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Information on EC - pseudoephedrine dehydrogenase

for references in articles please use BRENDA:EC1.1.1.422
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EC Tree
IUBMB Comments
The enzyme, characterized from the bacterium Arthrobacter sp. TS-15, acts on a broad range of different aryl-alkyl ketones, such as haloketones, ketoamines, diketones, and ketoesters. It accepts various types of aryl groups including phenyl-, pyridyl-, thienyl-, and furyl-rings, but the presence of an aromatic ring is essential for the activity. In addition, the presence of a functional group on the alkyl chain, such as an amine, a halogen, or a ketone, is also crucial. The enzyme exhibits a strict anti-Prelog enantioselectivity. When acting on diketones, it catalyses the reduction of only the keto group closest to the ring, with no further reduction to the diol. cf. EC, ephedrine dehydrogenase.
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The expected taxonomic range for this enzyme is: unclassified Arthrobacter
Reaction Schemes
PseDH, more
(+)-(1S,2S)-pseudoephedrine + NAD+ = (S)-2-methylamino-1-phenylpropan-1-one + NADH + H+
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