Information on EC 1.1.1.364 - dTDP-4-dehydro-6-deoxy-alpha-D-gulose 4-ketoreductase

for references in articles please use BRENDA:EC1.1.1.364

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EC Tree 1 Oxidoreductases 1.1 Acting on the CH-OH group of donors 1.1.1 With NAD⁺ or NADP⁺ as acceptor 1.1.1.364 dTDP-4-dehydro-6-deoxy-alpha-D-gulose 4-ketoreductase

IUBMB Comments

The enzyme forms an activated deoxy-α-D-allose, which is converted to mycinose after attachment to the aglycones of several macrolide antibiotics, including tylosin, chalcomycin, dihydrochalcomycin, and mycinamicin II.

The expected taxonomic range for this enzyme is: Bacteria, Archaea

Reaction Schemes

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dTDP-6-deoxy-alpha-D-allose

NAD(P)+

dTDP-4-dehydro-6-deoxy-alpha-D-gulose

NAD(P)H

H+

Synonyms
GerKI, more

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SYNONYM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

GerKI

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REACTION

REACTION DIAGRAM

COMMENTARY

ORGANISM

UNIPROT

LITERATURE

dTDP-6-deoxy-alpha-D-allose + NAD(P)+ = dTDP-4-dehydro-6-deoxy-alpha-D-gulose + NAD(P)H + H+

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PATHWAY SOURCE

PATHWAYS

BRENDA

dTDPLrhamnose biosynthesis

KEGG

Biosynthesis of secondary metabolites, Polyketide sugar unit biosynthesis

MetaCyc

dTDP-6-deoxy-alpha-D-allose biosynthesis

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SYSTEMATIC NAME

IUBMB Comments

dTDP-6-deoxy-alpha-D-allose:NAD(P)+ oxidoreductase

The enzyme forms an activated deoxy-alpha-D-allose, which is converted to mycinose after attachment to the aglycones of several macrolide antibiotics, including tylosin, chalcomycin, dihydrochalcomycin, and mycinamicin II.

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SUBSTRATE

PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

LITERATURE

COMMENTARY

Reversibility
r=reversible
ir=irreversible
?=not specified

dTDP-4-dehydro-6-deoxy-alpha-D-gulopyranose + NADH + H+

dTDP-6-deoxy-alpha-D-allopyranose + NAD+

2 entries

dTDP-4-dehydro-6-deoxy-alpha-D-gulopyranose + NADH + H+

dTDP-6-deoxy-alpha-D-allopyranose + NAD+

Streptomyces sp.

Q331Q7

722341

Substrates: the enzyme forms an activated deoxy-alpha-D-allose, which is converted to mycinose after attachment to the aglycones of several macrolide antibiotics, including tylosin, chalcomycin, dihydrochalcomycin, and mycinamicin II
Products: -

dTDP-4-dehydro-6-deoxy-alpha-D-gulopyranose + NADH + H+

dTDP-6-deoxy-alpha-D-allopyranose + NAD+

Streptomyces sp.

Q331Q7

722341

Substrates: dTDP-4-dehydro-6-deoxy-alpha-D-gulose i.e. dTDP-4-dehydro-6-deoxy-alpha-D-allose
Products: -

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

LITERATURE

COMMENTARY

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

dTDP-4-dehydro-6-deoxy-alpha-D-gulopyranose + NADH + H+

dTDP-6-deoxy-alpha-D-allopyranose + NAD+

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COFACTOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

NADH

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METALS and IONS

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

Mg2+

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only manually annotated data include textmining data from AMENDAenzyme occurrence in organism, localization and source tissue with reliability ranks include all textmining data from AMENDAenzyme occurrence in organism, localization and source tissue with reliability ranks + FRENDAco-occurrence of enzyme names and organism names (less precise)

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ORGANISM

COMMENTARY

LITERATURE

UNIPROT

SEQUENCE DB

SOURCE

Streptomyces sp.

722341

Q331Q7

SwissProt

brenda

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Highest Expressing Human Cell Lines

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

physiological function

Streptomyces sp.

Q331Q7

the enzyme forms an activated deoxy-alpha-D-allose, which is converted to mycinose after attachment to the aglycones of several macrolide antibiotics, including tylosin, chalcomycin, dihydrochalcomycin, and mycinamicin II

722341

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UNIPROT

ENTRY NAME

ORGANISM

NO. OF AA

NO. OF TRANSM. HELICES

MOLECULAR WEIGHT[Da]

SOURCE

SEQUENCE

LOCALIZATION PREDICTION

The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).

Q5SFA6 pBLAST

CHMD_STRBI

Streptomyces bikiniensis

326

36411

Swiss-Prot