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EC Tree
IUBMB Comments This bacterial enzyme is involved in the modification of secondary bile acids to form 3beta-bile acids (also known as iso-bile acids) via a 3-oxo intermediate. The enzyme catalyses a reversible reaction in vitro. Also acts on related bile acids. cf. EC 1.1.1.52, 3alpha-hydroxycholanate dehydrogenase (NAD+).
The enzyme appears in viruses and cellular organisms
Synonyms
3alpha-HSDH, alpha-hydroxy-cholanate dehydrogenase,
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alpha-hydroxy-cholanate dehydrogenase
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ambiguous
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3alpha-HSDH
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lithocholate + NADP+ = 3-oxo-5beta-cholan-24-oate + NADPH + H+
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lithocholate:NADP+ 3-oxidoreductase
This bacterial enzyme is involved in the modification of secondary bile acids to form 3beta-bile acids (also known as iso-bile acids) via a 3-oxo intermediate. The enzyme catalyses a reversible reaction in vitro. Also acts on related bile acids. cf. EC 1.1.1.52, 3alpha-hydroxycholanate dehydrogenase (NAD+).
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12alpha-hydroxy-3-oxo-5beta-cholan-24-oic acid + NADH + H+
3alpha,12alpha-dihydroxy-5beta-cholan-24-oic acid + NAD+
12alpha-hydroxy-3-oxo-5beta-cholan-24-oic acid + NADH + H+
3alpha,12alpha-dihydroxy-5beta-cholan-24-oic acid + NAD+
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12alpha-hydroxy-3-oxo-5beta-cholan-24-oic acid + NADH + H+
3alpha,12alpha-dihydroxy-5beta-cholan-24-oic acid + NAD+
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12alpha-hydroxy-3-oxo-5beta-cholan-24-oic acid + NADH + H+
3alpha,12alpha-dihydroxy-5beta-cholan-24-oic acid + NAD+
12alpha-hydroxy-3-oxo-5beta-cholan-24-oic acid + NADH + H+
3alpha,12alpha-dihydroxy-5beta-cholan-24-oic acid + NAD+
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12alpha-hydroxy-3-oxo-5beta-cholan-24-oic acid + NADH + H+
3alpha,12alpha-dihydroxy-5beta-cholan-24-oic acid + NAD+
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1280
12alpha-Hydroxy-3-oxo-5beta-cholan-24-oic acid
pH 7.0, 37°C
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4.85
12alpha-Hydroxy-3-oxo-5beta-cholan-24-oic acid
pH 7.0, 37°C
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gene Elen_0690
UniProt
brenda
gene Elen_0690
UniProt
brenda
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metabolism
the enzyme is involved in the biosynthetic pathway for the second most abundant class in the gut, 3beta-hydroxy(iso)bile acids
metabolism
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the enzyme is involved in the biosynthetic pathway for the second most abundant class in the gut, 3beta-hydroxy(iso)bile acids
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physiological function
the isoâbile acid pathway detoxifies deoxycholic acid and thus favors the growth of the keystone genus Bacteroides
physiological function
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the isoâbile acid pathway detoxifies deoxycholic acid and thus favors the growth of the keystone genus Bacteroides
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gene Elen_0690, DNA and amino acid sequence determination and analysis, recombinant overvexpression in Escherichia coli
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Devlin, A.; Fischbach, M.
A biosynthetic pathway for a prominent class of microbiota-derived bile acids
Nat. Chem. Biol.
11
685-690
2015
Eggerthella lenta (C8WMP0), Eggerthella lenta ATCC 25559 (C8WMP0)
brenda
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