This bacterial enzyme is involved, along with EC 1.1.1.52, 3alpha-hydroxycholanate dehydrogenase (NAD+), or EC 1.1.1.392, 3alpha-hydroxycholanate dehydrogenase (NADP+), in the modification of secondary bile acids to form 3beta-bile acids (also known as iso-bile acids). The enzyme catalyses the reaction in the reduction direction in vivo. Also acts on related 3-oxo bile acids. cf. EC 1.1.1.391, 3beta-hydroxycholanate 3-dehydrogenase (NAD+).
Specify your search results
The enzyme appears in viruses and cellular organisms
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYSTEMATIC NAME
IUBMB Comments
isolithocholate:NADP+ 3-oxidoreductase
This bacterial enzyme is involved, along with EC 1.1.1.52, 3alpha-hydroxycholanate dehydrogenase (NAD+), or EC 1.1.1.392, 3alpha-hydroxycholanate dehydrogenase (NADP+), in the modification of secondary bile acids to form 3beta-bile acids (also known as iso-bile acids). The enzyme catalyses the reaction in the reduction direction in vivo. Also acts on related 3-oxo bile acids. cf. EC 1.1.1.391, 3beta-hydroxycholanate 3-dehydrogenase (NAD+).
the organism also possesses 3beta-hyoxysteroid dehydrogenase activity that is active with the same substrate as the 3beta-hyoxysteroid dehydrogenase but is specific for 7beta-hydroxy groups, overview
the organism also possesses 3beta-hyoxysteroid dehydrogenase activity that is active with the same substrate as the 3beta-hyoxysteroid dehydrogenase but is specific for 7beta-hydroxy groups, overview
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
CLONED/commentary
ORGANISM
UNIPROT
LITERATURE
gene Rumgna_00694, DNA and amino acid sequence determination and analysis, encoded in a three-gene cluster that does not include any additional putative bile acid-metabolic genes, recombinant overvexpression in Escherichia coli
Chen, M.; Drury, J.E.; Christianson, D.W.; Penning, T.M.
Conversion of human steroid 5beta-reductase (AKR1D1) into 3beta-hydroxysteroid dehydrogenase by single point mutation E120H: example of perfect enzyme engineering
HOME
login
history
all enzymes
BRENDA home
History
1.1.1.393 3beta-hydroxycholanate 3-dehydrogenase (NADP+)
more
top
Information
