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IUBMB CommentsThe enzyme, characterized from bacteria, is involved in D-erythronate catabolism.
The enzyme appears in viruses and cellular organisms
Synonyms
D-erythronate 2-dehydrogenase,
denD,
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D-erythronate 2-dehydrogenase
D-erythronate 2-dehydrogenase

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D-erythronate 2-dehydrogenase
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denD

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D-erythronate + NAD+ = 2-dehydro-D-erythronate + NADH + H+
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D-erythronate:NAD+ 2-oxidoreductase
The enzyme, characterized from bacteria, is involved in D-erythronate catabolism.
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D-erythronate + NAD+
2-dehydro-D-erythronate + NADH + H+
D-erythronate + NADP+
2-dehydro-D-erythronate + NADPH + H+
D-erythronate + NAD+

2-dehydro-D-erythronate + NADH + H+
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D-erythronate + NAD+
2-dehydro-D-erythronate + NADH + H+
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D-erythronate + NADP+

2-dehydro-D-erythronate + NADPH + H+
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D-erythronate + NADP+
2-dehydro-D-erythronate + NADPH + H+
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NAD+
NAD+ is preferred over NADP+
NADP+
NAD+ is preferred over NADP+
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0.59
D-erythronate

cosubstrate NAD+, pH 8.0, 25°C
2.4
D-erythronate
cosubstrate NADP+, pH 8.0, 25°C
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3
D-erythronate

cosubstrate NADP+, pH 8.0, 25°C
19
D-erythronate
cosubstrate NAD+, pH 8.0, 25°C
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1.2
D-erythronate

cosubstrate NADP+, pH 8.0, 25°C
33
D-erythronate
cosubstrate NAD+, pH 8.0, 25°C
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UniProt
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UniProt
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DEND_CUPNH
Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337)
324
0
34270
Swiss-Prot
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DEND_HAEIN
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
315
0
35145
Swiss-Prot
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A0A6S6ZSS6_9BURK
324
0
34479
TrEMBL
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A0A653Y8N6_9GAMM
320
0
34296
TrEMBL
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A0A5E7PZ88_PSEFL
334
0
36307
TrEMBL
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A0A6H2HBE3_9BURK
345
0
35919
TrEMBL
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A0A6M4GZJ6_9PROT
310
0
32944
TrEMBL
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A0A346BAN0_9BURK
314
0
33384
TrEMBL
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A0A5E7ZMF8_9RHOB
327
0
34408
TrEMBL
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A0A5M9IYR1_9PSED
335
0
36054
TrEMBL
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A0A5E7CSY9_PSEFL
333
0
36376
TrEMBL
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A0A833Q194_BURGA
323
0
34461
TrEMBL
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A0A6S6ZC75_9BURK
323
0
34546
TrEMBL
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A0A7T6X9Z8_RALPI
327
0
34561
TrEMBL
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A0A7M2NNW3_9BURK
323
0
34027
TrEMBL
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A0A6S6ZDX5_9BURK
326
0
34521
TrEMBL
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A0A5E7F9G0_PSEFL
324
0
35382
TrEMBL
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A0A5E7SZ03_PSEFL
333
0
36246
TrEMBL
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A0A653SZD1_9HYPH
327
0
35202
TrEMBL
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A0A654DXI5_9GAMM
320
0
34422
TrEMBL
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A0A6M4H8Z5_9PROT
311
0
32950
TrEMBL
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A0A5E7JT57_PSEFL
334
0
36468
TrEMBL
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A0A5E6QP21_PSEFL
332
0
36266
TrEMBL
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A0A6S7DXQ1_9BURK
325
0
34377
TrEMBL
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A0A5M9IES0_PSEPA
313
0
34222
TrEMBL
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A0A6J4ZSJ6_9BURK
327
0
35126
TrEMBL
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A0A6J5EI34_9BURK
323
0
34503
TrEMBL
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B1G022_PARG4
Paraburkholderia graminis (strain ATCC 700544 / DSM 17151 / LMG 18924 / NCIMB 13744 / C4D1M)
326
0
35083
TrEMBL
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A0A5E7M182_PSEFL
333
0
36234
TrEMBL
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A0A5E7LDE7_PSEFL
332
0
36248
TrEMBL
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A0A5E6Q2X1_PSEFL
333
0
36254
TrEMBL
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A0A508WVN2_9HYPH
327
0
35617
TrEMBL
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A0A5E6Z9I4_PSEFL
324
0
34938
TrEMBL
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A0A5E7A1J3_PSEFL
332
0
36358
TrEMBL
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A0A6G8NQW8_9BURK
326
0
35227
TrEMBL
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A0A5S9Q1J5_9GAMM
315
0
35400
TrEMBL
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A0A2N7WSP2_9BURK
326
0
35083
TrEMBL
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A0A6S7CHL7_9BURK
325
0
34479
TrEMBL
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A0A5E6WWA3_PSEFL
333
0
36277
TrEMBL
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A0A346BDX0_9BURK
316
0
33947
TrEMBL
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A0A5E7YFK2_9BACT
318
0
34092
TrEMBL
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A0A5Q4ZSV9_9BURK
Paraburkholderia dioscoreae
326
0
34992
TrEMBL
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A0A7S4GZH0_9GAMM
320
0
34385
TrEMBL
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A0A6S7FF73_9BURK
323
0
34371
TrEMBL
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A0A6S7DXC9_9BURK
324
0
34828
TrEMBL
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A0A1X1P8C6_9BURK
323
0
34451
TrEMBL
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A0A6J5GXU4_9BURK
308
0
32910
TrEMBL
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A0A6J5ABA0_9BURK
326
0
35062
TrEMBL
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A0A508X730_9HYPH
327
0
35998
TrEMBL
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A0A5E7A9D7_PSEFL
332
0
36226
TrEMBL
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A0A5E6Q4U9_PSEFL
333
0
36278
TrEMBL
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A0A6S7B799_9BURK
326
0
34859
TrEMBL
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A0A6J5D823_9BURK
326
0
35387
TrEMBL
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A0A5E7RWW2_PSEFL
324
0
35493
TrEMBL
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A0A6G8NIY0_9BURK
321
0
34473
TrEMBL
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A0A6S7BY38_9BURK
326
0
35234
TrEMBL
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A0A6J5FXS1_9BURK
326
0
34822
TrEMBL
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A0A653JVX1_9BURK
339
0
35565
TrEMBL
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A0A5E6TKD4_PSEFL
333
0
36213
TrEMBL
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A0A6S7DMS3_9BURK
328
0
35196
TrEMBL
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A0A6J4ZIW8_9BURK
325
0
34416
TrEMBL
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A0A5E7SG05_PSEFL
333
0
36218
TrEMBL
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A0A346B780_9BURK
326
0
35084
TrEMBL
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A0A2M9H1P0_9BURK
325
0
34583
TrEMBL
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A0A6A7SFI9_9ZZZZ
323
0
34106
TrEMBL
other Location (Reliability: 5)
A0A6J5K9J6_9BURK
326
0
34953
TrEMBL
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A0A5E6WHP4_PSEFL
324
0
35524
TrEMBL
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A0A380TEV9_9ZZZZ
319
0
34613
TrEMBL
other Location (Reliability: 5)
A0A346BKD6_9BURK
314
0
33213
TrEMBL
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A0A653SZB3_9HYPH
330
0
35197
TrEMBL
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A0A6S7AWH2_9BURK
324
0
34632
TrEMBL
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A0A654BFC2_9BURK
321
0
34440
TrEMBL
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A0A5E8A5D8_9HYPH
329
0
35293
TrEMBL
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A0A5E6WWX1_PSEFL
333
0
36247
TrEMBL
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A0A6J5DDS7_9BURK
326
0
35379
TrEMBL
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Zhang, X.; Carter, M.; Vetting, M.; Francisco, B.; Zhao, S.; Al-Obaidi, N.; Solbiati, J.; Thiaville, J.; Crecy-Lagard, V.; Jacobson, M.; Almo, S.; Gerlt, J.
Assignment of function to a domain of unknown function: DUF1537 is a new kinase family in catabolic pathways for acid sugars
Proc. Natl. Acad. Sci. USA
113
E4161-E4169
2016
Cupriavidus necator (Q0KBD2), Cupriavidus necator DSM 428 (Q0KBD2)
brenda
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