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Information on EC 1.1.1.40 - malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) and Organism(s) Mus musculus and UniProt Accession P06801

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EC Tree
IUBMB Comments
The enzyme catalyses the oxidative decarboxylation of (S)-malate in the presence of NADP+ and divalent metal ions, and the decarboxylation of oxaloacetate. cf. EC 1.1.1.38, malate dehydrogenase (oxaloacetate-decarboxylating), and EC 1.1.1.39, malate dehydrogenase (decarboxylating).
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This record set is specific for:
Mus musculus
UNIPROT: P06801
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Word Map
The taxonomic range for the selected organisms is: Mus musculus
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Reaction Schemes
Synonyms
nadp-me, nadp-malate dehydrogenase, nadp-malic enzyme, nadp-mdh, nadp-dependent malic enzyme, nadp-dependent malate dehydrogenase, nadp-me2, malic enzyme 1, nadp malic enzyme, nadp-me1, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malic enzyme
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L-malate:NADP oxidoreductase
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malate dehydrogenase (decarboxylating, NADP)
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malate dehydrogenase (NADP, decarboxylating)
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malic enzyme
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NADP+ dependent malic enzyme
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NADP-linked decarboxylating malic enzyme
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NADP-malic enzyme
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NADP-ME
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NADP-specific malate dehydrogenase
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NADP-specific malic enzyme
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pyruvic-malic carboxylase
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TME
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
decarboxylation
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redox reaction
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oxidation
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reduction
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SYSTEMATIC NAME
IUBMB Comments
(S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)
The enzyme catalyses the oxidative decarboxylation of (S)-malate in the presence of NADP+ and divalent metal ions, and the decarboxylation of oxaloacetate. cf. EC 1.1.1.38, malate dehydrogenase (oxaloacetate-decarboxylating), and EC 1.1.1.39, malate dehydrogenase (decarboxylating).
CAS REGISTRY NUMBER
COMMENTARY hide
9028-47-1
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(S)-malate + NADP+
pyruvate + CO2 + NADPH
show the reaction diagram
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-
-
r
(S)-malate + NADP+
pyruvate + CO2 + NADPH
show the reaction diagram
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-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
(S)-malate + NADP+
pyruvate + CO2 + NADPH
show the reaction diagram
-
-
-
r
(S)-malate + NADP+
pyruvate + CO2 + NADPH
show the reaction diagram
-
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
during adipocyte differentiation, there is coordinate upregulation of ATP citrate lyase and cytosolic malic enzyme (ME1), which together with cytosolic malate dehydro­genase and at the expense of 1 ATP molecule, can convert citrate and NADH into acetyl-CoA, NADPH and pyruvate
physiological function
significance of malic enzyme in fat synthesis. Malic enzyme is the main NADPH source in nor­moxic 3T3-L1 adipocytes, with total NADPH production more than double that from the oxidative pentose phosphate path­way
additional information
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
MAOX_MOUSE
572
0
63954
Swiss-Prot
other Location (Reliability: 5)
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Liu, L.; Shah, S.; Fan, J.; Park, J.O.; Wellen, K.E.; Rabinowitz, J.D.
Malic enzyme tracers reveal hypoxia-induced switch in adipocyte NADPH pathway usage
Nat. Chem. Biol.
12
345-352
2016
Mus musculus, Mus musculus (P06801)
Manually annotated by BRENDA team