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Information on EC 1.1.1.358 - 2-dehydropantolactone reductase

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IUBMB Comments
The enzyme participates in an alternative pathway for biosynthesis of (R)-pantothenate (vitamin B5). This entry covers enzymes whose stereo specificity for NADP+ is not known. cf. EC 1.1.1.168 2-dehydropantolactone reductase (Re-specific) and EC 1.1.1.214, 2-dehydropantolactone reductase (Si-specific).
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Word Map
  • 1.1.1.358
  • sirtuins
  • deacetylation
  • histone
  • resveratrol
  • nad+-dependent
  • nicotinamide
  • longevity
  • nad+
  • lifespan
  • sirt1-mediated
  • calorie
  • sirtinol
  • sirts
  • high-fat
  • proliferator-activated
  • cardiomyocytes
  • mating
  • forkhead
  • sirt1-dependent
  • cr
  • diet-induced
  • caspase-3
  • polyphenolic
  • foxo3a
  • anti-aging
  • amp-activated
  • hdacs
  • senescence-associated
  • aging-associated
  • srebp-1c
  • cardioprotective
  • aging-related
  • mating-type
  • dinucleotide-dependent
  • sirt1-7
  • coactivator-1
  • hyperacetylation
  • resveratrol-induced
  • mir-34a
  • nafld
  • non-histone
  • pgc-1alpha
  • nampt
The expected taxonomic range for this enzyme is: Candida parapsilosis
Synonyms
ketopantoyl-lactone reductase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+
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PATHWAY SOURCE
PATHWAYS
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