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IUBMB Comments The enzyme from the archaeon Methanococcus maripaludis is activated by KCl (200 mM).
Synonyms
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UDP-N-acetyl-alpha-D-glucosamine + NAD+ = UDP-2-acetamido-3-dehydro-2-deoxy-alpha-D-glucopyranose + NADH + H+
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MetaCyc
UDP-3-acetamido-2-amino-2,3-dideoxy-alpha-D-glucopyranose biosynthesis
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UDP-N-acetyl-alpha-D-glucosamine:NAD+ 3-oxidoreductase
The enzyme from the archaeon Methanococcus maripaludis is activated by KCl (200 mM).
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UDP-N-acetyl-alpha-D-glucosamine + NAD+
UDP-2-acetamido-3-dehydro-2-deoxy-alpha-D-glucopyranose + NADH + H+
UDP-N-acetyl-alpha-D-glucosamine + NAD+
UDP-2-acetamido-3-dehydro-2-deoxy-alpha-D-glucopyranose + NADH + H+
Substrates: the enzyme is involved in the biosynthesis of glycan component sugars
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UDP-N-acetyl-alpha-D-glucosamine + NAD+
UDP-2-acetamido-3-dehydro-2-deoxy-alpha-D-glucopyranose + NADH + H+
Substrates: no activity is detected when NAD+ is replaced with NADP+. The MMP0352 protein does not catalyze the oxidation of the substrate analogs UDPGlc, UDPGalNAc, N-acetylglucosamine, and glucosamine
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UDP-N-acetyl-alpha-D-glucosamine + NAD+
UDP-2-acetamido-3-dehydro-2-deoxy-alpha-D-glucopyranose + NADH + H+
Substrates: the enzyme is involved in the biosynthesis of glycan component sugars
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K+
activity is 85% lower in the absence of KCl as compared with reactions containing 200 mM KCl
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UDP
2 mM, reduces activity by 50%
UDP-alpha-D-glucose
2 mM, reduces activity by 50%
UDP-alpha-N-acetyl-D-galactosamine
3 mM, reduces activity by 50%
additional information
N-acetyl-D-glucosamine, D-glucose, and D-glucosamine do not inhibit the reaction at 3-mM concentrations
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additional information
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N-acetyl-D-glucosamine, D-glucose, and D-glucosamine do not inhibit the reaction at 3-mM concentrations
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0.18
UDP-N-acetyl-alpha-D-glucosamine
pH 8.5, 37°C
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0.9
UDP-N-acetyl-alpha-D-glucosamine
pH 8.5, 37°C
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5
UDP-N-acetyl-alpha-D-glucosamine
pH 8.5, 37°C
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UniProt
brenda
Highest Expressing Human Cell Lines
Filter by:
Cell Line Links
Gene Links
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physiological function
the enzyme is involved in the biosynthesis of glycan component sugars
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GNNA_ACIF2
Acidithiobacillus ferrooxidans (strain ATCC 23270 / DSM 14882 / CIP 104768 / NCIMB 8455)
313
0
34048
Swiss-Prot
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UGNO_METMP
Methanococcus maripaludis (strain DSM 14266 / JCM 13030 / NBRC 101832 / S2 / LL)
311
0
34363
Swiss-Prot
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39000
8 * 39000, SDS-PAGE
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octamer
8 * 39000, SDS-PAGE
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-80°C, stable for at least several weeks in 20% glycerol
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expression in Escherichia coli BL21(DE3)
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analysis
high-throughput chromatographic analysis of UDPGlcNAc in a complex matrix of deproteinized cell extract
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Namboori, S.C.; Graham, D.E.
Enzymatic analysis of uridine diphosphate N-acetyl-D-glucosamine
Anal. Biochem.
381
94-100
2008
Methanococcus maripaludis (Q6M0B9), Methanococcus maripaludis
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