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Information on EC 1.1.1.36 - acetoacetyl-CoA reductase
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EC Tree
1.1.1.36 acetoacetyl-CoA reductaseSpecify your search results
Word Map
- 1.1.1.36
- polyhydroxyalkanoate
- beta-ketothiolase
- eutropha
-
ralstonia
-
poly3-hydroxybutyrate
- cupriavidus
- necator
-
medium-chain-length
-
2-enoyl-coa
- 3-hydroxyhexanoate
-
enoyl
-
poly3-hydroxybutyrate-co-3-hydroxyhexanoate
-
short-chain-length
- ramigera
- 3-hydroxyalkanoate
-
3r-hydroxyacyl-coas
- trans-2-enoyl-coa
-
phbhhx
-
pha-negative
-
zoogloea
-
r-3-hydroxybutyrate
-
copolyesters
- 3-hydroxyvalerate
-
poly3-hydroxybutyrate-co-3-hydroxyvalerate
- 3-ketothiolase
- scp-2
- synthesis
- biotechnology
The enzyme appears in viruses and cellular organisms
Synonyms
acetoacetyl-coa reductase, mfe-2, akr1b15, nadph-dependent acetoacetyl-coa reductase, ketoacyl reductase, d-3-hydroxyacyl-coa dehydrogenase, (3r)-hydroxyacyl-coa dehydrogenase, acetoacetyl coa reductase, nadh-preferring acetoacetyl-coa reductase, nadph-linked acetoacetyl-coa reductase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
(3R)-hydroxyacyl-CoA dehydrogenase
(R)-3-hydroxyacyl-CoA dehydrogenase
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-
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AAR
AcAc-CoA reductase
acetoacetyl CoA reductase
acetoacetyl coenzyme A reductase
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-
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acetoacetyl-CoA reductase
beta-ketoacyl reductase
beta-ketoacyl-CoA reductase
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-
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D(-)-beta-hydroxybutyryl CoA-NADP oxidoreductase
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-
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D-3-hydroxyacyl-CoA dehydrogenase
D-3-hydroxyacyl-CoA reductase
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-
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hydroxyacyl coenzyme-A dehydrogenase
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-
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ketoacyl reductase
MFE-2
MSMEG_6753
NADH-preferring acetoacetyl-CoA reductase
NADP-linked acetoacetyl CoA reductase
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-
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NADPH-dependent acetoacetyl-CoA reductase
NADPH-dependent acetoacetyl-coenzyme A reductase
NADPH:acetoacetyl-CoA reductase
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-
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PHA-specific acetoacetyl-CoA reductase
PhaB
PhbB
polyhydroxyalkanoate-specific acetoacetyl coenzyme A reductase
short chain beta-ketoacetyl(acetoacetyl)-CoA reductase
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-
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additional information
(3R)-hydroxyacyl-CoA dehydrogenase
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domain of multifunctional enzyme type 2 (MFE-2), (3R)-hydroxyacyl-CoA dehydrogenase/2-enoyl-CoA hydratase 2
(3R)-hydroxyacyl-CoA dehydrogenase
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domain of multifunctional enzyme type 2 (MFE-2), (3R)-hydroxyacyl-CoA dehydrogenase/2-enoyl-CoA hydratase 2
(3R)-hydroxyacyl-CoA dehydrogenase
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domain of multifunctional enzyme type 2 (MFE-2), (3R)-hydroxyacyl-CoA dehydrogenase/2-enoyl-CoA hydratase 2
D-3-hydroxyacyl-CoA dehydrogenase
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part of the multifunctional protein (MFP) containing crotonase, L-3-hydroxyacyl-CoA dehydrogenase, 2-enoyl-CoA hydratase 2 and 3-hydroxyacyl-CoA epimerase
D-3-hydroxyacyl-CoA dehydrogenase
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part of the multifunctional protein (MFP) containing crotonase, L-3-hydroxyacyl-CoA dehydrogenase, 2-enoyl-CoA hydratase 2 and 3-hydroxyacyl-CoA epimerase
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NADH-preferring acetoacetyl-CoA reductase
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NADPH-dependent acetoacetyl-CoA reductase
Cupriavidus necator H16 / ATCC 23440 / NCIB 10442 / S-10-1
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polyhydroxyalkanoate-specific acetoacetyl coenzyme A reductase
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-
additional information
FabG belongs to the short-chain dehydrogenase/reductase superfamily, whose members are homologous in sequence and have several conserved motifs
additional information
FabG belongs to the short-chain dehydrogenase/reductase superfamily, whose members are homologous in sequence and have several conserved motifs
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
(R)-3-hydroxyacyl-CoA + NADP+ = 3-oxoacyl-CoA + NADPH + H+
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-
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(R)-3-hydroxyacyl-CoA + NADP+ = 3-oxoacyl-CoA + NADPH + H+
catalytic site structure and catalytic triad Ser151, Tyr164, and Lys168
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
redox reaction
redox reaction
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-
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-
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PATHWAY SOURCE
PATHWAYS
KEGG
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SYSTEMATIC NAME
IUBMB Comments
(R)-3-hydroxyacyl-CoA:NADP+ oxidoreductase
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CAS REGISTRY NUMBER
COMMENTARY
9028-41-5
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(3R)-3-hydroxydecanoyl-CoA + NADP+
3-oxodecanoyl-CoA + NADPH + H+
-
(3R)-hydroxyacyl-CoA dehydrogenase
-
-
?
(3R)-hydroxyhexadecanoyl-CoA + NADP+
3-oxohexadecanoyl-CoA + NADPH + H+
-
-
-
-
?
(R)-3-hydroxybutyryl-CoA
trans-2-butenoyl-CoA + H2O
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dehydration, multifunctional type 2 enzyme
-
-
?
(R)-3-hydroxybutyryl-CoA + NAD+
acetoacetyl-CoA + NADH
-
oxidation, multifunctional type 2 enzyme
-
-
?
(R)-3-hydroxybutyryl-CoA + NADPH + H+
3-oxobutyryl-CoA + NADP+
-
-
-
-
r
2-methylacetoacetyl-CoA + NADPH
2-methyl-3-hydroxybutyryl-CoA + NADP+
-
-
-
?
acetoacetyl-CoA + NADH + H+
D-3-hydroxybutyryl-CoA + NAD+
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PHA-synthesis
-
ir
acetoacetyl-CoA + NADPH
?
-
biosynthesis of poly(D-3-hydroxybutyrate)
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-
?
acetoacetyl-CoA + NADPH + H+
(R)-3-hydroxybutanoyl-CoA +NADP+
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-
-
-
r
acetoacetyl-pantetheine + NADPH + H+
D-3-hydroxybutyryl-pantetheine + NADP+
-
-
-
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r
acetoacetyl-S-(D-pantetheine)11-pivalate + NADPH
3-hydroxybutyryl-S-(D-pantetheine)11-pivalate + NADP+
-
-
-
?
(R)-3-hydroxyacyl-CoA + NADP+
3-oxoacyl-CoA + NADPH + H+
-
-
-
r
(R)-3-hydroxyacyl-CoA + NADP+
3-oxoacyl-CoA + NADPH + H+
Cupriavidus necator H16 / ATCC 23440 / NCIB 10442 / S-10-1
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-
-
r
(R)-3-hydroxybutyryl-CoA + NAD+
acetoacetyl-CoA + NADH + H+
-
-
-
r
(R)-3-hydroxybutyryl-CoA + NAD+
acetoacetyl-CoA + NADH + H+
-
-
-
r
3-oxoacyl-CoA + NADPH + H+
(R)-3-hydroxyacyl-CoA + NADP+
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-
-
r
acetoacetyl-CoA + NADH + H+
(R)-3-hydroxybutyryl-CoA + NAD+
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-
-
r
acetoacetyl-CoA + NADH + H+
(R)-3-hydroxybutyryl-CoA + NAD+
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-
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r
acetoacetyl-CoA + NADH + H+
3-hydroxybutyryl-CoA + NAD+
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-
-
?
acetoacetyl-CoA + NADH + H+
3-hydroxybutyryl-CoA + NAD+
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-
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?
acetoacetyl-CoA + NADH + H+
D-beta-hydroxybutyryl-CoA + NAD+
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-
-
?
acetoacetyl-CoA + NADH + H+
L-3-hydroxybutyryl-CoA + NAD+
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-
-
-
?
acetoacetyl-CoA + NADH + H+
L-3-hydroxybutyryl-CoA + NAD+
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-
-
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?
acetoacetyl-CoA + NADH + H+
L-3-hydroxybutyryl-CoA + NAD+
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-
-
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?
acetoacetyl-CoA + NADH + H+
L-3-hydroxybutyryl-CoA + NAD+
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-
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?
acetoacetyl-CoA + NADH + H+
L-3-hydroxybutyryl-CoA + NAD+
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-
-
?
acetoacetyl-CoA + NADH + H+
L-3-hydroxybutyryl-CoA + NAD+
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low activity
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r
acetoacetyl-CoA + NADH + H+
L-beta-hydroxybutyryl-CoA + NAD+
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reverse only with L-form
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r
acetoacetyl-CoA + NADH + H+
L-beta-hydroxybutyryl-CoA + NAD+
Methylorubrum rhodesianum MB 126
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reverse only with L-form
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r
acetoacetyl-CoA + NADPH + H+
(3R)-3-hydroxybutyryl-CoA + NADP+
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-
-
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?
acetoacetyl-CoA + NADPH + H+
(3R)-3-hydroxybutyryl-CoA + NADP+
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-
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r
acetoacetyl-CoA + NADPH + H+
(3R)-3-hydroxybutyryl-CoA + NADP+
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r
acetoacetyl-CoA + NADPH + H+
(3R)-3-hydroxybutyryl-CoA + NADP+
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r
acetoacetyl-CoA + NADPH + H+
(3R)-3-hydroxybutyryl-CoA + NADP+
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-
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r
acetoacetyl-CoA + NADPH + H+
(R)-3-hydroxybutyryl-CoA + NADP+
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-
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?
acetoacetyl-CoA + NADPH + H+
(R)-3-hydroxybutyryl-CoA + NADP+
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?
acetoacetyl-CoA + NADPH + H+
(R)-3-hydroxybutyryl-CoA + NADP+
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r
acetoacetyl-CoA + NADPH + H+
(R)-3-hydroxybutyryl-CoA + NADP+
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step in the biosynthesis of polyhydroxybutyrate, a biodegradable thermoplastic polymer
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-
?
acetoacetyl-CoA + NADPH + H+
(R)-3-hydroxybutyryl-CoA + NADP+
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step in the enzyme-catalyzed synthesis system for production of poly(3-hydroxybutyrate) in vitro, overview
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?
acetoacetyl-CoA + NADPH + H+
(R)-3-hydroxybutyryl-CoA + NADP+
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-
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r
acetoacetyl-CoA + NADPH + H+
(R)-3-hydroxybutyryl-CoA + NADP+
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-
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?
acetoacetyl-CoA + NADPH + H+
(R)-3-hydroxybutyryl-CoA + NADP+
FabG1 exhibits NADPH-dependent activity of acetoacetyl-CoA reductase
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?
acetoacetyl-CoA + NADPH + H+
(R)-3-hydroxybutyryl-CoA + NADP+
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-
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?
acetoacetyl-CoA + NADPH + H+
(R)-3-hydroxybutyryl-CoA + NADP+
FabG1 exhibits NADPH-dependent activity of acetoacetyl-CoA reductase
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-
?
acetoacetyl-CoA + NADPH + H+
(R)-3-hydroxybutyryl-CoA + NADP+
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-
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?
acetoacetyl-CoA + NADPH + H+
(R)-3-hydroxybutyryl-CoA + NADP+
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-
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?
acetoacetyl-CoA + NADPH + H+
D-3-hydroxybutyryl-CoA + NADP+
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PHB synthesis
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?
acetoacetyl-CoA + NADPH + H+
D-3-hydroxybutyryl-CoA + NADP+
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PHB synthesis
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?
acetoacetyl-CoA + NADPH + H+
D-3-hydroxybutyryl-CoA + NADP+
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PHB synthesis
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-
?
acetoacetyl-CoA + NADPH + H+
D-3-hydroxybutyryl-CoA + NADP+
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PHB synthesis
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?
acetoacetyl-CoA + NADPH + H+
D-3-hydroxybutyryl-CoA + NADP+
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tricarboxylic acid cycle, poly-3-hydroxybutyrate synthesis, aerobic serine pathway
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r
acetoacetyl-CoA + NADPH + H+
D-3-hydroxybutyryl-CoA + NADP+
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tricarboxylic acid cycle, poly-3-hydroxybutyrate synthesis, aerobic serine pathway
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r
acetoacetyl-CoA + NADPH + H+
D-3-hydroxybutyryl-CoA + NADP+
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PHB synthesis
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?
acetoacetyl-CoA + NADPH + H+
D-3-hydroxybutyryl-CoA + NADP+
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high activity
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r
acetoacetyl-CoA + NADPH + H+
D-3-hydroxybutyryl-CoA + NADP+
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PHB synthesis
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?
acetoacetyl-CoA + NADPH + H+
D-3-hydroxybutyryl-CoA + NADP+
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PHB synthesis
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?
acetoacetyl-CoA + NADPH + H+
D-3-hydroxybutyryl-CoA + NADP+
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PHB synthesis
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r
acetoacetyl-CoA + NADPH + H+
D-3-hydroxybutyryl-CoA + NADP+
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PHB synthesis
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r
acetoacetyl-CoA + NADPH + H+
D-beta-hydroxybutyryl-CoA + NADP+
-
-
-
?
acetoacetyl-CoA + NADPH + H+
D-beta-hydroxybutyryl-CoA + NADP+
-
-
-
-
?
acetoacetyl-CoA + NADPH + H+
D-beta-hydroxybutyryl-CoA + NADP+
-
reverse only with D-form
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r
acetoacetyl-CoA + NADPH + H+
D-beta-hydroxybutyryl-CoA + NADP+
Methylorubrum rhodesianum MB 126
-
-
-
-
?
acetoacetyl-CoA + NADPH + H+
D-beta-hydroxybutyryl-CoA + NADP+
Methylorubrum rhodesianum MB 126
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reverse only with D-form
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r
D-3-hydroxyacyl-CoA + NAD+
3-ketoacyl-CoA + NADH + H+
-
-
-
-
?
S-acetoacetyl-N-acetylcysteamine + NADPH
3-hydroxybutyryl-N-acetylcysteamine + NADP+
-
-
-
?
S-acetoacetyl-N-acetylcysteamine + NADPH
3-hydroxybutyryl-N-acetylcysteamine + NADP+
-
-
-
?
S-acetoacetyl-N-acetylcysteamine + NADPH
3-hydroxybutyryl-N-acetylcysteamine + NADP+
-
-
-
?
S-acetoacetyl-N-acetylcysteamine + NADPH
3-hydroxybutyryl-N-acetylcysteamine + NADP+
Pigeon
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-
-
?
S-acetoacetyl-N-acetylcysteamine + NADPH
3-hydroxybutyryl-N-acetylcysteamine + NADP+
-
-
-
?
S-acetoacetyl-N-acetylcysteamine + NADPH
3-hydroxybutyryl-N-acetylcysteamine + NADP+
-
-
-
?
S-acetoacetyl-N-acetylcysteamine + NADPH
3-hydroxybutyryl-N-acetylcysteamine + NADP+
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-
-
-
?
additional information
?
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KCR catalyzes the first reduction during elongation of very-long-chain fatty acids, VLCFA, precursors of sphingolipids, triacylglycerols, cuticular waxes, and suberin in plants
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-
?
additional information
?
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the N-terminal enzyme part harbors 2 different (3R)-hydroxyacyl-CoA dehydrogenase activities with different substrate specificities, while the 2-enoyl-CoA hydratase 2 activity is located in the C-terminus
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-
?
additional information
?
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no oxidation of (R/S)-3-hydroxybutyryl-CoA is detected when using NADP+ as cofactor
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-
-
additional information
?
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no oxidation of (R/S)-3-hydroxybutyryl-CoA is detected when using NADP+ as cofactor
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-
-
additional information
?
-
no activity is detected when NADPH is replaced by NADH
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-
-
additional information
?
-
-
no activity is detected when NADPH is replaced by NADH
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-
-
additional information
?
-
no activity is detected when NADPH is replaced by NADH
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-
-
additional information
?
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a point mutation in the dehydrogenase region of the enzyme causes peroxisomal disease leading to severe abnormalities and an early death
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-
?
additional information
?
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-
not: D-3-hydroxyacyl-CoA's with chain length exceeding 6
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-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(R)-3-hydroxybutyryl-CoA
trans-2-butenoyl-CoA + H2O
-
dehydration, multifunctional type 2 enzyme
-
-
?
(R)-3-hydroxybutyryl-CoA + NAD+
acetoacetyl-CoA + NADH
-
oxidation, multifunctional type 2 enzyme
-
-
?
(R)-3-hydroxybutyryl-CoA + NADPH + H+
3-oxobutyryl-CoA + NADP+
-
-
-
-
r
acetoacetyl-CoA + NADH + H+
D-3-hydroxybutyryl-CoA + NAD+
-
PHA-synthesis
-
ir
acetoacetyl-CoA + NADPH
?
-
biosynthesis of poly(D-3-hydroxybutyrate)
-
-
?
(R)-3-hydroxyacyl-CoA + NADP+
3-oxoacyl-CoA + NADPH + H+
-
-
-
r
(R)-3-hydroxyacyl-CoA + NADP+
3-oxoacyl-CoA + NADPH + H+
Cupriavidus necator H16 / ATCC 23440 / NCIB 10442 / S-10-1
-
-
-
r
(R)-3-hydroxybutyryl-CoA + NAD+
acetoacetyl-CoA + NADH + H+
-
-
-
r
(R)-3-hydroxybutyryl-CoA + NAD+
acetoacetyl-CoA + NADH + H+
-
-
-
r
3-oxoacyl-CoA + NADPH + H+
(R)-3-hydroxyacyl-CoA + NADP+
-
-
-
r
acetoacetyl-CoA + NADH + H+
(R)-3-hydroxybutyryl-CoA + NAD+
-
-
-
r
acetoacetyl-CoA + NADH + H+
(R)-3-hydroxybutyryl-CoA + NAD+
-
-
-
r
acetoacetyl-CoA + NADH + H+
3-hydroxybutyryl-CoA + NAD+
-
-
-
?
acetoacetyl-CoA + NADH + H+
3-hydroxybutyryl-CoA + NAD+
-
-
-
?
acetoacetyl-CoA + NADH + H+
3