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Information on EC 1.1.1.417 - 3beta-hydroxysteroid-4beta-carboxylate 3-dehydrogenase (decarboxylating)

for references in articles please use BRENDA:EC1.1.1.417

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IUBMB Comments

This bacterial enzyme participates in the biosynthesis of bacterial sterols. Together with EC 1.14.13.246, 4β-methylsterol monooxygenase (SdmA) it forms an enzyme system that removes one methyl group from the C-4 position of 4,4-dimethylated steroid molecules. SdmA catalyses three successive oxidations of the C-4β methyl group, turning it into a carboxylate group; SdmB is a bifunctional enzyme that catalyses two different activities. As EC 1.1.1.417 it catalyses an oxidative decarboxylation that results in reduction of the 3β-hydroxy group at the C-3 carbon to an oxo group. As EC 1.1.1.270, 3β-hydroxysteroid 3-dehydrogenase, it reduces the 3-oxo group back to a 3β-hydroxyl. Since the remaining methyl group at C-4 is in an α orientation, it cannot serve as a substrate for a second round of demethylation by this system.

The expected taxonomic range for this enzyme is: Methylococcus capsulatus

Synonyms
sdmB, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + NAD(P)+ = a 4alpha-methyl-3-oxosteroid + NAD(P)H + CO2 + H+
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
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Highest Expressing Human Cell Lines
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