Information on EC 1.1.1.41 - isocitrate dehydrogenase (NAD+) and Organism(s) Agaricus bisporus and UniProt Accession P28834

for references in articles please use BRENDA:EC1.1.1.41
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This record set is specific for:
Agaricus bisporus
UNIPROT: P28834


The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea

EC NUMBER
COMMENTARY hide
1.1.1.41
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RECOMMENDED NAME
GeneOntology No.
isocitrate dehydrogenase (NAD+)
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
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oxidative decarboxylation
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redox reaction
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reduction
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reductive carboxylation
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
L-glutamine biosynthesis III
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TCA cycle II (plants and fungi)
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TCA cycle III (animals)
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citric acid cycle
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Citrate cycle (TCA cycle)
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Metabolic pathways
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Biosynthesis of secondary metabolites
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Microbial metabolism in diverse environments
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Biosynthesis of antibiotics
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SYSTEMATIC NAME
IUBMB Comments
isocitrate:NAD+ oxidoreductase (decarboxylating)
Requires Mn2+ or Mg2+ for activity. Unlike EC 1.1.1.42, isocitrate dehydrogenase (NADP+), oxalosuccinate cannot be used as a substrate. In eukaryotes, isocitrate dehydrogenase exists in two forms: an NAD+-linked enzyme found only in mitochondria and displaying allosteric properties, and a non-allosteric, NADP+-linked enzyme that is found in both mitochondria and cytoplasm [7]. The enzyme from some species can also use NADP+ but much more slowly [9].
CAS REGISTRY NUMBER
COMMENTARY hide
9001-58-5
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