, E.; Neugebauer, A.; Bhoga, U.; Bey, E.; Mueller-Vieira, U.; Messinger, J.; Thole, H.; Hartmann, R.W.
Substituted 6-phenyl-2-naphthols. Potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1): design, synthesis, biological evaluation, and pharmacokinetics
J. Med. Chem.
51
4685-4698
2008
Homo sapiens (P14061)
Manually annotated by BRENDA team
El-Kabbani, O.; Scammells, P.J.; Gosling, J.; Dhagat, U.; Endo, S.; Matsunaga, T.; Soda, M.; Hara, A.
Structure-guided design, synthesis, and evaluation of salicylic acid-based inhibitors targeting a selectivity pocket in the active site of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1)
J. Med. Chem.
52
3259-3264
2009
Homo sapiens
Manually annotated by BRENDA team
Lota, R.K.; Olusanjo, M.S.; Dhanani, S.; Owen, C.P.; Ahmed, S.
Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a range of 4-hydroxyphenyl ketones as potent and specific inhibitors of the type 3 of 17beta-hydroxysteroid dehydrogenase (17beta-HSD3)
J. Steroid Biochem. Mol. Biol.
111
128-137
2008
Rattus norvegicus
Manually annotated by BRENDA team
Bellemare, V.; Laberge, P.; Noel, S.; Tchernof, A.; Luu-The, V.
Differential estrogenic 17beta-hydroxysteroid dehydrogenase activity and type 12 17beta-hydroxysteroid dehydrogenase expression levels in preadipocytes and differentiated adipocytes
J. Steroid Biochem. Mol. Biol.
114
129-134
2009
Homo sapiens
Manually annotated by BRENDA team
Kruchten, P.; Werth, R.; Bey, E.; Oster, A.; Marchais-Oberwinkler, S.; Frotscher, M.; Hartmann, R.W.
Selective inhibition of 17beta-hydroxysteroid dehydrogenase type 1 (17betaHSD1) reduces estrogen responsive cell growth of T47-D breast cancer cells
J. Steroid Biochem. Mol. Biol.
114
200-206
2009
Homo sapiens
Manually annotated by BRENDA team
Al-Soud, Y.A.; Bey, E.; Oster, A.; Marchais-Oberwinkler, S.; Werth, R.; Kruchten, P.; Frotscher, M.; Hartmann, R.W.
The role of the heterocycle in bis(hydroxyphenyl)triazoles for inhibition of 17beta-hydroxysteroid dehydrogenase (17beta-HSD) type 1 and type 2
Mol. Cell. Endocrinol.
301
212-215
2009
Homo sapiens
Manually annotated by BRENDA team
Messinger, J.; Husen, B.; Koskimies, P.; Hirvelae, L.; Kallio, L.; Saarenketo, P.; Thole, H.
Estrone C15 derivatives--a new class of 17beta-hydroxysteroid dehydrogenase type 1 inhibitors
Mol. Cell. Endocrinol.
301
216-224
2009
Homo sapiens (P14061), Homo sapiens
Manually annotated by BRENDA team
Karkola, S.; Alho-Richmond, S.; Wahala, K.
Pharmacophore modelling of 17beta-HSD1 enzyme based on active inhibitors and enzyme structure
Mol. Cell. Endocrinol.
301
225-228
2009
Homo sapiens (P14061)
Manually annotated by BRENDA team
Brozic, P.; Kocbek, P.; Sova, M.; Kristl, J.; Martens, S.; Adamski, J.; Gobec, S.; Lanisnik Rizner, T.
Flavonoids and cinnamic acid derivatives as inhibitors of 17beta-hydroxysteroid dehydrogenase type 1
Mol. Cell. Endocrinol.
301
229-234
2009
Homo sapiens (P14061)
Manually annotated by BRENDA team
Nashev, L.G.; Schuster, D.; Laggner, C.; Sodha, S.; Langer, T.; Wolber, G.; Odermatt, A.
The UV-filter benzophenone-1 inhibits 17beta-hydroxysteroid dehydrogenase type 3: Virtual screening as a strategy to identify potential endocrine disrupting chemicals
Biochem. Pharmacol.
79
1189-1199
2010
Homo sapiens
Manually annotated by BRENDA team
Oster, A.; Klein, T.; Werth, R.; Kruchten, P.; Bey, E.; Negri, M.; Marchais-Oberwinkler, S.; Frotscher, M.; Hartmann, R.W.
Novel estrone mimetics with high 17beta-HSD1 inhibitory activity
Bioorg. Med. Chem.
18
3494-3505
2010
Homo sapiens (P14061)
Manually annotated by BRENDA team
London, S.E.; Itoh, Y.; Lance, V.A.; Wise, P.M.; Ekanayake, P.S.; Oyama, R.K.; Arnold, A.P.; Schlinger, B.A.
Neural expression and post-transcriptional dosage compensation of the steroid metabolic enzyme 17beta-HSD type 4
BMC Neurosci.
11
47
2010
Taeniopygia guttata
Manually annotated by BRENDA team
Chanplakorn, N.; Chanplakorn, P.; Suzuki, T.; Ono, K.; Chan, M.; Miki, Y.; Saji, S.; Ueno, T.; Toi, M.; Sasano, H.
Increased estrogen sulfatase (STS) and 17hydroxysteroid dehydrogenase type l(17-HSD1) following neoadjuvant aromatase inhibitor therapy in breast cancer patients
Breast Cancer Res. Treat.
120
639-648
2010
Homo sapiens
Manually annotated by BRENDA team
Hong, Y.; Chen, S.
Aromatase, estrone sulfatase, and 17beta-hydroxysteroid dehydrogenase: Structure-function studies and inhibitor development
Mol. Cell. Endocrinol.
340
120-126
2011
Homo sapiens
Manually annotated by BRENDA team
Negri, M.; Recanatini, M.; Hartmann, R.W.
Insights in 17beta-HSD1 enzyme kinetics and ligand binding by dynamic motion investigation
PLoS ONE
5
e12026
2010
Homo sapiens (P14061)
Manually annotated by BRENDA team
Starcevic, S.; Brozic, P.; Turk, S.; Cesar, J.; Lanisnik Rizner, T.; Gobec, S.
Synthesis and biological evaluation of (6- and 7-Phenyl) coumarin derivatives as selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1
J. Med. Chem.
54
248-261
2011
Homo sapiens (P14061)
Manually annotated by BRENDA team
Beranic, N.; Rizner, T.L.
Effects of progestins on local estradiol biosynthesis and action in the Z-12 endometriotic epithelial cell line
J. Steroid Biochem. Mol. Biol.
132
303-310
2012
Homo sapiens (P14061), Homo sapiens (P37059), Homo sapiens
Manually annotated by BRENDA team
Lima, D.; MacHado, A.; Reis-Henriques, M.; Rocha, E.; Santos, M.; Castro, L.
Cloning and expression analysis of the 17beta hydroxysteroid dehydrogenase type 12 (HSD17B12) in the neogastropod Nucella lapillus
J. Steroid Biochem. Mol. Biol.
134
8-14
2013
Nucella lapillus (K7S9E9), Nucella lapillus
Manually annotated by BRENDA team
Wang, C.L.; Ying, S.J.; Wang, Z.Y.; Xing, H.J.; Wang, L.Z.; He, D.Y.; Xiao, S.H.; Wang, F.
Molecular cloning and expression of 17beta-hydroxysteroid dehydrogenase type 2 gene in Hu sheep
Mol. Biol. Rep.
40
1073-1080
2013
Ovis aries
Manually annotated by BRENDA team
Spadaro, A.; Negri, M.; Marchais-Oberwinkler, S.; Bey, E.; Frotscher, M.
Hydroxybenzothiazoles as new nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1)
PLoS ONE
7
e29252
2012
Homo sapiens (P14061)
Manually annotated by BRENDA team
Zhang, C.; Chen, J.; Yin, D.; Lin, S.
The contribution of 17beta-hydroxysteroid dehydrogenase type 1 to the estradiol-estrone ratio in estrogen-sensitive breast cancer cells
PLoS ONE
7
e29835
2012
Homo sapiens (P14061), Homo sapiens (P37059)
Manually annotated by BRENDA team
Sivik, T.; Gunnarsson, C.; Fornander, T.; Nordenskjoeld, B.; Skoog, L.; Stal, O.; Jansson, A.
17beta-Hydroxysteroid dehydrogenase type 14 is a predictive marker for tamoxifen response in oestrogen receptor positive breast cancer
PLoS ONE
7
e40568
2012
Homo sapiens (Q9BPX1)
Manually annotated by BRENDA team
Muthusamy, S.; Andersson, S.; Kim, H.J.; Butler, R.; Waage, L.; Bergerheim, U.; Gustafsson, J.A.
Estrogen receptor beta and 17beta-hydroxysteroid dehydrogenase type 6, a growth regulatory pathway that is lost in prostate cancer
Proc. Natl. Acad. Sci. USA
108
20090-20094
2011
Homo sapiens (O14756)
Manually annotated by BRENDA team
Strugala, A.J.; Jagodzinski, P.P.
Conversion of estrone to 17 beta-estradiol in Jurkat acute T cell leukemia Hut-78 T- and Raji B lymphoma cell lines in vitro
Biomed. Pharmacother.
67
299-303
2013
Homo sapiens (P14061)
Manually annotated by BRENDA team
Tomaszycki, M.L.; Dzubur, E.
17beta-Hydroxysteroid dehydrogenase type IV, a Z-linked gene, is higher in females than in males in visual and auditory regions of developing zebra finches
Brain Res.
1520
95-106
2013
Taeniopygia guttata (H0YSD6)
Manually annotated by BRENDA team
Perspicace, E.; Giorgio, A.; Carotti, A.; Marchais-Oberwinkler, S.; Hartmann, R.W.
Novel N-methylsulfonamide and retro-N-methylsulfonamide derivatives as 17beta-hydroxysteroid dehydrogenase type 2 (17beta-HSD2) inhibitors with good ADME-related physicochemical parameters
Eur. J. Med. Chem.
69
201-215
2013
Homo sapiens (P14061), Homo sapiens (P37059)
Manually annotated by BRENDA team
Maltais, R.; Trottier, A.; Delhomme, A.; Barbeau, X.; Laguee, P.; Poirier, D.
Identification of fused 16beta,17beta-oxazinone-estradiol derivatives as a new family of non-estrogenic 17beta-hydroxysteroid dehydrogenase type 1 inhibitors
Eur. J. Med. Chem.
93
470-480
2015
Homo sapiens (P14061)
Manually annotated by BRENDA team
Shikina, S.; Chung, Y.J.; Chiu, Y.L.; Huang, Y.J.; Lee, Y.H.; Chang, C.F.
Molecular cloning and characterization of a steroidogenic enzyme, 17beta-hydroxysteroid dehydrogenase type 14, from the stony coral Euphyllia ancora (Cnidaria, Anthozoa)
Gen. Comp. Endocrinol.
228
95-104
2016
Fimbriaphyllia ancora (A0A0G2SJM3), Fimbriaphyllia ancora
Manually annotated by BRENDA team
Nashev, L.; Atanasov, A.; Baker, M.; Odermatt, A.
Cysteine-10 on 17beta-hydroxysteroid dehydrogenase 1 has stabilizing interactions in the cofactor binding region and renders sensitivity to sulfhydryl modifying chemicals
Int. J. Cell Biol.
2013
769536
2013
Homo sapiens (P14061)
Manually annotated by BRENDA team
Weber, S.; Salabei, J.K.; Moeller, G.; Kremmer, E.; Bhatnagar, A.; Adamski, J.; Barski, O.A.
Aldo-keto Reductase 1B15 (AKR1B15): a mitochondrial human aldo-keto reductase with activity toward steroids and 3-keto-acyl-CoA conjugates
J. Biol. Chem.
290
6531-6545
2015
Homo sapiens (C9JRZ8)
Manually annotated by BRENDA team
Herman, B.E.; Szabo, J.; Bacsa, I.; Woelfling, J.; Schneider, G.; Balint, M.; Hetenyi, C.; Mernyak, E.; Szecsi, M.
Comparative investigation of the in vitro inhibitory potencies of 13-epimeric estrones and D-secoestrones towards 17beta-hydroxysteroid dehydrogenase type 1
J. Enzyme Inhib. Med. Chem.
36 (Suppl.3)
61-69
2016
Homo sapiens (P14061)
Manually annotated by BRENDA team
Maltais, R.; Ayan, D.; Trottier, A.; Barbeau, X.; Laguee, P.; Bouchard, J.E.; Poirier, D.
Discovery of a non-estrogenic irreversible inhibitor of 17beta-hydroxysteroid dehydrogenase type 1 from 3-substituted-16beta-(m-carbamoylbenzyl)-estradiol derivatives
J. Med. Chem.
57
204-222
2014
Homo sapiens
Manually annotated by BRENDA team
Vuorinen, A.; Engeli, R.; Meyer, A.; Bachmann, F.; Griesser, U.J.; Schuster, D.; Odermatt, A.
Ligand-based pharmacophore modeling and virtual screening for the discovery of novel 17beta-hydroxysteroid dehydrogenase 2 inhibitors
J. Med. Chem.
57
5995-6007
2014
Homo sapiens (P37059)
Manually annotated by BRENDA team
Bertoletti, N.; Braun, F.; Lepage, M.; Moeller, G.; Adamski, J.; Heine, A.; Klebe, G.; Marchais-Oberwinkler, S.
New insights into human 17beta-hydroxysteroid dehydrogenase type 14: first crystal structures in complex with a steroidal ligand and with a potent nonsteroidal inhibitor
J. Med. Chem.
59
6961-6967
2016
Homo sapiens (Q9BPX1)
Manually annotated by BRENDA team
Verma, M.; Miki, Y.; Abe, K.; Suzuki, T.; Niikawa, H.; Suzuki, S.; Kondo, T.; Sasano, H.
Intratumoral localization and activity of 17beta-hydroxysteroid dehydrogenase type 1 in non-small cell lung cancer: A potent prognostic factor
J. Transl. Med.
11
167-177
2013
Homo sapiens (P14061)
Manually annotated by BRENDA team
Gargano, E.M.; Allegretta, G.; Perspicace, E.; Carotti, A.; Van Koppen, C.; Frotscher, M.; Marchais-Oberwinkler, S.; Hartmann, R.W.
17beta-Hydroxysteroid dehydrogenase type 2 inhibition: discovery of selective and metabolically stable compounds inhibiting both the human enzyme and its murine ortholog
PLoS ONE
10
e0134754
2015
Homo sapiens (P37059), Mus musculus (P51658)
Manually annotated by BRENDA team
Salah, M.; Abdelsamie, A.S.; Frotscher, M.
First dual inhibitors of steroid sulfatase (STS) and 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) designed multiple ligands as novel potential therapeutics for estrogen-dependent diseases
J. Med. Chem.
60
4086-4092
2017
Homo sapiens (P14061)
Manually annotated by BRENDA team
Wang, P.; Zheng, D.; Peng, W.; Wang, Y.; Wang, X.; Xiong, W.; Liang, R.
Characterization of 17beta-hydroxysteroid dehydrogenase and regulators involved in estrogen degradation in Pseudomonas putida SJTE-1
Appl. Microbiol. Biotechnol.
103
2413-2425
2019
Pseudomonas putida, Pseudomonas putida SJTE-1
Manually annotated by BRENDA team
Trottier, A.; Maltais, R.; Ayan, D.; Barbeau, X.; Roy, J.; Perreault, M.; Poulin, R.; Laguee, P.; Poirier, D.
Insight into the mode of action and selectivity of PBRM, a covalent steroidal inhibitor of 17beta-hydroxysteroid dehydrogenase type 1
Biochem. Pharmacol.
144
149-161
2017
Homo sapiens (P14061)
Manually annotated by BRENDA team
Ferrante, T.; Adinolfi, S.; DArrigo, G.; Poirier, D.; Daga, M.; Lolli, M.L.; Balliano, G.; Spyrakis, F.; Oliaro-Bosso, S.
Multiple catalytic activities of human 17beta-hydroxysteroid dehydrogenase type 7 respond differently to inhibitors
Biochimie
170
106-117
2020
Homo sapiens (P56937)
Manually annotated by BRENDA team
Boutin, S.; Roy, J.; Maltais, R.; Alata, W.; Calon, F.; Poirier, D.
Identification of steroidal derivatives inhibiting the transformations of allopregnanolone and estradiol by 17beta-hydroxysteroid dehydrogenase type 10
Bioorg. Med. Chem. Lett.
28
3554-3559
2018
Homo sapiens (Q99714)
Manually annotated by BRENDA team
Ye, X.; Wang, H.; Kan, J.; Li, J.; Huang, T.; Xiong, G.; Hu, Z.
A novel 17beta-hydroxysteroid dehydrogenase in Rhodococcus sp. P14 for transforming 17beta-estradiol to estrone
Chem. Biol. Interact.
276
105-112
2017
Rhodococcus sp. P14 (A0A1Z3FWF0)
Manually annotated by BRENDA team
Boutin, S.; Maltais, R.; Roy, J.; Poirier, D.
Synthesis of 17beta-hydroxysteroid dehydrogenase type 10 steroidal inhibitors selectivity, metabolic stability and enhanced potency
Eur. J. Med. Chem.
209
112909
2021
Homo sapiens
Manually annotated by BRENDA team
Li, T.; Stephen, P.; Zhu, D.W.; Shi, R.; Lin, S.X.
Crystal structures of human 17beta-hydroxysteroid dehydrogenase type 1 complexed with estrone and NADP+ reveal the mechanism of substrate inhibition
FEBS J.
286
2155-2166
2019
Homo sapiens (P14061)
Manually annotated by BRENDA team
Xiong, W.; Yin, C.; Wang, Y.; Lin, S.; Deng, Z.; Liang, R.
Characterization of an efficient estrogen-degrading bacterium Stenotrophomonas maltophilia SJTH1 in saline-, alkaline-, heavy metal-contained environments or solid soil and identification of four 17beta-estradiol-oxidizing dehydrogenases
J. Hazard. Mater.
385
121616
2020
Stenotrophomonas maltophilia, Stenotrophomonas maltophilia SJTH1
Manually annotated by BRENDA team
Cassetta, A.; Stojan, J.; Krastanova, I.; Kristan, K.; Brunskole Svegelj, M.; Lamba, D.; Lanisnik Rizner, T.
Structural basis for inhibition of 17beta-hydroxysteroid dehydrogenases by phytoestrogens The case of fungal 17beta-HSDcl
J. Steroid Biochem. Mol. Biol.
171
80-93
2017
Curvularia lunata (O93874)
Manually annotated by BRENDA team
Theriault, J.F.; Lin, S.X.
The dual sex hormone specificity for human reductive 17beta-hydroxysteroid dehydrogenase type 7 Synergistic function in estrogen and androgen control
J. Steroid Biochem. Mol. Biol.
186
61-65
2019
Homo sapiens (P56937)
Manually annotated by BRENDA team
Aka, J.; Calvo, E.; Lin, S.
Estradiol-independent modulation of breast cancer transcript profile by 17beta-hydroxysteroid dehydrogenase type 1
Mol. Cell. Endocrinol.
439
175-186
2017
Homo sapiens (P14061)
Manually annotated by BRENDA team
Salah, M.; Abdelsamie, A.S.; Frotscher, M.
Inhibitors of 17?-hydroxysteroid dehydrogenase type 1, 2 and 14 Structures, biological activities and future challenges
Mol. Cell. Endocrinol.
489
66-81
2019
Homo sapiens (P14061), Homo sapiens (P37059)
Manually annotated by BRENDA team
Penning, T.M.
AKR1C3 (type 5 17beta-hydroxysteroid dehydrogenase/prostaglandin F synthase) Roles in malignancy and endocrine disorders
Mol. Cell. Endocrinol.
489
82-91
2019
Homo sapiens (P42330)
Manually annotated by BRENDA team
Hilborn, E.; Stal, O.; Jansson, A.
Estrogen and androgen-converting enzymes 17beta-hydroxysteroid dehydrogenase and their involvement in cancer with a special focus on 17beta-hydroxysteroid dehydrogenase type 1, 2, and breast cancer
Oncotarget
8
30552-30562
2017
Homo sapiens (P14061), Homo sapiens (P37059)
Manually annotated by BRENDA team
Hilborn, E.; Stal, O.; Alexeyenko, A.; Jansson, A.
The regulation of hydroxysteroid 17beta-dehydrogenase type 1 and 2 gene expression in breast cancer cell lines by estradiol, dihydrotestosterone, microRNAs, and genes related to breast cancer
Oncotarget
8
62183-62194
2017
Homo sapiens (P37059)
Manually annotated by BRENDA team
Wojciechowicz, B.; Kotwica, G.; Zglejc, K.; Waszkiewicz, E.; Franczak, A.
Expression of 17?-hydroxysteroid dehydrogenase and the effects of LH, FSH and prolactin on oestrone and 17beta-oestradiol secretion in the endometrium of pigs during early pregnancy and the oestrous cycle
Reprod. Fertil. Dev.
29
975-984
2017
Sus scrofa (B2X0A4)
Manually annotated by BRENDA team
Liu, J.; He, P.; Lin, L.; Zhao, Y.; Deng, W.; Ding, H.; Li, Q.; Wang, Z.
Characterization of a highly specific monoclonal antibody against human aldo-keto reductase AKR1C3
Steroids
143
73-79
2019
Homo sapiens (P42330), Homo sapiens
Manually annotated by BRENDA team
Sali, V.K.; Mani, S.; Meenaloshani, G.; Velmurugan Ilavarasi, A.; Vasanthi, H.R.
Type 5 17-hydroxysteroid dehydrogenase/prostaglandin F synthase (AKR1C3) inhibition and potential anti-proliferative activity of cholest-4-ene-3,6-dione in MCF-7 breast cancer cells
Steroids
159
108638
2020
Homo sapiens (P42330)
Manually annotated by BRENDA team
Wang, P.; Zheng, D.; Wang, Y.; Liang, R.
One 3-oxoacyl-(acyl-carrier-protein) reductase functions as 17beta-hydroxysteroid dehydrogenase in the estrogen-degrading Pseudomonas putida SJTE-1
Biochem. Biophys. Res. Commun.
505
910-916
2018
Pseudomonas putida (ANI02794.1), Pseudomonas putida SJTE-1 (ANI02794.1)
Manually annotated by BRENDA team