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Information on EC 1.1.1.362 - aklaviketone reductase

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IUBMB Comments
The enzyme is involved in the synthesis of the aklavinone aglycone, a common precursor for several anthracycline antibiotics including aclacinomycins, daunorubicin and doxorubicin. The enzyme from the Gram-negative bacterium Streptomyces sp. C5 produces daunomycin.
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The expected taxonomic range for this enzyme is: Streptomyces sp.
Reaction Schemes
Synonyms
DauE, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
aklavinone + NADP+ = aklaviketone + NADPH + H+
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