The enzyme, found in the bacterium Bacillus subtilis, also catalyses the reaction of EC 1.1.1.18, inositol 2-dehydrogenase, and can also use D-glucose and D-xylose. It shows trace activity with D-ribose and D-fructose . It is part of a myo-inositol/D-chiro-inositol degradation pathway leading to acetyl-CoA.
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The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
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SYSTEMATIC NAME
IUBMB Comments
1D-chiro-inositol:NAD+ 1-oxidoreductase
The enzyme, found in the bacterium Bacillus subtilis, also catalyses the reaction of EC 1.1.1.18, inositol 2-dehydrogenase, and can also use D-glucose and D-xylose. It shows trace activity with D-ribose and D-fructose [1]. It is part of a myo-inositol/D-chiro-inositol degradation pathway leading to acetyl-CoA.
the enzyme can remove only the single equatorial hydrogen of the cyclitol or pyranose ring. Inositol dehydrogenase requires NAD+ and does not react with 2-deoxy-D-glucose or scyllo-inositol. Enzyme also functions as inositol dehydrogenase and accepts alpha-D-glucose and D-xylose
the enzyme can remove only the single equatorial hydrogen of the cyclitol or pyranose ring. Inositol dehydrogenase requires NAD+ and does not react with 2-deoxy-D-glucose or scyllo-inositol. Enzyme also functions as inositol dehydrogenase and accepts alpha-D-glucose and D-xylose
The enzyme also catalyses the reaction of EC 1.1.1.18, inositol 2-dehydrogenase, and can also use D-glucose and D-xylose. Inositol is the preferred substrate
The enzyme also catalyses the reaction of EC 1.1.1.18, inositol 2-dehydrogenase, and can also use D-glucose and D-xylose. Inositol is the preferred substrate
enzyme forms part of the iol operon for myo-inositol catabolism, consisting of 10 iol genes, iolA to iolJ. iolG corresponds to idh, encoding myo-inositol 2-dehydrogenase. Disruption of the iol promoter prevents synthesis of the iol transcript as well as that of Idh. Immediately upstream of the iol operon, two genes iolR and iolS with divergent orientations to the iol operon are localized. Disruption of iolR but not iolS causes constitutive synthesis of the iol transcript and Idh. The iolRS genes are cotranscribed from another inositol-inducible promoter
enzyme forms part of the iol operon for myo-inositol catabolism, consisting of 10 iol genes, iolA to iolJ. iolG corresponds to idh, encoding myo-inositol 2-dehydrogenase. Disruption of the iol promoter prevents synthesis of the iol transcript as well as that of Idh. Immediately upstream of the iol operon, two genes iolR and iolS with divergent orientations to the iol operon are localized. Disruption of iolR but not iolS causes constitutive synthesis of the iol transcript and Idh. The iolRS genes are cotranscribed from another inositol-inducible promoter
Yoshida, K.; Yamaguchi, M.; Morinaga, T.; Ikeuchi, M.; Kinehara, M.; Ashida, H.
Genetic modification of Bacillus subtilis for production of D-chiro-inositol, an investigational drug candidate for treatment of type 2 diabetes and polycystic ovary syndrome
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1.1.1.369 D-chiro-inositol 1-dehydrogenase
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