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Information on EC 1.1.1.356 - GDP-L-colitose synthase

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IUBMB Comments
The enzyme is involved in biosynthesis of L-colitose, a 3,6-dideoxyhexose found in the O-antigen of Gram-negative lipopolysaccharides, where it catalyses the reaction in the reverse direction. The enzyme also performs the NAD(P)H-dependent epimerisation at C-5 of the sugar. The enzyme from Yersinia pseudotuberculosis is Si-specific with respect to NAD(P)H .
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The expected taxonomic range for this enzyme is: Yersinia pseudotuberculosis
Synonyms
ColC, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
GDP-beta-L-colitose + NAD(P)+ = GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NAD(P)H + H+
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PATHWAY SOURCE
PATHWAYS
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