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Information on EC 1.1.1.6 - glycerol dehydrogenase
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1.1.1.6 glycerol dehydrogenaseIUBMB Comments
Also acts on propane-1,2-diol.
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Word Map
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
gldh, glycerol dehydrogenase, tmglydh, nad-linked glycerol dehydrogenase, glycerol:nad+ 2-oxidoreductase, glycerol nad 2-oxidoreductase, nad+-dependent glycerol dehydrogenase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
dehydrogenase, glycerol
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GDH
GDH2
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GLD
GldA
GLDH
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glycerin dehydrogenase
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glycerol dehydrogenase
glycerol NAD 2-oxidoreductase
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glycerol:NAD+ 2-oxidoreductase
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GlyDH
NAD-linked glycerol dehydrogenase
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NAD-specific glycerol dehydrogenase
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TmGlyDH
TTHADH
glycerol dehydrogenase
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type III polyol dehydrogenase family
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
glycerol + NAD+ = glycerone + NADH + H+
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glycerol + NAD+ = glycerone + NADH + H+
catalytic bi-bi mechanism
glycerol + NAD+ = glycerone + NADH + H+
the enzyme follows an ordered Bi-Bi mechanism kinetic model and shows product inhibition
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
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redox reaction
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reduction
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
glycerol:NAD+ 2-oxidoreductase
Also acts on propane-1,2-diol.
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CAS REGISTRY NUMBER
COMMENTARY
249285-11-8
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9028-14-2
this number also refers to EC 1.1.99.22
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
1,2,3-butanetriol + NAD+
1,3-dihydroxybutane-2-one + NADH
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?
1,2-butanediol + NAD+
1-hydroxy-2-butanone + NADH + H+
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?
1,2-ethanediol + NAD+
hydroxyacetaldehyde + NADH + H+
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?
1,3-butanediol + NAD+
?
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relative activity is 6.5% compared to oxidation of glycerol
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?
3-(2,2,2-trifluoroethoxy)propane-1,2-diol + NAD+
1-hydroxy-3-(2,2,2-trifluoroethoxy)propan-2-one + NADH + H+
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?
3-(2,2,2-trifluoroethoxy)propane-1,2-diol + NAD+
? + NADH + H+
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?
3-butoxypropane-1,2-diol + NAD+
1-hydroxy-3-butoxypropan-2-one + NADH + H+
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?
3-chloro-1,2-propanediol + NAD+
?
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130% of the activity with glycerol
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?
3-ethoxypropane-1,2-diol + NAD+
1-hydroxy-3-ethoxypropan-2-one + NADH + H+
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?
3-mercapto-1,2-propanediol + NAD+
?
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155% of the activity with glycerol
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?
3-methoxypropane-1,2-diol + NAD+
1-hydroxy-3-methoxypropan-2-one + NADH + H+
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?
3-phenoxypropane-1,2-diol + NAD+
1-hydroxy-3-phenoxypropan-2-one + NADH + H+
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?
3-propoxypropane-1,2-diol + NAD+
1-hydroxy-3-propoxypropan-2-one + NADH + H+
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?
3-[(propan-2-yl)oxy]propane-1,2-diol + NAD+
1-hydroxy-3-[(propan-2-yl)oxy]propan-2-one + NADH + H+
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?
3-[(propan-2-yl)oxy]propane-1,2-diol + NAD+
? + NADH + H+
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?
beta-glycerophosphate + NAD+
?
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relative activity is 2% compared to oxidation of glycerol
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?
diglycerol + NAD+
?
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relative activity is 21% compared to oxidation of glycerol
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?
ethanol + NAD+
acetaldehyde + NADH
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relative activity is 1% compared to oxidation of glycerol
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?
hydroxy-2-propanone + NADH
propylene glycol + NAD+
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relative activity is 27% compared to oxidation of glycerol
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?
i-inositol + NAD+
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relative activity is 18% compared to oxidation of glycerol
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?
isopropanol + NAD+
acetone + NADH
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relative activity is 17% compared to oxidation of glycerol
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?
sorbitol + NAD+
?
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relative activity is 3% compared to oxidation of glycerol
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?
(2R,3R)-2,3-butanediol + NAD+
(3R)-acetoin + NADH
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more than 99% enantiomeric excess of R-product
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r
(2R,3R)-2,3-butanediol + NAD+
(3R)-acetoin + NADH
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more than 99% enantiomeric excess of R-product
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r
(2R,3R)-2,3-butanediol + NAD+
? + NADH
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better substrate than glycerol
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?
(2R,3R)-2,3-butanediol + NAD+
? + NADH
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better substrate than glycerol
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?
(R)-1,2-propanediol + NAD+
? + NADH
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better substrate than glycerol
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?
(R)-1,2-propanediol + NAD+
hydroxyacetone + NADH
the enzyme prefers the R-enantiomer
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r
(R)-1,2-propanediol + NAD+
hydroxyacetone + NADH
Thermotoga maritima MSB8 / DSM 3109 / ATCC 43589
the enzyme prefers the R-enantiomer
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r
1,2-propanediol + NAD+
hydroxyacetone + NADH
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105% of the activity with glycerol
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?
1,2-propanediol + NAD+
hydroxyacetone + NADH
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relative activity is 116% compared to oxidation of glycerol
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?
1,2-propanediol + NAD+
hydroxyacetone + NADH
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relative activity is 116% compared to oxidation of glycerol
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?
1,2-propanediol + NAD+
hydroxyacetone + NADH
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as active as glycerol
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?
1,2-propanediol + NAD+
hydroxyacetone + NADH
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1,2-propanediol represses the global activator HilA that induces an invasive phenotype and repression of HilA could be weakened by glycerol dehydrogenase activity
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?
1,3-butanediol + NAD+
4-hydroxy-2-butanone + NADH + H+
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?
1,3-butanediol + NAD+
4-hydroxy-2-butanone + NADH + H+
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?
1,3-butanediol + NAD+
4-hydroxy-2-butanone + NADH + H+
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?
1,3-dichloro-2-propanol + NAD+
1,3-dichloro-2-propanone + NADH
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?
1,3-dichloro-2-propanol + NAD+
1,3-dichloro-2-propanone + NADH
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?
1,3-propanediol + NAD+
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relative rate of oxidation is 18% compared to oxidation of glycerol
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?
1,3-propanediol + NAD+
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relative rate of oxidation is 37% compared to oxidation of glycerol
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?
1,4-butanediol + NAD+
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relative activity is 0.3% compared to oxidation of glycerol
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?
1,4-butanediol + NAD+
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relative activity 17% compared to oxidation of glycerol
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?
2,3-butanediol + NAD+
3-hydroxybutane-2-one + NADH
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as active as glycerol
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?
DL-alpha-glycerophosphate + NAD+
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oxidation at 16% compared to oxidation of glycerol
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?
DL-alpha-glycerophosphate + NAD+
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relative activity 11%compared to oxidation of glycerol
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?
DL-glyceraldehyde + NAD+
3-hydroxypyruvaldehyde + NADH
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relative rate of reduction is 14%compared to reduction of dihydroxyacetone
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?
DL-glyceraldehyde + NAD+
3-hydroxypyruvaldehyde + NADH
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?
DL-glyceraldehyde + NAD+
3-hydroxypyruvaldehyde + NADH
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?
ethanediol + NAD+
glycolaldehyde + NADH
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reduction at concentration of 50 mM
r
ethanediol + NAD+
glycolaldehyde + NADH
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reduction at concentration of 50 mM
r
ethylene glycol + NAD+
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relative activity is 20% compared to oxidation of glycerol
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?
glycerol + N6-carboxymethyl-NAD+
glycerone + N6-carboxymethyl-NADH + H+
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r
glycerol + N6-carboxymethyl-NAD+
glycerone + N6-carboxymethyl-NADH + H+
Thermotoga maritima MSB8 / DSM 3109 / ATCC 43589
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r
glycerol + N6-CM-NAD+
glycerone + N6-carboxymethyl-NADH + H+
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r
glycerol + N6-CM-NAD+
glycerone + N6-carboxymethyl-NADH + H+
Thermotoga maritima MSB8 / DSM 3109 / ATCC 43589
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r
glycerol + NAD+
D-glyceraldehyde + NADH + H+
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no activity with NADP+. The enzyme shows much higher activity towards glycerol as compared to short chain primary and secondary alcohols. The thermostable enzyme is highly stereospecific in oxidation of glycerol and converts glycerol into D-glyceraldehyde
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