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Enzyme Nomenclature
Information on EC 1.1.1.369 - D-chiro-inositol 1-dehydrogenase
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The expected taxonomic range for this enzyme is: Bacteria
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EC NUMBER 
COMMENTARY 
1.1.1.369
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RECOMMENDED NAME
GeneOntology No.
D-chiro-inositol 1-dehydrogenase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
1D-chiro-inositol + NAD+ = 2D-2,3,5/4,6-pentahydroxycyclohexanone + NADH + H+
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
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SYSTEMATIC NAME
IUBMB Comments
1D-chiro-inositol:NAD+ 1-oxidoreductase
The enzyme, found in the bacterium Bacillus subtilis, also catalyses the reaction of EC 1.1.1.18, inositol 2-dehydrogenase, and can also use D-glucose and D-xylose. It shows trace activity with D-ribose and D-fructose [1]. It is part of a myo-inositol/D-chiro-inositol degradation pathway leading to acetyl-CoA.
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
physiological function
physiological function
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enzyme forms part of the iol operon for myo-inositol catabolism, consisting of 10 iol genes, iolA to iolJ. iolG corresponds to idh, encoding myo-inositol 2-dehydrogenase. Disruption of the iol promoter prevents synthesis of the iol transcript as well as that of Idh. Immediately upstream of the iol operon, two genes iolR and iolS with divergent orientations to the iol operon are localized. Disruption of iolR but not iolS causes constitutive synthesis of the iol transcript and Idh. The iolRS genes are cotranscribed from another inositol-inducible promoter
physiological function
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enzyme forms part of the iol operon for myo-inositol catabolism, consisting of 10 iol genes, iolA to iolJ. iolG corresponds to idh, encoding myo-inositol 2-dehydrogenase. Disruption of the iol promoter prevents synthesis of the iol transcript as well as that of Idh. Immediately upstream of the iol operon, two genes iolR and iolS with divergent orientations to the iol operon are localized. Disruption of iolR but not iolS causes constitutive synthesis of the iol transcript and Idh. The iolRS genes are cotranscribed from another inositol-inducible promoter
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
1D-chiro-inositol + NAD+
2D-2,3,5/4,6-pentahydroxycyclohexanone + NADH + H+
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the enzyme is part of a myo-inositol/D-chiro-inositol degradation pathway leading to acetyl-CoA
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r
1D-chiro-inositol + NAD+
2D-2,3,5/4,6-pentahydroxycyclohexanone + NADH + H+
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1D-chiro-inositol i.e. 1,2,4/3,5,6-cyclohexane-1,2,3,4,5,6-hexol
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r
1D-chiro-inositol + NAD+
2D-2,3,5/4,6-pentahydroxycyclohexanone + NADH + H+
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the enzyme is part of a myo-inositol/D-chiro-inositol degradation pathway leading to acetyl-CoA
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r
1D-chiro-inositol + NAD+
2D-2,3,5/4,6-pentahydroxycyclohexanone + NADH + H+
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1D-chiro-inositol i.e. 1,2,4/3,5,6-cyclohexane-1,2,3,4,5,6-hexol
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r
1D-chiro-inositol + NAD+
2D-2,3,5/4,6-pentahydroxycyclohexanone + NADH + H+
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?
1D-chiro-inositol + NAD+
2D-2,3,5/4,6-pentahydroxycyclohexanone + NADH + H+
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?
additional information
?
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the enzyme can remove only the single equatorial hydrogen of the cyclitol or pyranose ring. Inositol dehydrogenase requires NAD+ and does not react with 2-deoxy-D-glucose or scyllo-inositol. Enzyme also functions as inositol dehydrogenase and accepts alpha-D-glucose and D-xylose
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additional information
?
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the enzyme can remove only the single equatorial hydrogen of the cyclitol or pyranose ring. Inositol dehydrogenase requires NAD+ and does not react with 2-deoxy-D-glucose or scyllo-inositol. Enzyme also functions as inositol dehydrogenase and accepts alpha-D-glucose and D-xylose
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additional information
?
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The enzyme also catalyses the reaction of EC 1.1.1.18, inositol 2-dehydrogenase, and can also use D-glucose and D-xylose. Inositol is the preferred substrate
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additional information
?
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The enzyme also catalyses the reaction of EC 1.1.1.18, inositol 2-dehydrogenase, and can also use D-glucose and D-xylose. Inositol is the preferred substrate
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
1D-chiro-inositol + NAD+
2D-2,3,5/4,6-pentahydroxycyclohexanone + NADH + H+
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the enzyme is part of a myo-inositol/D-chiro-inositol degradation pathway leading to acetyl-CoA
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r
1D-chiro-inositol + NAD+
2D-2,3,5/4,6-pentahydroxycyclohexanone + NADH + H+
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the enzyme is part of a myo-inositol/D-chiro-inositol degradation pathway leading to acetyl-CoA
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r
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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pI VALUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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SUBUNITS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
tetramer
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
enzyme synthesis is induced by myo-inositol
enzyme synthesis is repressed by D-glucose
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LINKS TO OTHER DATABASES (specific for EC-Number 1.1.1.369)
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